A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease
Public ClinicalTrials.gov record NCT06587828. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The most clinically meaningful way to discover new targets of T cells in autoimmune diseases is to study the tissues of patients with active autoimmune disease mediated organ inflammation. These tissues contain both cytotoxic and helper T cells that are driving their disease, and these T cells are being guided by TCRs that recognize tissue-specific targets. By collecting tissue when a patient has active inflammation, it is possible to determine which T cells are activated and undergoing clonal expansion in the patient's diseased organ. TScan has developed a genome-wide, high-throughput technology to determine the natural, physiological target of any TCR (Kula, 2019). The goal of this study is to isolate T cells from inflamed tissues and matched blood samples and/or matched normal tissues (for patients with inflammatory bowel diseases). T cell clones that are expanded in diseased tissues relative to blood or normal tissues will be selected and the targets of their TCRs will be defined using TScan's genome-wide, high-throughput target ID technology. The goal of this study is to discover a collection of peptide targets, along with their associated TCRs to be developed as new tolerogenic therapies for patients with autoimmune diseases.
Study identification
- NCT ID
- NCT06587828
- Recruitment status
- Completed
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 238 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 3, 2023 (Actual)
- Primary completion
- Sep 10, 2026 (Actual)
- Completion
- Sep 10, 2026 (Actual)
- Last update posted
- Sep 15, 2026
2023 – 2026
United States locations
- U.S. sites
- 11
- U.S. states
- 9
- U.S. cities
- 10
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Knowledge Research Center | Orange | California | 92868 | — |
| Cura Clinical Research | Sherman Oaks | California | 91403 | — |
| Arnold Arthritis & Rheumatology | Skokie | Illinois | 60076 | — |
| University of Kentucky Research Foundation | Lexington | Kentucky | 40536 | — |
| Massachusetts Eye Research and Surgery Institution (MERSI) | Waltham | Massachusetts | 02451 | — |
| Susquehanna Research Group | Harrisburg | Pennsylvania | 17110 | — |
| Nexus Research | Cranston | Rhode Island | 02920 | — |
| RI Rheumatology | Cranston | Rhode Island | 02920 | — |
| Palmetto Gastroenterology Clinical Research, LLC | Summerville | South Carolina | 29486 | — |
| Novel Research | Bellaire | Texas | 77401 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06587828, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 15, 2026 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06587828 live on ClinicalTrials.gov.