Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing

ClinicalTrials.gov ID: NCT06406114

Public ClinicalTrials.gov record NCT06406114. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jul 21, 2026, 6:59 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Study identification

NCT ID: NCT06406114
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Massachusetts General Hospital; Other
Enrollment: 300 participants

Conditions and interventions

Conditions

Interventions

Beta-lactam antibiotic (cefazolin, cefuroxime, cefotaxime, ceftazidime, ceftriaxone, cefepime, pre-pen, penicillin G, ampicillin, and histamine) double-blind skin testing Drug
Culprit cephalosporin (cefazolin, ceftazidime, ceftriaxone, cefepime, cephalexin, cefaclor, cefadroxil, cefuroxime, cefpodoxime, cefdinir, or cefixime) double-blind placebo-controlled drug challenge Drug
Similar cephalosporin (cefepime, ceftriaxone, cefaclor, cephalexin, cefixime, or cefdinir) antibiotic double-blind placebo-controlled drug challenge Drug
Dissimilar cephalosporin (ceftriaxone or cefazolin) antibiotic double-blind placebo-controlled drug challenge Drug
Amoxicillin double-blind placebo-controlled drug challenge Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 70 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: May 4, 2025
Primary completion: Jun 30, 2028
Completion: Dec 30, 2028
Last update posted: May 25, 2026

2025 – 2028

United States locations

U.S. sites: 6
U.S. states: 6
U.S. cities: 6

Facility	City	State	ZIP	Site status
Mayo Clinic Arizona	Scottsdale	Arizona	14607	Recruiting
University of California, San Francisco	San Francisco	California	94143	Recruiting
Massachusetts General Hospital	Boston	Massachusetts	02114	Recruiting
Rochester General Hospital	Rochester	New York	14621	Recruiting
Vanderbilt University Medical Center	Nashville	Tennessee	37232	Recruiting
University of Texas Southwestern Medical Center	Dallas	Texas	75390	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06406114, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 25, 2026 · Synced Jul 21, 2026

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The complete protocol, eligibility criteria, and contact information for NCT06406114 live on ClinicalTrials.gov.

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