Testing the Addition of an IDH2 Inhibitor, Enasidenib, to Usual Treatment (Cedazuridine-Decitabine) for Higher-Risk Myelodysplastic Syndrome (MDS) With IDH2 Mutation (A MyeloMATCH Treatment Trial)

ClinicalTrials.gov ID: NCT06577441

Public ClinicalTrials.gov record NCT06577441. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 6, 2026, 7:32 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized Phase II Trial of Enasidenib-Based Therapies Versus Cedazuridine-Decitabine in Higher-Risk IDH2-Mutated Myelodysplastic Syndrome: A MyeloMATCH Sub-Study

Study identification

NCT ID: NCT06577441
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: National Cancer Institute (NCI); NIH
Enrollment: 54 participants

Conditions and interventions

Conditions

Myelodysplastic Syndrome

Interventions

Biospecimen Collection Procedure
Bone Marrow Aspiration Procedure
Bone Marrow Biopsy Procedure
Decitabine and Cedazuridine Drug
Enasidenib Drug

Procedure · Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 11, 2025
Primary completion: Feb 28, 2027
Completion: Feb 28, 2027
Last update posted: Apr 23, 2026

2025 – 2027

United States locations

U.S. sites: 137
U.S. states: 29
U.S. cities: 116

Facility	City	State	ZIP	Site status
Alta Bates Summit Medical Center-Herrick Campus	Berkeley	California	94704	Recruiting
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care	Irvine	California	92612	Recruiting
UC Irvine Health/Chao Family Comprehensive Cancer Center	Orange	California	92868	Recruiting
Mills Health Center	San Mateo	California	94401	Recruiting
UF Health Cancer Institute - Gainesville	Gainesville	Florida	32610	Recruiting
Miami Cancer Institute	Miami	Florida	33176	Recruiting
Memorial Hospital West	Pembroke Pines	Florida	33028	Recruiting
Phoebe Putney Memorial Hospital	Albany	Georgia	31701	Recruiting
Saint Luke's Cancer Institute - Boise	Boise	Idaho	83712	Recruiting
Kootenai Health - Coeur d'Alene	Coeur d'Alene	Idaho	83814	Recruiting
Saint Luke's Cancer Institute - Fruitland	Fruitland	Idaho	83619	Recruiting
Saint Luke's Cancer Institute - Meridian	Meridian	Idaho	83642	Recruiting
Saint Alphonsus Cancer Care Center-Nampa	Nampa	Idaho	83687	Recruiting
Saint Luke's Cancer Institute - Nampa	Nampa	Idaho	83687	Recruiting
Kootenai Clinic Cancer Services - Post Falls	Post Falls	Idaho	83854	Recruiting
Kootenai Clinic Cancer Services - Sandpoint	Sandpoint	Idaho	83864	Recruiting
Illinois CancerCare-Bloomington	Bloomington	Illinois	61704	Recruiting
Illinois CancerCare-Canton	Canton	Illinois	61520	Recruiting
Illinois CancerCare-Carthage	Carthage	Illinois	62321	Recruiting
Northwestern University	Chicago	Illinois	60611	Recruiting
Swedish Covenant Hospital	Chicago	Illinois	60625	Recruiting
University of Chicago Comprehensive Cancer Center	Chicago	Illinois	60637	Recruiting
Carle at The Riverfront	Danville	Illinois	61832	Recruiting
Northwestern Medicine Cancer Center Kishwaukee	DeKalb	Illinois	60115	Recruiting
Cancer Care Specialists of Illinois - Decatur	Decatur	Illinois	62526	Recruiting
Decatur Memorial Hospital	Decatur	Illinois	62526	Recruiting
Illinois CancerCare-Dixon	Dixon	Illinois	61021	Recruiting
Carle Physician Group-Effingham	Effingham	Illinois	62401	Recruiting
Crossroads Cancer Center	Effingham	Illinois	62401	Recruiting
Illinois CancerCare-Eureka	Eureka	Illinois	61530	Recruiting
NorthShore University HealthSystem-Evanston Hospital	Evanston	Illinois	60201	Recruiting
Illinois CancerCare-Galesburg	Galesburg	Illinois	61401	Recruiting
Northwestern Medicine Cancer Center Delnor	Geneva	Illinois	60134	Recruiting
NorthShore University HealthSystem-Glenbrook Hospital	Glenview	Illinois	60026	Recruiting
Northwestern Medicine Glenview Outpatient Center	Glenview	Illinois	60026	Recruiting
Northwestern Medicine Grayslake Outpatient Center	Grayslake	Illinois	60030	Recruiting
