A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

ClinicalTrials.gov ID: NCT06424288

Public ClinicalTrials.gov record NCT06424288. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 6, 2026, 2:08 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

EASi-HF Preserved - A Phase III Double-blind, Randomised, Parallel-group Superiority Trial to Evaluate Efficacy and Safety of the Combined Use of Oral Vicadrostat (BI 690517) and Empagliflozin Compared With Placebo and Empagliflozin in Participants With Symptomatic Heart Failure (HF: NYHA II-IV) and Left Ventricular Ejection Fraction (LVEF) ≥40%

Study identification

NCT ID: NCT06424288
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Boehringer Ingelheim; Industry
Enrollment: 6,000 participants

Conditions and interventions

Conditions

Heart Failure

Interventions

empagliflozin Drug
placebo Drug
vicadrostat Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 16, 2024
Primary completion: May 21, 2028
Completion: May 21, 2028
Last update posted: Apr 28, 2026

2024 – 2028

United States locations

U.S. sites: 94
U.S. states: 30
U.S. cities: 84

Facility	City	State	ZIP	Site status
Diagnostic and Medical Clinic	Mobile	Alabama	36604	Not yet recruiting
Mobile Heart Specialists, PC	Mobile	Alabama	36608	Recruiting
Velocity Clinical Research-Chula Vista	Chula Vista	California	91911	Recruiting
University of California Irvine	Orange	California	92868	Not yet recruiting
North America Research Institute	San Dimas	California	91773	Recruiting
Amicis Research Center - Valencia	Santa Clarita	California	91355	Recruiting
Orange County Research Center	Tustin	California	92780	Recruiting
Bridgeport Hospital	Bridgeport	Connecticut	06610	Not yet recruiting
Excel Medical Clinical Trials	Boca Raton	Florida	33434	Recruiting
Bay Area Cardiology	Brandon	Florida	33511	Recruiting
Clearwater Cardiovascular and Interventional Consultants	Clearwater	Florida	33756	Recruiting
Cardiology Associates Research Co.	Daytona Beach	Florida	32117	Recruiting
Malcom Randall VA Medical Center	Gainesville	Florida	32608	Recruiting
Velocity Clinical Research-Hallandale Beach-67888	Hallandale	Florida	33009	Recruiting
University of Florida Health Jacksonville	Jacksonville	Florida	32209	Recruiting
East Coast Institute for Research, LLC - Jacksonville	Jacksonville	Florida	32216	Not yet recruiting
First Coast Cardiovascular Institute	Jacksonville	Florida	32256	Recruiting
Clearwater Cardiovascular Consultants-Largo-69917	Largo	Florida	33777	Recruiting
University of Miami	Miami	Florida	33136	Not yet recruiting
Sacred Heart Medical Specialty Group	Miramar Beach	Florida	32550	Active, not recruiting
Advanced Research for Health Improvement, LLC	Naples	Florida	34102	Not yet recruiting
Southwest Florida Research, LLC	Naples	Florida	34102	Recruiting
Ocala Cardiovascular Research	Ocala	Florida	34471	Recruiting
Ocala Research Institute, Inc	Ocala	Florida	34471	Recruiting
Charlotte Cardiovascular Institute, PA	Port Charlotte	Florida	33952	Recruiting
East Coast Institute for Research, LLC-Saint Augustine-63032	Saint Augustine	Florida	32086	Recruiting
University of South Florida	Tampa	Florida	33612	Not yet recruiting
Cardiology Partners Clinical Research Institute	Wellington	Florida	33449	Recruiting
Cozy Research LLC	Wesley Chapel	Florida	33544	Recruiting
Clinical Site Partners, LLC	Winter Park	Florida	32789	Recruiting
Atlanta Clinical Research Centers	Atlanta	Georgia	30342	Recruiting
Columbus Regional Research Institute	Columbus	Georgia	31904	Recruiting
NSC Research Inc	Johns Creek	Georgia	30024	Recruiting
Kootenai Medical Center	Coeur d'Alene	Idaho	83814	Recruiting
Northwest Heart Clinical Research, LLC	Arlington Heights	Illinois	60005	Recruiting
Illinois Masonic Hospital	Chicago	Illinois	60657	Recruiting
Chicago Medical Research	Hazel Crest	Illinois	60429	Recruiting
Clinical Investigation Specialists, Inc.-Libertyville-69941	Libertyville	Illinois	60048	Recruiting
AMR Park Ridge	Park Ridge	Illinois	60068	Recruiting
Midwest Cardiovascular Research and Education Foundation	Elkhart	Indiana	46514	Recruiting
