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Recruiting Phase 3 Interventional

Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

ClinicalTrials.gov ID: NCT06500481

Public ClinicalTrials.gov record NCT06500481. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 3:54 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase III Randomized Clinical Trial of Proton Craniospinal Irradiation Versus Involved-Field Radiotherapy for Patients With Breast Cancer or Non-Small Cell Lung Cancer Leptomeningeal Metastasis (Radiate-LM)

Study identification

NCT ID
NCT06500481
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
NRG Oncology
Other
Enrollment
115 participants

Conditions and interventions

Interventions

  • Biospecimen Collection Procedure
  • Computed Tomography Procedure
  • Involved-Field Radiation Therapy Radiation
  • Lumbar Puncture Procedure
  • Magnetic Resonance Imaging Procedure
  • Positron Emission Tomography Procedure
  • Proton Beam Craniospinal Irradiation Radiation
  • Quality-of-Life Assessment Other

Procedure · Radiation · Other

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Mar 3, 2025
Primary completion
Jul 30, 2028
Completion
Jul 30, 2028
Last update posted
May 6, 2026

2025 – 2028

United States locations

U.S. sites
58
U.S. states
17
U.S. cities
48
Facility City State ZIP Site status
Mayo Clinic Hospital in Arizona Phoenix Arizona 85054 Recruiting
University of Arkansas for Medical Sciences Little Rock Arkansas 72205 Recruiting
UC San Diego Health System - Encinitas Encinitas California 92024 Recruiting
UC San Diego Moores Cancer Center La Jolla California 92093 Recruiting
UC San Diego Medical Center - Hillcrest San Diego California 92103 Recruiting
California Protons Cancer Therapy Center San Diego California 92121 Recruiting
Sibley Memorial Hospital Washington D.C. District of Columbia 20016 Recruiting
UM Sylvester Comprehensive Cancer Center at Aventura Aventura Florida 33180 Recruiting
UM Sylvester Comprehensive Cancer Center at Coral Gables Coral Gables Florida 33146 Recruiting
UM Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach Florida 33442 Recruiting
UM Sylvester Comprehensive Cancer Center at Doral Doral Florida 33166 Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami Florida 33136 Recruiting
Miami Cancer Institute Miami Florida 33176 Recruiting
UM Sylvester Comprehensive Cancer Center at Kendall Miami Florida 33176 Recruiting
UM Sylvester Comprehensive Cancer Center at Plantation Plantation Florida 33324 Recruiting
Alton Memorial Hospital Alton Illinois 62002 Recruiting
Northwestern University Chicago Illinois 60611 Recruiting
Northwestern Medicine Cancer Center Kishwaukee DeKalb Illinois 60115 Recruiting
Northwestern Medicine Cancer Center Delnor Geneva Illinois 60134 Recruiting
Memorial Hospital East Shiloh Illinois 62269 Recruiting
Northwestern Medicine Cancer Center Warrenville Warrenville Illinois 60555 Recruiting
University of Kansas Cancer Center Kansas City Kansas 66160 Recruiting
University of Kansas Cancer Center-Overland Park Overland Park Kansas 66210 Recruiting
Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore Maryland 21287 Recruiting
Wayne State University/Karmanos Cancer Institute Detroit Michigan 48201 Recruiting
Weisberg Cancer Treatment Center Farmington Hills Michigan 48334 Recruiting
McLaren Cancer Institute-Flint Flint Michigan 48532 Recruiting
Karmanos Cancer Institute at McLaren Greater Lansing Lansing Michigan 48910 Recruiting
Mayo Clinic in Rochester Rochester Minnesota 55905 Recruiting
Siteman Cancer Center at Saint Peters Hospital City of Saint Peters Missouri 63376 Recruiting
Siteman Cancer Center at West County Hospital Creve Coeur Missouri 63141 Recruiting
University of Kansas Cancer Center - North Kansas City Missouri 64154 Recruiting
University of Kansas Cancer Center - Lee's Summit Lee's Summit Missouri 64064 Recruiting
Mercy Hospital Springfield Springfield Missouri 65804 Recruiting
Washington University School of Medicine St Louis Missouri 63110 Recruiting
Mercy Hospital South St Louis Missouri 63128 Recruiting
Siteman Cancer Center-South County St Louis Missouri 63129 Recruiting
Siteman Cancer Center at Christian Hospital St Louis Missouri 63136 Recruiting
Memorial Sloan Kettering Basking Ridge Basking Ridge New Jersey 07920 Recruiting
Memorial Sloan Kettering Monmouth Middletown New Jersey 07748 Recruiting
Memorial Sloan Kettering Bergen Montvale New Jersey 07645 Recruiting
NYU Langone Hospital - Brooklyn Brooklyn New York 11220 Recruiting
Memorial Sloan Kettering Commack Commack New York 11725 Recruiting
Memorial Sloan Kettering Westchester East White Plains New York 10604 Recruiting
NYU Langone Hospital - Long Island Mineola New York 11501 Recruiting
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York New York 10016 Recruiting
New York Proton Center New York New York 10035 Recruiting
Memorial Sloan Kettering Cancer Center New York New York 10065 Recruiting
Montefiore Medical Center-Einstein Campus The Bronx New York 10461 Recruiting
Montefiore Medical Center - Moses Campus The Bronx New York 10467 Recruiting
Memorial Sloan Kettering Nassau Uniondale New York 11553 Recruiting
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210 Recruiting
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 Recruiting
Huntsman Cancer Institute/University of Utah Salt Lake City Utah 84112 Recruiting
Inova Alexandria Hospital Alexandria Virginia 22304 Recruiting
Inova Schar Cancer Institute Fairfax Virginia 22031 Recruiting
Inova Fair Oaks Hospital Fairfax Virginia 22033 Recruiting
Inova Loudoun Hospital Leesburg Virginia 20176 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06500481, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted May 6, 2026 · Synced May 8, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06500481 live on ClinicalTrials.gov.

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