A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy

ClinicalTrials.gov ID: NCT06541704

Public ClinicalTrials.gov record NCT06541704. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 3:56 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Multicenter, Randomized, Double-Masked, Placebo-Controlled Phase 3 Study of the Efficacy, Safety, and Tolerability of Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration

Study identification

NCT ID: NCT06541704
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Regeneron Pharmaceuticals; Industry
Enrollment: 975 participants

Conditions and interventions

Conditions

Interventions

Cemdisiran Drug
Placebo Drug
Pozelimab Drug

Drug

Eligibility (public fields only)

Age range: 50 Years to 85 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 29, 2024
Primary completion: Nov 28, 2027
Completion: May 20, 2032
Last update posted: May 6, 2026

2024 – 2032

United States locations

U.S. sites: 152
U.S. states: 33
U.S. cities: 122

Facility	City	State	ZIP	Site status
Barnet Dulaney Perkins Eye Center-Ophthamalogy	Chandler	Arizona	85224	Recruiting
Barnet Dulaney Perkins Eye Center	Phoenix	Arizona	85016	Recruiting
Associated Retina Consultants	Phoenix	Arizona	85020	Recruiting
Retinal Research Institute	Phoenix	Arizona	85053	Recruiting
Retina Macula Institute of Arizona	Scottsdale	Arizona	85255	Recruiting
Retina Associates of Tuscan	Tucson	Arizona	85712	Recruiting
Retina Partners of Northwest Arkansas, PLLC	Springdale	Arkansas	72764	Recruiting
Retina Vitreous Associates Medical Group	Beverly Hills	California	90211	Recruiting
Retina Specialists of Beverly Hills- Department of Ophthalmology	Beverly Hills	California	90212	Recruiting
The Retina Partners	Encino	California	91436	Recruiting
Eye Medical Center of Fresno	Fresno	California	93720	Recruiting
Retina Consultants of Orange County	Fullerton	California	92835	Recruiting
Salehi Retina Institute dba Retina Associates of Southern California	Huntington Beach	California	92647	Recruiting
University of California Irvine	Irvine	California	92617	Recruiting
University of California San Diego, Jacobs Retina Center	La Jolla	California	92093	Recruiting
South Coast Retina Center	Long Beach	California	90807	Recruiting
American Institute of Research	Los Angeles	California	90017	Recruiting
Kaiser Permanente Los Angeles Medical Center	Los Angeles	California	90027	Recruiting
Jules Stein Eye Institute in David Geffen School of Medicine at Ucla	Los Angeles	California	90095	Recruiting
Retinal Consultants Medical Group Inc Modesto	Modesto	California	95356	Recruiting
Northern California Retina Vitreous Associates Medical Group, Inc.	Mountain View	California	94040	Recruiting
California Retina Consultants	Oxnard	California	93036	Recruiting
Desert Retina Consultants	Palm Desert	California	92211	Withdrawn
California Eye Specialists Medical Group Inc.	Pasadena	California	91107	Recruiting
Retina Consultants San Diego	Poway	California	92064	Recruiting
California Eye Specialists Medical Group, Inc.	Redlands	California	92373	Recruiting
Optic Eye Care	Rowland Heights	California	91748	Recruiting
UC Davis Health Eye Center	Sacramento	California	95817	Recruiting
Vrmg Inc	Sacramento	California	95825	Recruiting
Retinal Consultants Medical Group (RCMG) - Greenback Lane Retina Center	Sacramento	California	95841	Recruiting
West Coast Retina Medical Group, Inc.	San Francisco	California	94109	Recruiting
Orange County Retina Medical Group	Santa Ana	California	92705	Recruiting
Macula Retina Vitreous Research Institute	Torrance	California	90503	Recruiting
University of Colorado	Aurora	Colorado	80045	Recruiting
Retina Consultants of Southern Colorado	Colorado Springs	Colorado	80909	Recruiting
Retina Specialists of Colorado - Denver	Denver	Colorado	80222	Recruiting
Southwest Retina Research Center	Durango	Colorado	81303	Recruiting
Colorado Retina - Lakewood	Lakewood	Colorado	80228	Recruiting
Eye care Center of Northern Colorado doing business as Advanced Vision Research Institute	Longmont	Colorado	80503	Recruiting
