A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
Public ClinicalTrials.gov record NCT06612268. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Global Phase 3, Randomised, Double-blind and Placebo-controlled Study Evaluating the Efficacy and Safety of Etavopivat in Adolescents and Adults With Sickle Cell Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is conducted to confirm whether etavopivat works well at reducing the number of Vaso-occlusive crisis VOCs (sickle cell pain crises) caused by obstructions in blood vessels in adults and adolescents living with sickle cell disease. The study will also evaluate how well etavopivat can reduce the damage to different organs, improve your exercise tolerance and reduce fatigue in people with sickle cell disease.The participants will either get etavopivat or placebo. Which treatment the participants will get is decided by chance. Etavopivat is a new medicine and is currently being tested in other studies in addition to this one. The study will last for about 2 years.
Study identification
- NCT ID
- NCT06612268
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 510 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 12 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 17, 2025 (Actual)
- Primary completion
- Aug 27, 2027 (Estimated)
- Completion
- Aug 12, 2029 (Estimated)
- Last update posted
- Sep 17, 2026
2025 – 2029
United States locations
- U.S. sites
- 49
- U.S. states
- 27
- U.S. cities
- 40
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Uni of Alabama at Birmingham | Birmingham | Alabama | 35233 | Recruiting |
| Univer South Alabama Ped/Onc | Mobile | Alabama | 36604 | Recruiting |
| Phoenix Children's Hsptl | Phoenix | Arizona | 85016 | Recruiting |
| Arkansas Children's Hospital | Little Rock | Arkansas | 72202 | Recruiting |
| Children's Hospital Los Angeles - Endocrinology | Los Angeles | California | 90027 | Recruiting |
| UCLA Health | Los Angeles | California | 90095 | Completed |
| Valley Children's Hospital | Madera | California | 93636 | Recruiting |
| University Of California Irvine | Orange | California | 92868 | Completed |
| Stanford University_Palo Alto | Palo Alto | California | 94304 | Recruiting |
| Harbor-UCLA Medical Center | Torrance | California | 90502 | Recruiting |
| Clinical and Transl Res Center | Aurora | Colorado | 80045 | Completed |
| Nemours/AI duPont Hosp-Chld | Wilmington | Delaware | 19803 | Recruiting |
| Childrens National Medical Ctr | Washington D.C. | District of Columbia | 20010 | Recruiting |
| MedStar Hlth Res Institute | Washington D.C. | District of Columbia | 20010 | Recruiting |
| Memorial Healthcare | Hollywood | Florida | 33021 | Recruiting |
| Children's Healthcare Atlanta | Atlanta | Georgia | 30329 | Recruiting |
| Childrens Hospital of Chicago | Chicago | Illinois | 60611 | Recruiting |
| Univer Of Illinois at Chicago | Chicago | Illinois | 60612 | Recruiting |
| Children's Hosp-New Orleans | New Orleans | Louisiana | 70118 | Recruiting |
| Boston Children's Hospital | Boston | Massachusetts | 02115 | Recruiting |
| Boston Medical Center | Boston | Massachusetts | 02118-2393 | Recruiting |
| Henry Ford Hospital_Detroit | Detroit | Michigan | 48202 | Completed |
| University of Minnesota | Minneapolis | Minnesota | 55455 | Recruiting |
| Washington University-St.Louis | St Louis | Missouri | 63110 | Recruiting |
| Children's Nebraska | Omaha | Nebraska | 68114 | Recruiting |
| Cure 4 the Kids Foundation | Las Vegas | Nevada | 89135 | Completed |
| Newark Beth Israel MC | Newark | New Jersey | 07112-2027 | Recruiting |
| NYC Health+Hospitals | Brooklyn | New York | 11203 | Recruiting |
| Interfaith Medical Center | Brooklyn | New York | 11238 | Recruiting |
| Northwell Health | Mount Kisco | New York | 10549 | Completed |
| Cohen Children's Medical Ctr | Queens | New York | 11040 | Recruiting |
| Jacobi Medical Center | The Bronx | New York | 10461 | Recruiting |
| Montefiore Medical Ctr | The Bronx | New York | 10467 | Recruiting |
| Duke Comprehen Sickle Cell | Durham | North Carolina | 27710 | Recruiting |
| Duke University Medical Center | Durham | North Carolina | 27710 | Recruiting |
| East Carolina Univ-Greenville | Greenville | North Carolina | 27834 | Recruiting |
| Atrium Health-Wake Forest Bapt | Winston-Salem | North Carolina | 27157 | Recruiting |
| Univ Hosp Cleveland Med Ctr | Cleveland | Ohio | 44106 | Recruiting |
| Ohio State Univ Wexner Med Ctr | Columbus | Ohio | 43203 | Recruiting |
| Univ of OK Health Sciences Ctr | Oklahoma City | Oklahoma | 73104 | Recruiting |
| Children's Hosptl Philadelphia | Philadelphia | Pennsylvania | 19104 | Recruiting |
| St Christopher Hosp for Child | Philadelphia | Pennsylvania | 19134 | Recruiting |
| University of Tennessee Health Science Center | Memphis | Tennessee | 38104 | Recruiting |
| St. Jude Children's Res Hosp | Memphis | Tennessee | 38105 | Recruiting |
| UT Health University of Texas | Houston | Texas | 77030 | Recruiting |
| Inova Health System | Fairfax | Virginia | 22031 | Recruiting |
| Children's Hsptl Of The Kings | Norfolk | Virginia | 23507 | Recruiting |
| Virginia Comm Univ Medical Ctr | Richmond | Virginia | 23298 | Recruiting |
| Mary Bridge Children's Health | Tacoma | Washington | 98405 | Not yet recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 119 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06612268, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 17, 2026 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06612268 live on ClinicalTrials.gov.