A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

ClinicalTrials.gov ID: NCT06667076

Public ClinicalTrials.gov record NCT06667076. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 10, 2026, 9:42 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2b, Open-Label, Two-cohort Study of Subcutaneous Amivantamab in Combination With Lazertinib as First-Line Treatment, or Subcutaneous Amivantamab in Combination With Platinum-Based Chemotherapy as Second-line Treatment, for Common EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Study identification

NCT ID: NCT06667076
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Janssen Research & Development, LLC; Industry
Enrollment: 480 participants

Conditions and interventions

Conditions

Carcinoma, Non-Small-Cell Lung

Interventions

Amivantamab Drug
Chemotherapy: Carboplatin Drug
Chemotherapy: Pemetrexed Drug
Lazertinib Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 15, 2024
Primary completion: May 22, 2029
Completion: Dec 25, 2030
Last update posted: May 7, 2026

2024 – 2030

United States locations

U.S. sites: 150
U.S. states: 34
U.S. cities: 120

Facility	City	State	ZIP	Site status
Southern Cancer Center, PC	Daphne	Alabama	36526	Recruiting
Clearview Cancer Institute	Huntsville	Alabama	35805	Recruiting
City of Hope Phoenix	Goodyear	Arizona	85338	Recruiting
The Oncology Institute of Hope and Innovation	Cerritos	California	90703	Recruiting
City of Hope Corona	Corona	California	92882	Recruiting
City of Hope	Duarte	California	91010	Recruiting
Providence Medical Foundation	Fullerton	California	92835	Recruiting
Oncology Physicians Network Healthcare	Glendale	California	91203	Completed
Los Angeles Cancer Network	Glendale	California	91204	Recruiting
Glendale Adventist Medical Center	Glendale	California	91206	Recruiting
Marin Cancer Center	Greenbrae	California	94904	Recruiting
City of Hope Seacliff	Huntington Beach	California	92648	Recruiting
City of Hope Orange County Lennar Foundation Cancer Center	Irvine	California	92618	Recruiting
University of California San Diego Health	La Jolla	California	92093	Recruiting
City of Hope Antelope Valley	Lancaster	California	93534	Recruiting
City of Hope Long Beach Elm	Long Beach	California	90813	Recruiting
Cancer and Blood Specialty Clinic	Los Alamitos	California	90720	Recruiting
USC Norris Comprehensive Cancer Center	Los Angeles	California	90033	Recruiting
Cedars Sinai Medical Center	Los Angeles	California	90048	Recruiting
Valkyrie Clinical Trials	Los Angeles	California	90067	Recruiting
Valkyrie Clinical Trials Murrieta	Murrieta	California	92562	Recruiting
Kaiser Permanente Oakland Medical Center	Oakland	California	94611	Recruiting
St. Joseph Hospital Center for Cancer Prevention and Treatment	Orange	California	92868	Recruiting
University of California Irvine	Orange	California	92868	Recruiting
Sutter Health Palo Alto Medical Foundation	Palo Alto	California	94301	Recruiting
Kaiser Permanente Roseville Medical Center	Roseville	California	95661	Recruiting
UC Davis Comprehensive Cancer Center	Sacramento	California	95630	Recruiting
Sutter Institute for Medical Research	Sacramento	California	95816	Recruiting
California Pacific Medical Center	San Francisco	California	94115	Recruiting
Kaiser Permanente San Francisco Medical Center	San Francisco	California	94115	Recruiting
UCSF Zuckerberg San Francisco General Hospital	San Francisco	California	94143	Recruiting
Sansum Clinic	Santa Barbara	California	93105	Recruiting
Kaiser Permanente Santa Clara Medical Center	Santa Clara	California	95051	Recruiting
Providence Medical Foundation 1	Santa Rosa	California	95403	Recruiting
City of Hope South Pasadena	South Pasadena	California	91030	Recruiting
City of Hope Upland	Upland	California	91786	Recruiting
Kaiser Permanente Northern California	Vallejo	California	94589	Recruiting
Kaiser Permanente Walnut Creek Medical Center	Walnut Creek	California	94596	Recruiting
John Muir Health Clinical Research Center	Walnut Creek	California	94598	Recruiting
National Jewish Health	Denver	Colorado	80206	Recruiting
