ClinicalTrials.gov record
Recruiting Phase 3 Interventional

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

ClinicalTrials.gov ID: NCT06500455

Public ClinicalTrials.gov record NCT06500455. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced May 10, 2026, 9:41 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase III Trial of Single Fraction Stereotactic Radiosurgery (SRS) Versus Fractionated SRS (FSRS) for Intact Brain Metastases

Study identification

NCT ID
NCT06500455
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
NRG Oncology
Other
Enrollment
269 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Dec 11, 2024
Primary completion
Jun 29, 2028
Completion
Jun 29, 2028
Last update posted
May 3, 2026

2024 – 2028

United States locations

U.S. sites
256
U.S. states
37
U.S. cities
186
Facility City State ZIP Site status
Banner University Medical Center - Tucson Tucson Arizona 85719 Suspended
University of Arizona Cancer Center-North Campus Tucson Arizona 85719 Suspended
University of Arkansas for Medical Sciences Little Rock Arkansas 72205 Recruiting
Kaiser Permanente-Anaheim Anaheim California 92806 Recruiting
Kaiser Permanente-Bellflower Bellflower California 90706 Recruiting
City of Hope Corona Corona California 92882 Recruiting
City of Hope Comprehensive Cancer Center Duarte California 91010 Recruiting
UC San Diego Health System - Encinitas Encinitas California 92024 Recruiting
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care Irvine California 92612 Recruiting
City of Hope at Irvine Lennar Irvine California 92618 Recruiting
UC San Diego Moores Cancer Center La Jolla California 92093 Recruiting
City of Hope Antelope Valley Lancaster California 93534 Recruiting
Kaiser Permanente Los Angeles Medical Center Los Angeles California 90027 Recruiting
Cedars Sinai Medical Center Los Angeles California 90048 Recruiting
Providence Queen of The Valley Napa California 94558 Recruiting
Kaiser Permanente-Ontario Ontario California 91761 Recruiting
UC Irvine Health/Chao Family Comprehensive Cancer Center Orange California 92868 Recruiting
Stanford Cancer Institute Palo Alto Palo Alto California 94304 Recruiting
UC San Diego Medical Center - Hillcrest San Diego California 92103 Recruiting
Providence Medical Foundation - Santa Rosa Santa Rosa California 95403 Recruiting
City of Hope South Pasadena South Pasadena California 91030 Recruiting
City of Hope South Bay Torrance California 90503 Recruiting
City of Hope Upland Upland California 91786 Recruiting
John Muir Medical Center-Walnut Creek Walnut Creek California 94598 Recruiting
UCHealth University of Colorado Hospital Aurora Colorado 80045 Recruiting
UCHealth Memorial Hospital Central Colorado Springs Colorado 80909 Recruiting
Memorial Hospital North Colorado Springs Colorado 80920 Recruiting
Poudre Valley Hospital Fort Collins Colorado 80524 Recruiting
Cancer Care and Hematology-Fort Collins Fort Collins Colorado 80528 Recruiting
UCHealth Greeley Hospital Greeley Colorado 80631 Recruiting
Medical Center of the Rockies Loveland Colorado 80538 Recruiting
Hartford Hospital Hartford Connecticut 06102 Active, not recruiting
The Hospital of Central Connecticut New Britain Connecticut 06050 Active, not recruiting
UM Sylvester Comprehensive Cancer Center at Aventura Aventura Florida 33180 Recruiting
Boca Raton Regional Hospital Boca Raton Florida 33486 Recruiting
UM Sylvester Comprehensive Cancer Center at Coral Gables Coral Gables Florida 33146 Recruiting
UM Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach Florida 33442 Recruiting
UM Sylvester Comprehensive Cancer Center at Doral Doral Florida 33166 Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami Florida 33136 Recruiting
Miami Cancer Institute Miami Florida 33176 Recruiting
UM Sylvester Comprehensive Cancer Center at Kendall Miami Florida 33176 Recruiting
UM Sylvester Comprehensive Cancer Center at Plantation Plantation Florida 33324 Recruiting
