A Research Study Comparing How Well Different Doses of the Medicine NNC0487-0111 Lower Blood Sugar in People With Type 2 Diabetes
Public ClinicalTrials.gov record NCT06542874. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
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Official title
Safety and Efficacy of Once-weekly Subcutaneous and Once-daily Oral NNC0487-0111 in Participants With Type 2 Diabetes - a Dose Finding Study
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The study will look at how well different doses of a new medicine called NNC0487-0111 help lower the blood sugar and body weight in people with type 2 diabetes. NNC0487-0111 is a new medicine which cannot be prescribed by doctors but has previously been tested in humans. Participants will either get NNC0487-0111, which is given as tablets or as injections, or placebo. Which treatment the participant get is decided by chance.The study will last for about 43 weeks.
Study identification
- NCT ID
- NCT06542874
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 448 participants
Conditions and interventions
Conditions
Interventions
- NNC0487-0111 subcutanous Drug
- Placebo (NNC0487-0111 subcutanous) Drug
- NNC0487-0111 oral Drug
- Placebo (NNC0487-0111 oral) Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 7, 2024 (Actual)
- Primary completion
- Oct 1, 2025 (Actual)
- Completion
- Oct 24, 2025 (Actual)
- Last update posted
- Oct 2, 2026
2024 – 2025
United States locations
- U.S. sites
- 39
- U.S. states
- 19
- U.S. cities
- 33
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Uni of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Velocity Clin Research LA | Los Angeles | California | 90057 | — |
| Southern Cal Clinical Research | Santa Ana | California | 92701 | — |
| Chase Medical Research LLC | Waterbury | Connecticut | 06708 | — |
| Fleming Island Ctr for Clin Res | Fleming Island | Florida | 32003 | — |
| Encore Medical Research LLC | Hollywood | Florida | 33024 | — |
| South Broward Research LLC | Miramar | Florida | 33027 | — |
| Florida Inst For Clin Res | Orlando | Florida | 32825 | — |
| Florida Institute for Clinical research | Orlando | Florida | 32825 | — |
| Cedar-Crosse Research Center | Chicago | Illinois | 60607 | — |
| Cotton O'Neil Clinical Research Center | Topeka | Kansas | 66606 | — |
| Advanced Internal Medicine, PLLC | Paducah | Kentucky | 42001 | — |
| Medstar Research Institute_Hyattsville | Hyattsville | Maryland | 20782 | — |
| MD Medical Research | Oxon Hill | Maryland | 20745 | — |
| Brigham & Women's Hospital | Boston | Massachusetts | 02115 | — |
| ActivMed Practice & Research LLC | Methuen | Massachusetts | 01844 | — |
| Arcturus HC PLC Troy Med Res | Troy | Michigan | 48098 | — |
| Arcturus Healthcare, PLC | Troy | Michigan | 48098 | — |
| Clinical Research Professionals | Chesterfield | Missouri | 63005 | — |
| StudyMetrix Research LLC | City of Saint Peters | Missouri | 63303 | — |
| AMC Community Endocrinology | Albany | New York | 12203 | — |
| Centricity Rsrch MHCity Multi | Morehead City | North Carolina | 28557 | — |
| Piedmont Healthcare/Research | Statesville | North Carolina | 28625 | — |
| Lillestol Research LLC | Fargo | North Dakota | 58104 | — |
| Plains Clinical Research Center, LLC_Fargo | Fargo | North Dakota | 58104 | — |
| Alliance for Multispec Res | Norman | Oklahoma | 73069 | — |
| Jefferson Endocrinology Assocs | Philadelphia | Pennsylvania | 19107-6810 | — |
| Preferred Primary Care Physicians_Pittsburgh | Pittsburgh | Pennsylvania | 15236 | — |
| Health Concepts | Rapid City | South Dakota | 57702 | — |
| Holston Medical Group | Kingsport | Tennessee | 37660 | — |
| Clinical Research Associates | Nashville | Tennessee | 37203 | — |
| MidState Endocrine Associates | Nashville | Tennessee | 37203 | — |
| Velocity Clinical Res-Dallas | Dallas | Texas | 75230 | — |
| Victorium Clinical Research | Houston | Texas | 77024 | — |
| Synergy Groups Medical | Houston | Texas | 77061 | — |
| PlanIt Research, PLLC | Houston | Texas | 77079 | — |
| Radiance Clinical Research | Lampasas | Texas | 76550 | — |
| Tekton Research | McKinney | Texas | 75069 | — |
| Hillcrest Family Health Center | Waco | Texas | 76708 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 98 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06542874, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 2, 2026 · Synced Nov 7, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06542874 live on ClinicalTrials.gov.