Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

ClinicalTrials.gov ID: NCT06589804

Public ClinicalTrials.gov record NCT06589804. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 12:28 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Randomized Phase III Trial of Pembrolizumab vs. Pembrolizumab/Cetuximab in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma With Platinum Refractory Disease

Study identification

NCT ID: NCT06589804
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: National Cancer Institute (NCI); NIH
Enrollment: 158 participants

Conditions and interventions

Conditions

Interventions

Biospecimen Collection Procedure
Cetuximab Biological
Computed Tomography Procedure
Magnetic Resonance Imaging Procedure
Pembrolizumab Biological
Positron Emission Tomography Procedure

Procedure · Biological

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 26, 2025
Primary completion: Nov 29, 2029
Completion: Nov 29, 2029
Last update posted: May 5, 2026

2025 – 2029

United States locations

U.S. sites: 177
U.S. states: 30
U.S. cities: 146

Facility	City	State	ZIP	Site status
University of Arkansas for Medical Sciences	Little Rock	Arkansas	72205	Recruiting
Fremont - Rideout Cancer Center	Marysville	California	95901	Active, not recruiting
VA Palo Alto Health Care System	Palo Alto	California	94304	Suspended
UCHealth Memorial Hospital Central	Colorado Springs	Colorado	80909	Recruiting
Memorial Hospital North	Colorado Springs	Colorado	80920	Recruiting
Poudre Valley Hospital	Fort Collins	Colorado	80524	Recruiting
Cancer Care and Hematology-Fort Collins	Fort Collins	Colorado	80528	Recruiting
Lutheran Hospital - Cancer Centers of Colorado	Golden	Colorado	80401	Recruiting
UCHealth Greeley Hospital	Greeley	Colorado	80631	Recruiting
Medical Center of the Rockies	Loveland	Colorado	80538	Recruiting
Mount Sinai Medical Center	Miami Beach	Florida	33140	Recruiting
Saint Alphonsus Cancer Care Center-Boise	Boise	Idaho	83706	Recruiting
Saint Alphonsus Cancer Care Center-Caldwell	Caldwell	Idaho	83605	Recruiting
Kootenai Health - Coeur d'Alene	Coeur d'Alene	Idaho	83814	Recruiting
Saint Alphonsus Cancer Care Center-Nampa	Nampa	Idaho	83687	Recruiting
Kootenai Clinic Cancer Services - Post Falls	Post Falls	Idaho	83854	Recruiting
Kootenai Clinic Cancer Services - Sandpoint	Sandpoint	Idaho	83864	Recruiting
Advocate Good Shepherd Hospital	Barrington	Illinois	60010	Recruiting
University of Chicago Comprehensive Cancer Center	Chicago	Illinois	60637	Recruiting
Advocate Illinois Masonic Medical Center	Chicago	Illinois	60657	Recruiting
AMG Crystal Lake - Oncology	Crystal Lake	Illinois	60014	Recruiting
Cancer Care Specialists of Illinois - Decatur	Decatur	Illinois	62526	Recruiting
Decatur Memorial Hospital	Decatur	Illinois	62526	Recruiting
Advocate Good Samaritan Hospital	Downers Grove	Illinois	60515	Recruiting
Crossroads Cancer Center	Effingham	Illinois	62401	Recruiting
Advocate Sherman Hospital	Elgin	Illinois	60123	Recruiting
Advocate South Suburban Hospital	Hazel Crest	Illinois	60429	Recruiting
AMG Libertyville - Oncology	Libertyville	Illinois	60048	Recruiting
Condell Memorial Hospital	Libertyville	Illinois	60048	Recruiting
Illinois CancerCare-Macomb	Macomb	Illinois	61455	Recruiting
UC Comprehensive Cancer Center at Silver Cross	New Lenox	Illinois	60451	Recruiting
Cancer Care Center of O'Fallon	O'Fallon	Illinois	62269	Recruiting
Advocate Christ Medical Center	Oak Lawn	Illinois	60453-2699	Recruiting