Moffitt Cancer Center-International Plaza Tampa Florida 33607 Recruiting
Moffitt Cancer Center - McKinley Campus Tampa Florida 33612 Recruiting
Moffitt Cancer Center Tampa Florida 33612 Recruiting
Moffitt Cancer Center at Wesley Chapel Wesley Chapel Florida 33544 Recruiting
Emory University Hospital Midtown Atlanta Georgia 30308 Recruiting
Piedmont Hospital Atlanta Georgia 30309 Recruiting
Emory University Hospital/Winship Cancer Institute Atlanta Georgia 30322 Recruiting
Emory Saint Joseph's Hospital Atlanta Georgia 30342 Recruiting
WellStar Cobb Hospital Austell Georgia 30106 Recruiting
Wellstar Kennestone Hospital Marietta Georgia 30060 Recruiting
Hawaii Cancer Care Inc - Waterfront Plaza Honolulu Hawaii 96813 Recruiting
Queen's Cancer Cenrer - POB I Honolulu Hawaii 96813 Recruiting
Queen's Medical Center Honolulu Hawaii 96813 Recruiting
University of Hawaii Cancer Center Honolulu Hawaii 96813 Recruiting
Queen's Cancer Center - Kuakini Honolulu Hawaii 96817 Recruiting
Kapiolani Medical Center for Women and Children Honolulu Hawaii 96826 Recruiting
Castle Medical Center Kailua Hawaii 96734 Suspended
Wilcox Memorial Hospital and Kauai Medical Clinic Lihue Hawaii 96766 Recruiting
Hawaii Cancer Care - Westridge ‘Aiea Hawaii 96701 Recruiting
The Queen's Medical Center - West Oahu ‘Ewa Beach Hawaii 96706 Recruiting
Centralia Oncology Clinic Centralia Illinois 62801 Recruiting
Northwestern University Chicago Illinois 60611 Recruiting
Rush MD Anderson Cancer Center Chicago Illinois 60612 Recruiting
University of Chicago Comprehensive Cancer Center Chicago Illinois 60637 Recruiting
Carle at The Riverfront Danville Illinois 61832 Recruiting
Cancer Care Specialists of Illinois - Decatur Decatur Illinois 62526 Recruiting
Decatur Memorial Hospital Decatur Illinois 62526 Recruiting
Carle Physician Group-Effingham Effingham Illinois 62401 Recruiting
Crossroads Cancer Center Effingham Illinois 62401 Recruiting
Elmhurst Memorial Hospital Elmhurst Illinois 60126 Recruiting
Carle Physician Group-Mattoon/Charleston Mattoon Illinois 61938 Recruiting
Loyola University Medical Center Maywood Illinois 60153 Recruiting
Edward Hospital/Cancer Center Naperville Illinois 60540 Recruiting
UC Comprehensive Cancer Center at Silver Cross New Lenox Illinois 60451 Recruiting
Cancer Care Center of O'Fallon O'Fallon Illinois 62269 Recruiting
HSHS Saint Elizabeth's Hospital O'Fallon Illinois 62269 Recruiting
Northwestern Medicine Orland Park Orland Park Illinois 60462 Recruiting
University of Chicago Medicine-Orland Park Orland Park Illinois 60462 Recruiting
Memorial Hospital East Shiloh Illinois 62269 Recruiting
Southern Illinois University School of Medicine Springfield Illinois 62702 Recruiting
Springfield Clinic Springfield Illinois 62702 Recruiting
Springfield Memorial Hospital Springfield Illinois 62781 Recruiting
Carle Cancer Center Urbana Illinois 61801 Recruiting
Northwestern Medicine Cancer Center Warrenville Warrenville Illinois 60555 Recruiting
Northwest Cancer Center - Main Campus Crown Point Indiana 46307 Recruiting
UChicago Medicine Northwest Indiana Crown Point Indiana 46307 Recruiting
Northwest Oncology LLC Dyer Indiana 46311 Recruiting
Goshen Center for Cancer Care Goshen Indiana 46526 Recruiting
Northwest Cancer Center - Hobart Hobart Indiana 46342 Recruiting
Saint Mary Medical Center Hobart Indiana 46342 Recruiting
The Community Hospital Munster Indiana 46321 Recruiting
Women's Diagnostic Center - Munster Munster Indiana 46321 Recruiting
Northwest Cancer Center - Valparaiso Valparaiso Indiana 46383 Recruiting
Mary Greeley Medical Center Ames Iowa 50010 Recruiting
McFarland Clinic - Ames Ames Iowa 50010 Recruiting
University of Iowa/Holden Comprehensive Cancer Center Iowa City Iowa 52242 Recruiting
University of Kansas Cancer Center Kansas City Kansas 66160 Recruiting
The University of Kansas Cancer Center - Olathe Olathe Kansas 66061 Recruiting
