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Recruiting Phase 3 Interventional

Trial of Therapeutic Cancer Vaccine OSE2101 in Patients With Non-Small Cell Lung Cancer and Secondary Resistance to Immune Checkpoint Inhibitor

ClinicalTrials.gov ID: NCT06472245

Public ClinicalTrials.gov record NCT06472245. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jul 24, 2026, 4:49 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomised, Open-label, Phase 3 Trial Comparing the Efficacy and Safety of OSE2101 Versus Docetaxel in HLA-A2 Positive Patients With Metastatic Non-Small Cell Lung Cancer (NSCLC) With Secondary Resistance to Immune Checkpoint Inhibitor

Study identification

NCT ID
NCT06472245
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
OSE Immunotherapeutics
Industry
Enrollment
363 participants

Conditions and interventions

Interventions

  • OSE2101 Drug
  • Docetaxel Drug
  • NGS HLAA2 assay Device

Drug · Device

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Dec 2, 2024
Primary completion
Dec 14, 2027
Completion
Dec 14, 2028
Last update posted
Jul 22, 2026

2024 – 2028

United States locations

U.S. sites
79
U.S. states
16
U.S. cities
59
Facility City State ZIP Site status
Clinical Research Advisors, LLC Beverly Hills California 90211 Recruiting
Clinical Research Advisors - Encino Encino California 90211 Active, not recruiting
Clinical Research Advisors - West Hollywood Los Angeles California 90048 Active, not recruiting
Clinical Research Advisors - Korea Town Los Angeles California 90211 Active, not recruiting
SCL Health - Saint Joseph Hospital Cancer Center Littleton Colorado 80218 Withdrawn
Lutheran Medical Center - Cancer Centers of Colorado Wheat Ridge Colorado 80033-6013 Recruiting
Eastern Connecticut Hematology and Oncology Associates Norwich Connecticut 06360 Recruiting
Georgetown Lombardi Comprehensive Cancer Center Washington D.C. District of Columbia 20007 Recruiting
Comprehensive Hematology Oncology - Bradenton Clinic Bradenton Florida 34210 Active, not recruiting
Comprehensive Hematology Oncology - Brandon Clinic Brandon Florida 33511 Active, not recruiting
Cancer Specialists of North Florida - Fleming Island Fleming Island Florida 32003 Recruiting
Cancer Specialists of North Florida - Riverside Jacksonville Florida 32204 Recruiting
Cancer Specialists of North Florida Southside Jacksonville Florida 32207 Active, not recruiting
Cancer Specialists of North Florida - Northside Jacksonville Florida 32218 Recruiting
Cancer Specialists of North Florida - Southpoint Jacksonville Florida 32256-6932 Recruiting
Cancer Specialists of North Florida - Baptist South Jacksonville Florida 32258 Active, not recruiting
Cancer Specialists of North Florida Jacksonville Beach Florida 32250 Recruiting
Comprehensive Hematology Oncology - Largo Clinic Largo Florida 33770 Active, not recruiting
Cancer Specialists of North Florida - Beaches Neptune Beach Florida 32266 Active, not recruiting
Comprehensive Hematology Oncology - Palm Harbor Clinic Palm Harbor Florida 34685 Active, not recruiting
Cancer Specialists Of North Florida - St. Augustine Saint Augustine Florida 32086 Recruiting
Comprehensive Hematology Oncology - Bayfront Clinic St. Petersburg Florida 33709 Active, not recruiting
Comprehensive Hematology Oncology St. Petersburg Florida 33709 Recruiting
Comprehensive Hematology Oncology - Trinity Clinic Trinity Florida 34655 Recruiting
University of Illinois Cancer Center Chicago Illinois 60612 Recruiting
Alliance for Multispecialty Research (AMR) - Kansas City Oncology Merriam Kansas 66204 Withdrawn
Mary Bird Perkins Cancer Center - Baton Rouge Baton Rouge Louisiana 70809 Active, not recruiting
Pontchartrain Cancer Center - Covington Office Covington Louisiana 70433 Recruiting
Pontchartrain Cancer Center - Hammond Office Hammond Louisiana 70403-1452 Recruiting
Ascension Saint Agnes Hospital Baltimore Maryland 21229 Recruiting
University of Massachusetts Memorial Medical Center Worcester Massachusetts 01655 Recruiting
Nebraska Hematology-Oncology - Revive Research Institute LLC Lincoln Nebraska 68506 Recruiting
New York Cancer & Blood Specialists - Babylon Medical Oncology Babylon New York 11702 Active, not recruiting
Optum Medical Care - Carmel/Brewster Campus Brewster New York 10509 Terminated
Brooklyn Radiation Oncology Brooklyn New York 11201 Terminated
Optum Medical Care - Fishkill Westage Campus Fishkill New York 12524 Terminated
