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Recruiting Phase 3 Interventional

A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)

ClinicalTrials.gov ID: NCT06585787

Public ClinicalTrials.gov record NCT06585787. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 3, 2026, 7:52 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Safety and Efficacy of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this study is to evaluate the safety and efficacy of KarXT in adult participants with mild to severe Alzheimer's Disease (AD) with moderate to severe psychosis related to AD.

Study identification

NCT ID
NCT06585787
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Enrollment
406 participants

Conditions and interventions

Interventions

Drug

Eligibility (public fields only)

Age range
55 Years to 90 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Sep 25, 2024
Primary completion
Nov 23, 2026
Completion
Dec 21, 2026
Last update posted
Aug 25, 2026

2024 – 2026

United States locations

U.S. sites
99
U.S. states
19
U.S. cities
71
Facility City State ZIP Site status
Local Institution - 1227 Chandler Arizona 85224 Completed
Gilbert Neurology Partners - PLLC - Avacare Gilbert Arizona 85297 Recruiting
Banner Alzheimer's Institute Phoenix Arizona 85006-2528 Recruiting
Local Institution - 1220 Scottsdale Arizona 85260-6742 Completed
Advanced Research Center, Inc. Anaheim California 92805-5854 Recruiting
Inland Psychiatric Medical Group (IPMG)-Chino Chino California 91710 Recruiting
Local Institution - 1230 Long Beach California 90805 Completed
USC - The Memory and Aging Center (MAC) - Alzheimer Disease Research Center (ADRC) Los Angeles California 90033-5313 Recruiting
Local Institution - 1219 Los Angeles California 90095 Withdrawn
Local Institution - 1001 Orange California 92866 Completed
Local Institution - 1228 Orange California 92868-2847 Completed
Local Institution - 1043 Pasadena California 91106 Active, not recruiting
Local Institution - 1213 Rancho Cucamonga California 91730 Active, not recruiting
University of Connecticut Health Center Farmington Connecticut 06030 Recruiting
Local Institution - 1225 Atlantis Florida 33462 Completed
Envision Trials LLC Bonita Springs Florida 34134 Recruiting
Local Institution - 1138 Cutler Bay Florida 33189-1230 Active, not recruiting
Arrow Clinical Trials Daytona Beach Florida 32117-5532 Recruiting
Local Institution - 1224 Deerfield Beach Florida 33442 Completed
Local Institution - 1164 Doral Florida 33122-1620 Active, not recruiting
Local Institution - 1264 Gulf Breeze Florida 32561 Not yet recruiting
Local Institution - 1120 Hialeah Florida 33012-4648 Active, not recruiting
Local Institution - 1237 Hialeah Florida 33013 Completed
Local Institution - 1229 Homestead Florida 33030 Active, not recruiting
Local Institution - 1040 Lady Lake Florida 32159 Completed
Local Institution - 1159 Miami Florida 33032 Active, not recruiting
Local Institution - 1021 Miami Florida 33122-1335 Active, not recruiting
Local Institution - 1125 Miami Florida 33135-1601 Active, not recruiting
Local Institution - 1236 Miami Florida 33135-2968 Active, not recruiting
Local Institution - 1115 Miami Florida 33135 Active, not recruiting
Local Institution - 1010 Miami Florida 33137 Completed
Local Institution - 1143 Miami Florida 33145-2455 Completed
Local Institution - 1113 Miami Florida 33155-6630 Active, not recruiting
Local Institution - 1129 Miami Florida 33165-3947 Active, not recruiting
Local Institution - 1150 Miami Florida 33165 Active, not recruiting
Local Institution - 1006 Miami Florida 33173-1474 Active, not recruiting
Local Institution - 1111 Miami Florida 33173 Active, not recruiting
Local Institution - 1158 Miami Florida 33175 Completed
Local Institution - 1235 Miami Florida 33176-1451 Completed
Local Institution - 1147 Miami Florida 33176-7947 Completed
Local Institution - 1234 Miami Florida 33176 Active, not recruiting
Local Institution - 1105 Miami Florida 33179-2537 Completed
Local Institution - 1157 Miami Florida 33184-1412 Active, not recruiting
Local Institution - 1126 Miami Gardens Florida 33056-4000 Active, not recruiting
Local Institution - 1209 Miami Lakes Florida 33014 Completed
Local Institution - 1118 Miami Lakes Florida 33016 Active, not recruiting