University of Kansas Cancer Center-Overland Park Overland Park Kansas 66210 Recruiting
Baptist Health Hardin Elizabethtown Kentucky 42701 Recruiting
University of Kentucky/Markey Cancer Center Lexington Kentucky 40536 Recruiting
The James Graham Brown Cancer Center at University of Louisville Louisville Kentucky 40202 Recruiting
Norton Brownsboro Hospital and Medical Campus Louisville Kentucky 40241 Recruiting
UofL Health Medical Center Northeast Louisville Kentucky 40245 Recruiting
Owensboro Health Mitchell Memorial Cancer Center Owensboro Kentucky 42303 Recruiting
MaineHealth Maine Medical Center - Portland Portland Maine 04102 Recruiting
MaineHealth Cancer Care Center of York County Sanford Maine 04073 Recruiting
MaineHealth Maine Medical Center- Scarborough Scarborough Maine 04074 Recruiting
Maryland Proton Treatment Center Baltimore Maryland 21201 Recruiting
University of Maryland/Greenebaum Cancer Center Baltimore Maryland 21201 Recruiting
Sinai Hospital of Baltimore Baltimore Maryland 21215 Recruiting
UM Upper Chesapeake Medical Center Bel Air Maryland 21014 Recruiting
Central Maryland Radiation Oncology in Howard County Columbia Maryland 21044 Recruiting
University of Maryland Shore Medical Center at Easton Easton Maryland 21601 Recruiting
UM Baltimore Washington Medical Center/Tate Cancer Center Glen Burnie Maryland 21061 Recruiting
UM Capital Region Medical Center Largo Maryland 20774 Recruiting
William E Kahlert Regional Cancer Center/Sinai Hospital Westminster Maryland 21157 Recruiting
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor Michigan 48106 Recruiting
University of Michigan Rogel Cancer Center Ann Arbor Michigan 48109 Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan 48114 Recruiting
Henry Ford Cancer Institute-Downriver Brownstown Michigan 48183 Recruiting
Henry Ford Macomb Hospital-Clinton Township Clinton Township Michigan 48038 Recruiting
Henry Ford Hospital Detroit Michigan 48202 Recruiting
Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan 48154 Recruiting
MyMichigan Medical Center Saginaw Saginaw Michigan 48601 Recruiting
MyMichigan Medical Center Tawas Tawas City Michigan 48764 Recruiting
Henry Ford West Bloomfield Hospital West Bloomfield Michigan 48322 Recruiting
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan 48197 Recruiting
Fairview Clinics and Surgery Center Maple Grove Maple Grove Minnesota 55369 Recruiting
Hennepin County Medical Center Minneapolis Minnesota 55415 Recruiting
University of Minnesota/Masonic Cancer Center Minneapolis Minnesota 55455 Recruiting
Monticello Cancer Center Monticello Minnesota 55362 Recruiting
Coborn Cancer Center at Saint Cloud Hospital Saint Cloud Minnesota 56303 Recruiting
Ridgeview Medical Center Waconia Minnesota 55387 Recruiting
Siteman Cancer Center at Saint Peters Hospital City of Saint Peters Missouri 63376 Recruiting
MU Health - University Hospital/Ellis Fischel Cancer Center Columbia Missouri 65212 Recruiting
Siteman Cancer Center at West County Hospital Creve Coeur Missouri 63141 Recruiting
Parkland Health Center - Farmington Farmington Missouri 63640 Recruiting
Mercy Hospital Springfield Springfield Missouri 65804 Recruiting
Washington University School of Medicine St Louis Missouri 63110 Recruiting
Siteman Cancer Center-South County St Louis Missouri 63129 Recruiting
Siteman Cancer Center at Christian Hospital St Louis Missouri 63136 Recruiting
Nebraska Medicine-Bellevue Bellevue Nebraska 68123 Recruiting
Nebraska Medicine-Village Pointe Omaha Nebraska 68118 Recruiting
University of Nebraska Medical Center Omaha Nebraska 68198 Recruiting
Renown Regional Medical Center Reno Nevada 89502 Recruiting
Memorial Sloan Kettering Basking Ridge Basking Ridge New Jersey 07920 Recruiting
Jefferson Cherry Hill Hospital Cherry Hill New Jersey 08002 Recruiting
Saint Barnabas Medical Center Livingston New Jersey 07039 Recruiting
Memorial Sloan Kettering Monmouth Middletown New Jersey 07748 Recruiting
