A Study to Evaluate IPN10200 Safety and Efficacy in the Prevention of Episodic or Chronic Migraine in Adults
Public ClinicalTrials.gov record NCT06625060. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicentre, Randomised, Double-blind, Placebo-controlled, Dose Escalation and Dose Finding Phase II Study to Evaluate the Safety and Efficacy of IPN10200 in the Prevention of Episodic or Chronic Migraine in Adults
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
A migraine is a headache with severe throbbing pain or a pulsating sensation, usually on one side of the head. It is often accompanied by feeling or being sick and a sensitivity to bright lights and sound. Migraines are caused by a series of events when the brain gets stimulated or activated, which causes the release of chemicals that cause pain. Corabotase (also known as IPN10200) is a medication that stops the release of these chemical messengers. Participants with episodic migraine (EM) or chronic migraine (CM) will be included in both Step 1 and Step 2. "Headache days" are when participants experience headaches that meet the criteria for a migraine or a headache without the additional migraine-specific symptoms. "Migraine days" occur when the headache displays clear migraine characteristics. This study aims to determine: * The safety and efficacy of injecting Corabotase directly into the muscles of the head and neck to prevent EM and CM, * The right amount (dose) of Corabotase to inject at each point, * The total amount (dose) of Corabotase that provides the best balance between safety and efficacy preventing migraines. Participants will need to complete a daily electronic migraine Diary (eDiary) and questionnaires throughout the study. The total study duration for a participant will be up to 44 weeks.
Study identification
- NCT ID
- NCT06625060
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 670 participants
Conditions and interventions
Conditions
Interventions
- Corabotase Biological
- Placebo Other
- Corabotase dose A Biological
- Corabotase dose B Biological
Biological · Other
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 10, 2024 (Actual)
- Primary completion
- Oct 31, 2027 (Estimated)
- Completion
- Oct 31, 2027 (Estimated)
- Last update posted
- Sep 8, 2026
2024 – 2027
United States locations
- U.S. sites
- 68
- U.S. states
- 22
- U.S. cities
- 54
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Central Research Associates | Birmingham | Alabama | 35205 | — |
| Rehabilitation & Neurological Services, LLC | Huntsville | Alabama | 35801 | — |
| MD First Research - Chandler - Neurology | Chandler | Arizona | 85224 | — |
| MD First Research - Chandler | Chandler | Arizona | 85286 | — |
| Axiom Research, LLC | Apple Valley | California | 92308 | — |
| Profound Research. LLC - NCSC | Carlsbad | California | 92011 | — |
| M3Wake -PRI Encino | Encino | California | 91316 | — |
| WR-PRI Encino | Encino | California | 91316 | — |
| Neuro-Pain Medical Center | Fresno | California | 93710 | — |
| Fullerton Neurological Center - Neurology | Fullerton | California | 92832 | — |
| Neurology Center of North Orange County | Fullerton | California | 92832 | — |
| Kaizen Brain Center | La Jolla | California | 92037 | — |
| Pharmacology Research Institute (PRI) | Los Alamitos | California | 90720 | — |
| Pharmacology Research Institute (PRI) - Los Alamitos/Long Beach | Newport Beach | California | 92660 | — |
| Profound Research, LLC | Pasadena | California | 91105 | — |
| Acclaim Clinical Research - Internal Medicine | San Diego | California | 92101 | — |
| Clinical Trials Management LLC | Thousand Oaks | California | 91360 | — |
| Alliance Clinical West Hills (Focus Clinical Research) | West Hills | California | 91307 | — |
| Advanced Neuroscience Research Center, LLC | Fort Collins | Colorado | 80501 | — |
| Advanced Neuroscience Research Center, LLC - Neurology | Fort Collins | Colorado | 80524 | — |