Saint Josephs Hospital Cancer Centers of Colorado	Denver	Colorado	80218	Completed
Lutheran Hospital Cancer Centers of Colorado	Golden	Colorado	80401	Completed
Rocky Mountain Cancer Centers	Lone Tree	Colorado	80124	Recruiting
Yale New Haven Hospital Yale Cancer Center	New Haven	Connecticut	06520	Recruiting
ChristianaCare Helen F Graham Cancer Center and Research Institute	Newark	Delaware	19713	Recruiting
MedStar Georgetown University Hospital	Washington D.C.	District of Columbia	20007	Recruiting
Washington DC VA Medical Center	Washington D.C.	District of Columbia	20422	Recruiting
Baptist Lynn Cancer Institute	Boca Raton	Florida	33486	Recruiting
The Oncology Institute of Hope and Innovation 1	Fort Lauderdale	Florida	33316	Recruiting
Florida Cancer Specialists	Fort Myers	Florida	33916	Recruiting
Univ of Florida	Gainesville	Florida	32610	Recruiting
Memorial Regional Hospital	Hollywood	Florida	33021 5421	Recruiting
Baptist MD Anderson Cancer Center	Jacksonville	Florida	32207	Recruiting
Mayo Clinic	Jacksonville	Florida	32224	Recruiting
Sylvester Comprehensive Cancer Center	Miami	Florida	33136	Recruiting
Baptist Health Miami Cancer Institute	Miami	Florida	33176	Recruiting
AdventHealth Orlando	Orlando	Florida	32803	Recruiting
Orlando Health Cancer Institute	Orlando	Florida	32806	Recruiting
Memorial Cancer Institute	Pembroke Pines	Florida	33026	Recruiting
Florida Cancer Specialists & Research Institute 1	St. Petersburg	Florida	33701	Recruiting
Moffitt Cancer Center	Tampa	Florida	33612	Recruiting
Florida Cancer Specialists & Research Institute	West Palm Beach	Florida	33401	Recruiting
University Cancer And Blood Center LLC	Athens	Georgia	30607	Recruiting
Grady Health System Correll Pavilion	Atlanta	Georgia	30303	Recruiting
Piedmont Healthcare	Atlanta	Georgia	30309	Recruiting
Piedmont Cancer Institute	Atlanta	Georgia	30318	Recruiting
Winship Cancer Institute Emory University	Atlanta	Georgia	30322	Recruiting
City of Hope Cancer Center	Newnan	Georgia	30265	Recruiting
Rush University Medical Center Rush University Cancer Center Chicago	Chicago	Illinois	60607	Recruiting
University of Illinois at Chicago	Chicago	Illinois	60612	Recruiting
Cancer Care Specialists of Central Illinois	Decatur	Illinois	62526	Recruiting
Hope and Healing Cancer Services	Hinsdale	Illinois	60521	Completed
Illinois Cancer Specialists	Niles	Illinois	60714	Recruiting
Illinois CancerCare	Peoria	Illinois	61615	Recruiting
City of Hope Chicago	Zion	Illinois	60099	Recruiting
Fort Wayne Medical Oncology and Hematology	Fort Wayne	Indiana	46804	Recruiting
Investigative Clinical Research of Indiana, LLC	Noblesville	Indiana	46062	Recruiting
Accellacare of McFarland	Ames	Iowa	50010	Recruiting
University of Kansas Cancer Center	Fairway	Kansas	66205	Recruiting
University of Maryland	Baltimore	Maryland	21201	Recruiting
Maryland Oncology Hematology P A	Silver Spring	Maryland	20904	Recruiting
Boston University Medical Center	Boston	Massachusetts	02118	Recruiting
Beth Israel Deaconess Medical Center	Boston	Massachusetts	02215	Recruiting
Dana Farber Cancer Institute	Boston	Massachusetts	02215	Recruiting
University of Michigan Health System	Ann Arbor	Michigan	48105	Recruiting
Trinity Health St Joseph Mercy Ann Arbor	Ypsilanti	Michigan	48197	Recruiting
University Of Minnesota	Minneapolis	Minnesota	55455	Recruiting
Mayo Clinic Rochester	Rochester	Minnesota	55905	Recruiting
Jackson Oncology Associates	Jackson	Mississippi	39202	Recruiting
Truman Medical Ctr West	Kansas City	Missouri	64108	Recruiting
Oncology Hematology Associates	Springfield	Missouri	65807	Recruiting
Washington University School Of Medicine	St Louis	Missouri	63110	Recruiting
Dartmouth Hitchcock Medical Center	Lebanon	New Hampshire	03756	Recruiting
Hunterdon Hematology Oncology	Flemington	New Jersey	08822	Completed
Morristown Medical Center	Morristown	New Jersey	07960	Recruiting
Rutgers Cancer Institute of New Jersey	New Brunswick	New Jersey	08901	Recruiting
Overlook Medical Center	Summit	New Jersey	07901	Recruiting
