Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas

ClinicalTrials.gov ID: NCT06422806

Public ClinicalTrials.gov record NCT06422806. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 4:31 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized Phase III Trial of Doxorubicin + Pembrolizumab Versus Doxorubicin Alone for the Treatment of Dedifferentiated Liposarcoma (DDLPS), Undifferentiated Pleomorphic Sarcoma (UPS) and Related Poorly Differentiated Sarcomas

Study identification

NCT ID: NCT06422806
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: National Cancer Institute (NCI); NIH
Enrollment: 365 participants

Conditions and interventions

Conditions

Interventions

Biospecimen Collection Procedure
Diagnostic Imaging Testing Procedure
Doxorubicin Drug
Echocardiography Test Procedure
Multigated Acquisition Scan Procedure
Pembrolizumab Biological

Procedure · Drug · Biological

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Sep 10, 2024
Primary completion: Jun 29, 2026
Completion: Jun 29, 2026
Last update posted: May 6, 2026

2024 – 2026

United States locations

U.S. sites: 240
U.S. states: 35
U.S. cities: 198

Facility	City	State	ZIP	Site status
Mayo Clinic Hospital in Arizona	Phoenix	Arizona	85054	Recruiting
Banner University Medical Center - Tucson	Tucson	Arizona	85719	Recruiting
University of Arizona Cancer Center-North Campus	Tucson	Arizona	85719	Recruiting
Kaiser Permanente Dublin	Dublin	California	94568	Recruiting
Kaiser Permanente-Fremont	Fremont	California	94538	Recruiting
Kaiser Permanente Fresno Orchard Plaza	Fresno	California	93720	Recruiting
Kaiser Permanente-Fresno	Fresno	California	93720	Recruiting
UC San Diego Moores Cancer Center	La Jolla	California	92093	Recruiting
Keck Medicine of USC Koreatown	Los Angeles	California	90020	Recruiting
Los Angeles General Medical Center	Los Angeles	California	90033	Recruiting
USC / Norris Comprehensive Cancer Center	Los Angeles	California	90033	Recruiting
Cedars-Sinai Medical Center	Los Angeles	California	90048	Recruiting
Kaiser Permanente- Modesto MOB II	Modesto	California	95356	Recruiting
Kaiser Permanente-Modesto	Modesto	California	95356	Recruiting
USC Norris Oncology/Hematology-Newport Beach	Newport Beach	California	92663	Recruiting
Kaiser Permanente-Oakland	Oakland	California	94611	Recruiting
Stanford Cancer Institute Palo Alto	Palo Alto	California	94304	Recruiting
VA Palo Alto Health Care System	Palo Alto	California	94304	Suspended
Huntington Memorial Hospital	Pasadena	California	91105	Recruiting
Kaiser Permanente-Roseville	Roseville	California	95661	Recruiting
Kaiser Permanente Downtown Commons	Sacramento	California	95814	Recruiting
Kaiser Permanente-South Sacramento	Sacramento	California	95823	Recruiting
Kaiser Permanente-San Francisco	San Francisco	California	94115	Recruiting
UCSF Medical Center-Mission Bay	San Francisco	California	94158	Recruiting
Kaiser Permanente-Santa Teresa-San Jose	San Jose	California	95119	Recruiting
Kaiser Permanente San Leandro	San Leandro	California	94577	Recruiting
Kaiser San Rafael-Gallinas	San Rafael	California	94903	Recruiting
Kaiser Permanente Medical Center - Santa Clara	Santa Clara	California	95051	Recruiting
Kaiser Permanente-Santa Rosa	Santa Rosa	California	95403	Recruiting
Kaiser Permanente-South San Francisco	South San Francisco	California	94080	Recruiting
Kaiser Permanente-Vallejo	Vallejo	California	94589	Recruiting
Kaiser Permanente-Walnut Creek	Walnut Creek	California	94596	Recruiting
UCHealth University of Colorado Hospital	Aurora	Colorado	80045	Recruiting
Poudre Valley Hospital	Fort Collins	Colorado	80524	Recruiting
Cancer Care and Hematology-Fort Collins	Fort Collins	Colorado	80528	Recruiting
UCHealth Greeley Hospital	Greeley	Colorado	80631	Recruiting
