A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (Also Known as RO7790121) in Participants With Moderately to Severely Active Ulcerative Colitis

ClinicalTrials.gov ID: NCT06588855

Public ClinicalTrials.gov record NCT06588855. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 5, 2026, 4:29 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase III, Multicenter, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Induction Therapy With RO7790121 in Patients With Moderately to Severely Active Ulcerative Colitis

Study identification

NCT ID: NCT06588855
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Hoffmann-La Roche; Industry
Enrollment: 350 participants

Conditions and interventions

Conditions

Moderately to Severely Active Ulcerative Colitis

Interventions

Afimkibart Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 16 Years to 80 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 10, 2024
Primary completion: Jan 29, 2027
Completion: Jan 29, 2031
Last update posted: May 3, 2026

2024 – 2031

United States locations

U.S. sites: 71
U.S. states: 23
U.S. cities: 61

Facility	City	State	ZIP	Site status
Digestive Health Specialists of the Southeast (Gastroenterology Associates of Dothan) - Dothan	Dothan	Alabama	36305	Recruiting
Mayo Clinic Hospital	Scottsdale	Arizona	85259	Recruiting
Arizona Digestive Health, P.C (ADH)	Sun City	Arizona	85351	Recruiting
Om Research LLC	Apple Valley	California	92307	Recruiting
Valley View Internal Medicine	Garden Grove	California	92845	Recruiting
Gastro Care Associates	Lancaster	California	93534	Recruiting
University of Southern California	Los Angeles	California	90033-1057	Recruiting
Hoag Memorial Hospital Presbyterian;Hoag Center for Research and Education	Newport Beach	California	92663	Recruiting
Stanford Medicine Outpatient Center	Redwood City	California	94063	Recruiting
Peak Gastroenterology Associates	Colorado Springs	Colorado	80907	Recruiting
Hi Tech and Global Research, LLC	Coral Gables	Florida	33134	Recruiting
The Sister Life Research	Hialeah	Florida	33013	Recruiting
LCC Medical Research Institute, LLC	Miami	Florida	33126	Recruiting
Allied Biomedical Research Institute	Miami	Florida	33155	Recruiting
Ambert Medical Research	Miami	Florida	33176	Withdrawn
Integrity Trials LLC	Orlando	Florida	32807	Recruiting
Digestive and Liver Center of Florida	Orlando	Florida	32825	Recruiting
Advanced Medical Research Center	Port Orange	Florida	32127	Recruiting
University of South Florida School of Medicine Morsani Center for Advanced Health Care	Tampa	Florida	33612	Recruiting
Guardian Angel Research Center, LLC	Tampa	Florida	33614	Recruiting
Santos Research Center, CORP	Tampa	Florida	33615	Recruiting
Cleveland Clinic Florida	Weston	Florida	33331	Recruiting
Randomize Now, LLC	Atlanta	Georgia	30308	Recruiting
Atlanta Gastroenterology Associates	Atlanta	Georgia	30342	Recruiting
Gastroenterology Associates of Central Georgia	Macon	Georgia	31201	Recruiting
Grand Teton Research Group, PLLC	Idaho Falls	Idaho	83404	Recruiting
Illinois Gastroenterology Group-Glenview powered by GI Alliance	Glenview	Illinois	60026	Recruiting
GI Alliance - Gurnee	Gurnee	Illinois	60031	Recruiting
Gastro Health Partners, LLC	New Albany	Indiana	47150	Recruiting
Kansas Gastroenterology, LLC under Clinical Trials Network	Wichita	Kansas	67226	Recruiting
One GI: GHP - Gastroenterology Health Partners Louisville	Louisville	Kentucky	40218	Recruiting
Louisiana Research Center - GastroIntestinal Associates	Shreveport	Louisiana	71105	Recruiting
Allied Gastrointestinal Associates, PA	Flowood	Mississippi	39232	Recruiting
Delta Gastroenterology & Endoscopy Center	Southaven	Mississippi	38671	Recruiting
Dartmouth-Hitchcock Medical Center-Norris Cotton Cancer Center	Lebanon	New Hampshire	03756	Recruiting
Ellipsis Research Group	Brooklyn	New York	11215	Recruiting
NYU Inflammatory Bowel Disease Center	New York	New York	10016	Recruiting
Weill Cornell Medical College	New York	New York	10021	Recruiting
DiGiovanna Inst for Med Ed&Res	North Massapequa	New York	11758	Recruiting
Queens Village Medical Care	Queens Village	New York	11428	Recruiting
Gastroenterology Group Of Rochester, LLP	Rochester	New York	14618	Recruiting
James J Peters Veterans Administration Medical Center - NAVREF	The Bronx	New York	10468	Recruiting
Charlotte Gastroenterology and Hepatology, P.L.L.C	Charlotte	North Carolina	28207	Recruiting
Omega Research North Carolina, LLC	Fuquay-Varina	North Carolina	27526	Recruiting
Peters Medical Research (PMR), LLC	High Point	North Carolina	27260	Recruiting
Dayton Gastroenterology, Inc.	Beavercreek	Ohio	45440	Recruiting
University of Cincinnati Hospital	Cincinnati	Ohio	45267	Recruiting
Cleveland Clinic Foundation	Cleveland	Ohio	44195	Recruiting
Ohio Gastroenterology Group	Columbus	Ohio	43202	Recruiting
Ohio State University	Columbus	Ohio	43210	Recruiting
Gastro Intestinal Research Institute of Northern Ohio	Westlake	Ohio	44145	Recruiting
Frontier Clinical Re search, LLC	Uniontown	Pennsylvania	15401	Recruiting
University Gastroenterology	Providence	Rhode Island	02904	Recruiting
Gastroenterology Associates	Greenville	South Carolina	29607	Recruiting
Gastro One	Cordova	Tennessee	38018	Recruiting
Uni of Texas Medical Branch	Galveston	Texas	77555	Recruiting
GI Alliance	Garland	Texas	75044	Recruiting
Amel Med LLC	Georgetown	Texas	78628	Recruiting
Cano Medical Center	Harlingen	Texas	78550	Recruiting
Texas Digestive Specialists	Harlingen	Texas	78550	Recruiting
Integrity Advanced Therapeutics PLLC	Houston	Texas	77090	Not yet recruiting
GI Alliance - Bay Area Gastroenterology	Lubbock	Texas	79410	Recruiting
TDDC dba GI Alliance Research	Mansfield	Texas	76063	Not yet recruiting
Southern Star Research Institute, LLC.	San Antonio	Texas	78229	Recruiting
Baylor Scott and White Medical Center	Temple	Texas	76508	Recruiting
Tyler Research Institute, LLC	Tyler	Texas	75701	Recruiting
University of Texas Health Center at Tyler	Tyler	Texas	75708	Recruiting
TDDC GI Alliance research Webster	Webster	Texas	77598	Recruiting
Gastroenterology Associates of Tidewater	Chesapeake	Virginia	23320	Recruiting
Emeritas Research Group	Lansdowne Town Center	Virginia	20176	Recruiting
Gastroenterology Consultants of SWVA	Roanoke	Virginia	24018	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 128 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06588855, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 3, 2026 · Synced May 5, 2026

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The complete protocol, eligibility criteria, and contact information for NCT06588855 live on ClinicalTrials.gov.

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