Holy Name Medical Center	Teaneck	New Jersey	07666	Completed
University of New Mexico	Albuquerque	New Mexico	87102	Recruiting
Hematology-Oncology Associates of CNY	East Syracuse	New York	13057	Recruiting
Laura & Isaac Perlmutter Cancer Center at NYU Langone Hospital - Long Island	Mineola	New York	11501	Recruiting
NYU Langone Health Laura and Isaac Perlmutter Cancer Center	New York	New York	10016	Recruiting
Herbert Irving Comprehensive Cancer Center Columbia University Medical Center	New York	New York	10032	Recruiting
Ellis Hospital	Schenectady	New York	12308	Recruiting
New York Cancer and Blood Specialists	Shirley	New York	11967	Recruiting
Montefiore Medical Center	The Bronx	New York	10461	Recruiting
Clinical Research Alliance Inc	Westbury	New York	11590	Completed
Atrium Health	Charlotte	North Carolina	28204	Recruiting
Duke University Medical Center	Durham	North Carolina	27710	Completed
Regional Medical Oncology Center	Wilson	North Carolina	27893	Recruiting
Atrium Health Wake Forest Baptist Comprehensive Cancer Center	Winston-Salem	North Carolina	27157	Recruiting
University of Cincinnati	Cincinnati	Ohio	45219	Completed
Cincinnati Veterans Affairs Medical Center	Cincinnati	Ohio	45220	Recruiting
Oncology Associates of Oregon PC Willamette Valley Cancer Institute	Eugene	Oregon	97401	Recruiting
Oregon Health And Science University	Portland	Oregon	97239	Recruiting
Lankenau Institute for Medical Research Main Line Health Bryn Mawr Hospital	Bryn Mawr	Pennsylvania	19010	Completed
Lankenau Institute for Medical Research Main Line Health Paoli Hospital	Paoli	Pennsylvania	19301	Completed
Philadelphia VA Medical Center	Philadelphia	Pennsylvania	19104	Recruiting
Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	19107	Recruiting
Jefferson Health Northeast	Philadelphia	Pennsylvania	19114	Recruiting
McGlinn Cancer Institute Reading Hospital	West Reading	Pennsylvania	19611	Recruiting
Lankenau Institute for Medical Research	Wynnewood	Pennsylvania	19096	Completed
Medical University of South Carolina	Charleston	South Carolina	29425	Recruiting
Avera Medical Group	Sioux Falls	South Dakota	57105	Completed
Tennessee Oncology - Chattanooga	Chattanooga	Tennessee	37404	Recruiting
Tennessee Cancer Specialists	Knoxville	Tennessee	37909	Recruiting
University of Tennessee	Knoxville	Tennessee	37920	Recruiting
Baptist Cancer Center	Memphis	Tennessee	38120	Completed
SCRI Oncology Partners	Nashville	Tennessee	37203	Recruiting
Tennessee Oncology	Nashville	Tennessee	37203	Recruiting
Texas Oncology South	Austin	Texas	78745	Recruiting
Parkland Health and Hospital System	Dallas	Texas	75235	Recruiting
Texas Oncology DFW	Dallas	Texas	75246	Recruiting
UT Southwestern Medical Center	Dallas	Texas	75390	Recruiting
Renovatio Clinical	El Paso	Texas	79915	Completed
JPS Health Network	Fort Worth	Texas	76104	Recruiting
MD Anderson Cancer Center	Houston	Texas	77030	Recruiting
Oncology Consultants Texas	Houston	Texas	77030	Recruiting
Community Clinical Trials	Kingwood	Texas	77339	Recruiting
Texas Oncology Odessa-West Texas Cancer Center	Odessa	Texas	79761	Completed
Texas Oncology San Antonio Northeast	San Antonio	Texas	78217	Recruiting
Renovatio Clinical 1	The Woodlands	Texas	77380	Completed
The University of Texas Health Science Center at Tyler	Tyler	Texas	75701	Recruiting
Texas Oncology - Northeast	Tyler	Texas	75702	Recruiting
Texas Oncology-Gulf Coast	Webster	Texas	77598	Recruiting
Huntsman Cancer Institute	Salt Lake City	Utah	84112	Recruiting
Virginia Cancer Specialists	Fairfax	Virginia	22031	Recruiting
Vista Oncology	Olympia	Washington	98506	Recruiting
Summit Cancer Centers	Spokane	Washington	99208	Recruiting
Northwest Cancer Specialists - Vancouver	Vancouver	Washington	98684	Completed

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 50 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06667076, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 7, 2026 · Synced May 10, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06667076 live on ClinicalTrials.gov.

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