Independent directory Public ClinicalTrials.gov records United States
ClinicalTrials.gov record
Active, not recruiting Phase 3 Interventional

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

ClinicalTrials.gov ID: NCT06500455

Public ClinicalTrials.gov record NCT06500455. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 21, 2026, 7:41 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase III Trial of Single Fraction Stereotactic Radiosurgery (SRS) Versus Fractionated SRS (FSRS) for Intact Brain Metastases

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This phase III trial compares the effectiveness of fractionated stereotactic radiosurgery (FSRS) to usual care stereotactic radiosurgery (SRS) in treating patients with cancer that has spread from where it first started to the brain. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. FSRS delivers a high dose of radiation to the tumor over 3 treatments. SRS is a type of external radiation therapy that uses special equipment to position the patient and precisely give a single large dose of radiation to a tumor. FSRS may be more effective compared to SRS in treating patients with cancer that has spread to the brain.

Study identification

NCT ID
NCT06500455
Recruitment status
Active, not recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
NRG Oncology
Other
Enrollment
274 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Dec 12, 2024 (Actual)
Primary completion
Jun 30, 2028 (Estimated)
Completion
Jun 30, 2033 (Estimated)
Last update posted
Sep 14, 2026

2024 – 2033

United States locations

U.S. sites
262
U.S. states
38
U.S. cities
192
Facility City State ZIP Site status
Banner University Medical Center - Tucson Tucson Arizona 85719 —
University of Arizona Cancer Center-North Campus Tucson Arizona 85719 —
Mercy Hospital Fort Smith Fort Smith Arkansas 72903 —
University of Arkansas for Medical Sciences Little Rock Arkansas 72205 —
Kaiser Permanente-Anaheim Anaheim California 92806 —
Kaiser Permanente-Bellflower Bellflower California 90706 —
City of Hope Corona Corona California 92882 —
City of Hope Comprehensive Cancer Center Duarte California 91010 —
UC San Diego Health System - Encinitas Encinitas California 92024 —
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care Irvine California 92612 —
City of Hope at Irvine Lennar Irvine California 92618 —
UC San Diego Moores Cancer Center La Jolla California 92093 —
City of Hope Antelope Valley Lancaster California 93534 —
Kaiser Permanente Los Angeles Medical Center Los Angeles California 90027 —
Cedars-Sinai Medical Center Los Angeles California 90048 —
Providence Queen of The Valley Napa California 94558 —
Kaiser Permanente-Ontario Ontario California 91761 —
UC Irvine Health/Chao Family Comprehensive Cancer Center Orange California 92868 —
Stanford Cancer Institute Palo Alto Palo Alto California 94304 —
UC San Diego Medical Center - Hillcrest San Diego California 92103 —
Providence Medical Foundation - Santa Rosa Santa Rosa California 95403 —
City of Hope South Pasadena South Pasadena California 91030 —
City of Hope South Bay Torrance California 90503 —
City of Hope Upland Upland California 91786 —
John Muir Medical Center-Walnut Creek Walnut Creek California 94598 —
UCHealth University of Colorado Hospital Aurora Colorado 80045 —
UCHealth Memorial Hospital Central Colorado Springs Colorado 80909 —
Memorial Hospital North Colorado Springs Colorado 80920 —
Poudre Valley Hospital Fort Collins Colorado 80524 —
Cancer Care and Hematology-Fort Collins Fort Collins Colorado 80528 —
UCHealth Greeley Hospital Greeley Colorado 80631 —
Medical Center of the Rockies Loveland Colorado 80538 —
Hartford Hospital Hartford Connecticut 06102 —