Medical Center of the Rockies	Loveland	Colorado	80538	Recruiting
Smilow Cancer Hospital-Derby Care Center	Derby	Connecticut	06418	Recruiting
Smilow Cancer Hospital Care Center-Fairfield	Fairfield	Connecticut	06824	Recruiting
Smilow Cancer Hospital Care Center at Greenwich	Greenwich	Connecticut	06830	Recruiting
Smilow Cancer Hospital Care Center - Guilford	Guilford	Connecticut	06437	Recruiting
Yale University	New Haven	Connecticut	06520	Recruiting
Smilow Cancer Hospital Care Center at Long Ridge	Stamford	Connecticut	06902	Recruiting
Smilow Cancer Hospital-Torrington Care Center	Torrington	Connecticut	06790	Recruiting
Smilow Cancer Hospital Care Center-Trumbull	Trumbull	Connecticut	06611	Recruiting
Smilow Cancer Hospital-Waterbury Care Center	Waterbury	Connecticut	06708	Recruiting
Smilow Cancer Hospital Care Center - Waterford	Waterford	Connecticut	06385	Recruiting
Beebe South Coastal Health Campus	Millville	Delaware	19967	Recruiting
Helen F Graham Cancer Center	Newark	Delaware	19713	Recruiting
Medical Oncology Hematology Consultants PA	Newark	Delaware	19713	Recruiting
Beebe Health Campus	Rehoboth Beach	Delaware	19971	Recruiting
UM Sylvester Comprehensive Cancer Center at Coral Gables	Coral Gables	Florida	33146	Recruiting
UM Sylvester Comprehensive Cancer Center at Coral Springs	Coral Springs	Florida	33065	Recruiting
UM Sylvester Comprehensive Cancer Center at Deerfield Beach	Deerfield Beach	Florida	33442	Recruiting
UF Health Cancer Institute - Gainesville	Gainesville	Florida	32610	Recruiting
UM Sylvester Comprehensive Cancer Center at Hollywood	Hollywood	Florida	33021	Recruiting
Mayo Clinic in Florida	Jacksonville	Florida	32224-9980	Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center	Miami	Florida	33136	Recruiting
UM Sylvester Comprehensive Cancer Center at Kendall	Miami	Florida	33176	Recruiting
University of Miami Sylvester Comprehensive Cancer Center at Sole Mia	North Miami	Florida	33181	Recruiting
UM Sylvester Comprehensive Cancer Center at Plantation	Plantation	Florida	33324	Recruiting
Moffitt Cancer Center - McKinley Campus	Tampa	Florida	33612	Recruiting
Moffitt Cancer Center	Tampa	Florida	33612	Recruiting
Emory University Hospital Midtown	Atlanta	Georgia	30308	Recruiting
Kaiser Permanente Moanalua Medical Center	Honolulu	Hawaii	96819	Recruiting
Saint Alphonsus Cancer Care Center-Boise	Boise	Idaho	83706	Suspended
Saint Alphonsus Cancer Care Center-Caldwell	Caldwell	Idaho	83605	Suspended
Kootenai Health - Coeur d'Alene	Coeur d'Alene	Idaho	83814	Recruiting
Saint Alphonsus Cancer Care Center-Nampa	Nampa	Idaho	83687	Suspended
Kootenai Clinic Cancer Services - Post Falls	Post Falls	Idaho	83854	Recruiting
Kootenai Clinic Cancer Services - Sandpoint	Sandpoint	Idaho	83864	Recruiting
Advocate Outpatient Center - Aurora	Aurora	Illinois	60506	Recruiting
Advocate Good Shepherd Hospital	Barrington	Illinois	60010	Recruiting
Illinois CancerCare-Bloomington	Bloomington	Illinois	61704	Recruiting
Illinois CancerCare-Canton	Canton	Illinois	61520	Recruiting
Illinois CancerCare-Carthage	Carthage	Illinois	62321	Recruiting
Centralia Oncology Clinic	Centralia	Illinois	62801	Recruiting
Northwestern University	Chicago	Illinois	60611	Recruiting
University of Illinois	Chicago	Illinois	60612	Recruiting
University of Chicago Comprehensive Cancer Center	Chicago	Illinois	60637	Active, not recruiting
Advocate Illinois Masonic Medical Center	Chicago	Illinois	60657	Recruiting
AMG Crystal Lake - Oncology	Crystal Lake	Illinois	60014	Recruiting
Carle at The Riverfront	Danville	Illinois	61832	Recruiting
Northwestern Medicine Cancer Center Kishwaukee	DeKalb	Illinois	60115	Recruiting
Cancer Care Specialists of Illinois - Decatur	Decatur	Illinois	62526	Recruiting
Decatur Memorial Hospital	Decatur	Illinois	62526	Recruiting