Retina Group of New England	Waterford	Connecticut	06385	Terminated
Advanced Retina Institute-Ophthalmology	Bonita Springs	Florida	34134	Recruiting
Advanced Research	Coral Springs	Florida	33067	Recruiting
Retina Group of Florida	Fort Lauderdale	Florida	33308	Recruiting
National Ophthalmic Research Institute	Fort Myers	Florida	33912	Withdrawn
ClearVista Clinical Research, Retina Center Tampa Bay	Hudson	Florida	34667	Recruiting
Florida Retina Institute, Jacksonville Perimeter Park- Ophthalmology	Jacksonville	Florida	32216	Recruiting
Florida Retina Consultants	Lakeland	Florida	33805	Recruiting
Bascom Palmer Eye Institute	Naples	Florida	34103	Recruiting
Florida Retina Institute - Orlando	Orlando	Florida	32806	Recruiting
Retina Care Specialists	Palm Beach Gardens	Florida	33410	Recruiting
Eye Associates of Pinellas	Pinellas Park	Florida	33782	Recruiting
Retina Group of Florida, RAS-Sarasota Retina Center-Ophthalmology	Sarasota	Florida	34232	Recruiting
Retina Vitreous Associates of Florida Saint Petersburg	St. Petersburg	Florida	33711	Recruiting
University of South Florida Ophthalmology	Tampa	Florida	33612	Recruiting
Center for Retina and Macular Disease	Winter Haven	Florida	33880	Recruiting
Southeast Retina Center	Augusta	Georgia	30909	Recruiting
Georgia Retina - Marietta	Marietta	Georgia	30060	Recruiting
University of Illinois at Chicago	Chicago	Illinois	60612	Recruiting
Retinal Vitreal Consultants	Chicago	Illinois	60616	Recruiting
The University of Chicago	Chicago	Illinois	60637	Recruiting
University Retina and Macula Associates PC - Lemont	Lemont	Illinois	60439	Recruiting
Illinois Retina Associates	Oak Park	Illinois	60304	Recruiting
Springfield Clinic Main Campus East	Springfield	Illinois	62703	Recruiting
Retina Associates, LLC	Lenexa	Kansas	66215	Recruiting
University of Louisville	Louisville	Kentucky	40202	Recruiting
Retina Associates New Orleans	Metairie	Louisiana	70006	Recruiting
Ross Davis Retina	Metairie	Louisiana	70006	Recruiting
Ochsner Health	New Orleans	Louisiana	70121	Recruiting
Eye Assoc. of NE LA dba Haik Humble Eye Ctr	West Monroe	Louisiana	71291	Recruiting
Eye Associates of Northeast Louisiana dba Haik Humble Eye Center	West Monroe	Louisiana	71291	Recruiting
The Retina Care Center	Baltimore	Maryland	21209	Recruiting
The Retina Group of Washington	Chevy Chase	Maryland	20815	Recruiting
Cumberland Valley Retina Consultants-Ophthalmology	Hagerstown	Maryland	21740	Recruiting
Mid Atlantic Retina Specialist	Hagerstown	Maryland	21740	Recruiting
Massachusetts Eye And Ear Infirmary	Boston	Massachusetts	02114	Recruiting
Opthalmic Consultants of Boston	Boston	Massachusetts	02114	Recruiting
New England Retina Consultants, PC	Springfield	Massachusetts	01107	Recruiting
Retina Associates of Michigan	Grand Blanc	Michigan	48439	Recruiting
Mississippi Retina Associates	Madison	Mississippi	39110	Recruiting
Deep Blue Retina Clinical Research PLLC	Southaven	Mississippi	38671	Recruiting
Retina Research Institute, LLC	St Louis	Missouri	63144	Recruiting
Mid Atlantic Retina - Cherry Hill	Cherry Hill	New Jersey	08034	Recruiting
New Jersey Retina	Teaneck	New Jersey	07666	Recruiting
New Jersey Retina	Toms River	New Jersey	08755	Recruiting
Vision Research Center at Eye Associates of New Mexico	Albuquerque	New Mexico	87109	Recruiting
University of New Mexico, HSC	Albuquerque	New Mexico	87131	Recruiting
Sight MD	Brentwood	New York	11717	Recruiting
Retina Vitreous Surgeons of Central New York, PC	Liverpool	New York	13088	Recruiting
MaculaCare, PLLC	New York	New York	10021	Recruiting
New York Ear & Eye- East 85th	New York	New York	10028	Recruiting
Northwell Health- Manhattan, Ear, Eye and Throat Hospital- Ophthalmology	New York	New York	10065	Recruiting
Retina Associates of New York, Upper East Side	New York	New York	10075	Recruiting
Seeta Eye center	Poughkeepsie	New York	12603	Recruiting
Western Carolina Retinal Associates	Asheville	North Carolina	28803	Recruiting
NC Retina Associates	Cary	North Carolina	27511	Recruiting
Graystone Eye	Hickory	North Carolina	28602	Recruiting