St. Francis Medical Group-Indiana Heart Physicians, Inc	Indianapolis	Indiana	46237	Recruiting
Indiana Medical Research Institute	Merrillville	Indiana	46410	Recruiting
Cardiovascular Research of Northwest Indiana, LLC	Munster	Indiana	46321	Recruiting
Reid Hospital	Richmond	Indiana	47374	Recruiting
The Iowa Clinic, PC	West Des Moines	Iowa	50266	Recruiting
West Houston Area Clinical Trial Consultants, LLC	Wichita	Kansas	67226	Not yet recruiting
Norton Heart Specialists	Louisville	Kentucky	40205	Not yet recruiting
Grace Research, LLC-Bossier City-51040	Bossier City	Louisiana	71111	Recruiting
Heart Clinic of Hammond	Hammond	Louisiana	70403	Recruiting
Grace Research, LLC-Shreveport-64616	Shreveport	Louisiana	71105	Recruiting
Louisiana Heart Center - Slidell	Slidell	Louisiana	70458	Recruiting
Ascension Saint Agnes Heart Care	Baltimore	Maryland	21229	Recruiting
AMR Dearborn	Dearborn	Michigan	48126	Recruiting
Sparrow Clinical Research Institute	Lansing	Michigan	48910-0826	Recruiting
Henry Ford Providence Hospital	Southfield	Michigan	48075	Not yet recruiting
Trinity Health Michigan D/B/A Michigan Heart	Ypsilanti	Michigan	48197	Recruiting
Minneapolis VA Health Care System	Minneapolis	Minnesota	55417	Recruiting
Jackson Heart Clinic, P.A.	Jackson	Mississippi	39216	Recruiting
Kansas City VA Medical Center	Kansas City	Missouri	64128	Not yet recruiting
North Kansas City Hospital	North Kansas City	Missouri	64116	Not yet recruiting
St. Louis Heart and Vascular, P.C.	St Louis	Missouri	63136	Recruiting
Velocity Clinical Research-Lincoln-69943	Lincoln	Nebraska	68506	Recruiting
Advanced Heart Care, LLC	Bridgewater	New Jersey	08807	Recruiting
Garden State Heart Care, PC	Manalapan	New Jersey	07726	Recruiting
Cardio Metabolic Institute	Somerset	New Jersey	08873	Recruiting
NYU Langone Health	New York	New York	10001	Not yet recruiting
Mount Sinai Hospital-New York-52529	New York	New York	10029	Recruiting
Cardiac Care and Vascular Medicine, PLLC	The Bronx	New York	10469	Recruiting
Medication Management, LLC	Greensboro	North Carolina	27405	Recruiting
WakeMed	Raleigh	North Carolina	27610	Not yet recruiting
K and R Research LLC	Marion	Ohio	43302	Recruiting
Mercy Health St. Vincent Medical Center	Toledo	Ohio	43608	Not yet recruiting
Bon Secours Medical Group Greenville Specialty Care, LLC	Greenville	South Carolina	29607	Recruiting
Monument Health	Rapid City	South Dakota	57701	Recruiting
Helios CR Inc	Jackson	Tennessee	38305	Recruiting
East Coast Institute For Research LLC	Jefferson City	Tennessee	37760	Recruiting
Pharmatex Research	Amarillo	Texas	79109	Recruiting
Amarillo Heart Clinical Research Institute, Incorporated	Amarillo	Texas	79124	Recruiting
Texas Health Research and Education Institute	Dallas	Texas	75231	Not yet recruiting
Southwest Family Medicine Associates	Dallas	Texas	75235	Recruiting
University of Texas Southwestern Medical Center	Dallas	Texas	75390	Recruiting
Helios CR Inc	Fort Worth	Texas	76104	Recruiting
Private Practice Leadership, LLC	Katy	Texas	77493	Recruiting
Texas Cardiology Research Center PLLC	Kingwood	Texas	77339	Recruiting
DCOL Center for Clinical Research	Longview	Texas	75605	Recruiting
North Texas Research Associates	McKinney	Texas	75071	Recruiting
Texas Institute Of Cardiology	McKinney	Texas	75071	Recruiting
University of Utah Health	Salt Lake City	Utah	84108	Recruiting
Carient Heart and Vascular	Manassas	Virginia	20109	Recruiting
Sentara Norfolk General Hospital	Norfolk	Virginia	23507	Recruiting
Selma Medical Associates, Winchester	Winchester	Virginia	22601	Recruiting
Virginia Mason Medical Center	Seattle	Washington	98101	Recruiting
Drug Research and Analysis Corporation	Madison	Wisconsin	53717	Recruiting
ProHealth Care Research Institute and Cardiology Associates	Waukesha	Wisconsin	53188	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 555 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06424288, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 28, 2026 · Synced May 6, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06424288 live on ClinicalTrials.gov.

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