Illinois CancerCare-Dixon	Dixon	Illinois	61021	Recruiting
Advocate Good Samaritan Hospital	Downers Grove	Illinois	60515	Recruiting
Carle Physician Group-Effingham	Effingham	Illinois	62401	Recruiting
Crossroads Cancer Center	Effingham	Illinois	62401	Recruiting
Advocate Sherman Hospital	Elgin	Illinois	60123	Recruiting
Elmhurst Memorial Hospital	Elmhurst	Illinois	60126	Recruiting
Illinois CancerCare-Eureka	Eureka	Illinois	61530	Recruiting
Illinois CancerCare-Galesburg	Galesburg	Illinois	61401	Recruiting
Northwestern Medicine Cancer Center Delnor	Geneva	Illinois	60134	Recruiting
Northwestern Medicine Glenview Outpatient Center	Glenview	Illinois	60026	Recruiting
Northwestern Medicine Grayslake Outpatient Center	Grayslake	Illinois	60030	Recruiting
Ingalls Memorial Hospital	Harvey	Illinois	60426	Active, not recruiting
Advocate South Suburban Hospital	Hazel Crest	Illinois	60429	Recruiting
Illinois CancerCare-Kewanee Clinic	Kewanee	Illinois	61443	Recruiting
Northwestern Medicine Lake Forest Hospital	Lake Forest	Illinois	60045	Recruiting
AMG Libertyville - Oncology	Libertyville	Illinois	60048	Recruiting
Condell Memorial Hospital	Libertyville	Illinois	60048	Recruiting
Illinois CancerCare-Macomb	Macomb	Illinois	61455	Recruiting
Carle Physician Group-Mattoon/Charleston	Mattoon	Illinois	61938	Recruiting
Edward Hospital/Cancer Center	Naperville	Illinois	60540	Recruiting
UC Comprehensive Cancer Center at Silver Cross	New Lenox	Illinois	60451	Active, not recruiting
Cancer Care Center of O'Fallon	O'Fallon	Illinois	62269	Recruiting
Advocate Christ Medical Center	Oak Lawn	Illinois	60453-2699	Recruiting
Northwestern Medicine Orland Park	Orland Park	Illinois	60462	Recruiting
University of Chicago Medicine-Orland Park	Orland Park	Illinois	60462	Active, not recruiting
Illinois CancerCare-Ottawa Clinic	Ottawa	Illinois	61350	Recruiting
Advocate Lutheran General Hospital	Park Ridge	Illinois	60068	Recruiting
Illinois CancerCare-Pekin	Pekin	Illinois	61554	Recruiting
Illinois CancerCare-Peoria	Peoria	Illinois	61615	Recruiting
Illinois CancerCare-Peru	Peru	Illinois	61354	Recruiting
Edward Hospital/Cancer Center?Plainfield	Plainfield	Illinois	60585	Recruiting
Illinois CancerCare-Princeton	Princeton	Illinois	61356	Recruiting
Southern Illinois University School of Medicine	Springfield	Illinois	62702	Recruiting
Springfield Clinic	Springfield	Illinois	62702	Recruiting
Springfield Memorial Hospital	Springfield	Illinois	62781	Recruiting
Carle Cancer Center	Urbana	Illinois	61801	Recruiting
Northwestern Medicine Cancer Center Warrenville	Warrenville	Illinois	60555	Recruiting
Illinois CancerCare - Washington	Washington	Illinois	61571	Recruiting
UChicago Medicine Northwest Indiana	Crown Point	Indiana	46307	Active, not recruiting
Indiana University/Melvin and Bren Simon Cancer Center	Indianapolis	Indiana	46202	Recruiting
Sidney and Lois Eskenazi Hospital	Indianapolis	Indiana	46202	Recruiting
UI Health Care Mission Cancer and Blood - Ankeny Clinic	Ankeny	Iowa	50023	Recruiting
Saint Anthony Regional Hospital	Carroll	Iowa	51401	Recruiting
UI Health Care Mission Cancer and Blood - West Des Moines Clinic	Clive	Iowa	50325	Recruiting
UI Health Care Mission Cancer and Blood - Des Moines Clinic	Des Moines	Iowa	50309	Recruiting
Broadlawns Medical Center	Des Moines	Iowa	50314	Recruiting
UI Health Care Mission Cancer and Blood - Laurel Clinic	Des Moines	Iowa	50314	Recruiting
UI Healthcare Mission Cancer and Blood - Fort Dodge	Fort Dodge	Iowa	50501	Recruiting
University of Iowa/Holden Comprehensive Cancer Center	Iowa City	Iowa	52242	Recruiting
UI Health Care Mission Cancer and Blood - Waukee Clinic	Waukee	Iowa	50263	Recruiting
The James Graham Brown Cancer Center at University of Louisville	Louisville	Kentucky	40202	Recruiting
UofL Health Medical Center Northeast	Louisville	Kentucky	40245	Recruiting