NorthShore University HealthSystem-Highland Park Hospital	Highland Park	Illinois	60035	Recruiting
Illinois CancerCare-Kewanee Clinic	Kewanee	Illinois	61443	Recruiting
Northwestern Medicine Lake Forest Hospital	Lake Forest	Illinois	60045	Recruiting
Illinois CancerCare-Macomb	Macomb	Illinois	61455	Recruiting
Carle Physician Group-Mattoon/Charleston	Mattoon	Illinois	61938	Recruiting
Loyola University Medical Center	Maywood	Illinois	60153	Recruiting
UC Comprehensive Cancer Center at Silver Cross	New Lenox	Illinois	60451	Recruiting
Cancer Care Center of O'Fallon	O'Fallon	Illinois	62269	Recruiting
HSHS Saint Elizabeth's Hospital	O'Fallon	Illinois	62269	Recruiting
Northwestern Medicine Orland Park	Orland Park	Illinois	60462	Recruiting
University of Chicago Medicine-Orland Park	Orland Park	Illinois	60462	Recruiting
Illinois CancerCare-Ottawa Clinic	Ottawa	Illinois	61350	Recruiting
Illinois CancerCare-Pekin	Pekin	Illinois	61554	Recruiting
Illinois CancerCare-Peoria	Peoria	Illinois	61615	Recruiting
Illinois CancerCare-Peru	Peru	Illinois	61354	Recruiting
Illinois CancerCare-Princeton	Princeton	Illinois	61356	Recruiting
Southern Illinois University School of Medicine	Springfield	Illinois	62702	Recruiting
Springfield Clinic	Springfield	Illinois	62702	Recruiting
Springfield Memorial Hospital	Springfield	Illinois	62781	Recruiting
Carle Cancer Center	Urbana	Illinois	61801	Recruiting
Northwestern Medicine Cancer Center Warrenville	Warrenville	Illinois	60555	Recruiting
Illinois CancerCare - Washington	Washington	Illinois	61571	Recruiting
UChicago Medicine Northwest Indiana	Crown Point	Indiana	46307	Recruiting
UI Health Care Mission Cancer and Blood - Ankeny Clinic	Ankeny	Iowa	50023	Recruiting
UI Health Care Mission Cancer and Blood - West Des Moines Clinic	Clive	Iowa	50325	Recruiting
Iowa Methodist Medical Center	Des Moines	Iowa	50309	Recruiting
UI Health Care Mission Cancer and Blood - Des Moines Clinic	Des Moines	Iowa	50309	Recruiting
Mercy Medical Center - Des Moines	Des Moines	Iowa	50314	Recruiting
UI Health Care Mission Cancer and Blood - Laurel Clinic	Des Moines	Iowa	50314	Recruiting
University of Iowa/Holden Comprehensive Cancer Center	Iowa City	Iowa	52242	Recruiting
UI Healthcare Mission Cancer and Blood - Pella	Pella	Iowa	50219	Recruiting
UI Health Care Mission Cancer and Blood - Waukee Clinic	Waukee	Iowa	50263	Recruiting
The James Graham Brown Cancer Center at University of Louisville	Louisville	Kentucky	40202	Recruiting
UofL Health Medical Center Northeast	Louisville	Kentucky	40245	Recruiting
LSU Health Baton Rouge-North Clinic	Baton Rouge	Louisiana	70805	Recruiting
Our Lady of the Lake Physician Group	Baton Rouge	Louisiana	70808	Recruiting
Our Lady of The Lake	Baton Rouge	Louisiana	70808	Recruiting
Walter Reed National Military Medical Center	Bethesda	Maryland	20889-5600	Recruiting
Tufts Medical Center	Boston	Massachusetts	02111	Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Brighton	Brighton	Michigan	48114	Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Canton	Canton	Michigan	48188	Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital	Chelsea	Michigan	48118	Recruiting
Cancer Hematology Centers - Flint	Flint	Michigan	48503	Recruiting
Genesee Hematology Oncology PC	Flint	Michigan	48503	Suspended
Genesys Hurley Cancer Institute	Flint	Michigan	48503	Recruiting
Trinity Health Saint Mary Mercy Livonia Hospital	Livonia	Michigan	48154	Recruiting
Trinity Health Saint Joseph Mercy Oakland Hospital	Pontiac	Michigan	48341	Recruiting
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus	Ypsilanti	Michigan	48197	Recruiting
Essentia Health Saint Joseph's Medical Center	Brainerd	Minnesota	56401	Recruiting
Essentia Health - Deer River Clinic	Deer River	Minnesota	56636	Recruiting
Essentia Health Cancer Center	Duluth	Minnesota	55805	Recruiting
Essentia Health Hibbing Clinic	Hibbing	Minnesota	55746	Recruiting