The Hospital of Central Connecticut New Britain Connecticut 06050 —
UM Sylvester Comprehensive Cancer Center at Aventura Aventura Florida 33180 —
Boca Raton Regional Hospital Boca Raton Florida 33486 —
UM Sylvester Comprehensive Cancer Center at Coral Gables Coral Gables Florida 33146 —
UM Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach Florida 33442 —
UM Sylvester Comprehensive Cancer Center at Doral Doral Florida 33166 —
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami Florida 33136 —
Miami Cancer Institute Miami Florida 33176 —
UM Sylvester Comprehensive Cancer Center at Kendall Miami Florida 33176 —
UM Sylvester Comprehensive Cancer Center at Plantation Plantation Florida 33324 —
Moffitt Cancer Center-International Plaza Tampa Florida 33607 —
Moffitt Cancer Center - McKinley Campus Tampa Florida 33612 —
Moffitt Cancer Center Tampa Florida 33612 —
Moffitt Cancer Center at Wesley Chapel Wesley Chapel Florida 33544 —
Emory University Hospital Midtown Atlanta Georgia 30308 —
Piedmont Hospital Atlanta Georgia 30309 —
Emory University Hospital/Winship Cancer Institute Atlanta Georgia 30322 —
Emory Saint Joseph's Hospital Atlanta Georgia 30342 —
WellStar Cobb Hospital Austell Georgia 30106 —
Wellstar Kennestone Hospital Marietta Georgia 30060 —
Hawaii Cancer Care Inc - Waterfront Plaza Honolulu Hawaii 96813 —
Queen's Cancer Cenrer - POB I Honolulu Hawaii 96813 —
Queen's Medical Center Honolulu Hawaii 96813 —
University of Hawaii Cancer Center Honolulu Hawaii 96813 —
Queen's Cancer Center - Kuakini Honolulu Hawaii 96817 —
Kapiolani Medical Center for Women and Children Honolulu Hawaii 96826 —
Castle Medical Center Kailua Hawaii 96734 —
Wilcox Memorial Hospital and Kauai Medical Clinic Lihue Hawaii 96766 —
Hawaii Cancer Care - Westridge ‘Aiea Hawaii 96701 —
The Queen's Medical Center - West Oahu ‘Ewa Beach Hawaii 96706 —
Centralia Oncology Clinic Centralia Illinois 62801 —
Northwestern University Chicago Illinois 60611 —
Rush MD Anderson Cancer Center Chicago Illinois 60612 —
University of Chicago Comprehensive Cancer Center Chicago Illinois 60637 —
Carle at The Riverfront Danville Illinois 61832 —
Cancer Care Specialists of Illinois - Decatur Decatur Illinois 62526 —
Decatur Memorial Hospital Decatur Illinois 62526 —
Carle Physician Group-Effingham Effingham Illinois 62401 —
Crossroads Cancer Center Effingham Illinois 62401 —
Elmhurst Memorial Hospital Elmhurst Illinois 60126 —
Carle Physician Group-Mattoon/Charleston Mattoon Illinois 61938 —
Loyola University Medical Center Maywood Illinois 60153 —
Edward Hospital/Cancer Center Naperville Illinois 60540 —
UC Comprehensive Cancer Center at Silver Cross New Lenox Illinois 60451 —
Cancer Care Center of O'Fallon O'Fallon Illinois 62269 —
HSHS Saint Elizabeth's Hospital O'Fallon Illinois 62269 —
Northwestern Medicine Orland Park Orland Park Illinois 60462 —
University of Chicago Medicine-Orland Park Orland Park Illinois 60462 —
Memorial Hospital East Shiloh Illinois 62269 —
Southern Illinois University School of Medicine Springfield Illinois 62702 —
Springfield Clinic Springfield Illinois 62702 —
Springfield Memorial Hospital Springfield Illinois 62781 —
Carle Cancer Center Urbana Illinois 61801 —
Northwestern Medicine Cancer Center Warrenville Warrenville Illinois 60555 —
Northwest Cancer Center - Crown Point Crown Point Indiana 46307 —
UChicago Medicine Northwest Indiana Crown Point Indiana 46307 —
Northwest Oncology LLC Dyer Indiana 46311 —
Goshen Center for Cancer Care Goshen Indiana 46526 —
Northwest Cancer Center - Hobart Hobart Indiana 46342 —
Saint Mary Medical Center Hobart Indiana 46342 —
The Community Hospital Munster Indiana 46321 —
Women's Diagnostic Center - Munster Munster Indiana 46321 —
