ClinicalTrials.gov record
Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer
ClinicalTrials.gov ID: NCT06475989
Public ClinicalTrials.gov record NCT06475989. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 8, 2026, 8:10 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Phase III Study of BRAF-Targeted Therapy vs Cabozantinib in RAI-Refractory Differentiated Thyroid Cancer With BRAF V600Em
Study identification
- NCT ID
- NCT06475989
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- ECOG-ACRIN Cancer Research Group
- Network
- Enrollment
- 264 participants
Conditions and interventions
Interventions
- Biospecimen Collection Procedure
- Cabozantinib Drug
- Computed Tomography Procedure
- Dabrafenib Drug
- Magnetic Resonance Imaging Procedure
- Questionnaire Administration Other
- Trametinib Drug
Procedure · Drug · Other
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 21, 2024
- Primary completion
- Sep 29, 2030
- Completion
- Sep 29, 2030
- Last update posted
- May 4, 2026
2024 – 2030
United States locations
- U.S. sites
- 112
- U.S. states
- 17
- U.S. cities
- 94
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mercy Hospital Fort Smith | Fort Smith | Arkansas | 72903 | Recruiting |
| CARTI Cancer Center | Little Rock | Arkansas | 72205 | Recruiting |
| Smilow Cancer Hospital-Derby Care Center | Derby | Connecticut | 06418 | Recruiting |
| Smilow Cancer Hospital Care Center-Fairfield | Fairfield | Connecticut | 06824 | Recruiting |
| Smilow Cancer Hospital Care Center at Glastonbury | Glastonbury | Connecticut | 06033 | Recruiting |
| Smilow Cancer Hospital Care Center at Greenwich | Greenwich | Connecticut | 06830 | Recruiting |
| Smilow Cancer Hospital Care Center - Guilford | Guilford | Connecticut | 06437 | Recruiting |
| Smilow Cancer Hospital Care Center at Saint Francis | Hartford | Connecticut | 06105 | Recruiting |
| Smilow Cancer Center/Yale-New Haven Hospital | New Haven | Connecticut | 06510 | Recruiting |
| Yale University | New Haven | Connecticut | 06520 | Recruiting |
| Yale-New Haven Hospital North Haven Medical Center | North Haven | Connecticut | 06473 | Recruiting |
| Smilow Cancer Hospital Care Center at Long Ridge | Stamford | Connecticut | 06902 | Recruiting |
| Smilow Cancer Hospital-Torrington Care Center | Torrington | Connecticut | 06790 | Recruiting |
| Smilow Cancer Hospital Care Center-Trumbull | Trumbull | Connecticut | 06611 | Recruiting |
| Smilow Cancer Hospital-Waterbury Care Center | Waterbury | Connecticut | 06708 | Recruiting |
| Smilow Cancer Hospital Care Center - Waterford | Waterford | Connecticut | 06385 | Recruiting |
| Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | 83706 | Recruiting |
| Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho | 83605 | Recruiting |
| Kootenai Health - Coeur d'Alene | Coeur d'Alene | Idaho | 83814 | Recruiting |
| Walter Knox Memorial Hospital | Emmett | Idaho | 83617 | Suspended |
| Idaho Urologic Institute-Meridian | Meridian | Idaho | 83642 | Recruiting |
| Saint Alphonsus Cancer Care Center-Nampa | Nampa | Idaho | 83687 | Recruiting |
| Kootenai Clinic Cancer Services - Post Falls | Post Falls | Idaho | 83854 | Recruiting |
| Kootenai Clinic Cancer Services - Sandpoint | Sandpoint | Idaho | 83864 | Recruiting |
| OSF Saint Anthony's Health Center | Alton | Illinois | 62002 | Recruiting |
| Saint Mary's Hospital | Centralia | Illinois | 62801 | Recruiting |
| Northwestern University | Chicago | Illinois | 60611 | Recruiting |
| University of Illinois | Chicago | Illinois | 60612 | Recruiting |
| Northwestern Medicine Cancer Center Kishwaukee | DeKalb | Illinois | 60115 | Recruiting |
| Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | 60134 | Recruiting |
| Northwestern Medicine Glenview Outpatient Center | Glenview | Illinois | 60026 | Recruiting |
| Northwestern Medicine Grayslake Outpatient Center | Grayslake | Illinois | 60030 | Recruiting |
| Northwestern Medicine Lake Forest Hospital | Lake Forest | Illinois | 60045 | Recruiting |
| Good Samaritan Regional Health Center | Mount Vernon | Illinois | 62864 | Recruiting |
| Northwestern Medicine Orland Park | Orland Park | Illinois | 60462 | Recruiting |
| Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | 60555 | Recruiting |
| Mercy Hospital | Cedar Rapids | Iowa | 52403 | Recruiting |
| Oncology Associates at Mercy Medical Center | Cedar Rapids | Iowa | 52403 | Recruiting |
| Central Care Cancer Center - Garden City | Garden City | Kansas | 67846 | Recruiting |
| Central Care Cancer Center - Great Bend | Great Bend | Kansas | 67530 | Recruiting |
| Sanford Joe Lueken Cancer Center | Bemidji | Minnesota | 56601 | Recruiting |
| Minnesota Oncology - Burnsville | Burnsville | Minnesota | 55337 | Recruiting |
| Cambridge Medical Center | Cambridge | Minnesota | 55008 | Recruiting |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | Recruiting |
| Fairview Southdale Hospital | Edina | Minnesota | 55435 | Recruiting |
| Fairview Clinics and Surgery Center Maple Grove | Maple Grove | Minnesota | 55369 | Recruiting |
| Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | 55109 | Recruiting |
| Saint John's Hospital - Healtheast | Maplewood | Minnesota | 55109 | Recruiting |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | Recruiting |