Memorial Sloan Kettering Bergen Montvale New Jersey 07645 Recruiting
Jersey Shore Medical Center Neptune City New Jersey 07753 Recruiting
Rutgers Cancer Institute of New Jersey New Brunswick New Jersey 08903 Recruiting
Rutgers New Jersey Medical School Newark New Jersey 07101 Recruiting
Newark Beth Israel Medical Center Newark New Jersey 07112 Recruiting
The Valley Hospital - Luckow Pavilion Paramus New Jersey 07652 Recruiting
Valley Health System Ridgewood Campus Ridgewood New Jersey 07450 Recruiting
Sidney Kimmel Cancer Center Washington Township Sewell New Jersey 08080 Recruiting
Robert Wood Johnson University Hospital Somerset Somerville New Jersey 08876 Recruiting
Community Medical Center Toms River New Jersey 08755 Recruiting
University of New Mexico Cancer Center Albuquerque New Mexico 87106 Recruiting
New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn New York 11215 Recruiting
NYU Langone Hospital - Brooklyn Brooklyn New York 11220 Recruiting
Memorial Sloan Kettering Commack Commack New York 11725 Recruiting
Memorial Sloan Kettering Westchester East White Plains New York 10604 Recruiting
The New York Hospital Medical Center of Queens Flushing New York 11355 Recruiting
Northwell Health/Center for Advanced Medicine Lake Success New York 11042 Recruiting
NYU Langone Hospital - Long Island Mineola New York 11501 Recruiting
Mount Sinai Chelsea New York New York 10011 Recruiting
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York New York 10016 Recruiting
Mount Sinai West New York New York 10019 Recruiting
Mount Sinai Hospital New York New York 10029 Recruiting
Manhattan Eye Ear and Throat Hospital New York New York 10065 Recruiting
Memorial Sloan Kettering Cancer Center New York New York 10065 Recruiting
NYP/Weill Cornell Medical Center New York New York 10065 Recruiting
Lenox Hill Hospital New York New York 10075 Recruiting
University of Rochester Rochester New York 14642 Recruiting
Stony Brook University Medical Center Stony Brook New York 11794 Recruiting
State University of New York Upstate Medical University Syracuse New York 13210 Recruiting
SUNY Upstate Medical Center-Community Campus Syracuse New York 13215 Recruiting
Montefiore Medical Center-Einstein Campus The Bronx New York 10461 Recruiting
Montefiore Medical Center-Weiler Hospital The Bronx New York 10461 Recruiting
Montefiore Medical Center - Moses Campus The Bronx New York 10467 Recruiting
Memorial Sloan Kettering Nassau Uniondale New York 11553 Recruiting
Sanford Broadway Medical Center Fargo North Dakota 58122 Recruiting
Sanford Roger Maris Cancer Center Fargo North Dakota 58122 Recruiting
UH Seidman Cancer Center at UH Avon Health Center Avon Ohio 44011 Recruiting
Indu and Raj Soin Medical Center Beavercreek Ohio 45431 Active, not recruiting
University of Cincinnati Cancer Center-UC Medical Center Cincinnati Ohio 45219 Recruiting
Case Western Reserve University Cleveland Ohio 44106 Recruiting
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210 Recruiting
Riverside Methodist Hospital Columbus Ohio 43214 Recruiting
Grant Medical Center Columbus Ohio 43215 Recruiting
Delaware Health Center-Grady Cancer Center Delaware Ohio 43015 Recruiting
Grady Memorial Hospital Delaware Ohio 43015 Recruiting
Kettering Medical Center Kettering Ohio 45429 Active, not recruiting
UH Seidman Cancer Center at Lake Health Mentor Campus Mentor Ohio 44060 Recruiting
University of Cincinnati Cancer Center-West Chester West Chester Ohio 45069 Recruiting
Saint Elizabeth Youngstown Hospital Youngstown Ohio 44501 Active, not recruiting
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 Recruiting
Clackamas Radiation Oncology Center Clackamas Oregon 97015 Recruiting
Legacy Mount Hood Medical Center Gresham Oregon 97030 Recruiting
Legacy Good Samaritan Hospital and Medical Center Portland Oregon 97210 Recruiting
Providence Portland Medical Center Portland Oregon 97213 Recruiting
Providence Saint Vincent Medical Center Portland Oregon 97225 Recruiting