North Carolina Retina Associates	Wake Forest	North Carolina	27587	Recruiting
Piedmont Retina Specialist	Winston-Salem	North Carolina	27103	Recruiting
Cincinnati Eye Institute	Cincinnati	Ohio	45242	Recruiting
University Hospitals Cleveland Medical Center	Cleveland	Ohio	44106	Recruiting
The Ohio State University	Columbus	Ohio	43212	Recruiting
Midwest Retina, Inc	Dublin	Ohio	43016	Recruiting
Retina Vitreous Center - Edmond	Edmond	Oklahoma	73013	Recruiting
Tulsa Retina Consultants	Tulsa	Oklahoma	74114	Recruiting
Verum Research LLC	Eugene	Oregon	97401	Recruiting
Retina Northwest, The Highlands Building	Portland	Oregon	97221	Recruiting
EyeHealth Northwest	Portland	Oregon	97225	Recruiting
OHSU-Casey Eye Institute, Marquam Hill-Ophthalmology	Portland	Oregon	97239	Recruiting
Cascade Medical Research Institute LLC	Springfield	Oregon	97477	Recruiting
Mid Atlantic Retina	Bethlehem	Pennsylvania	18017	Recruiting
Erie Retinal Surgery & Erie Retina Research	Erie	Pennsylvania	16507	Recruiting
Mid Atlantic Retina, Wills Eye Hospital	Philadelphia	Pennsylvania	19107	Recruiting
Vision Research Solutions - the Eye Institute	Philadelphia	Pennsylvania	19141	Recruiting
Sewickley Eye Group	Sewickley	Pennsylvania	15143	Recruiting
Retina Consultants of Carolina	Greenville	South Carolina	29605	Recruiting
Charleston Neuroscience Institute LLC	Ladson	South Carolina	29456	Recruiting
Charleston Neuroscience Institute, LLC	Mt. Pleasant	South Carolina	29464	Recruiting
Palmetto Retina Center	West Columbia	South Carolina	29169	Recruiting
Black Hills Regional Eye Institute	Rapid City	South Dakota	57701	Recruiting
Tennessee Retina, PC	Nashville	Tennessee	37203	Recruiting
Vanderbilt Eye Institute	Nashville	Tennessee	37232	Recruiting
Retina Research Institute of Texas	Abilene	Texas	79606	Recruiting
Austin Research Center for Retina	Austin	Texas	78705	Recruiting
Austin Retina Associates	Austin	Texas	78705	Recruiting
Austin Clinical Research LLC	Austin	Texas	78750	Withdrawn
Retina Consultants Texas	Bellaire	Texas	77401	Recruiting
Star Retina PLLC	Burleson	Texas	76028	Recruiting
Retina Foundation of the Southwest	Dallas	Texas	75231	Recruiting
Texas Retina Associates	Dallas	Texas	75231	Recruiting
University of Texas Southwestern Medical Center	Dallas	Texas	75390	Recruiting
Retina Consultants of Texas	Katy	Texas	77494	Recruiting
Valley Retina Institute, P.A.	McAllen	Texas	78503	Recruiting
Red River Research Partners (Formerly AXIS Clinical)	Plano	Texas	75024	Recruiting
Austin Retina Associates	Round Rock	Texas	78681	Recruiting
Medical Center Ophthalmology Associates	San Antonio	Texas	78240	Recruiting
Retina Associates of South Texas	San Antonio	Texas	78240	Recruiting
Retina Consultants of Texas	San Antonio	Texas	78240	Recruiting
Retina Consultants of Texas Brown Retina Institute	San Antonio	Texas	78251	Recruiting
Retina Center of Texas	Southlake	Texas	76092	Recruiting
Retina Consultants Texas	The Woodlands	Texas	77384	Recruiting
Tyler Retina Research Institute- Ophthalmology	Tyler	Texas	75703	Recruiting
Retina Associates Of Utah Retina Specialist	Salt Lake City	Utah	84107	Recruiting
Rocky Mountain Retina Consultants	Salt Lake City	Utah	84107	Recruiting
Salt Lake Retina- Ophthalmology	West Jordan	Utah	84088	Recruiting
University of Vermont	Burlington	Vermont	05401	Recruiting
Southeastern Retina Associates	Bristol	Virginia	24201	Recruiting
Retina Group of Washington	Fairfax	Virginia	22031	Recruiting
Piedmont Eye Center	Lynchburg	Virginia	24502	Recruiting
Virginia Eye Institute	Richmond	Virginia	23226	Recruiting
Retina Institute of Virginia	Richmond	Virginia	23235	Completed
Spokane Eye Clinical Research	Spokane	Washington	99204	Recruiting
West Virginia University Eye Institute	Morgantown	West Virginia	26506	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 64 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06541704, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 6, 2026 · Synced May 8, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06541704 live on ClinicalTrials.gov.

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