Northwest Cancer Center - Valparaiso Valparaiso Indiana 46383 —
Mary Greeley Medical Center Ames Iowa 50010 —
McFarland Clinic - Ames Ames Iowa 50010 —
University of Iowa/Holden Comprehensive Cancer Center Iowa City Iowa 52242 —
University of Kansas Cancer Center Kansas City Kansas 66160 —
The University of Kansas Cancer Center - Olathe Olathe Kansas 66061 —
University of Kansas Cancer Center-Overland Park Overland Park Kansas 66210 —
Baptist Health Hardin Elizabethtown Kentucky 42701 —
University of Kentucky/Markey Cancer Center Lexington Kentucky 40536 —
The James Graham Brown Cancer Center at University of Louisville Louisville Kentucky 40202 —
Norton Brownsboro Hospital and Medical Campus Louisville Kentucky 40241 —
UofL Health Medical Center Northeast Louisville Kentucky 40245 —
Owensboro Health Mitchell Memorial Cancer Center Owensboro Kentucky 42303 —
MaineHealth Maine Medical Center - Portland Portland Maine 04102 —
MaineHealth Cancer Care Center of York County Sanford Maine 04073 —
MaineHealth Maine Medical Center- Scarborough Scarborough Maine 04074 —
Maryland Proton Treatment Center Baltimore Maryland 21201 —
University of Maryland/Greenebaum Cancer Center Baltimore Maryland 21201 —
Sinai Hospital of Baltimore Baltimore Maryland 21215 —
UM Upper Chesapeake Medical Center Bel Air Maryland 21014 —
Central Maryland Radiation Oncology in Howard County Columbia Maryland 21044 —
University of Maryland Shore Medical Center at Easton Easton Maryland 21601 —
UM Baltimore Washington Medical Center/Tate Cancer Center Glen Burnie Maryland 21061 —
UM Capital Region Medical Center Largo Maryland 20774 —
William E Kahlert Regional Cancer Center/Sinai Hospital Westminster Maryland 21157 —
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor Michigan 48106 —
University of Michigan Rogel Cancer Center Ann Arbor Michigan 48109 —
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan 48114 —
Henry Ford Cancer Institute-Downriver Brownstown Michigan 48183 —
Henry Ford Macomb Hospital-Clinton Township Clinton Township Michigan 48038 —
Henry Ford Hospital Detroit Michigan 48202 —
Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan 48154 —
Henry Ford Health Providence Novi Hospital Novi Michigan 48374 —
MyMichigan Medical Center Saginaw Saginaw Michigan 48601 —
MyMichigan Medical Center Tawas Tawas City Michigan 48764 —
Henry Ford West Bloomfield Hospital West Bloomfield Michigan 48322 —
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan 48197 —
Minnesota Oncology Hematology PA-Chaska Chaska Minnesota 55318 —
Fairview Clinics and Surgery Center Maple Grove Maple Grove Minnesota 55369 —
Hennepin County Medical Center Minneapolis Minnesota 55415 —
University of Minnesota/Masonic Cancer Center Minneapolis Minnesota 55455 —
Monticello Cancer Center Monticello Minnesota 55362 —
Coborn Cancer Center at Saint Cloud Hospital Saint Cloud Minnesota 56303 —
Ridgeview Medical Center Waconia Minnesota 55387 —
University of Mississippi Medical Center Jackson Mississippi 39216 —
Siteman Cancer Center at Saint Peters Hospital City of Saint Peters Missouri 63376 —
MU Health - University Hospital/Ellis Fischel Cancer Center Columbia Missouri 65212 —
Siteman Cancer Center at West County Hospital Creve Coeur Missouri 63141 —
Parkland Health Center - Farmington Farmington Missouri 63640 —
Mercy Hospital Springfield Springfield Missouri 65804 —
Washington University School of Medicine St Louis Missouri 63110 —
Siteman Cancer Center-South County St Louis Missouri 63129 —
Siteman Cancer Center at Christian Hospital St Louis Missouri 63136 —
Nebraska Medicine-Bellevue Bellevue Nebraska 68123 —
Nebraska Medicine-Village Pointe Omaha Nebraska 68118 —
