ClinicalTrials.gov record
Study to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (Axitinib Implant) in Subjects With Neovascular Age- Related Macular Degeneration
ClinicalTrials.gov ID: NCT06495918
Public ClinicalTrials.gov record NCT06495918. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multicenter, Double-Masked, Randomized, Parallel Group Study to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (Axitinib Implant) in Subjects With Neovascular Age- Related Macular Degeneration
Study identification
- NCT ID
- NCT06495918
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Ocular Therapeutix, Inc.
- Industry
- Enrollment
- 825 participants
Conditions and interventions
Conditions
Interventions
- OTX-TKI Drug
- Aflibercept Drug
Drug
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 26, 2024
- Primary completion
- Jan 7, 2027
- Completion
- Jan 7, 2027
- Last update posted
- Jun 16, 2025
2024 – 2027
United States locations
- U.S. sites
- 84
- U.S. states
- 29
- U.S. cities
- 76
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Associated Retina Consultant | Gilbert | Arizona | 85297 | — |
| Associated Retina Consultants, Ltd. | Phoenix | Arizona | 85020 | — |
| Retinal Research Institute, LLC | Phoenix | Arizona | 85053 | — |
| Retina Macula Institute of Arizona | Scottsdale | Arizona | 85255 | — |
| California Retina Consultants | Bakersfield | California | 93309 | — |
| The Retina Partners | Encino | California | 91436 | — |
| Retina Consultants of Orange County | Fullerton | California | 92835 | — |
| Atlantis Eyecare | Huntington Beach | California | 92647 | — |
| Salehi Retina Institute, Inc., dba Retina Associates of Southern California | Huntington Beach | California | 92647 | — |
| Kaiser Permanente Division of Research | Oakland | California | 94611 | — |
| California Retina Consultants | Oxnard | California | 93036 | — |
| Stanford Health Care - Byers Eye Institute | Palo Alto | California | 94303 | — |
| Stanford University School of Medicine, Byers Eye Institute | Palo Alto | California | 94303 | — |
| California Eye Specialists Medical Group, INC | Pasadena | California | 91107 | — |
| Retinal Consultants Medical Group | Sacramento | California | 95841 | — |
| Orange County Retina Medical Group | Santa Ana | California | 92705 | — |
| California Retina Consultants | Santa Barbara | California | 93103 | — |
| Macula Retina Vitreous Research Institute | Torrance | California | 90503 | — |
| Bay Area Retina Associates | Walnut Creek | California | 94598 | — |
| Retina Consultants of Southern Colorado | Colorado Springs | Colorado | 80909 | — |
| RSC Research, LLC | Denver | Colorado | 80210 | — |
| Colorado Retina Associates | Lakewood | Colorado | 80228 | — |
| Retina Consultants, P.C | Manchester | Connecticut | 06042 | — |
| Retina Group of New England | Waterford | Connecticut | 06385 | — |
| Advanced Research LLC. | Deerfield Beach | Florida | 33064 | — |
| Rand Eye Institute | Deerfield Beach | Florida | 33064 | — |
| Retina Group of Florida | Fort Lauderdale | Florida | 33308 | — |
| Florida Retina Consultants | Lakeland | Florida | 33805 | — |
| South Florida Retina Institute | Miami | Florida | 33145 | — |
| Florida Retina Institude | Orlando | Florida | 32806 | — |
| Retina Specialty Institute | Pensacola | Florida | 32503 | — |
| MedEye Associates | South Miami | Florida | 33143 | — |
| Retina Vitreous Associates of Florida- Saint Petersburg | St. Petersburg | Florida | 33711 | — |
| Retina Vitreous Associates of Florida | Tampa | Florida | 33617 | — |
| Southeast Retina Center | Augusta | Georgia | 30909 | — |
