A Study of Aticaprant 10 mg as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy and Long-term Extension Treatment With Aticaprant
Public ClinicalTrials.gov record NCT06514742. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Multicenter, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Aticaprant 10 mg as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy and an Open Label Long-term Extension Treatment With Aticaprant
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate how well aticaprant works as compared with placebo when given along with an antidepressant therapy in improving the depressive symptoms in adult participants with major depressive disorder (MDD) with moderate to severe anhedonia (ANH+) who have not responded well to current antidepressant therapy with a selective serotonin reuptake inhibitor/serotonin-norepinephrine reuptake inhibitor (SSRI or SNRI).
Study identification
- NCT ID
- NCT06514742
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 101 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 64 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 26, 2024 (Actual)
- Primary completion
- Apr 8, 2025 (Actual)
- Completion
- Apr 24, 2025 (Actual)
- Last update posted
- Feb 17, 2026
2024 – 2025
United States locations
- U.S. sites
- 39
- U.S. states
- 16
- U.S. cities
- 36
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UAB Huntsville Regional Medical Campus | Huntsville | Alabama | 35801 | — |
| IMA Clinical Research PC | Phoenix | Arizona | 85012 | — |
| Noble Clinical Research | Tucson | Arizona | 85704 | — |
| Advanced Research Center Inc | Anaheim | California | 92805 | — |
| CI Trials | Bellflower | California | 90706 | — |
| Behavioral Research Specialists LLC | Glendale | California | 91206 | — |
| Sun Valley Research Center | Imperial | California | 92251 | — |
| ATP Clinical Research | Orange | California | 92866 | — |
| Lumos Clinical Research Center LLC | San Jose | California | 95124 | — |
| Viking Clinical Research Ltd | Temecula | California | 92591 | — |
| Sunwise Clinical Research | Walnut Creek | California | 94596 | — |
| MCB Clinical Research Centers LLC | Colorado Springs | Colorado | 80910 | — |
| Humanity Clinical Research Corp | Aventura | Florida | 33180 | — |
| Elligo Independent Research Sites Mindful Behavioral Health | Boca Raton | Florida | 33431 | — |
| Gulfcoast Medical Research Center | Fort Myers | Florida | 33912 | — |
| New Life Medical Research Center, Inc. | Hialeah | Florida | 33012 | — |
| LCC Medical Research Institute Inc | Miami | Florida | 33126 | — |
| Floridian Clinical Research LLC | Miami | Florida | 33135 | — |
| Medquest Translational Sciences | Miami Lakes | Florida | 33016 | — |
| Best Choice Medical and Research Service | Pembroke Pines | Florida | 33024 | — |
| K2 Medical Research | Tampa | Florida | 33607 | — |
| Neuroscience Research Institute | West Palm Beach | Florida | 33407 | — |
| Accelerated Clinical Trials LLC | Peachtree Corners | Georgia | 30071 | — |
| Southern Illinois University School of Medicine | Springfield | Illinois | 62702 | — |
| DelRicht Research | New Orleans | Louisiana | 70115 | — |
| CBH Health | Gaithersburg | Maryland | 20877 | — |
| Integrative Clinical Trials LLC | Brooklyn | New York | 11229 | — |
| Fieve Clinical Research Inc | New York | New York | 10017 | — |
| New Hope Clinical Research | Charlotte | North Carolina | 28211 | — |
| Patient Priority Clinical Sites LLC | Cincinnati | Ohio | 45215 | — |
| OSU Department of Psychiatry and Behavioral Health | Columbus | Ohio | 43210 | — |
| Conrad Clinical Research | Edmond | Oklahoma | 73013 | — |
| Suburban Research Associates | Media | Pennsylvania | 19063 | — |
| UTHealth Houston Center for Interventional Psychiatry | Houston | Texas | 77030 | — |
| Brain Health Consultants | Houston | Texas | 77046 | — |
| Red Oak Psychiatry Associates | Houston | Texas | 77090 | — |
| Revival Research Institute LLC | McKinney | Texas | 75071 | — |
| Perceptive Pharma Research | Richmond | Texas | 77407 | — |
| Northwest Clinical Research Center | Bellevue | Washington | 98007 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 45 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06514742, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 17, 2026 · Synced Oct 18, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06514742 live on ClinicalTrials.gov.