Advocate Outpatient Center - Oak Lawn	Oak Lawn	Illinois	60453	Recruiting
University of Chicago Medicine-Orland Park	Orland Park	Illinois	60462	Recruiting
Advocate High Tech Medical Park	Palos Heights	Illinois	60463	Recruiting
Advocate Lutheran General Hospital	Park Ridge	Illinois	60068	Recruiting
Illinois CancerCare-Peoria	Peoria	Illinois	61615	Recruiting
UW Health Carbone Cancer Center Rockford	Rockford	Illinois	61114	Recruiting
Memorial Hospital East	Shiloh	Illinois	62269	Recruiting
Southern Illinois University School of Medicine	Springfield	Illinois	62702	Recruiting
Springfield Clinic	Springfield	Illinois	62702	Recruiting
Springfield Memorial Hospital	Springfield	Illinois	62781	Recruiting
UChicago Medicine Northwest Indiana	Crown Point	Indiana	46307	Recruiting
Mary Greeley Medical Center	Ames	Iowa	50010	Recruiting
McFarland Clinic - Ames	Ames	Iowa	50010	Recruiting
McFarland Clinic - Boone	Boone	Iowa	50036	Suspended
Mercy Hospital	Cedar Rapids	Iowa	52403	Recruiting
Oncology Associates at Mercy Medical Center	Cedar Rapids	Iowa	52403	Recruiting
McFarland Clinic - Trinity Cancer Center	Fort Dodge	Iowa	50501	Recruiting
McFarland Clinic - Jefferson	Jefferson	Iowa	50129	Suspended
McFarland Clinic - Marshalltown	Marshalltown	Iowa	50158	Recruiting
HaysMed	Hays	Kansas	67601	Recruiting
University of Kansas Cancer Center	Kansas City	Kansas	66160	Recruiting
Lawrence Memorial Hospital	Lawrence	Kansas	66044	Recruiting
The University of Kansas Cancer Center - Olathe	Olathe	Kansas	66061	Recruiting
University of Kansas Cancer Center-Overland Park	Overland Park	Kansas	66210	Recruiting
University of Kansas Hospital-Indian Creek Campus	Overland Park	Kansas	66211	Recruiting
Salina Regional Health Center	Salina	Kansas	67401	Recruiting
University of Kansas Health System Saint Francis Campus	Topeka	Kansas	66606	Recruiting
University of Kansas Hospital-Westwood Cancer Center	Westwood	Kansas	66205	Recruiting
University of Maryland/Greenebaum Cancer Center	Baltimore	Maryland	21201	Recruiting
Boston Medical Center	Boston	Massachusetts	02118	Recruiting
Trinity Health Saint Joseph Mercy Hospital Ann Arbor	Ann Arbor	Michigan	48106	Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Brighton	Brighton	Michigan	48114	Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Canton	Canton	Michigan	48188	Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital	Chelsea	Michigan	48118	Recruiting
Cancer Hematology Centers - Flint	Flint	Michigan	48503	Recruiting
Genesee Hematology Oncology PC	Flint	Michigan	48503	Suspended
Genesys Hurley Cancer Institute	Flint	Michigan	48503	Recruiting
Hurley Medical Center	Flint	Michigan	48503	Recruiting
University of Michigan Health - Sparrow Lansing	Lansing	Michigan	48912	Recruiting
Trinity Health Saint Mary Mercy Livonia Hospital	Livonia	Michigan	48154	Recruiting
Trinity Health Saint Joseph Mercy Oakland Hospital	Pontiac	Michigan	48341	Recruiting
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus	Ypsilanti	Michigan	48197	Recruiting
Sanford Joe Lueken Cancer Center	Bemidji	Minnesota	56601	Recruiting
Minnesota Oncology - Burnsville	Burnsville	Minnesota	55337	Recruiting
Mercy Hospital	Coon Rapids	Minnesota	55433	Recruiting
Fairview Southdale Hospital	Edina	Minnesota	55435	Recruiting
Saint John's Hospital - Healtheast	Maplewood	Minnesota	55109	Recruiting
Abbott-Northwestern Hospital	Minneapolis	Minnesota	55407	Recruiting
Hennepin County Medical Center	Minneapolis	Minnesota	55415	Recruiting
Park Nicollet Clinic - Saint Louis Park	Saint Louis Park	Minnesota	55416	Recruiting
