First in Human Study of TUB-030 in Patients With Advanced Solid Tumors

ClinicalTrials.gov ID: NCT06657222

Public ClinicalTrials.gov record NCT06657222. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 18, 2026, 2:23 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Multicenter FIH Dose Escalation and Optimization Phase I/IIa Trial to Investigate Safety, Tolerability, PK, and Efficacy of the 5T4 ADC TUB-030 in Patients With Advanced Solid Tumors (5-STAR 1-01)

Study identification

NCT ID: NCT06657222
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: Tubulis GmbH; Industry
Enrollment: 250 participants

Conditions and interventions

Conditions

Interventions

TUB-030 Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 12, 2024
Primary completion: Nov 30, 2028
Completion: Nov 30, 2028
Last update posted: Mar 2, 2026

2024 – 2028

United States locations

U.S. sites: 12
U.S. states: 9
U.S. cities: 12

Facility	City	State	ZIP	Site status
Yale Cancer Center	New Haven	Connecticut	06510	Recruiting
University of Miami	Miami	Florida	33136	Recruiting
Dana Farber Cancer Institute	Boston	Massachusetts	02215	Recruiting
Mayo Clinic	Rochester	Minnesota	55905	Recruiting
Washington University	St Louis	Missouri	63130	Recruiting
Mount Sinai	New York	New York	11766	Recruiting
Cleveland Clinic	Cleveland	Ohio	44195	Recruiting
Ohio State University	Columbus	Ohio	43210	Recruiting
NEXT Oncology Austin	Austin	Texas	78758	Recruiting
NEXT Oncology - Dallas	Irving	Texas	75039	Recruiting
NEXT Oncology - San Antonio	San Antonio	Texas	78229	Recruiting
Fred Hutchinson Cancer Center	Seattle	Washington	98109	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06657222, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Mar 2, 2026 · Synced May 18, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06657222 live on ClinicalTrials.gov.

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