University of Nebraska Medical Center Omaha Nebraska 68198 —
Renown Regional Medical Center Reno Nevada 89502 —
Memorial Sloan Kettering Basking Ridge Basking Ridge New Jersey 07920 —
Jefferson Cherry Hill Hospital Cherry Hill New Jersey 08002 —
Saint Barnabas Medical Center Livingston New Jersey 07039 —
Memorial Sloan Kettering Monmouth Middletown New Jersey 07748 —
Memorial Sloan Kettering Bergen Montvale New Jersey 07645 —
Jersey Shore Medical Center Neptune City New Jersey 07753 —
Rutgers Cancer Institute of New Jersey New Brunswick New Jersey 08903 —
Rutgers New Jersey Medical School Newark New Jersey 07101 —
Newark Beth Israel Medical Center Newark New Jersey 07112 —
The Valley Hospital - Luckow Pavilion Paramus New Jersey 07652 —
Valley Health System Ridgewood Campus Ridgewood New Jersey 07450 —
Sidney Kimmel Cancer Center Washington Township Sewell New Jersey 08080 —
Robert Wood Johnson University Hospital Somerset Somerville New Jersey 08876 —
Community Medical Center Toms River New Jersey 08755 —
University of New Mexico Cancer Center Albuquerque New Mexico 87106 —
New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn New York 11215 —
NYU Langone Hospital - Brooklyn Brooklyn New York 11220 —
Memorial Sloan Kettering Commack Commack New York 11725 —
The New York Hospital Medical Center of Queens Flushing New York 11355 —
Memorial Sloan Kettering Westchester Harrison New York 10604 —
Northwell Health/Center for Advanced Medicine Lake Success New York 11042 —
NYU Langone Hospital - Long Island Mineola New York 11501 —
Mount Sinai Chelsea New York New York 10011 —
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York New York 10016 —
Mount Sinai West New York New York 10019 —
Mount Sinai Hospital New York New York 10029 —
Manhattan Eye Ear and Throat Hospital New York New York 10065 —
Memorial Sloan Kettering Cancer Center New York New York 10065 —
NYP/Weill Cornell Medical Center New York New York 10065 —
Lenox Hill Hospital New York New York 10075 —
Mount Sinai South Nassau Oceanside New York 11572 —
University of Rochester Rochester New York 14642 —
Stony Brook University Medical Center Stony Brook New York 11794 —
State University of New York Upstate Medical University Syracuse New York 13210 —
SUNY Upstate Medical Center-Community Campus Syracuse New York 13215 —
Montefiore Medical Center-Einstein Campus The Bronx New York 10461 —
Montefiore Medical Center-Weiler Hospital The Bronx New York 10461 —
Montefiore Medical Center - Moses Campus The Bronx New York 10467 —
Memorial Sloan Kettering Nassau Uniondale New York 11553 —
Sanford Broadway Medical Center Fargo North Dakota 58122 —
Sanford Roger Maris Cancer Center Fargo North Dakota 58122 —
UH Seidman Cancer Center at UH Avon Health Center Avon Ohio 44011 —
Indu and Raj Soin Medical Center Beavercreek Ohio 45431 —
University of Cincinnati Cancer Center-UC Medical Center Cincinnati Ohio 45219 —
Case Western Reserve University Cleveland Ohio 44106 —
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210 —
Riverside Methodist Hospital Columbus Ohio 43214 —
Grant Medical Center Columbus Ohio 43215 —
Delaware Health Center-Grady Cancer Center Delaware Ohio 43015 —
Grady Memorial Hospital Delaware Ohio 43015 —
Kettering Medical Center Kettering Ohio 45429 —
UH Seidman Cancer Center at Lake Health Mentor Campus Mentor Ohio 44060 —
University of Cincinnati Cancer Center-West Chester West Chester Ohio 45069 —
Saint Elizabeth Youngstown Hospital Youngstown Ohio 44501 —
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 —
Clackamas Radiation Oncology Center Clackamas Oregon 97015 —
Legacy Mount Hood Medical Center Gresham Oregon 97030 —
Legacy Good Samaritan Hospital and Medical Center Portland Oregon 97210 —
Providence Portland Medical Center Portland Oregon 97213 —
Providence Saint Vincent Medical Center Portland Oregon 97225 —
Legacy Meridian Park Hospital Tualatin Oregon 97062 —
Saint Luke's Cancer Center - Allentown Allentown Pennsylvania 18104 —
Saint Luke's University Hospital-Bethlehem Campus Bethlehem Pennsylvania 18015 —
Chambersburg Hospital Chambersburg Pennsylvania 17201 —
Northeast Radiation Oncology Center Dunmore Pennsylvania 18512 —
Saint Luke's Hospital-Anderson Campus Easton Pennsylvania 18045 —
Penn State Milton S Hershey Medical Center Hershey Pennsylvania 17033-0850 —
NRG Oncology Philadelphia Pennsylvania 19103 —
University of Pennsylvania/Abramson Cancer Center Philadelphia Pennsylvania 19104 —
Thomas Jefferson University Hospital Philadelphia Pennsylvania 19107 —
Jefferson Torresdale Hospital Philadelphia Pennsylvania 19114 —
UPMC-Presbyterian Hospital Pittsburgh Pennsylvania 15213 —
UPMC-Shadyside Hospital Pittsburgh Pennsylvania 15232 —
Saint Luke's Hospital - Upper Bucks Campus Quakertown Pennsylvania 18951 —
Saint Luke's Hospital - Monroe Campus Stroudsburg Pennsylvania 18360 —
Reading Hospital West Reading Pennsylvania 19611 —
WellSpan Health-York Cancer Center York Pennsylvania 17403 —
WellSpan Health-York Hospital York Pennsylvania 17403 —
Saint Francis Hospital Greenville South Carolina 29601 —
Saint Francis Cancer Center Greenville South Carolina 29607 —
Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota 57104 —
Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota 57117-5134 —
Vanderbilt Breast Center at One Hundred Oaks Nashville Tennessee 37204 —
Vanderbilt University/Ingram Cancer Center Nashville Tennessee 37232 —
MD Anderson in The Woodlands Conroe Texas 77384 —
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center Houston Texas 77030 —
Memorial Hermann Texas Medical Center Houston Texas 77030 —
UT MD Anderson Cancer Center Houston Texas 77030 —
MD Anderson West Houston Houston Texas 77079 —
UT MD Anderson - League City League City Texas 77573 —
University of Texas Health Science Center at San Antonio San Antonio Texas 78229 —
MD Anderson in Sugar Land Sugar Land Texas 77478 —
Huntsman Cancer Institute/University of Utah Salt Lake City Utah 84112 —
University of Vermont Medical Center Burlington Vermont 05401 —
University of Vermont and State Agricultural College Burlington Vermont 05405 —
University of Virginia Cancer Center Charlottesville Virginia 22908 —
VCU Massey Comprehensive Cancer Center Richmond Virginia 23298 —
Valley Medical Center Renton Washington 98055 —
Legacy Cancer Institute Medical Oncology and Day Treatment Vancouver Washington 98684 —
Legacy Salmon Creek Hospital Vancouver Washington 98686 —
Langlade Hospital and Cancer Center Antigo Wisconsin 54409 —
ThedaCare Regional Cancer Center Appleton Wisconsin 54911 —
Gundersen Lutheran Medical Center La Crosse Wisconsin 54601 —
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center Madison Wisconsin 53718 —
University of Wisconsin Carbone Cancer Center - University Hospital Madison Wisconsin 53792 —
Medical College of Wisconsin Milwaukee Wisconsin 53226 —
Aspirus Cancer Care - James Beck Cancer Center Rhinelander Wisconsin 54501 —
Aspirus Cancer Care - Stevens Point Stevens Point Wisconsin 54481 —
Aspirus Regional Cancer Center Wausau Wisconsin 54401 —
Aspirus Cancer Care - Wisconsin Rapids Wisconsin Rapids Wisconsin 54494 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 8 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06500455, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Sep 14, 2026 · Synced Oct 21, 2026

Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT06500455 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →