A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

ClinicalTrials.gov ID: NCT06612268

Public ClinicalTrials.gov record NCT06612268. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 19, 2026, 9:07 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Global Phase 3, Randomised, Double-blind and Placebo-controlled Study Evaluating the Efficacy and Safety of Etavopivat in Adolescents and Adults With Sickle Cell Disease

Study identification

NCT ID: NCT06612268
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Novo Nordisk A/S; Industry
Enrollment: 408 participants

Conditions and interventions

Conditions

Sickle Cell Disease

Interventions

Etavopivat Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 12 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Feb 16, 2025
Primary completion: Aug 26, 2027
Completion: Mar 11, 2029
Last update posted: Apr 23, 2026

2025 – 2029

United States locations

U.S. sites: 49
U.S. states: 27
U.S. cities: 40

Facility	City	State	ZIP	Site status
Uni of Alabama at Birmingham	Birmingham	Alabama	35233	Recruiting
Univer South Alabama Ped/Onc	Mobile	Alabama	36604	Recruiting
Phoenix Children's Hsptl	Phoenix	Arizona	85016	Recruiting
Arkansas Children's Hospital	Little Rock	Arkansas	72202	Recruiting
Children's Hospital Los Angeles - Endocrinology	Los Angeles	California	90027	Recruiting
UCLA Health	Los Angeles	California	90095	Recruiting
Valley Children's Hospital	Madera	California	93636	Recruiting
University Of California Irvine	Orange	California	92868	Completed
Stanford University_Palo Alto	Palo Alto	California	94304	Recruiting
Harbor-UCLA Medical Center	Torrance	California	90502	Recruiting
Clinical and Transl Res Center	Aurora	Colorado	80045	Completed
Nemours/AI duPont Hosp-Chld	Wilmington	Delaware	19803	Recruiting
Childrens National Medical Ctr	Washington D.C.	District of Columbia	20010	Recruiting
MedStar Hlth Res Institute	Washington D.C.	District of Columbia	20010	Recruiting
Memorial Healthcare	Hollywood	Florida	33021	Recruiting
Children's Healthcare Atlanta	Atlanta	Georgia	30329	Recruiting
Childrens Hospital of Chicago	Chicago	Illinois	60611	Recruiting
Univer Of Illinois at Chicago	Chicago	Illinois	60612	Recruiting
Children's Hosp-New Orleans	New Orleans	Louisiana	70118	Recruiting
Boston Children's Hospital	Boston	Massachusetts	02115	Recruiting
Boston Medical Center	Boston	Massachusetts	02118-2393	Recruiting
Henry Ford Hospital_Detroit	Detroit	Michigan	48202	Completed
University of Minnesota	Minneapolis	Minnesota	55455	Recruiting
Washington University-St.Louis	St Louis	Missouri	63110	Recruiting
Children's Nebraska	Omaha	Nebraska	68114	Recruiting
Cure 4 the Kids Foundation	Las Vegas	Nevada	89135	Completed
Newark Beth Israel MC	Newark	New Jersey	07112-2027	Not yet recruiting
NYC Health+Hospitals	Brooklyn	New York	11203	Recruiting
Interfaith Medical Center	Brooklyn	New York	11238	Recruiting
Northwell Health	Mount Kisco	New York	10549	Completed
Cohen Children's Medical Ctr	Queens	New York	11040	Recruiting
Jacobi Medical Center	The Bronx	New York	10461	Recruiting
Montefiore Medical Ctr	The Bronx	New York	10467	Recruiting
Duke Comprehen Sickle Cell	Durham	North Carolina	27710	Recruiting
Duke University Medical Center	Durham	North Carolina	27710	Recruiting
East Carolina Univ-Greenville	Greenville	North Carolina	27834	Recruiting
Atrium Health-Wake Forest Bapt	Winston-Salem	North Carolina	27157	Recruiting
Univ Hosp Cleveland Med Ctr	Cleveland	Ohio	44106	Recruiting
Ohio State Univ Wexner Med Ctr	Columbus	Ohio	43203	Recruiting
Univ of OK Health Sciences Ctr	Oklahoma City	Oklahoma	73104	Recruiting
Children's Hosptl Philadelphia	Philadelphia	Pennsylvania	19104	Recruiting
St Christopher Hosp for Child	Philadelphia	Pennsylvania	19134	Recruiting
University of Tennessee Health Science Center	Memphis	Tennessee	38104	Recruiting
St. Jude Children's Res Hosp	Memphis	Tennessee	38105	Recruiting
UT Health University of Texas	Houston	Texas	77030	Recruiting
Inova Health System	Fairfax	Virginia	22031	Recruiting
Children's Hsptl Of The Kings	Norfolk	Virginia	23507	Recruiting
Virginia Comm Univ Medical Ctr	Richmond	Virginia	23298	Recruiting
Mary Bridge Children's Health	Tacoma	Washington	98405	Not yet recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 116 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06612268, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 23, 2026 · Synced May 19, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06612268 live on ClinicalTrials.gov.

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