A Study of Valemetostat Tosylate Plus Pembrolizumab Versus Pembrolizumab Alone in First-Line NSCLC Without Actionable Genomic Alterations

ClinicalTrials.gov ID: NCT06644768

Public ClinicalTrials.gov record NCT06644768. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jun 25, 2026, 3:48 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Multicenter, Randomized, Open-Label, Phase 1b/2 Trial Of Valemetostat Tosylate Plus Pembrolizumab Vs Pembrolizumab Alone in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Whose Tumors Express PD-L1 With Tumor Proportion Score ≥50% Without Actionable Genomic Alterations

Study identification

NCT ID: NCT06644768
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: Daiichi Sankyo; Industry
Enrollment: 137 participants

Conditions and interventions

Conditions

Interventions

valemetostat tosylate Drug
pembrolizumab Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 29, 2024
Primary completion: Mar 29, 2028
Completion: Apr 29, 2030
Last update posted: Oct 8, 2025

2024 – 2030

United States locations

U.S. sites: 12
U.S. states: 7
U.S. cities: 11

Facility	City	State	ZIP	Site status
University of California San Diego (Ucsd)-Moores Cancer Center	La Jolla	California	92037	Recruiting
California Research Institute	Los Angeles	California	90027	Recruiting
Valkyrie Clinical Trials	Los Angeles	California	90067	Recruiting
Mayo Clinic Hospital	Jacksonville	Florida	32224	Not yet recruiting
BRCR Global	Plantation	Florida	33322-5426	Recruiting
University of Kentucky Medical Center	Lexington	Kentucky	40536	Recruiting
Pikeville Medical Center	Pikeville	Kentucky	41501	Recruiting
Mayo Clinic - Rochester	Rochester	Minnesota	55904	Not yet recruiting
Columbia University Irving Medical Center	New York	New York	10032	Not yet recruiting
Montefiore Medical Center	The Bronx	New York	10461	Recruiting
Thomas Jefferson University, Sidney Kimmel Cancer Center	Philadelphia	Pennsylvania	19107	Recruiting
Virginia Cancer Specialist	Fairfax	Virginia	22031	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 33 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06644768, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Oct 8, 2025 · Synced Jun 25, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06644768 live on ClinicalTrials.gov.

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