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Recruiting Phase 3 Interventional

A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer

ClinicalTrials.gov ID: NCT06662786

Public ClinicalTrials.gov record NCT06662786. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 10, 2026, 4:58 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, Open-label Phase 3 Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer

Study identification

NCT ID
NCT06662786
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Janssen Research & Development, LLC
Industry
Enrollment
1,000 participants

Conditions and interventions

Interventions

  • 5-fluorouracil Drug
  • Amivantamab Biological
  • Cetuximab Biological
  • Irinotecan Hydrochloride Drug
  • Leucovorin calcium/Levoleucovorin Drug
  • Oxaliplatin Drug

Drug · Biological

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Oct 17, 2024
Primary completion
Dec 14, 2028
Completion
Jan 19, 2032
Last update posted
May 7, 2026

2024 – 2032

United States locations

U.S. sites
77
U.S. states
31
U.S. cities
66
Facility City State ZIP Site status
Banner MD Anderson Cancer Center Gilbert Arizona 85234 Recruiting
St. Bernard's Medical Center Jonesboro Arkansas 72401 Recruiting
Highlands Oncology Group Springdale Arkansas 72762 Recruiting
CBCC Global Research Bakersfield California 93309 Recruiting
Los Angeles Cancer Network Glendale California 91204 Recruiting
Cancer and Blood Specialty Clinic Los Alamitos California 90720 Recruiting
USC Norris Comprehensive Cancer Center Los Angeles California 90033 Recruiting
UCLA Santa Monica California 90404 Recruiting
Providence Medical Foundation Santa Rosa California 95403 Recruiting
Torrance Memorial Physicians Network Torrance California 90505 Recruiting
Rocky Mountain Cancer Centers Denver Colorado 80218 Recruiting
Yale University School Of Medicine New Haven Connecticut 06519 Recruiting
Georgetown Univ Medical Center Lombardi Cancer Center Washington D.C. District of Columbia 20007 Recruiting
Florida Cancer Specialists South Fort Myers Florida 33901 Recruiting
AdventHealth Medical Group Oncology and Hematology at Orlando Orlando Florida 32804 Recruiting
Florida Cancer Specialists North Region St. Petersburg Florida 33701-4553 Recruiting
Florida Cancer Specialists East West Palm Beach Florida 33401-3406 Recruiting
Grady Memorial Hospital Atlanta Georgia 30303 Recruiting
Winship Cancer Institute Emory University Atlanta Georgia 30322 Recruiting
Illinois CancerCare Peoria Illinois 61615 Recruiting
Fort Wayne Medical Oncology & Hematology Fort Wayne Indiana 46804 Recruiting
University of Iowa Hospital Iowa City Iowa 52242 Recruiting
Mission Cancer Blood Waukee Iowa 50263 Recruiting
Cancer Center of Kansas Wichita Kansas 67214 Recruiting
Ochsner Clinic Foundation New Orleans Louisiana 70121 Recruiting
MedStar Franklin Square Medical Center Baltimore Maryland 21237 Recruiting
VA Ann Arbor Healthcare System Ann Arbor Michigan 48105 Recruiting
University of Michigan Ann Arbor Michigan 48109 Recruiting
Henry Ford Hospital Detroit Michigan 48202 Recruiting
Start Midwest Grand Rapids Michigan 49503 Recruiting
Hattiesburg Clinic Hattiesburg Mississippi 39401 Recruiting
Washington University School Of Medicine St Louis Missouri 63110 Recruiting
Nebraska Cancer Specialists Midwest Cancer Center Omaha Nebraska 68130 Recruiting
Comprehensive Cancer Centers of Nevada Las Vegas Nevada 89169 Recruiting
Astera Cancer Care East Brunswick New Jersey 08816 Recruiting
Rutgers Cancer Institute New Brunswick New Jersey 08901 Recruiting
University of New Mexico Cancer Center Albuquerque New Mexico 87102 Recruiting
Perlmutter Cancer Center at NYU Long Island Mineola New York 11501 Recruiting
Mount Sinai New York New York 10003 Recruiting
Mount Sinai West New York New York 10009 Recruiting
NYU Langone Medical Center NYU Hematology Associates New York New York 10016 Recruiting
Herbert Irving Comprehensive Cancer Center Columbia University Medical Center New York New York 10032 Recruiting
New York Cancer and Blood Specialists Shirley New York 11967 Recruiting
Montefiore Einstein Comprehensive Cancer Center The Bronx New York 10461 Recruiting
University of North Carolina at Chapel Hill Chapel Hill North Carolina 27599 Recruiting
Gabrail Cancer Center Canton Ohio 44718 Recruiting
University Hospitals Cleveland Medical Center Cleveland Ohio 44106 Recruiting
Cleveland Clinic Cancer Center Fairview Hospital Moll Pavilion Cleveland Ohio 44111 Recruiting
Taussig Cancer Insititute Cleveland Clinic Cleveland Ohio 44195 Recruiting
Cleveland Clinic Cancer Center Independence Family Health Center Independence Ohio 44131 Recruiting
Cleveland Clinic Cancer Center Mansfield Mansfield Ohio 44906 Recruiting
Cleveland Clinic Cancer Center Hillcrest Hospital Mayfield Heights Ohio 44124 Recruiting
Cleveland Clinic Cancer Centers Sandusky Sandusky Ohio 44870 Recruiting
Cleveland Clinic Cancer Center Strongsville Strongsville Ohio 44136 Recruiting
Cleveland Clinic Cancer Center South Pointe Hospital Warrensville Heights Ohio 44122 Recruiting
Wooster Milltown Specialty and Surgery Center Wooster Ohio 44691 Recruiting
Oregon Health And Science University Portland Oregon 97239 Recruiting
Thomas Jefferson University Philadelphia Pennsylvania 19107 Recruiting
Fox Chase Cancer Center Philadelphia Pennsylvania 19111 Recruiting
University Of Pittsburgh Medical Center UPMC Hillman Cancer Center Pittsburgh Pennsylvania 15232 1301 Recruiting
SCRI Oncology Partners Nashville Tennessee 37203 Recruiting
Texas Oncology West Texas Abilene Texas 79606 Recruiting
Texas Oncology DFW Dallas Texas 75246 Recruiting
UT Southwestern Dallas Texas 75390 Recruiting
MD Anderson Cancer Center Houston Texas 77030 Recruiting
Baylor Scott and White Health 1 Round Rock Texas 78665 Recruiting
Texas Oncology - San Antonio San Antonio Texas 78240 Recruiting
Baylor Scott and White Health Temple Texas 76508 Recruiting
Virginia Cancer Specialists Arlington Virginia 22201 Recruiting
Inova Schar Cancer Institute Dept of Fairfax Hospital Fairfax Virginia 22031 Recruiting
Richmond VA Medical Center Richmond Virginia 23249 Recruiting
VCU Massey Comprehensive Cancer Center Richmond Virginia 23298 Recruiting
Swedish Cancer Institute Edmonds Edmonds Washington 98026 Recruiting
Swedish Cancer Institute Issaquah Issaquah Washington 98029 Recruiting
Swedish Cancer Institute Seattle Washington 98104 Recruiting
Fred Hutchinson Cancer Research Center Seattle Washington 98109 Recruiting
William S. Middleton Memorial VA Madison Wisconsin 53705 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 158 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06662786, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted May 7, 2026 · Synced May 10, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06662786 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →