ClinicalTrials.gov record
The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)
ClinicalTrials.gov ID: NCT06383390
Public ClinicalTrials.gov record NCT06383390. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Event-Driven Study to Investigate the Effect of Retatrutide on the Incidence of Major Adverse Cardiovascular Events and Major Adverse Kidney Events in Participants With Body Mass Index ≥27 kg/m2 and Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function. The trial will enroll adults with body mass index 27 kg/m\^2 or higher and Atherosclerotic Cardiovascular Disease and/or chronic kidney disease. The study will last for about 5 years. Participants will have up to 27 clinic visits with the study doctor.
Study identification
- NCT ID
- NCT06383390
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 10,000 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 45 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 30, 2024 (Actual)
- Primary completion
- Feb 2029 (Estimated)
- Completion
- Feb 2029 (Estimated)
- Last update posted
- Oct 8, 2026
2024 – 2029
United States locations
- U.S. sites
- 204
- U.S. states
- 34
- U.S. cities
- 162
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alabama Kidney Research | Alabaster | Alabama | 35007 | — |
| Central Research Associates | Birmingham | Alabama | 35205 | — |
| Alliance for Multispecialty Research, LLC | Daphne | Alabama | 36526 | — |
| Nephrology Consultants | Huntsville | Alabama | 35805 | — |
| Alliance for Multispecialty Research, LLC | Mobile | Alabama | 36608 | — |
| Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC | Gilbert | Arizona | 85296 | — |
| Sun City Clinical Research | Glendale | Arizona | 85304 | — |
| Arizona Kidney Disease & Hypertension Center (AKDHC) - Thunderbird | Glendale | Arizona | 85306 | — |
| Helios Clinical Research - SAZ-PDV-026 | Paradise Valley | Arizona | 85253 | — |
| Banner University Medical Center Phoenix | Phoenix | Arizona | 85006 | — |
| Elite Clinical Studies, LLC | Phoenix | Arizona | 85018 | — |
| Absolute Clinical Research | Phoenix | Arizona | 85051 | — |
| Scottsdale Clinical Trials | Scottsdale | Arizona | 85260 | — |
| Clinical Research Institute of Arizona (CRI) - Sun City West | Sun City West | Arizona | 85375 | — |
| Synexus Clinical Research US, Inc./Orange Grove Family Practice | Tucson | Arizona | 85741 | — |
| Cardiology and Medicine Clinic | Little Rock | Arkansas | 72204 | — |
| Trident Clinical Research Services, Inc. | Apple Valley | California | 92307 | — |
| Invivo - Bakersfield | Bakersfield | California | 93309 | — |
| American Institute of Research | Beverly Hills | California | 90211 | — |
| Hope Clinical Research, Inc. | Canoga Park | California | 91303 | — |
| Valley Clinical Trials, Inc. | Covina | California | 91723 | — |
| North Coast Cardiology | Encinitas | California | 92024 | — |
| Neighborhood Healthcare Institute of Health | Escondido | California | 92025 | — |
| HB Clinical Trials - Fountain Valley | Fountain Valley | California | 92708 | — |
| Care Access - Huntington Beach | Huntington Beach | California | 92648 | — |
| Irvine Clinical Research | Irvine | California | 92614 | — |
| Scripps Whittier Diabetes Institute | La Jolla | California | 92037 | — |
| Long Beach Research Institute | Long Beach | California | 90805 | — |
| Ark Clinical Research | Long Beach | California | 90815 | — |
| North America Research Institute | Lynwood | California | 90262 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| Desert Oasis Healthcare Medical Group | Palm Springs | California | 92262 | — |
| California Liver Research Institute | Pasadena | California | 91105 | — |
| Western University of Health Sciences | Pomona | California | 91766 | — |
| California Kidney Specialists | San Dimas | California | 91773 | — |
| Southern California Clinical Research | Santa Ana | California | 92701 | — |
| Care Access - Santa Clarita | Santa Clarita | California | 91321 | — |
| Encompass Clinical Research | Spring Valley | California | 91978 | — |
| Valiance Clinical Research | Tarzana | California | 91356 | — |