Regions Hospital	Saint Paul	Minnesota	55101	Recruiting
United Hospital	Saint Paul	Minnesota	55102	Recruiting
Saint Francis Medical Center	Cape Girardeau	Missouri	63703	Recruiting
Siteman Cancer Center at Saint Peters Hospital	City of Saint Peters	Missouri	63376	Recruiting
Siteman Cancer Center at West County Hospital	Creve Coeur	Missouri	63141	Recruiting
University Health Truman Medical Center	Kansas City	Missouri	64108	Recruiting
University of Kansas Cancer Center - Briarcliff	Kansas City	Missouri	64116	Recruiting
University of Kansas Cancer Center - North	Kansas City	Missouri	64154	Recruiting
University of Kansas Cancer Center - Lee's Summit	Lee's Summit	Missouri	64064	Recruiting
Lake Regional Hospital	Osage Beach	Missouri	65065	Recruiting
Washington University School of Medicine	St Louis	Missouri	63110	Recruiting
Mercy Hospital South	St Louis	Missouri	63128	Recruiting
Siteman Cancer Center-South County	St Louis	Missouri	63129	Recruiting
Siteman Cancer Center at Christian Hospital	St Louis	Missouri	63136	Recruiting
Community Hospital of Anaconda	Anaconda	Montana	59711	Recruiting
Billings Clinic Cancer Center	Billings	Montana	59101	Recruiting
Bozeman Health Deaconess Hospital	Bozeman	Montana	59715	Recruiting
Benefis Sletten Cancer Institute	Great Falls	Montana	59405	Recruiting
Logan Health Medical Center	Kalispell	Montana	59901	Recruiting
Community Medical Center	Missoula	Montana	59804	Recruiting
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center	Lebanon	New Hampshire	03756	Recruiting
Memorial Sloan Kettering Basking Ridge	Basking Ridge	New Jersey	07920	Recruiting
Jefferson Cherry Hill Hospital	Cherry Hill	New Jersey	08002	Recruiting
Memorial Sloan Kettering Monmouth	Middletown	New Jersey	07748	Recruiting
Memorial Sloan Kettering Bergen	Montvale	New Jersey	07645	Recruiting
Sidney Kimmel Cancer Center Washington Township	Sewell	New Jersey	08080	Recruiting
Memorial Sloan Kettering Commack	Commack	New York	11725	Recruiting
Glens Falls Hospital	Glens Falls	New York	12801	Recruiting
Memorial Sloan Kettering Westchester	Harrison	New York	10604	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
State University of New York Upstate Medical University	Syracuse	New York	13210	Recruiting
SUNY Upstate Medical Center-Community Campus	Syracuse	New York	13215	Recruiting
Memorial Sloan Kettering Nassau	Uniondale	New York	11553	Recruiting
Upstate Cancer Center at Verona	Verona	New York	13478	Recruiting
UNC Lineberger Comprehensive Cancer Center	Chapel Hill	North Carolina	27599	Recruiting
Margaret R Pardee Memorial Hospital	Hendersonville	North Carolina	28791	Recruiting
FirstHealth of the Carolinas-Moore Regional Hospital	Pinehurst	North Carolina	28374	Recruiting
Sanford Bismarck Medical Center	Bismarck	North Dakota	58501	Recruiting
Sanford Broadway Medical Center	Fargo	North Dakota	58122	Recruiting
Sanford Roger Maris Cancer Center	Fargo	North Dakota	58122	Recruiting
Miami Valley Hospital South	Centerville	Ohio	45459	Recruiting
Miami Valley Hospital	Dayton	Ohio	45409	Recruiting
Miami Valley Hospital North	Dayton	Ohio	45415	Recruiting
Atrium Medical Center-Middletown Regional Hospital	Franklin	Ohio	45005-1066	Recruiting
Miami Valley Cancer Care and Infusion	Greenville	Ohio	45331	Recruiting
ProMedica Flower Hospital	Sylvania	Ohio	43560	Recruiting
Upper Valley Medical Center	Troy	Ohio	45373	Recruiting
Cancer Centers of Southwest Oklahoma Research	Lawton	Oklahoma	73505	Recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Recruiting
