A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)

ClinicalTrials.gov ID: NCT06585787

Public ClinicalTrials.gov record NCT06585787. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 8:09 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Safety and Efficacy of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease

Study identification

NCT ID: NCT06585787
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company; Industry
Enrollment: 406 participants

Conditions and interventions

Conditions

Alzheimer Disease

Interventions

KarXT Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 55 Years to 90 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Sep 25, 2024
Primary completion: Nov 23, 2026
Completion: Dec 21, 2026
Last update posted: Apr 29, 2026

2024 – 2026

United States locations

U.S. sites: 97
U.S. states: 19
U.S. cities: 69

Facility	City	State	ZIP	Site status
Chandler Clinical Trials, LLC	Chandler	Arizona	85224	Recruiting
Gilbert Neurology Partners - PLLC - Avacare	Gilbert	Arizona	85297	Recruiting
Banner Alzheimer's Institute	Phoenix	Arizona	85006-2528	Recruiting
Scottsdale Clinical Trials	Scottsdale	Arizona	85260-6742	Recruiting
Advanced Research Center, Inc.	Anaheim	California	92805-5854	Recruiting
Inland Psychiatric Medical Group (IPMG)-Chino	Chino	California	91710	Recruiting
Long Beach Research Institute, LLC	Long Beach	California	90805	Recruiting
USC - The Memory and Aging Center (MAC) - Alzheimer Disease Research Center (ADRC)	Los Angeles	California	90033-5313	Recruiting
Local Institution - 1219	Los Angeles	California	90095	Withdrawn
Local Institution - 1001	Orange	California	92866	Completed
NRC Research Institute - Orange - PPDS	Orange	California	92868-2847	Recruiting
SC3 Research - Pasadena - 960 E. Green St	Pasadena	California	91106	Recruiting
Prospective Research Innovations 8577 Haven Ave	Rancho Cucamonga	California	91730	Recruiting
University of Connecticut Health Center	Farmington	Connecticut	06030	Recruiting
Genesis Trust Research Group	Atlantis	Florida	33462	Recruiting
Envision Trials LLC	Bonita Springs	Florida	34134	Recruiting
JY Research Institute Inc	Cutler Bay	Florida	33189-1230	Recruiting
Arrow Clinical Trials	Daytona Beach	Florida	32117-5532	Recruiting
Quantum Laboratories, Inc - West Palm Beach Office	Deerfield Beach	Florida	33442	Recruiting
Integrity Clinical Research LLC - 21st Street	Doral	Florida	33122-1620	Recruiting
New Life Medical Research Center -3750 W 16th Ave	Hialeah	Florida	33012-4648	Recruiting
Research in Miami, Inc	Hialeah	Florida	33013	Recruiting
Nexus Clinical Research Center- NRC	Homestead	Florida	33030	Recruiting
K2 Medical Research - Lady Lake	Lady Lake	Florida	32159	Recruiting
Homestead Associates in Research Inc	Miami	Florida	33032	Recruiting
Premier Clinical Research Institute	Miami	Florida	33122-1335	Recruiting
Wellness Research Center Inc - Miami	Miami	Florida	33135-1601	Recruiting
A & D Doctor Center	Miami	Florida	33135-2968	Recruiting
Floridian Neuroscience Institute-1901 SW 1 St	Miami	Florida	33135	Recruiting
Miami Jewish Health Systems	Miami	Florida	33137	Recruiting
MedOne Clinical Research LLC	Miami	Florida	33145-2455	Recruiting
My Community Research Center, Inc - 7480 Bird Rd	Miami	Florida	33155-6630	Recruiting
Future Care Solution LLC	Miami	Florida	33165-3947	Recruiting
Reliant Medical Research	Miami	Florida	33165	Recruiting
Novel Clinical Research Center, LLC.	Miami	Florida	33173-1474	Recruiting
Dade Research Center - Miami FL - 7600 SW 87th Ave	Miami	Florida	33173	Recruiting
Local Institution - 1158	Miami	Florida	33175	Completed
Serenity Research Center	Miami	Florida	33176-1451	Recruiting
IMIC LLC- 9380 SW 150th Str	Miami	Florida	33176-7947	Recruiting
New Gen Health	Miami	Florida	33176	Recruiting
Floridian Research Institute- Ives Dairy Road	Miami	Florida	33179-2537	Recruiting
High Quality Research	Miami	Florida	33184-1412	Recruiting
New Med Research	Miami Gardens	Florida	33056-4000	Recruiting
Panax Clinical Research	Miami Lakes	Florida	33014	Recruiting
Angels Clinical Research Institute - Miami Lakes - Palm Springs - PPDS	Miami Lakes	Florida	33016	Recruiting
Aqualane Clinical Research	Naples	Florida	34105	Recruiting
