A Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM).

ClinicalTrials.gov ID: NCT06412666

Public ClinicalTrials.gov record NCT06412666. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jul 21, 2026, 7:53 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2/3 Multicenter, Randomized, Double-Blind, Placebo-Controlled and Open-Label Extension Trial to Evaluate the Efficacy and Safety of Aficamten in a Pediatric Population With Symptomatic Obstructive Hypertrophic Cardiomyopathy

Study identification

NCT ID: NCT06412666
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2, Phase 3
Lead sponsor: Cytokinetics; Industry
Enrollment: 55 participants

Conditions and interventions

Conditions

Interventions

Aficamten Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 12 Years to 17 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: May 28, 2024
Primary completion: Dec 31, 2029
Completion: Dec 31, 2029
Last update posted: Apr 12, 2026

2024 – 2030

United States locations

U.S. sites: 26
U.S. states: 20
U.S. cities: 25

Facility	City	State	ZIP	Site status
Phoenix Children's Hospital	Phoenix	Arizona	85016	Recruiting
Children's Hospital Los Angeles	Los Angeles	California	90027	Recruiting
University of California, Los Angeles (UCLA)	Los Angeles	California	90095	Recruiting
UCSF Benioff Children's Hospital	San Francisco	California	94158	Not yet recruiting
Children's Hospital Colorado	Aurora	Colorado	80045	Recruiting
Children's National Hospital	Washington D.C.	District of Columbia	20010	Recruiting
Nicklaus Children's Hospital	Miami	Florida	33155	Recruiting
Ann & Robert H. Lurie Children's Hospital	Chicago	Illinois	60611	Recruiting
University of Iowa	Iowa City	Iowa	52242	Withdrawn
Children's Hospital New Orleans	New Orleans	Louisiana	70018	Recruiting
University of Michigan	Ann Arbor	Michigan	48109	Recruiting
Children's Hospital of Michigan	Detroit	Michigan	48201	Recruiting
Mayo Clinic	Rochester	Minnesota	55905	Recruiting
Children's Mercy Hospital	Kansas City	Missouri	64108	Recruiting
University of Nebraska Medical Center	Omaha	Nebraska	68198	Recruiting
Morristown Medical Center	Morristown	New Jersey	07960	Recruiting
NYP/Columbia University Medical Center	New York	New York	10027	Recruiting
Children's Hospital at Montefiore	The Bronx	New York	10467	Recruiting
Duke Clinical Research Institute	Durham	North Carolina	27701	Recruiting
Oregon Health & Science University	Portland	Oregon	97239	Recruiting
Children's Hospital of Philadelphia	Philadelphia	Pennsylvania	19104	Recruiting
LeBonheur Children's Hospital	Memphis	Tennessee	38103	Recruiting
Vanderbilt University Medical Center	Nashville	Tennessee	37235	Recruiting
Dell Children's Hospital	Austin	Texas	78723	Recruiting
UT Southwestern	Dallas	Texas	75390	Recruiting
Children's Wisconsin	Milwaukee	Wisconsin	53226	Not yet recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 12 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06412666, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 12, 2026 · Synced Jul 21, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06412666 live on ClinicalTrials.gov.

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