Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

ClinicalTrials.gov ID: NCT06677060

Public ClinicalTrials.gov record NCT06677060. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 19, 2026, 8:24 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase III, Randomised, Placebo-controlled, Event-driven Study to Evaluate the Effect of Baxdrostat in Combination With Dapagliflozin Compared With Dapagliflozin Alone on the Risk of Incident Heart Failure and Cardiovascular Death

Study identification

NCT ID: NCT06677060
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: AstraZeneca; Industry
Enrollment: 11,300 participants

Conditions and interventions

Conditions

Heart Failure

Interventions

Baxdrostat and dapagliflozin Drug
Placebo and dapagliflozin Other

Drug · Other

Eligibility (public fields only)

Age range: 40 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 13, 2025
Primary completion: Dec 16, 2029
Completion: Dec 16, 2029
Last update posted: May 17, 2026

2025 – 2029

United States locations

U.S. sites: 194
U.S. states: 41
U.S. cities: 176

Facility	City	State	ZIP	Site status
Research Site	Birmingham	Alabama	35205	Recruiting
Research Site	Centreville	Alabama	35042	Recruiting
Research Site	Fairhope	Alabama	36532	Recruiting
Research Site	Huntsville	Alabama	35801	Recruiting
Research Site	Mobile	Alabama	36608	Recruiting
Research Site	Sheffield	Alabama	35660	Not yet recruiting
Research Site	Vestavia Hills	Alabama	35216	Recruiting
Research Site	Anchorage	Alaska	99508	Not yet recruiting
Research Site	Gilbert	Arizona	85296	Recruiting
Research Site	Glendale	Arizona	85308	Recruiting
Research Site	Tempe	Arizona	85283	Recruiting
Research Site	Tucson	Arizona	85712	Recruiting
Research Site	Dublin	California	94568	Withdrawn
Research Site	Huntington Beach	California	92648	Recruiting
Research Site	Inglewood	California	90301	Recruiting
Research Site	La Jolla	California	92037	Recruiting
Research Site	Lakewood	California	90805	Withdrawn
Research Site	Lincoln	California	95648	Recruiting
Research Site	Loma Linda	California	92357	Recruiting
Research Site	Los Angeles	California	90035	Recruiting
Research Site	Los Angeles	California	90073	Not yet recruiting
Research Site	Sacramento	California	95841	Recruiting
Research Site	San Diego	California	92120	Recruiting
Research Site	San Dimas	California	91773	Recruiting
Research Site	San Francisco	California	94115	Not yet recruiting
Research Site	San Francisco	California	94121	Not yet recruiting
Research Site	Santa Maria	California	93454	Recruiting
Research Site	Sherman Oaks	California	91403	Suspended
Research Site	Thousand Oaks	California	91360	Recruiting
Research Site	Aurora	Colorado	80012	Recruiting
Research Site	Englewood	Colorado	80110	Recruiting
Research Site	Bridgeport	Connecticut	06606	Recruiting
Research Site	Stamford	Connecticut	06905	Recruiting
Research Site	Waterbury	Connecticut	06708	Recruiting
Research Site	Crystal River	Florida	34429	Recruiting
Research Site	Fort Lauderdale	Florida	33316	Recruiting
Research Site	Fort Myers	Florida	33912	Recruiting
Research Site	Gainesville	Florida	32608	Withdrawn
Research Site	Hialeah	Florida	33012	Recruiting
Research Site	Jacksonville	Florida	32216	Recruiting
Research Site	Lakeland	Florida	33813	Recruiting
Research Site	Miami	Florida	33125	Not yet recruiting
Research Site	Miami	Florida	33135	Suspended
Research Site	Miami	Florida	33173	Not yet recruiting
Research Site	Ocoee	Florida	34761	Recruiting
Research Site	Orlando	Florida	32822	Recruiting
Research Site	Palmetto Bay	Florida	33157	Recruiting
Research Site	Saint Augustine	Florida	32086	Recruiting
Research Site	Albany	Georgia	31707	Recruiting
Research Site	Atlanta	Georgia	30303	Recruiting
Research Site	Canton	Georgia	30114	Recruiting
Research Site	Columbus	Georgia	31904	Recruiting
Research Site	Cordele	Georgia	31015	Recruiting
Research Site	Suwanee	Georgia	30024	Recruiting