| Care Access - Thousand Oaks | Thousand Oaks | California | 91360 | — |
| Med Partners, Inc. dba Premiere Medical Center of Burbank, Inc. | Toluca Lake | California | 91602 | — |
| Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Torrance | California | 90502 | — |
| UCLA South Bay Endocrinology | Torrance | California | 90505 | — |
| InvivoCure | Van Nuys | California | 91405 | — |
| National Institute of Clinical Research (NICR) - High Desert | Victorville | California | 92392 | — |
| Synexus Clinical Research US, Inc. | Vista | California | 92083 | — |
| Millennium Clinical Trials | Westlake Village | California | 91361 | — |
| Western Nephrology | Arvada | Colorado | 80002 | — |
| University of Colorado Anschutz Medical Campus | Aurora | Colorado | 80045 | — |
| Cardiology Associates of Fairfield County, P.C. | Stamford | Connecticut | 06905 | — |
| Chase Medical Research, LLC | Waterbury | Connecticut | 06708 | — |
| Omega Research Orlando | Altamonte Springs | Florida | 32714 | — |
| Excel Medical Clinical Trials | Boca Raton | Florida | 33434 | — |
| American Research Institute | Cutler Bay | Florida | 33157 | — |
| Fleming Island Center for Clinical Research | Fleming Island | Florida | 32003 | — |
| Jellinger and Lerman, MD PA dba The Center for Diabetes and Endocrine Care | Fort Lauderdale | Florida | 33312 | — |
| Florida Kidney Physicians - Fort Lauderdale | Fort Lauderdale | Florida | 33316 | — |
| East Coast Institute for Research, LLC | Jacksonville | Florida | 32216 | — |
| Lakeview Institute of Clinical Research | Leesburg | Florida | 34748 | — |
| Flourish Research - Miami, LLC | Miami | Florida | 33135 | — |
| New Age Medical Research Corporation | Miami | Florida | 33186 | — |
| Onhealth Research Center | Miami | Florida | 33186 | — |
| Inpatient Research Clinic | Miami Lakes | Florida | 33014 | — |
| CTR Oakwater, LLC | Orlando | Florida | 32806 | — |
| Florida Kidney Physicians, LLC | Port Charlotte | Florida | 33952 | — |
| Florida Kidney Physicians - Tampa | Riverview | Florida | 33578 | — |
| Cardiovascular Center of Sarasota | Sarasota | Florida | 34239 | — |
| Care Access - Tamarac | Tamarac | Florida | 33321 | — |
| MOORE Clinical Research, Inc. d/b/a TrueBlue Clinical Research | Tampa | Florida | 33607 | — |
| Care Access - Tampa | Tampa | Florida | 33625 | — |
| American Clinical Trials - Acworth | Acworth | Georgia | 30101 | — |
| Atlanta Diabetes Associates | Atlanta | Georgia | 30318 | — |
| Emory University School of Medicine | Atlanta | Georgia | 30322 | — |
| Fides Clinical Research | Atlanta | Georgia | 30342 | — |
| Southeastern Clinical Research Institute | Augusta | Georgia | 30904 | — |
| American Clinical Trials - Douglasville | Douglasville | Georgia | 30134 | — |
| Center for Advanced Research & Education | Gainesville | Georgia | 30501 | — |
| The Jones Center Clinical Research | Macon | Georgia | 31210 | — |
| North Georgia Clinical Research | Woodstock | Georgia | 30189 | — |
| Great Lakes Clinical Trials - Ravenswood | Chicago | Illinois | 60640 | — |
| Clinical Investigation Specialists | Gurnee | Illinois | 60031 | — |
| Nephrology Associates of Northern Illinois and Indiana (NANI) - Hinsdale | Hinsdale | Illinois | 60521 | — |
| Accellacare - DuPage | Lombard | Illinois | 60148 | — |
| Alliance for Multispecialty Research, LLC | Niles | Illinois | 60714 | — |
| Rockford Nephrology Associates | Rockford | Illinois | 61107 | — |
| Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative | Springfield | Illinois | 62711 | — |
| Qualmedica Research, LLC | Evansville | Indiana | 47715 | — |
| Nephrology Associates of Northern Illinois and Indiana (NANI) - Fort Wayne | Fort Wayne | Indiana | 46804 | — |
| Indiana University Health Methodist Hospital | Indianapolis | Indiana | 46202 | — |
| Nephrology Associates of Northern Illinois and Indiana - IKS - Indianapolis South | Indianapolis | Indiana | 46227 | — |
| Care Access - South Indianapolis | Indianapolis | Indiana | 46254 | — |
| Reid Physician Associates | Richmond | Indiana | 47374 | — |