Aqualane Clinical Research Naples Florida 34105 Recruiting
Sensible HealthCare, LLC Ocoee Florida 34761-2964 Recruiting
Charter Research Orlando Orlando Florida 32803 Recruiting
Nova Psychiatry Orlando Florida 32803 Recruiting
Combined Research Orlando Phase I-IV LLC Orlando Florida 32807-3555 Recruiting
Local Institution - 1204 Ormond Beach Florida 32174-3101 Active, not recruiting
Local Institution - 1205 Port Orange Florida 32127-5169 Active, not recruiting
Local Institution - 1133 Sweetwater Florida 33182 Completed
Local Institution - 1123 Tampa Florida 33614-2869 Active, not recruiting
Guardian Angel Research Tampa Florida 33614 Recruiting
Interventional Psychiatry of Tampa Bay Tampa Florida 33629-5837 Recruiting
Charter Research The Villages Florida 32162-2698 Recruiting
Local Institution - 1233 Wellington Florida 33414 Withdrawn
Premiere Research Institute at Palm Beach Neurology, PA West Palm Beach Florida 33407-3209 Recruiting
Agile Clinical Research Trials, LLC Atlanta Georgia 30328-5532 Recruiting
McLean Hospital Belmont Massachusetts 02478-1064 Recruiting
Tufts Medical Center - 800 Washington St - PPDS Boston Massachusetts 02111-1552 Recruiting
Boston Neuro Research Center North Dartmouth Massachusetts 02747-2612 Recruiting
Local Institution - 1250 South Dartmouth Massachusetts 02747 Completed
Elixia Health - Springfield - Elixia - PPDS Springfield Massachusetts 01103 Recruiting
Neurobehavioral Medicine Group (NBMG) Bloomfield Township Michigan 48302-1909 Recruiting
Precise Research Centers Flowood Mississippi 39232 Recruiting
Tekton Research, LLC - Saint Louis Psychiatry - PPDS St Louis Missouri 63128 Recruiting
Advanced Memory Research Institute - CenExel - PPDS Toms River New Jersey 08755 Recruiting
Local Institution - 1232 Toms River New Jersey 08755 Active, not recruiting
Mid Hudson Medical Research PLLC New Windsor New York 12553-7754 Recruiting
Local Institution - 1231 Syracuse New York 13203 Withdrawn
SUNY Upstate Medical University Syracuse New York 13210-2306 Recruiting
Five Towns Neurology, PC Woodmere New York 11598-1739 Recruiting
Triad Clinical Trials - 515 College Rd Greensboro North Carolina 27410-3311 Recruiting
AMC Research, LLC - Flourish - PPDS Matthews North Carolina 28105-8336 Recruiting
Local Institution - 5005 Morehead City North Carolina 28557 Withdrawn
West Clinical Research Morehead City North Carolina 28557 Recruiting
Local Institution - 1252 Shelby North Carolina 28150-3803 Withdrawn
Ohio State University Columbus Ohio 43221 Recruiting
Local Institution - 1258 Dayton Ohio 45417-3445 Not yet recruiting
Insight Clinical Trials LLC - Independence Independence Ohio 44131 Recruiting
The Rivus Wellness & Research Institute Oklahoma City Oklahoma 73112 Recruiting
Alzheimer's Disease and Memory Disorders Center at Rhode Island Hospital Providence Rhode Island 02903 Recruiting
Vanderbilt Psychiatric Hospital Nashville Tennessee 37212-3133 Recruiting
Senior Adults Specialty Research Austin Texas 78757-7566 Recruiting
Local Institution - 1260 Dallas Texas 75231-6079 Not yet recruiting
Epic Medical Research LLC - DeSoto DeSoto Texas 75115-2043 Recruiting
Advanced Neuro Research Center - El Paso El Paso Texas 79912-1743 Recruiting
Local Institution - 1262 Fort Worth Texas 76104-4143 Not yet recruiting
Local Institution - 1261 Houston Texas 77030-1312 Not yet recruiting
University Hills Clinical Research - 102 Decker Ct Irving Texas 75062-2898 Recruiting
Local Institution - 1238 Plano Texas 75093-8225 Completed
Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases San Antonio Texas 78229-3901 Recruiting
Local Institution - 1134 Stafford Texas 77477-3929 Completed
Conquest Research, LLC - Virginia - Vienna Vienna Virginia 22182 Recruiting
Northwest Clinical Research Center Bellevue Washington 98007-4879 Recruiting
Local Institution - 1254 Kirkland Washington 98034 Withdrawn

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 193 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06585787, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Aug 25, 2026 · Synced Sep 3, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06585787 live on ClinicalTrials.gov.

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