Louisiana Hematology Oncology Associates LLC	Baton Rouge	Louisiana	70809	Suspended
Dana-Farber Cancer Institute	Boston	Massachusetts	02215	Recruiting
University of Michigan Rogel Cancer Center	Ann Arbor	Michigan	48109	Recruiting
Henry Ford Cancer Institute-Downriver	Brownstown	Michigan	48183	Recruiting
Henry Ford Macomb Hospital-Clinton Township	Clinton Township	Michigan	48038	Recruiting
Henry Ford Medical Center-Fairlane	Dearborn	Michigan	48126	Recruiting
Henry Ford Hospital	Detroit	Michigan	48202	Recruiting
Allegiance Health	Jackson	Michigan	49201	Recruiting
Henry Ford Medical Center-Columbus	Novi	Michigan	48377	Recruiting
Henry Ford West Bloomfield Hospital	West Bloomfield	Michigan	48322	Recruiting
Henry Ford Wyandotte Hospital	Wyandotte	Michigan	48192	Recruiting
Sanford Joe Lueken Cancer Center	Bemidji	Minnesota	56601	Recruiting
Mercy Hospital	Coon Rapids	Minnesota	55433	Recruiting
Essentia Health - Deer River Clinic	Deer River	Minnesota	56636	Recruiting
Essentia Health Cancer Center	Duluth	Minnesota	55805	Recruiting
Essentia Health Hibbing Clinic	Hibbing	Minnesota	55746	Recruiting
Abbott-Northwestern Hospital	Minneapolis	Minnesota	55407	Recruiting
Mayo Clinic in Rochester	Rochester	Minnesota	55905	Recruiting
Essentia Health Sandstone	Sandstone	Minnesota	55072	Recruiting
Essentia Health Virginia Clinic	Virginia	Minnesota	55792	Recruiting
Siteman Cancer Center at West County Hospital	Creve Coeur	Missouri	63141	Recruiting
Washington University School of Medicine	St Louis	Missouri	63110	Recruiting
Siteman Cancer Center-South County	St Louis	Missouri	63129	Recruiting
Community Hospital of Anaconda	Anaconda	Montana	59711	Recruiting
Billings Clinic Cancer Center	Billings	Montana	59101	Recruiting
Bozeman Health Deaconess Hospital	Bozeman	Montana	59715	Recruiting
Benefis Sletten Cancer Institute	Great Falls	Montana	59405	Recruiting
Logan Health Medical Center	Kalispell	Montana	59901	Recruiting
Community Medical Center	Missoula	Montana	59804	Recruiting
Nebraska Medicine-Bellevue	Bellevue	Nebraska	68123	Recruiting
Nebraska Medicine-Village Pointe	Omaha	Nebraska	68118	Recruiting
University of Nebraska Medical Center	Omaha	Nebraska	68198	Recruiting
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center	Lebanon	New Hampshire	03756	Recruiting
Memorial Sloan Kettering Basking Ridge	Basking Ridge	New Jersey	07920	Recruiting
Memorial Sloan Kettering Bergen	Montvale	New Jersey	07645	Recruiting
University of New Mexico Cancer Center	Albuquerque	New Mexico	87106	Recruiting
Roswell Park Cancer Institute	Buffalo	New York	14263	Recruiting
Northwell Health/Center for Advanced Medicine	Lake Success	New York	11042	Recruiting
Laura and Isaac Perlmutter Cancer Center at NYU Langone	New York	New York	10016	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
University of Rochester	Rochester	New York	14642	Recruiting
Montefiore Medical Center-Einstein Campus	The Bronx	New York	10461	Recruiting
Montefiore Medical Center - Moses Campus	The Bronx	New York	10467	Recruiting
Memorial Sloan Kettering Nassau	Uniondale	New York	11553	Recruiting
Duke University Medical Center	Durham	North Carolina	27710	Recruiting
Sanford Bismarck Medical Center	Bismarck	North Dakota	58501	Recruiting
Sanford Broadway Medical Center	Fargo	North Dakota	58122	Recruiting
Sanford Roger Maris Cancer Center	Fargo	North Dakota	58122	Recruiting
UH Seidman Cancer Center at UH Avon Health Center	Avon	Ohio	44011	Recruiting
UHHS-Chagrin Highlands Medical Center	Beachwood	Ohio	44122	Recruiting
Miami Valley Hospital South	Centerville	Ohio	45459	Recruiting
Case Western Reserve University	Cleveland	Ohio	44106	Recruiting
Cleveland Clinic Foundation	Cleveland	Ohio	44195	Recruiting
Ohio State University Comprehensive Cancer Center	Columbus	Ohio	43210	Recruiting