Saint Alphonsus Cancer Care Center-Ontario	Ontario	Oregon	97914	Recruiting
Providence Willamette Falls Medical Center	Oregon City	Oregon	97045	Recruiting
Providence Portland Medical Center	Portland	Oregon	97213	Recruiting
Providence Saint Vincent Medical Center	Portland	Oregon	97225	Recruiting
Lehigh Valley Hospital-Cedar Crest	Allentown	Pennsylvania	18103	Recruiting
Lehigh Valley Hospital - Muhlenberg	Bethlehem	Pennsylvania	18017	Recruiting
Pocono Medical Center	East Stroudsburg	Pennsylvania	18301	Recruiting
Jefferson Torresdale Hospital	Philadelphia	Pennsylvania	19114	Recruiting
Medical University of South Carolina	Charleston	South Carolina	29425	Recruiting
Avera Cancer Institute - Mitchell	Mitchell	South Dakota	57301	Recruiting
Avera Cancer Institute at Pierre	Pierre	South Dakota	57501	Recruiting
Sanford Cancer Center Oncology Clinic	Sioux Falls	South Dakota	57104	Recruiting
Avera Cancer Institute	Sioux Falls	South Dakota	57105	Recruiting
Sanford USD Medical Center - Sioux Falls	Sioux Falls	South Dakota	57117-5134	Recruiting
Avera Cancer Institute at Yankton	Yankton	South Dakota	57078	Recruiting
Dartmouth Cancer Center - North	Saint Johnsbury	Vermont	05819	Recruiting
VCU Massey Cancer Center at Stony Point	Richmond	Virginia	23235	Recruiting
VCU Massey Comprehensive Cancer Center	Richmond	Virginia	23298	Recruiting
West Virginia University Charleston Division	Charleston	West Virginia	25304	Recruiting
Aurora Cancer Care-Southern Lakes VLCC	Burlington	Wisconsin	53105	Recruiting
Aurora Saint Luke's South Shore	Cudahy	Wisconsin	53110	Recruiting
Marshfield Medical Center-EC Cancer Center	Eau Claire	Wisconsin	54701	Recruiting
Aurora Health Care Germantown Health Center	Germantown	Wisconsin	53022	Recruiting
Aurora Cancer Care-Grafton	Grafton	Wisconsin	53024	Recruiting
Aurora BayCare Medical Center	Green Bay	Wisconsin	54311	Recruiting
Aurora Cancer Care-Kenosha South	Kenosha	Wisconsin	53142	Recruiting
Gundersen Lutheran Medical Center	La Crosse	Wisconsin	54601	Recruiting
Aurora Bay Area Medical Group-Marinette	Marinette	Wisconsin	54143	Recruiting
Marshfield Medical Center-Marshfield	Marshfield	Wisconsin	54449	Recruiting
Aurora Cancer Care-Milwaukee	Milwaukee	Wisconsin	53209	Recruiting
Aurora Saint Luke's Medical Center	Milwaukee	Wisconsin	53215	Recruiting
Aurora Sinai Medical Center	Milwaukee	Wisconsin	53233	Recruiting
ProHealth D N Greenwald Center	Mukwonago	Wisconsin	53149	Recruiting
ProHealth Oconomowoc Memorial Hospital	Oconomowoc	Wisconsin	53066	Recruiting
Vince Lombardi Cancer Clinic - Oshkosh	Oshkosh	Wisconsin	54904	Recruiting
Aurora Cancer Care-Racine	Racine	Wisconsin	53406	Recruiting
Vince Lombardi Cancer Clinic-Sheboygan	Sheboygan	Wisconsin	53081	Recruiting
Marshfield Medical Center-River Region at Stevens Point	Stevens Point	Wisconsin	54482	Recruiting
Aurora Medical Center in Summit	Summit	Wisconsin	53066	Recruiting
Vince Lombardi Cancer Clinic-Two Rivers	Two Rivers	Wisconsin	54241	Recruiting
ProHealth Waukesha Memorial Hospital	Waukesha	Wisconsin	53188	Recruiting
UW Cancer Center at ProHealth Care	Waukesha	Wisconsin	53188	Recruiting
Aurora Cancer Care-Milwaukee West	Wauwatosa	Wisconsin	53226	Recruiting
Aurora West Allis Medical Center	West Allis	Wisconsin	53227	Recruiting
Marshfield Medical Center - Weston	Weston	Wisconsin	54476	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06589804, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 5, 2026 · Synced May 8, 2026

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