ClinicalTrials.gov record
A Study of Remternetug (LY3372993) in Early Alzheimer's Disease (TRAILRUNNER-ALZ 3)
ClinicalTrials.gov ID: NCT06653153
Public ClinicalTrials.gov record NCT06653153. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Study of Remternetug Versus Placebo in Early Alzheimer's Disease Participants at Risk for Cognitive and Functional Decline
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to measure the difference in time to developing or worsening memory, thinking, or functional problems due to Alzheimer's disease occurring in participants receiving study drug compared to placebo. Participation could last up to 255 weeks including screening, a double-blind treatment period, and a double-blind observation period. In addition, eligible participants who receive placebo during the double-blind treatment period may choose to extend their study participation to receive open-label remternetug in an extension period.
Study identification
- NCT ID
- NCT06653153
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,400 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 55 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 24, 2024 (Actual)
- Primary completion
- Apr 2029 (Estimated)
- Completion
- Oct 2030 (Estimated)
- Last update posted
- Oct 7, 2026
2024 – 2030
United States locations
- U.S. sites
- 123
- U.S. states
- 34
- U.S. cities
- 111
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Parkway Medical Center | Birmingham | Alabama | 35215 | — |
| MD First Research - Chandler | Chandler | Arizona | 85286 | — |
| Care Access - 801 South Power Road, Mesa | Mesa | Arizona | 85206 | — |
| Banner Alzheimer's Institute | Phoenix | Arizona | 85006 | — |
| Banner Alzheimer's Institute Tucson | Tucson | Arizona | 85718 | — |
| Neuro-Pain Medical Center | Fresno | California | 93710 | — |
| Care Access - Huntington Beach | Huntington Beach | California | 92648 | — |
| Inglewood Clinical | Inglewood | California | 90301 | — |
| Irvine Clinical Research | Irvine | California | 92614 | — |
| Healthy Brain Clinic | Long Beach | California | 90804 | — |
| Riverside Clinical | Riverside | California | 92506 | — |
| Clinical Trials Research | Sacramento | California | 95821 | — |
| Artemis Institute for Clinical Research | San Diego | California | 92103 | — |
| Sharp Neurocognitive Research Center | San Diego | California | 92123 | — |
| Ray Dolby Brain Health Center | San Francisco | California | 94114 | — |
| The Neuron Clinic - San Marcos | San Marcos | California | 92069 | — |
| Syrentis Clinical Research | Santa Ana | California | 92705 | — |
| Providence Medical Foundation | Santa Rosa | California | 95403 | — |
| California Neuroscience Research, LLC | Sherman Oaks | California | 91403 | — |
| Care Access - Aurora | Aurora | Colorado | 80012 | — |
| Mountain Neurological Research Center | Basalt | Colorado | 81621 | — |
| Alpine Clinical Research Center | Boulder | Colorado | 80301 | — |
| CenExel Rocky Mountain Clinical Research | Englewood | Colorado | 80113 | — |
| Invicro | New Haven | Connecticut | 06510 | — |
| Ki Health Partners, LLc, dba New England Institute for Clinical Research | Stamford | Connecticut | 06905 | — |
| JEM Research Institute | Atlantis | Florida | 33462 | — |
| VIN - Aventura | Aventura | Florida | 33180 | — |
| Bradenton Research Center, Inc. | Bradenton | Florida | 34205 | — |
| K2 Medical Research WINTER GARDEN | Clermont | Florida | 34711 | — |
| TecTum Research | Davie | Florida | 33024 | — |
| Brain Matters Research | Delray Beach | Florida | 33445 | — |
| Neuropsychiatric Research Center of Southwest Florida | Fort Myers | Florida | 33912 | — |
| Indago Research & Health Center, Inc | Hialeah | Florida | 33012 | — |
| K2 MEDICAL Research THE VILLAGES | Lady Lake | Florida | 32159 | — |
| ClinCloud | Maitland | Florida | 32751 | — |
| K2 Medical Research ORLANDO | Maitland | Florida | 32751 | — |
| ClinCloud | Melbourne | Florida | 32940 | — |
| Merritt Island Medical Research, LLC | Merritt Island | Florida | 32952 | — |
| VIN-Andrew Lerman | Miami | Florida | 33133 | — |
| New Age Medical Research Corporation | Miami | Florida | 33186 | — |
| Adult Medicine of Lake County, Inc. | Mt. Dora | Florida | 32757 | — |
| Aqualane Clinical Research | Naples | Florida | 34105 | — |
| Suncoast Clinical Research, Inc. | New Port Richey | Florida | 34652 | — |
| Renstar Medical Research | Ocala | Florida | 34470 | — |
| Charter Research - Winter Park | Orlando | Florida | 32803 | — |
| AdventHealth Orlando | Orlando | Florida | 32804 | — |
| Emerald Coast Neurology - Airport Boulevard | Pensacola | Florida | 32504 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| Alzheimer's Research and Treatment Center | Stuart | Florida | 34997 | — |
| Axiom Brain Health LLC | Tampa | Florida | 33609 | — |
| Stedman Clinical Trials | Tampa | Florida | 33613 | — |
| Care Access - Tampa | Tampa | Florida | 33625 | — |
| Charter Research - Lady Lake | The Villages | Florida | 32162 | — |
| Alzheimer's Research and Treatment Center | Wellington | Florida | 33414 | — |
| Palm Beach Neurology | West Palm Beach | Florida | 33407 | — |
| Conquest Research | Winter Park | Florida | 32789 | — |
| Columbus Memory Center, LLC | Columbus | Georgia | 31909 | — |
| Care Access - Decatur | Decatur | Georgia | 30030 | — |
| Center for Advanced Research & Education | Gainesville | Georgia | 30501 | — |
| North Georgia Clinical Research | Woodstock | Georgia | 30189 | — |
| Northwest Clinical Trials | Boise | Idaho | 83704 | — |
| Care Access - Arlington Heights | Arlington Heights | Illinois | 60005 | — |
| Re:Cognition Health - Chicago | Chicago | Illinois | 60611 | — |
| Great Lakes Clinical Trials - Andersonville | Chicago | Illinois | 60640 | — |
| Alexian Brothers Medical Center | Elk Grove Village | Illinois | 60007 | — |
| Care Access - South Indianapolis | Indianapolis | Indiana | 46227 | — |
| Josephson Wallack Munshower Neurology, PC | Indianapolis | Indiana | 46256 | — |
| Cedar Valley Medical Specialists | Waterloo | Iowa | 50701 | — |
| Cotton O'Neil Clinical Research Center | Topeka | Kansas | 66606 | — |
| Care Access - Lake Charles (Bayou Pines) | Lake Charles | Louisiana | 70601 | — |
| Tandem Clinical Research | Marrero | Louisiana | 70072 | — |
| Acadia Hospital | Bangor | Maine | 04401 | — |
| Care Access - Baltimore | Baltimore | Maryland | 21213 | — |
| Adams Clinical Boston | Boston | Massachusetts | 02116 | — |
| Boston Clinical Trials | Boston | Massachusetts | 02131 | — |
| Boston Center for Memory | Newton | Massachusetts | 02459 | — |
| Care Access - Quincy | Quincy | Massachusetts | 02169 | — |
| MedVadis Research Corporation | Waltham | Massachusetts | 02451 | — |
| Adams Clinical Watertown | Watertown | Massachusetts | 02472 | — |
| Revival Research Institute, LLC | Dearborn | Michigan | 48126 | — |
| QUEST Research Institute | Farmington Hills | Michigan | 48334 | — |
| HealthPartners Neuroscience Center | Saint Paul | Minnesota | 55130 | — |
| Private Practice - Dr. Ronald Louis Schwartz | Hattiesburg | Mississippi | 39401 | — |
| Citizens Memorial Hospital District | Bolivar | Missouri | 65613 | — |
| Clinical Research Professionals | Chesterfield | Missouri | 63005 | — |
| University Of Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| Vector Clinical Trials | Las Vegas | Nevada | 89128 | — |
| Care Access - Hoboken | Hoboken | New Jersey | 07030 | — |
| The Cognitive and Research Center of New Jersey - Ridgewood | Ridgewood | New Jersey | 07450 | — |
| The Cognitive and Research Center of New Jersey | Springfield | New Jersey | 07081 | — |
| Advanced Memory Research Institute of New Jersey | Toms River | New Jersey | 08755 | — |
| IMA Clinical Research | Albuquerque | New Mexico | 87109 | — |
| Care Access - Charlotte | Charlotte | North Carolina | 28210 | — |
| Medication Management | Greensboro | North Carolina | 27405 | — |
| Monroe Biomedical Research | Monroe | North Carolina | 28112 | — |
| Care Access - Lima | Lima | Ohio | 45805 | — |
| North Star Medical Research | Middleburg Heights | Ohio | 44130 | — |
| Summit Headlands | Portland | Oregon | 97210 | — |
| Clinical Research of Philadelphia | Philadelphia | Pennsylvania | 19114 | — |
| Keystone Clinical Studies | Plymouth Meeting | Pennsylvania | 19462 | — |
| Rhode Island Mood & Memory Research Institute | East Providence | Rhode Island | 02914 | — |
| Butler Hospital | Providence | Rhode Island | 02906 | — |
| Tribe Clinical Research, LLC- Greenville | Greenville | South Carolina | 29607 | — |
| Palmetto Clinical Research | Summerville | South Carolina | 29485 | — |
| Neurology Clinic, P.C. | Cordova | Tennessee | 38018 | — |
| Genesis Neuroscience Clinic | Knoxville | Tennessee | 37909 | — |
| Senior Adults Specialty Research | Austin | Texas | 78757 | — |
| Gadolin Research | Beaumont | Texas | 77702 | — |
| Kerwin Medical Center - Oak Cliff | Dallas | Texas | 75216 | — |
| Kerwin Medical Center | Dallas | Texas | 75231 | — |
| Care Access - Georgetown | Georgetown | Texas | 78633 | — |
| Care Access - Houston | Houston | Texas | 77054 | — |
| The University of Texas Health Science Center at Houston | Houston | Texas | 77054 | — |
| Next Level Urgent Care | Houston | Texas | 77057 | — |
| El Faro Health and Therapeutics | Rio Grande City | Texas | 78582 | — |
| Central Texas Neurology Consultants, PA | Round Rock | Texas | 78681 | — |
| IMA Clinical Research San Antonio | San Antonio | Texas | 78229 | — |
| Consano Clinical Research, LLC | Shavano Park | Texas | 78231 | — |
| Care Access - Arlington 2 | Arlington | Virginia | 22206 | — |
| Re:Cognition Health | Fairfax | Virginia | 22031 | — |
| Eastern Virginia Medical School (EVMS) Medical Group | Norfolk | Virginia | 23510 | — |
| Northwest Clinical Research Center | Bellevue | Washington | 98007 | — |
| Rainier Clinical Research Center | Renton | Washington | 98057 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 139 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06653153, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 7, 2026 · Synced Oct 18, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06653153 live on ClinicalTrials.gov.