| New England Institute for Neurology and Headache (NEINH)/Medical Practice | Stamford | Connecticut | 06901 | — |
| Neurology Offices | Boca Raton | Florida | 33432 | — |
| AGA Clinical Trials | Hialeah | Florida | 33012 | — |
| M3 Wake Research/MSRA, LLC | Lake City | Florida | 32055 | — |
| M3 Wake Research/MSRA,LLC | Lake City | Florida | 32055 | — |
| Renstar Medical Research | Ocala | Florida | 34471 | — |
| Clinical Neuroscience Solutions, Inc. | Orlando | Florida | 32801 | — |
| Emerald Coast Center For Neurological Disorders | Pensacola | Florida | 32502 | — |
| Conquest Research | Winter Park | Florida | 32789 | — |
| NeuroTrials Research, Inc. | Atlanta | Georgia | 30309 | — |
| Crescent City Headache and Neurology Center, LLC | Chalmette | Louisiana | 70043 | — |
| Ochsner Health Center - Covington | Covington | Louisiana | 70433 | — |
| DelRicht Research | New Orleans | Louisiana | 70112 | — |
| DelRicht Research at Touro Medical Center | New Orleans | Louisiana | 70115 | — |
| LSU Healthcare Network Orthopedic & Sports Medicine | New Orleans | Louisiana | 70115 | — |
| MedStar Neurosciences and Rehabilitation Research Network | Baltimore | Maryland | 21218 | — |
| MedStar Neurosciences and Rehabilitation | Baltimore | Maryland | 21218 | — |
| MedStar Franklin Square Hospital Center | Baltimore | Maryland | 21237 | — |
| Medstar Franklin Square Medical Center | Baltimore | Maryland | 21237 | — |
| Neurology Center of NE,PC - Neurology | Foxborough | Massachusetts | 02035 | — |
| MedVadis Research | Waltham | Massachusetts | 02451 | — |
| Mass Institute of Clinical Research | Westborough | Massachusetts | 01581 | — |
| Michigan Head Pain & Neurological Institute - Neurology/Pain | Ann Arbor | Michigan | 48104 | — |
| Michigan Head Pain & Neurological Institute | Ann Arbor | Michigan | 48104 | — |
| Michigan Center of Medical Research | Grand Blanc | Michigan | 48439 | — |
| Minneapolis Clinic-Neurology | Burnsville | Minnesota | 55306 | — |
| Papillion Research Center/Avacare | Papillion | Nebraska | 68046 | — |
| Alliance Clinical Las Vegas (Excel Clinical Research) - Internal Medicine | Las Vegas | Nevada | 89101 | — |
| Integrative Clinical Trials, LLC | Brooklyn | New York | 11229 | — |
| Montefiore Medical Center: Headache Center | The Bronx | New York | 10461 | — |
| Upstate Clinical Research Associates - Research Center | Williamsville | New York | 14221 | — |
| Upstate Clinical Research Associates | Williamsville | New York | 14221 | — |
| UC Gardner Neuroscience Institute | Cincinnati | Ohio | 45219 | — |
| Neurology Diagnostics, Inc. | Dayton | Ohio | 45459 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | — |
| Preferred Primary Care Physicians - Curry Hollow | Pittsburgh | Pennsylvania | 15236 | — |
| Clinical Neuroscience Solutions, Inc - Memphis | Memphis | Tennessee | 38119 | — |
| Clinical Neuroscience Solutions, Inc. | Memphis | Tennessee | 38119 | — |
| Zenos Clinical Research - Internal Medicine | Dallas | Texas | 75201 | — |
| Lone Star Neurology | Frisco | Texas | 75034 | — |
| Elevate Clinical Research - Houston | Houston | Texas | 77002 | — |
| Javara Inc. - Houston, TX | Houston | Texas | 77002 | — |
| Javara Inc. - New Caney, TX | New Caney | Texas | 77357 | — |
| J. Lewis Research-Site Number:8400053 | Salt Lake City | Utah | 84101 | — |
| ChronicleBio | West Valley City | Utah | 84119 | — |
| Puget Sound Neurology - Neurology | Tacoma | Washington | 98409 | — |
| Marshall Health Clinical Research Center | Huntington | West Virginia | 25701 | — |
| Frontier Clinical Research, LLC - Kingwood | Kingwood | West Virginia | 26537 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 94 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06625060, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 8, 2026 · Synced Oct 24, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06625060 live on ClinicalTrials.gov.