A Study in Patients With Moderate to Severe Plaque Psoriasis to Evaluate the Efficacy and Safety of ESK-001
Public ClinicalTrials.gov record NCT06588738. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double-Blind, Placebo and Active Comparator Controlled Phase 3 Study in Patients With Moderate to Severe Plaque Psoriasis to Evaluate the Efficacy and Safety of ESK-001 (ONWARD2)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The goal of this clinical trial is to learn if ESK-001 works to treat moderate to severe plaque psoriasis. The main questions it aims to answer are: * Does ESK-001 reduce the severity of people's psoriasis? * How safe is ESK-001 in people with moderate to severe plaque psoriasis? The study includes 2 comparators: a placebo control (a 'dummy' tablet that does not contain the medicine ESK-001 but looks just like it) and an active control (apremilast, which is a medicine approved to treat psoriasis). People taking part in this study must be men or women aged at least 18 years and have had plaque psoriasis for at least 6 months, currently moderate to severe. Participants will: * take drug every day for 24 weeks. * visit the clinic for checkups and tests. * fill out questionnaires about their psoriasis, itch severity, and change in quality of life. * be assessed for health issues and side effects, physical examinations, vital signs, heart electrical activity measurements, and psychological health. * provide blood and urine samples.
Study identification
- NCT ID
- NCT06588738
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 862 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 20, 2024 (Actual)
- Primary completion
- Sep 23, 2025 (Actual)
- Completion
- Dec 18, 2025 (Actual)
- Last update posted
- Aug 10, 2026
2024 – 2025
United States locations
- U.S. sites
- 43
- U.S. states
- 16
- U.S. cities
- 39
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Total Skin and Beauty Dermatology Center, PC | Birmingham | Alabama | 35203 | — |
| Chandler Clinical Trials | Chandler | Arizona | 85224 | — |
| Noble Clinical Research | Tucson | Arizona | 85704 | — |
| Zenith Research Inc. | Beverly Hills | California | 90211-1705 | — |
| Raoof MD | Encino | California | 91436 | — |
| Long Beach Research Institute | Long Beach | California | 90805 | — |
| Dermatology Research Associates | Los Angeles | California | 90045 | — |
| Empire Clinical Research - Pomona | Pomona | California | 91767 | — |
| Integrative Skin Science and Research | Sacramento | California | 95815 | — |
| UC San Diego | San Diego | California | 92122 | — |
| Southern California Clinical Research | Santa Ana | California | 92701 | — |
| Clinical Science Institute Dermatology Institute | Santa Monica | California | 90404 | — |
| FXM Clinical Research Ft. Lauderdale LLC | Fort Lauderdale | Florida | 33308 | — |
| Direct Helpers Research Center (DHRC) | Hialeah | Florida | 33012 | — |
| AppleMed Research Group under WCG | Miami | Florida | 33126 | — |
| FAX Pharma Clinical Research Inc | Miami | Florida | 33146 | — |
| FXM Clinical Research - Miami LLC | Miami | Florida | 33175 | — |
| Las Mercedes Medical Research | Miami | Florida | 33196 | — |
| FXM Clinical Research Miramar LLC | Miramar | Florida | 33027 | — |
| Renstar Medical Research | Ocala | Florida | 34470 | — |
| DS Research of Southern Indiana | Clarksville | Indiana | 47129 | — |
| The Indiana Clinical Trials Center | Plainfield | Indiana | 46168 | — |
| DS Research of Kentucky | Louisville | Kentucky | 40241 | — |
| Michigan Center for Research Company | Clarkston | Michigan | 48346 | — |
| Henry Ford Medical Center - Farmington Road | Detroit | Michigan | 48202 | — |
| Revival Research Institute | Troy | Michigan | 48084 | — |
| Grekin Skin Institute | Warren | Michigan | 48088 | — |
| Associated Skin Care Specialists - Minnesota Clinical Study Center | New Brighton | Minnesota | 55112 | — |
| Schlessinger MD | Omaha | Nebraska | 68144 | — |
| Las Vegas Clinical Trials | Las Vegas | Nevada | 89030 | — |
| NYC Health and Hospitals Elmhurst | Elmhurst | New York | 11373 | — |
| Pioneer Clinical Research NY | New York | New York | 10016 | — |
| Cameron Dermatology | New York | New York | 10023 | — |
| DermResearchCenter of New York | Stony Brook | New York | 11790 | — |
| Asheville Clinical Trials | Asheville | North Carolina | 28803 | — |
| WDC Cosmetic and Research | Wilmington | North Carolina | 28405 | — |
| Optima Research Boardman | Boardman | Ohio | 44512 | — |
| Clinical Partners LLC | Johnston | Rhode Island | 02919 | — |
| Modern Research Associates PLLC | Dallas | Texas | 75231 | — |
| SMS Clinical Research | Mesquite | Texas | 75149 | — |
| Progressive Clinical Research - San Antonio | San Antonio | Texas | 78213 | — |
| Center for Clinical Studies (CCS) - Webster/Clear Lake Location | Webster | Texas | 77598 | — |
| Jordan Valley Dermatology | South Jordan | Utah | 84095 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 81 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06588738, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 10, 2026 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06588738 live on ClinicalTrials.gov.