Spastic Paraplegia - Centers of Excellence Research Network
Public ClinicalTrials.gov record NCT06553976. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Spastic Paraplegia - Centers of Excellence Research Network (SP-CERN) - Natural History Study Pilot
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The Spastic Paraplegia - Centers of Excellence Research Network (SP-CERN) is a collaborative research consortium dedicated to advancing the understanding, diagnosis, and treatment of hereditary spastic paraplegia (HSP) and primary lateral sclerosis (PLS). Aims of the consortium are to a) perform natural history studies of HSP subtypes, b) discover and validate biomarkers and clinician- and patient-reported outcome measures, c) uncover HSP's molecular pathophysiology and develop rational therapeutic targets, and d) perform sufficiently powered clinical trials. The current pilot study is aimed at enrolling 100 individuals with hereditary spastic paraplegia type 4 (SPG4) or hereditary spastic paraplegia type 5A (SPG5A).
Study identification
- NCT ID
- NCT06553976
- Recruitment status
- Recruiting
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 100 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- Not listed
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 4, 2024 (Actual)
- Primary completion
- Jun 4, 2026 (Estimated)
- Completion
- Jun 4, 2027 (Estimated)
- Last update posted
- Mar 18, 2026
2024 – 2027
United States locations
- U.S. sites
- 11
- U.S. states
- 8
- U.S. cities
- 9
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Miami Miller School of Medicine | Miami | Florida | 33136 | Not yet recruiting |
| University of Iowa Carver College of Medicine | Iowa City | Iowa | 52242 | Not yet recruiting |
| Boston Children's Hospital | Boston | Massachusetts | 02215 | Recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02215 | Not yet recruiting |
| University of Michigan School of Medicine | Ann Arbor | Michigan | 48109 | Not yet recruiting |
| Columbia University - Irving Medical Center | New York | New York | 10032 | Not yet recruiting |
| Cincinnati Children's Hospital Medical Center | Cincinnati | Ohio | 45229-3039 | Not yet recruiting |
| Scottish Rite for Children | Dallas | Texas | 75219 | Not yet recruiting |
| Texas Children's Hospital | Houston | Texas | 77035 | Not yet recruiting |
| Seattle Children's Hospital | Seattle | Washington | 98105 | Not yet recruiting |
| University of Washington School of Medicine | Seattle | Washington | 98195 | Not yet recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06553976, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 18, 2026 · Synced Nov 6, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06553976 live on ClinicalTrials.gov.