| Iowa Diabetes and Endocrinology Research Center | West Des Moines | Iowa | 50266 | — |
| The University of Kansas - Clinical Research Center | Fairway | Kansas | 66205 | — |
| Alliance for Multispecialty Research, LLC | Newton | Kansas | 67114 | — |
| Cotton O'Neil Clinical Research Center | Topeka | Kansas | 66606 | — |
| Cotton O'Neil Diabetes & Endocrinology | Topeka | Kansas | 66606 | — |
| Qualmedica Research | Bowling Green | Kentucky | 42101 | — |
| Alliance for Multispecialty Research, LLC | Lexington | Kentucky | 40509 | — |
| Monroe Biomedical Research - Louisville | Louisville | Kentucky | 40213 | — |
| Care Access - Lake Charles | Lake Charles | Louisiana | 70601 | — |
| IMA Clinical Research Monroe - Armand | Monroe | Louisiana | 71201 | — |
| Alliance for Multispecialty Research, LLC | New Orleans | Louisiana | 70119 | — |
| Sinai Hospital Of Baltimore | Baltimore | Maryland | 21209 | — |
| Care Access - Baltimore | Baltimore | Maryland | 21213 | — |
| Ascension Saint Agnes Heart Care | Baltimore | Maryland | 21229 | — |
| MedStar Good Samaritan Hospital | Baltimore | Maryland | 21239 | — |
| Jadestone Clinical Research | Beltsville | Maryland | 20705 | — |
| Anderson Medical Research | Ft. Washington | Maryland | 20744 | — |
| MedStar Health Research Institute (MedStar Physician Based Research Network) | Hyattsville | Maryland | 20782 | — |
| NECCR PrimaCare Research | Fall River | Massachusetts | 02721 | — |
| Care Access - Quincy | Quincy | Massachusetts | 02169 | — |
| Revival Research Institute, LLC | Dearborn | Michigan | 48126 | — |
| Elixia MKC, LLC | Pontiac | Michigan | 48341 | — |
| Lake Michigan Nephrology | Saint Joseph | Michigan | 49085 | — |
| Great Lakes Research Institute | Southfield | Michigan | 48075 | — |
| Arcturus Healthcare , PLC, Troy Internal Medicine Research Division | Troy | Michigan | 48098 | — |
| StudyMetrix Research | City of Saint Peters | Missouri | 63303 | — |
| Alliance for Multispecialty Research, LLC | Kansas City | Missouri | 64114 | — |
| Clinvest Headlands Llc | Springfield | Missouri | 65807 | — |
| Mercury Street Medical Group, PLLC | Butte | Montana | 59701 | — |
| Boeson Research MSO | Missoula | Montana | 59804 | — |
| Henderson Clinical Trials | Henderson | Nevada | 89052 | — |
| DaVita Clinical Research - Las Vegas | Las Vegas | Nevada | 89107 | — |
| Excel Clinical Research, LLC | Las Vegas | Nevada | 89109 | — |
| Alliance for Multispecialty Research, LLC | Las Vegas | Nevada | 89119 | — |
| Advanced Biomedical Research of America - South Eastern Avenue | Las Vegas | Nevada | 89123 | — |
| Vector Clinical Trials | Las Vegas | Nevada | 89128 | — |
| Albany Medical College, Division of Community Endocrinology | Albany | New York | 12203 | — |
| Capital Cardiology Associates | Albany | New York | 12211 | — |
| Westchester Medical Center Advanced Physicians Service | Kingston | New York | 12401 | — |
| St. Francis Hospital & Heart Center | New Hyde Park | New York | 11576 | — |
| NYU Langone Health | New York | New York | 10016 | — |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | — |
| Saratoga Clinical Research | Saratoga Springs | New York | 12866 | — |
| Care Access - Fayetteville | Fayetteville | North Carolina | 28314 | — |
| Medication Management | Greensboro | North Carolina | 27401 | — |
| Physician's East Endocrinology | Greenville | North Carolina | 27834 | — |
| IMA Clinical Research - Lenoir | Lenoir | North Carolina | 28645 | — |
| West Clinical Research | Morehead City | North Carolina | 28557 | — |
| Accellacare - Raleigh | Raleigh | North Carolina | 27609 | — |
| Accellacare - Wilmington - 1917 Tradd Court | Wilmington | North Carolina | 28401 | — |
| Advanced Medical Research | Maumee | Ohio | 43537 | — |
| Alliance for Multispecialty Research, LLC | Norman | Oklahoma | 73069 | — |
| Heritage Valley Multispecialty Group, Inc | Beaver | Pennsylvania | 15009 | — |
| Northeast Clinical Research Center | Bethlehem | Pennsylvania | 18017 | — |
| Capital Area Research, LLC | Camp Hill | Pennsylvania | 17011 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | — |
| Lancaster General Hospital | Lancaster | Pennsylvania | 17602 | — |
| Clinical Renal Associates Ltd. | Media | Pennsylvania | 19063 | — |
| Tristar Clinical Investigations | Philadelphia | Pennsylvania | 19114 | — |
| Preferred Primary Care Physicians, Preferred Clinical Research-St. Clair | Pittsburgh | Pennsylvania | 15243 | — |
| Guthrie Medical Group, P.C. | Sayre | Pennsylvania | 18840 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Walker Family Care | Little River | South Carolina | 29566 | — |
| Care Access - Mauldin | Mauldin | South Carolina | 29662 | — |
| Circle Clinical Research | Sioux Falls | South Dakota | 57104 | — |
| Alliance for Multispecialty Research, LLC | Knoxville | Tennessee | 37920 | — |
| Care Access - Memphis 2 | Memphis | Tennessee | 38119 | — |
| IMA Clinical Research Austin | Austin | Texas | 78745 | — |
| Headlands Research - Brownsville | Brownsville | Texas | 78526 | — |
| South Texas Clinical Research | Corpus Christi | Texas | 78404 | — |
| Private Practice - Dr. Osvaldo A. Brusco | Corpus Christi | Texas | 78414 | — |
| Baylor Soltero CV Research Center | Dallas | Texas | 75226 | — |
| Velocity Clinical Research, Dallas | Dallas | Texas | 75230 | — |
| North Texas Endocrine Center | Dallas | Texas | 75231 | — |
| Renal Disease Research Institute | Dallas | Texas | 75246 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75390-9302 | — |
| Soma Clinical Trials | Denison | Texas | 75020 | — |
| South Texas Research Institute | Edinburg | Texas | 78539 | — |
| Medresearch Inc | El Paso | Texas | 79902-4646 | — |
| Diabetes and Thyroid Center of Ft. Worth | Fort Worth | Texas | 76132 | — |
| Valley Institute of Research - Fort Worth | Fort Worth | Texas | 76164 | — |
| Juno Research | Houston | Texas | 77040 | — |
| Biopharma Informatic, LLC | Houston | Texas | 77043 | — |
| Aqua Research Institute | Houston | Texas | 77058 | — |
| Northwest Houston Cardiology - Cypress | Houston | Texas | 77070 | — |
| Clinical Trial Network | Houston | Texas | 77074 | — |
| PlanIt Research, PLLC | Houston | Texas | 77079 | — |
| Biopharma Informatic, LLC | Houston | Texas | 77084 | — |
| Research Physicians Network, LLC | Houston | Texas | 77089 | — |
| Accurate Clinical Research, Inc | Humble | Texas | 77346 | — |
| Texas Institute for Kidney and Endocrine Disorders | Lufkin | Texas | 75904 | — |
| Wellness Clinical Research | McKinney | Texas | 75069 | — |
| Revival Research Institute, LLC | McKinney | Texas | 75071 | — |
| PRX Research | Mesquite | Texas | 75149 | — |
| Southern Endocrinology Associates | Mesquite | Texas | 75149 | — |
| Clinical Advancement Center | San Antonio | Texas | 78212 | — |
| Discovery Clinical Trials - San Antonio | San Antonio | Texas | 78229 | — |
| IMA Clinical Research San Antonio | San Antonio | Texas | 78229 | — |
| Endeavor Clinical Trials | San Antonio | Texas | 78240 | — |
| DaVita Clinical Research - North Houston | Shenandoah | Texas | 77384 | — |
| Medrasa Clinical Research | Wylie | Texas | 75098 | — |
| Alpine Research Organization | Clinton | Utah | 84015 | — |
| Alliance for Multispecialty Research, LLC | Layton | Utah | 84041 | — |
| Synexus Clinical Research US, Inc. | Salt Lake City | Utah | 84106 | — |
| Utah Kidney Research Institute | Salt Lake City | Utah | 84115 | — |
| Alliance for Multispecialty Research, LLC | Norfolk | Virginia | 23502 | — |
| Dominion Medical Associates, Inc. | Richmond | Virginia | 23219 | — |
| Eastside Research Associates | Redmond | Washington | 98052 | — |
| Universal Research Group | Tacoma | Washington | 98405 | — |
| IMA Clinical Research West Virginia | Morgantown | West Virginia | 26505 | — |
| St. Vincent Hospital d/b/a Prevea Health | Green Bay | Wisconsin | 54303 | — |
| Clinical Investigation Specialists | Kenosha | Wisconsin | 53144 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 538 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06383390, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 8, 2026 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06383390 live on ClinicalTrials.gov.