Legacy Meridian Park Hospital Tualatin Oregon 97062 Recruiting
Saint Luke's Cancer Center - Allentown Allentown Pennsylvania 18104 Recruiting
Saint Luke's University Hospital-Bethlehem Campus Bethlehem Pennsylvania 18015 Recruiting
Chambersburg Hospital Chambersburg Pennsylvania 17201 Recruiting
Northeast Radiation Oncology Center Dunmore Pennsylvania 18512 Recruiting
Saint Luke's Hospital-Anderson Campus Easton Pennsylvania 18045 Recruiting
Penn State Milton S Hershey Medical Center Hershey Pennsylvania 17033-0850 Recruiting
NRG Oncology Philadelphia Pennsylvania 19103 Recruiting
University of Pennsylvania/Abramson Cancer Center Philadelphia Pennsylvania 19104 Recruiting
Thomas Jefferson University Hospital Philadelphia Pennsylvania 19107 Recruiting
Jefferson Torresdale Hospital Philadelphia Pennsylvania 19114 Recruiting
UPMC-Presbyterian Hospital Pittsburgh Pennsylvania 15213 Recruiting
UPMC-Shadyside Hospital Pittsburgh Pennsylvania 15232 Recruiting
Saint Luke's Hospital - Upper Bucks Campus Quakertown Pennsylvania 18951 Recruiting
Saint Luke's Hospital - Monroe Campus Stroudsburg Pennsylvania 18360 Recruiting
Reading Hospital West Reading Pennsylvania 19611 Recruiting
WellSpan Health-York Cancer Center York Pennsylvania 17403 Recruiting
WellSpan Health-York Hospital York Pennsylvania 17403 Recruiting
Saint Francis Hospital Greenville South Carolina 29601 Recruiting
Saint Francis Cancer Center Greenville South Carolina 29607 Recruiting
Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota 57104 Recruiting
Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota 57117-5134 Recruiting
Vanderbilt Breast Center at One Hundred Oaks Nashville Tennessee 37204 Recruiting
Vanderbilt University/Ingram Cancer Center Nashville Tennessee 37232 Recruiting
MD Anderson in The Woodlands Conroe Texas 77384 Recruiting
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center Houston Texas 77030 Recruiting
M D Anderson Cancer Center Houston Texas 77030 Recruiting
Memorial Hermann Texas Medical Center Houston Texas 77030 Recruiting
MD Anderson West Houston Houston Texas 77079 Recruiting
MD Anderson League City League City Texas 77573 Recruiting
University of Texas Health Science Center at San Antonio San Antonio Texas 78229 Recruiting
MD Anderson in Sugar Land Sugar Land Texas 77478 Recruiting
Huntsman Cancer Institute/University of Utah Salt Lake City Utah 84112 Recruiting
University of Vermont Medical Center Burlington Vermont 05401 Recruiting
University of Vermont and State Agricultural College Burlington Vermont 05405 Recruiting
VCU Massey Comprehensive Cancer Center Richmond Virginia 23298 Recruiting
Valley Medical Center Renton Washington 98055 Recruiting
Legacy Cancer Institute Medical Oncology and Day Treatment Vancouver Washington 98684 Recruiting
Legacy Salmon Creek Hospital Vancouver Washington 98686 Recruiting
Langlade Hospital and Cancer Center Antigo Wisconsin 54409 Recruiting
ThedaCare Regional Cancer Center Appleton Wisconsin 54911 Recruiting
Gundersen Lutheran Medical Center La Crosse Wisconsin 54601 Recruiting
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center Madison Wisconsin 53718 Recruiting
University of Wisconsin Carbone Cancer Center - University Hospital Madison Wisconsin 53792 Recruiting
Medical College of Wisconsin Milwaukee Wisconsin 53226 Recruiting
Aspirus Cancer Care - James Beck Cancer Center Rhinelander Wisconsin 54501 Recruiting
Aspirus Cancer Care - Stevens Point Stevens Point Wisconsin 54481 Recruiting
Aspirus Regional Cancer Center Wausau Wisconsin 54401 Recruiting
Aspirus Cancer Care - Wisconsin Rapids Wisconsin Rapids Wisconsin 54494 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06500455, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted May 3, 2026 · Synced May 10, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06500455 live on ClinicalTrials.gov.

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