Clinical Research Alliance Lake Success New York 11042 Terminated
Optum Medical Care - Mount Kisco Campus 90 Mount Kisco New York 10549 Terminated
New York Cancer & Blood Specialists - New Hyde Park New Hyde Park New York 11042 Recruiting
Optum Hematology Oncology - Lake Success New Hyde Park New York 11042 Terminated
New York Cancer & Blood Specialists - Cancer Center - Research Headquarters New York New York 10028 Recruiting
New York Cancer & Blood Specialists - Central Park Medical Oncology New York New York 10028 Active, not recruiting
New York Cancer & Blood Specialists - Patchogue Medical Oncology Patchogue New York 11772 Recruiting
New York Cancer & Blood Specialists - Port Jefferson Medical Oncology Port Jefferson Station New York 11776 Active, not recruiting
New York Cancer & Blood Specialists - Port Jefferson Station Medical Oncology Port Jefferson Station New York 11776 Active, not recruiting
Optum Medical Care - Poughkeepsie Poughkeepsie New York 12601 Terminated
New York Cancer & Blood Specialists - Eastchester Cancer Care Center The Bronx New York 10469 Active, not recruiting
New York Cancer & Blood Specialists - Riverhead Medical Oncology The Bronx New York 10469 Active, not recruiting
Mercy Health - Perrysburg Cancer Center Perrysburg Ohio 43551 Active, not recruiting
Mercy Health - St. Anne Cancer Center Toledo Ohio 43623 Active, not recruiting
Bon Secours Hematology and Oncology Greenville South Carolina 29607 Recruiting
Tennessee Oncology - Chattanooga - Medical Park II Chattanooga Tennessee 36404 Active, not recruiting
Tennessee Oncology - Chattanooga - Downtown Chattanooga Tennessee 37403 Recruiting
Tennessee Oncology - Chattanooga - GHCR Site I Chattanooga Tennessee 37403 Recruiting
Tennessee Oncology - Chattanooga - Memorial Plaza Chattanooga Tennessee 37404 Recruiting
Tennessee Oncology - Cleveland Clinic Cleveland Tennessee 37311 Recruiting
Tennessee Oncology - Cookeville Clinic Cookeville Tennessee 38501 Active, not recruiting
Tennessee Oncology - Dickson Clinic Dickson Tennessee 37055 Active, not recruiting
Tennessee Oncology - Franklin Clinic Franklin Tennessee 37067 Recruiting
Tennessee Oncology - Gallatin Clinic Gallatin Tennessee 37066 Active, not recruiting
Tennessee Oncology - Hendersonville Clinic Hendersonville Tennessee 37075 Active, not recruiting
Tennessee Oncology - Hermitage - Summit Clinic Hermitage Tennessee 37076 Active, not recruiting
Tennessee Oncology - Lebanon Clinic Lebanon Tennessee 37090 Active, not recruiting
Tennessee Oncology - Murfreesboro Clinic Murfreesboro Tennessee 37129 Active, not recruiting
Tennessee Oncology - Nashville - Centennial Center for Blood Cancers Clinic Nashville Tennessee 37203 Active, not recruiting
Tennessee Oncology - Nashville - Centennial Clinic - Medical Oncology Nashville Tennessee 37203 Active, not recruiting
Tennessee Oncology - Nashville - Midtown Center for Blood Cancers Nashville Tennessee 37203 Active, not recruiting
Tennessee Oncology - Nashville - St. Thomas Midtown Clinic Nashville Tennessee 37203 Active, not recruiting
Tennessee Oncology - Nashville - St. Thomas West Clinic Nashville Tennessee 37205 Recruiting
Tennessee Oncology - Nashville - Skyline Clinic Nashville Tennessee 37207 Active, not recruiting
Tennessee Oncology - Nashville - Southern Hills Clinic Nashville Tennessee 37211 Active, not recruiting
Greco-Hainsworth Tennessee Oncology Centers for Research (GHCR) - Corporate Nashville Tennessee 37232 Recruiting
Tennessee Oncology - Shelbyville Clinic Shelbyville Tennessee 37160 Recruiting
Tennessee Oncology - Smyrna Clinic Smyrna Tennessee 37167 Recruiting
Northwest Medical Specialties - Bonney Lake Bonney Lake Washington 98391 Active, not recruiting
Northwest Medical Specialties - Federal Way Federal Way Washington 98003 Active, not recruiting
Northwest Medical Specialties - Gig Harbor Gig Harbor Washington 98332 Recruiting
Northwest Medical Specialties - Puyallup Medical Oncology Puyallup Washington 98373 Recruiting
Northwest Medical Specialties - Tacoma Tacoma Washington 98405 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 128 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06472245, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jul 22, 2026 · Synced Jul 24, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06472245 live on ClinicalTrials.gov.

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