A Study to Evaluate the Efficacy, Safety, and Tolerability of E2086 Compared to Placebo and Active Comparator in Adult Participants With Narcolepsy Type 1
Public ClinicalTrials.gov record NCT06462404. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Single-Dose, 5-Period Crossover Study to Evaluate the Efficacy, Safety, and Tolerability of E2086 Compared to Placebo and Active Comparator in Adult Subjects With Narcolepsy Type 1
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary purpose of this study is to evaluate the efficacy of single oral doses of E2086 compared to placebo in the treatment of excessive daytime sleepiness (EDS) as assessed by the Maintenance of Wakefulness Test (MWT) in adult participants with narcolepsy type 1 (NT1).
Study identification
- NCT ID
- NCT06462404
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1
- Enrollment
- 22 participants
Conditions and interventions
Conditions
Interventions
- E2086 Drug
- E2086 Placebo Drug
- Active Comparator Drug
- Active Comparator Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 20, 2024 (Actual)
- Primary completion
- Mar 17, 2025 (Actual)
- Completion
- Mar 17, 2025 (Actual)
- Last update posted
- Jun 4, 2025
2024 – 2025
United States locations
- U.S. sites
- 12
- U.S. states
- 8
- U.S. cities
- 12
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| SDS Clinical Trials | Santa Ana | California | 48911 | — |
| PharmaDev Clinical Research | Miami | Florida | 33126 | — |
| Sleep Practioners, LLC | Macon | Georgia | 31210 | — |
| Clinical Research Institute | Stockbridge | Georgia | 30281 | — |
| Sound Asleep Research, Inc. | Lansing | Michigan | 48911 | — |
| Research Carolina Elite | Denver | North Carolina | 28037 | — |
| Medical Care Inc. | Goldsboro | North Carolina | 27534 | — |
| Advances Repiratory and Sleep Medicine | Greensboro | North Carolina | 27410 | — |
| Intrepid Research, LLC | Cincinnati | Ohio | 45245 | — |
| Bogan Sleep Consultants, LLC | Columbia | South Carolina | 29201 | — |
| Sleep Therapy and Research Center | San Antonio | Texas | 78229 | — |
| Comprehensive Sleep Medicine Associates | Sugar Land | Texas | 77478 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06462404, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 4, 2025 · Synced Oct 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06462404 live on ClinicalTrials.gov.