| Hennepin County Medical Center | Minneapolis | Minnesota | 55415 | Recruiting |
| Health Partners Inc | Minneapolis | Minnesota | 55454 | Recruiting |
| Monticello Cancer Center | Monticello | Minnesota | 55362 | Recruiting |
| New Ulm Medical Center | New Ulm | Minnesota | 56073 | Recruiting |
| Fairview Northland Medical Center | Princeton | Minnesota | 55371 | Recruiting |
| North Memorial Medical Health Center | Robbinsdale | Minnesota | 55422 | Recruiting |
| Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | 55416 | Recruiting |
| Regions Hospital | Saint Paul | Minnesota | 55101 | Recruiting |
| United Hospital | Saint Paul | Minnesota | 55102 | Recruiting |
| Saint Francis Regional Medical Center | Shakopee | Minnesota | 55379 | Recruiting |
| Lakeview Hospital | Stillwater | Minnesota | 55082 | Recruiting |
| Sanford Thief River Falls Medical Center | Thief River Falls | Minnesota | 56701 | Recruiting |
| Ridgeview Medical Center | Waconia | Minnesota | 55387 | Recruiting |
| Rice Memorial Hospital | Willmar | Minnesota | 56201 | Recruiting |
| Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota | 55125 | Recruiting |
| Sanford Cancer Center Worthington | Worthington | Minnesota | 56187 | Recruiting |
| Fairview Lakes Medical Center | Wyoming | Minnesota | 55092 | Recruiting |
| Saint Louis Cancer and Breast Institute-Ballwin | Ballwin | Missouri | 63011 | Recruiting |
| Central Care Cancer Center - Bolivar | Bolivar | Missouri | 65613 | Recruiting |
| Cox Cancer Center Branson | Branson | Missouri | 65616 | Recruiting |
| Southeast Cancer Center | Cape Girardeau | Missouri | 63703 | Recruiting |
| Freeman Health System | Joplin | Missouri | 64804 | Recruiting |
| Mercy Hospital Joplin | Joplin | Missouri | 64804 | Recruiting |
| Lake Regional Hospital | Osage Beach | Missouri | 65065 | Recruiting |
| Delbert Day Cancer Institute at PCRMC | Rolla | Missouri | 65401 | Recruiting |
| Mercy Clinic-Rolla-Cancer and Hematology | Rolla | Missouri | 65401 | Recruiting |
| Heartland Regional Medical Center | Saint Joseph | Missouri | 64506 | Recruiting |
| Mercy Hospital Springfield | Springfield | Missouri | 65804 | Recruiting |
| CoxHealth South Hospital | Springfield | Missouri | 65807 | Recruiting |
| Saint Louis Cancer and Breast Institute-South City | St Louis | Missouri | 63109 | Recruiting |
| Mercy Hospital South | St Louis | Missouri | 63128 | Recruiting |
| Mercy Hospital Saint Louis | St Louis | Missouri | 63141 | Recruiting |
| Mercy Hospital Washington | Washington | Missouri | 63090 | Recruiting |
| Community Hospital of Anaconda | Anaconda | Montana | 59711 | Recruiting |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | Recruiting |
| Bozeman Health Deaconess Hospital | Bozeman | Montana | 59715 | Recruiting |
| Benefis Sletten Cancer Institute | Great Falls | Montana | 59405 | Recruiting |
| Great Falls Clinic | Great Falls | Montana | 59405 | Recruiting |
| Logan Health Medical Center | Kalispell | Montana | 59901 | Recruiting |
| Community Medical Center | Missoula | Montana | 59804 | Recruiting |
| Sanford Bismarck Medical Center | Bismarck | North Dakota | 58501 | Recruiting |
| Sanford South University Medical Center | Fargo | North Dakota | 58103 | Recruiting |
| Southpointe-Sanford Medical Center Fargo | Fargo | North Dakota | 58103 | Recruiting |
| Sanford Medical Center Fargo | Fargo | North Dakota | 58104 | Recruiting |
| Sanford Broadway Medical Center | Fargo | North Dakota | 58122 | Recruiting |
| Sanford Roger Maris Cancer Center | Fargo | North Dakota | 58122 | Recruiting |
| Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma | 73120 | Recruiting |
| Saint Alphonsus Cancer Care Center-Baker City | Baker City | Oregon | 97814 | Recruiting |
| Saint Alphonsus Cancer Care Center-Ontario | Ontario | Oregon | 97914 | Recruiting |
| UPMC Hillman Cancer Center Erie | Erie | Pennsylvania | 16505 | Recruiting |
| University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh | Pennsylvania | 15232 | Recruiting |
| Smilow Cancer Hospital Care Center - Westerly | Westerly | Rhode Island | 02891 | Recruiting |
| Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota | 57104 | Recruiting |
| Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | 57117-5134 | Recruiting |
| Marshfield Medical Center-EC Cancer Center | Eau Claire | Wisconsin | 54701 | Recruiting |
| Marshfield Medical Center-Marshfield | Marshfield | Wisconsin | 54449 | Recruiting |
| Marshfield Medical Center - Minocqua | Minocqua | Wisconsin | 54548 | Recruiting |
| Cancer Center of Western Wisconsin | New Richmond | Wisconsin | 54017 | Recruiting |
| Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin | 54868 | Recruiting |
| Marshfield Medical Center-River Region at Stevens Point | Stevens Point | Wisconsin | 54482 | Recruiting |
| Marshfield Medical Center - Weston | Weston | Wisconsin | 54476 | Recruiting |
| Billings Clinic-Cody | Cody | Wyoming | 82414 | Recruiting |
| Welch Cancer Center | Sheridan | Wyoming | 82801 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06475989, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 4, 2026 · Synced May 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06475989 live on ClinicalTrials.gov.