Sensible HealthCare, LLC	Ocoee	Florida	34761-2964	Recruiting
Local Institution - 1257	Orlando	Florida	32803	Not yet recruiting
Nova Psychiatry	Orlando	Florida	32803	Recruiting
Combined Research Orlando Phase I-IV LLC	Orlando	Florida	32807-3555	Recruiting
Neurology Associates of Ormond Beach	Ormond Beach	Florida	32174-3101	Recruiting
Progressive Medical Research (Duplicate)	Port Orange	Florida	32127	Recruiting
Cordova Research Institute- Sweetwater	Sweetwater	Florida	33182	Recruiting
Angels Clinical Research Institute Tampa - Palm Springs - PPDS	Tampa	Florida	33614-2846	Recruiting
Guardian Angel Research	Tampa	Florida	33614	Recruiting
Interventional Psychiatry of Tampa Bay	Tampa	Florida	33629-5837	Recruiting
Local Institution - 1256	The Villages	Florida	32162-2698	Not yet recruiting
Local Institution - 1233	Wellington	Florida	33414	Withdrawn
Premiere Research Institute at Palm Beach Neurology, PA	West Palm Beach	Florida	33407-3209	Recruiting
Agile Clinical Research Trials, LLC	Atlanta	Georgia	30328-5532	Recruiting
McLean Hospital	Belmont	Massachusetts	02478-1064	Recruiting
Tufts Medical Center - 800 Washington St - PPDS	Boston	Massachusetts	02111-1552	Recruiting
Boston Neuro Research Center	North Dartmouth	Massachusetts	02747-2612	Recruiting
Local Institution - 1250	South Dartmouth	Massachusetts	02747	Not yet recruiting
Elixia Health - Springfield - Elixia - PPDS	Springfield	Massachusetts	01103	Recruiting
Neurobehavioral Medicine Group (NBMG)	Bloomfield Township	Michigan	48302-1909	Recruiting
Precise Research Centers	Flowood	Mississippi	39232	Recruiting
Local Institution - 1255	St Louis	Missouri	63128	Not yet recruiting
Advanced Memory Research Institute - CenExel - PPDS	Toms River	New Jersey	08755	Recruiting
Bio Behavioral Health	Toms River	New Jersey	08755	Recruiting
Local Institution - 1251	New Windsor	New York	12553-7754	Not yet recruiting
Local Institution - 1231	Syracuse	New York	13203	Withdrawn
Local Institution - 1240	Syracuse	New York	13210-2306	Not yet recruiting
Five Towns Neurology, PC	Woodmere	New York	11598-1739	Recruiting
Triad Clinical Trials - 515 College Rd	Greensboro	North Carolina	27410-3311	Recruiting
AMC Research, LLC - Flourish - PPDS	Matthews	North Carolina	28105-8336	Recruiting
Local Institution - 5005	Morehead City	North Carolina	28557	Withdrawn
West Clinical Research	Morehead City	North Carolina	28557	Recruiting
Local Institution - 1252	Shelby	North Carolina	28150-3803	Not yet recruiting
Ohio State University	Columbus	Ohio	43221	Recruiting
Local Institution - 1258	Dayton	Ohio	45417-3445	Not yet recruiting
Insight Clinical Trials LLC - Independence	Independence	Ohio	44131	Recruiting
The Rivus Wellness & Research Institute	Oklahoma City	Oklahoma	73112	Recruiting
Alzheimer's Disease and Memory Disorders Center at Rhode Island Hospital	Providence	Rhode Island	02903	Recruiting
Vanderbilt Psychiatric Hospital	Nashville	Tennessee	37212-3133	Recruiting
Local Institution - 1263	Austin	Texas	78757-7566	Not yet recruiting
Local Institution - 1260	Dallas	Texas	75231-6079	Not yet recruiting
Epic Medical Research LLC - DeSoto - HyperCore - PPDS	DeSoto	Texas	75115-2043	Recruiting
Advanced Neuro Research Center - El Paso	El Paso	Texas	79912-1743	Recruiting
Local Institution - 1262	Fort Worth	Texas	76104-4143	Not yet recruiting
Local Institution - 1261	Houston	Texas	77030-1312	Not yet recruiting
AIM Trials	Plano	Texas	75093-8225	Recruiting
Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases	San Antonio	Texas	78229-3901	Recruiting
Local Institution - 1134	Stafford	Texas	77477-3929	Completed
Conquest Research, LLC - Virginia - Vienna	Vienna	Virginia	22182	Recruiting
Local Institution - 1253	Bellevue	Washington	98007-4879	Not yet recruiting
Local Institution - 1254	Kirkland	Washington	98034	Withdrawn

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 189 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06585787, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 29, 2026 · Synced May 8, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06585787 live on ClinicalTrials.gov.

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