| University Retina and Macula Associates, PC | Oak Forest | Illinois | 60452 | — |
| Illinois Retina Associates | Oak Park | Illinois | 60304 | — |
| Springfield Clinic Opthalmology Department | Springfield | Illinois | 62703 | — |
| Associate Vitreoretinal and Uveitis Consultants | Carmel | Indiana | 46032 | — |
| Retina Partners Midwest, P.C. | Carmel | Indiana | 46290 | — |
| Retina Partners Midwest | Indianapolis | Indiana | 46290 | — |
| Wolfe Clinic PC dba Wolfe Eye Clinic | West Des Moines | Iowa | 50026 | — |
| The Retina Group of Washington - Chevy Chase | Chevy Chase | Maryland | 20815 | — |
| Cumberland Valley Retina Consultants | Hagerstown | Maryland | 21740 | — |
| Mid Atlantic Retina Specialists | Hagerstown | Maryland | 21740 | — |
| Retina Specialists - Towson Office | Towson | Maryland | 21204 | — |
| Associated Retinal Consultants, P.C. | Royal Oak | Michigan | 48073 | — |
| Retina Consultants of Minnesota | Minneapolis | Minnesota | 55435 | — |
| Mississippi Retina Associates | Madison | Mississippi | 39110 | — |
| The Retina Institute | St Louis | Missouri | 63128 | — |
| Sierra Eye Associates | Reno | Nevada | 89502 | — |
| Envision Ocular, LLC | Bloomfield | New Jersey | 07003 | — |
| Vision Research Center Eye Associates of New Mexico | Albuquerque | New Mexico | 87109 | — |
| Retina Vitreous Surgeons of CNY, PC | Liverpool | New York | 13088 | — |
| Asheville Eye Associates (AEA) - Asheville | Asheville | North Carolina | 28803 | — |
| Cincinnati Eye Institute | Cincinnati | Ohio | 45242 | — |
| EyeHealth Northwest | Portland | Oregon | 97225 | — |
| Erie Retina Research | Erie | Pennsylvania | 16507 | — |
| Palmetto Retina Center, LLC | Aiken | South Carolina | 29802 | — |
| Charleston Neuroscience Instititute, LLC | Beaufort | South Carolina | 29902 | — |
| Palmetto Retina Center, LLC | Florence | South Carolina | 29501 | — |
| Palmetto Retina Center, LLC | West Columbia | South Carolina | 29169 | — |
| Black Hills Regional Eye Institute, LLP | Rapid City | South Dakota | 57701 | — |
| Charles Retina Institute | Germantown | Tennessee | 38138 | — |
| Southeastern Retina Associates PC | Johnson City | Tennessee | 37604 | — |
| Tennessee Retina, PC | Nashville | Tennessee | 37203 | — |
| Retina Research Institute of Texas | Abilene | Texas | 79606 | — |
| Texas Retina Associates | Arlington | Texas | 76012 | — |
| Austin Research Center for Retina | Austin | Texas | 78705 | — |
| Austin Retina Associates | Austin | Texas | 78705 | — |
| Retina Consultants of Texas | Beaumont | Texas | 77707 | — |
| Retina Consultants of Texas | Bellaire | Texas | 77401 | — |
| Star Vision Research | Burleson | Texas | 76028 | — |
| Texas Retina Associates | Dallas | Texas | 75231 | — |
| Texas Retina Center | Houston | Texas | 77030 | — |
| Retina Consultants of Texas | Katy | Texas | 77494 | — |
| Retina Consultants of Texas | San Antonio | Texas | 78240 | — |
| Retina Center of Texas | Southlake | Texas | 76092 | — |
| Retina Consultants of Texas | The Woodlands | Texas | 77384 | — |
| Retina Associates of Utah | Salt Lake City | Utah | 84107 | — |
| Rocky Mountain Retina Consultants | Salt Lake City | Utah | 84107 | — |
| Retina Group of Washington | Fairfax | Virginia | 22031 | — |
| Vistar Eye Center | Roanoke | Virginia | 24019 | — |
| Eye Clinic of Wisconsin, SC | Wausau | Wisconsin | 54403 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 13 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06495918, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 16, 2025 · Synced Jun 26, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06495918 live on ClinicalTrials.gov.