A Study Evaluating the Efficacy and Safety of Pirtobrutinib in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Public ClinicalTrials.gov record NCT06588478. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Open-Label, Randomized Study Evaluating the Efficacy and Safety of 3 Doses of Pirtobrutinib in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Who Previously Received Treatment With a Covalent Bruton Tyrosine Kinase Inhibitor
Study identification
- NCT ID
- NCT06588478
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Loxo Oncology, Inc.
- Industry
- Enrollment
- 249 participants
Conditions and interventions
Conditions
Not listed
Interventions
Not listed
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 2, 2025
- Primary completion
- May 31, 2028
- Completion
- Nov 30, 2028
- Last update posted
- May 18, 2026
2025 – 2028
United States locations
- U.S. sites
- 21
- U.S. states
- 17
- U.S. cities
- 20
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Ironwood Cancer & Research Centers | Chandler | Arizona | 85224 | Recruiting |
| City of Hope National Medical Center | Duarte | California | 91010 | Recruiting |
| City of Hope National Medical Center | Irvine | California | 92618 | Recruiting |
| Palo Alto Medical Foundation Research Institute (PAMFRI) | Palo Alto | California | 94304 | Recruiting |
| Stanford Cancer Center | Palo Alto | California | 94304 | Recruiting |
| Rocky Mountain Cancer Center | Aurora | Colorado | 80012 | Recruiting |
| University of Miami Hospital and Clinics, Sylvester Cancer Center | Miami | Florida | 33136 | Recruiting |
| City of Hope National Medical Center, Atlanta Cancer Center | Newnan | Georgia | 30265 | Recruiting |
| Mission Cancer + Blood | Waukee | Iowa | 50263 | Recruiting |
| Saint Elizabeth Medical Center Edgewood | Edgewood | Kentucky | 41017 | Recruiting |
| American Oncology Partners, PA | Bethesda | Maryland | 20817 | Recruiting |
| Boston Medical Center | Boston | Massachusetts | 02118 | Recruiting |
| Gulfport Memorial Hospital | Gulfport | Mississippi | 39501 | Recruiting |
| Comprehensive Cancer Centers of Nevada | Henderson | Nevada | 89074 | Recruiting |
| East Carolina University | Greenville | North Carolina | 27834 | Recruiting |
| Williamette Valley Cancer Institute & Research Center | Eugene | Oregon | 97401 | Recruiting |
| Cancer Care Associates Of York | York | Pennsylvania | 17403 | Recruiting |
| The West Clinic, PLLC dba West Cancer Center | Germantown | Tennessee | 38138 | Recruiting |
| USO-Texas Oncology-Central/South Texas | Austin | Texas | 78705 | Recruiting |
| Sarah Cannon Research Institute/SCRI | The Woodlands | Texas | 77380 | Recruiting |
| USO-Virginia Oncology Associates | Hampton | Virginia | 23666 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 74 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06588478, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 18, 2026 · Synced May 20, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06588478 live on ClinicalTrials.gov.