Miami Valley Hospital	Dayton	Ohio	45409	Recruiting
Premier Blood and Cancer Center	Dayton	Ohio	45409	Recruiting
Miami Valley Hospital North	Dayton	Ohio	45415	Recruiting
Atrium Medical Center-Middletown Regional Hospital	Franklin	Ohio	45005-1066	Recruiting
Miami Valley Cancer Care and Infusion	Greenville	Ohio	45331	Recruiting
Upper Valley Medical Center	Troy	Ohio	45373	Recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Recruiting
Saint Alphonsus Cancer Care Center-Ontario	Ontario	Oregon	97914	Suspended
Oregon Health and Science University	Portland	Oregon	97239	Recruiting
Pennsylvania Hospital	Philadelphia	Pennsylvania	19107	Recruiting
Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	19107	Recruiting
Fox Chase Cancer Center	Philadelphia	Pennsylvania	19111	Recruiting
Allegheny General Hospital	Pittsburgh	Pennsylvania	15212	Recruiting
University of Pittsburgh Cancer Institute (UPCI)	Pittsburgh	Pennsylvania	15232	Recruiting
Medical University of South Carolina	Charleston	South Carolina	29425	Recruiting
Sanford Cancer Center Oncology Clinic	Sioux Falls	South Dakota	57104	Recruiting
Sanford USD Medical Center - Sioux Falls	Sioux Falls	South Dakota	57117-5134	Recruiting
Vanderbilt University/Ingram Cancer Center	Nashville	Tennessee	37232	Recruiting
University of Virginia Cancer Center	Charlottesville	Virginia	22908	Recruiting
VCU Massey Comprehensive Cancer Center	Richmond	Virginia	23298	Recruiting
ThedaCare Regional Cancer Center	Appleton	Wisconsin	54911	Recruiting
Duluth Clinic Ashland	Ashland	Wisconsin	54806	Recruiting
Aurora Cancer Care-Southern Lakes VLCC	Burlington	Wisconsin	53105	Recruiting
Aurora Saint Luke's South Shore	Cudahy	Wisconsin	53110	Recruiting
Marshfield Medical Center-EC Cancer Center	Eau Claire	Wisconsin	54701	Recruiting
Aurora Health Care Germantown Health Center	Germantown	Wisconsin	53022	Recruiting
Aurora Cancer Care-Grafton	Grafton	Wisconsin	53024	Recruiting
Aurora BayCare Medical Center	Green Bay	Wisconsin	54311	Recruiting
Aurora Cancer Care-Kenosha South	Kenosha	Wisconsin	53142	Recruiting
Aurora Bay Area Medical Group-Marinette	Marinette	Wisconsin	54143	Recruiting
Marshfield Medical Center-Marshfield	Marshfield	Wisconsin	54449	Recruiting
Aurora Cancer Care-Milwaukee	Milwaukee	Wisconsin	53209	Recruiting
Aurora Saint Luke's Medical Center	Milwaukee	Wisconsin	53215	Recruiting
Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting
Aurora Sinai Medical Center	Milwaukee	Wisconsin	53233	Recruiting
ProHealth D N Greenwald Center	Mukwonago	Wisconsin	53149	Recruiting
ProHealth Oconomowoc Memorial Hospital	Oconomowoc	Wisconsin	53066	Recruiting
Vince Lombardi Cancer Clinic - Oshkosh	Oshkosh	Wisconsin	54904	Recruiting
Aurora Cancer Care-Racine	Racine	Wisconsin	53406	Recruiting
Vince Lombardi Cancer Clinic-Sheboygan	Sheboygan	Wisconsin	53081	Recruiting
Marshfield Medical Center-River Region at Stevens Point	Stevens Point	Wisconsin	54482	Recruiting
Aurora Medical Center in Summit	Summit	Wisconsin	53066	Recruiting
Vince Lombardi Cancer Clinic-Two Rivers	Two Rivers	Wisconsin	54241	Recruiting
ProHealth Waukesha Memorial Hospital	Waukesha	Wisconsin	53188	Recruiting
UW Cancer Center at ProHealth Care	Waukesha	Wisconsin	53188	Recruiting
Aurora Cancer Care-Milwaukee West	Wauwatosa	Wisconsin	53226	Recruiting
Aurora West Allis Medical Center	West Allis	Wisconsin	53227	Recruiting
Marshfield Medical Center - Weston	Weston	Wisconsin	54476	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 10 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06422806, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 6, 2026 · Synced May 8, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06422806 live on ClinicalTrials.gov.

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