Hennepin County Medical Center	Minneapolis	Minnesota	55415	Recruiting
Essentia Health Sandstone	Sandstone	Minnesota	55072	Recruiting
Essentia Health Virginia Clinic	Virginia	Minnesota	55792	Recruiting
Parkland Health Center - Farmington	Farmington	Missouri	63640	Recruiting
Sainte Genevieve County Memorial Hospital	Sainte Genevieve	Missouri	63670	Recruiting
Missouri Baptist Medical Center	St Louis	Missouri	63131	Recruiting
Missouri Baptist Sullivan Hospital	Sullivan	Missouri	63080	Recruiting
BJC Outpatient Center at Sunset Hills	Sunset Hills	Missouri	63127	Recruiting
Community Hospital of Anaconda	Anaconda	Montana	59711	Recruiting
Billings Clinic Cancer Center	Billings	Montana	59101	Recruiting
Bozeman Health Deaconess Hospital	Bozeman	Montana	59715	Recruiting
Benefis Sletten Cancer Institute	Great Falls	Montana	59405	Recruiting
Logan Health Medical Center	Kalispell	Montana	59901	Recruiting
Community Medical Center	Missoula	Montana	59804	Recruiting
Saint Barnabas Medical Center	Livingston	New Jersey	07039	Recruiting
Monmouth Medical Center	Long Branch	New Jersey	07740	Recruiting
Rutgers Cancer Institute of New Jersey	New Brunswick	New Jersey	08903	Recruiting
Community Medical Center	Toms River	New Jersey	08755	Recruiting
University of New Mexico Cancer Center	Albuquerque	New Mexico	87106	Recruiting
Roswell Park Cancer Institute	Buffalo	New York	14263	Recruiting
Duke University Medical Center	Durham	North Carolina	27710	Recruiting
East Carolina University	Greenville	North Carolina	27834	Recruiting
Essentia Health Cancer Center-South University Clinic	Fargo	North Dakota	58103	Recruiting
Ohio State University Comprehensive Cancer Center	Columbus	Ohio	43210	Recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Recruiting
Geisinger Medical Center	Danville	Pennsylvania	17822	Recruiting
University of Pittsburgh Cancer Institute (UPCI)	Pittsburgh	Pennsylvania	15232	Recruiting
Geisinger Wyoming Valley/Henry Cancer Center	Wilkes-Barre	Pennsylvania	18711	Recruiting
Prisma Health Cancer Institute - Spartanburg	Boiling Springs	South Carolina	29316	Recruiting
Prisma Health Cancer Institute - Easley	Easley	South Carolina	29640	Recruiting
Prisma Health Cancer Institute - Butternut	Greenville	South Carolina	29605	Recruiting
Prisma Health Cancer Institute - Faris	Greenville	South Carolina	29605	Recruiting
Prisma Health Cancer Institute - Eastside	Greenville	South Carolina	29615	Recruiting
Prisma Health Cancer Institute - Greer	Greer	South Carolina	29650	Recruiting
Prisma Health Cancer Institute - Seneca	Seneca	South Carolina	29672	Recruiting
University of Tennessee - Knoxville	Knoxville	Tennessee	37920	Recruiting
Huntsman Cancer Institute/University of Utah	Salt Lake City	Utah	84112	Recruiting
VCU Massey Comprehensive Cancer Center	Richmond	Virginia	23298	Recruiting
Swedish Cancer Institute-Edmonds	Edmonds	Washington	98026	Recruiting
Swedish Cancer Institute-Issaquah	Issaquah	Washington	98029	Recruiting
Swedish Medical Center-First Hill	Seattle	Washington	98122	Recruiting
Duluth Clinic Ashland	Ashland	Wisconsin	54806	Recruiting
Saint Vincent Hospital Cancer Center Green Bay	Green Bay	Wisconsin	54301	Recruiting
Saint Vincent Hospital Cancer Center at Saint Mary's	Green Bay	Wisconsin	54303	Recruiting
Gundersen Lutheran Medical Center	La Crosse	Wisconsin	54601	Recruiting
William S Middleton VA Medical Center	Madison	Wisconsin	53705	Recruiting
Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting
Marshfield Medical Center-River Region at Stevens Point	Stevens Point	Wisconsin	54482	Recruiting
Marshfield Medical Center - Weston	Weston	Wisconsin	54476	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06577441, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 23, 2026 · Synced May 6, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06577441 live on ClinicalTrials.gov.

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