Research Site	Tucker	Georgia	30084	Not yet recruiting
Research Site	Woodstock	Georgia	30189	Recruiting
Research Site	Idaho Falls	Idaho	83404	Recruiting
Research Site	Champaign	Illinois	61822	Recruiting
Research Site	Chicago	Illinois	60616	Recruiting
Research Site	Chicago	Illinois	60621	Recruiting
Research Site	Chicago	Illinois	60631	Recruiting
Research Site	Gurnee	Illinois	60031	Recruiting
Research Site	Island Lake	Illinois	60042	Recruiting
Research Site	Park Ridge	Illinois	60068	Recruiting
Research Site	Indianapolis	Indiana	46202	Recruiting
Research Site	Munster	Indiana	46321	Recruiting
Research Site	Richmond	Indiana	47374	Recruiting
Research Site	South Bend	Indiana	46617	Recruiting
Research Site	El Dorado	Kansas	67042	Recruiting
Research Site	Lenexa	Kansas	66219	Recruiting
Research Site	Newton	Kansas	67114	Recruiting
Research Site	Wichita	Kansas	67218	Withdrawn
Research Site	Lexington	Kentucky	40509	Recruiting
Research Site	Owensboro	Kentucky	42301	Recruiting
Research Site	Paducah	Kentucky	42001	Recruiting
Research Site	Alexandria	Louisiana	71303	Recruiting
Research Site	Bossier City	Louisiana	71111	Not yet recruiting
Research Site	Shreveport	Louisiana	71101	Recruiting
Research Site	Baltimore	Maryland	21229	Recruiting
Research Site	Beltsville	Maryland	20705	Recruiting
Research Site	Lutherville-Timonium	Maryland	21093	Recruiting
Research Site	Potomac	Maryland	20854	Recruiting
Research Site	Boston	Massachusetts	02115	Recruiting
Research Site	New Bedford	Massachusetts	02740	Recruiting
Research Site	Roslindale	Massachusetts	02131	Recruiting
Research Site	Farmington Hills	Michigan	48336	Recruiting
Research Site	Flint	Michigan	48532	Recruiting
Research Site	Troy	Michigan	48098	Recruiting
Research Site	Ypsilanti	Michigan	48197	Not yet recruiting
Research Site	Mankato	Minnesota	56001	Recruiting
Research Site	Minneapolis	Minnesota	55417	Recruiting
Research Site	Columbia	Missouri	65201	Recruiting
Research Site	Kansas City	Missouri	64111	Recruiting
Research Site	Kansas City	Missouri	64151	Recruiting
Research Site	St Louis	Missouri	63136	Recruiting
Research Site	Kalispell	Montana	59901	Withdrawn
Research Site	Missoula	Montana	59804	Recruiting
Research Site	Norfolk	Nebraska	68701	Recruiting
Research Site	Omaha	Nebraska	68134	Recruiting
Research Site	Carson City	Nevada	89706	Recruiting
Research Site	Portsmouth	New Hampshire	03801	Withdrawn
Research Site	Eatontown	New Jersey	07724	Not yet recruiting
Research Site	Pennington	New Jersey	08534	Recruiting
Research Site	Somerset	New Jersey	08873	Recruiting
Research Site	Albuquerque	New Mexico	87102	Recruiting
Research Site	Albuquerque	New Mexico	87108	Recruiting
Research Site	Albany	New York	12208	Recruiting
Research Site	Albany	New York	12211	Not yet recruiting
Research Site	Brooklyn	New York	11201	Recruiting
Research Site	Brooklyn	New York	11220	Recruiting
Research Site	Massapequa	New York	11758	Recruiting
Research Site	New York	New York	10029	Not yet recruiting
Research Site	Queens Village	New York	11428	Recruiting
Research Site	Charlotte	North Carolina	28287	Recruiting
Research Site	Durham	North Carolina	27701	Recruiting
Research Site	Fayetteville	North Carolina	28304	Recruiting
Research Site	Kernersville	North Carolina	27284	Withdrawn
Research Site	Monroe	North Carolina	28112	Recruiting
Research Site	New Bern	North Carolina	28562	Recruiting
Research Site	Raleigh	North Carolina	27607	Recruiting
Research Site	Rocky Mount	North Carolina	27804	Recruiting
Research Site	Fargo	North Dakota	58104	Recruiting
Research Site	Beavercreek	Ohio	45431	Recruiting
Research Site	Canton	Ohio	44718	Recruiting
Research Site	Cincinnati	Ohio	45219	Recruiting
Research Site	Cincinnati	Ohio	45220	Recruiting
Research Site	Columbus	Ohio	43215	Recruiting
Research Site	Columbus	Ohio	43228	Not yet recruiting
Research Site	Dayton	Ohio	45424	Not yet recruiting
Research Site	Maumee	Ohio	43537	Recruiting
Research Site	Toledo	Ohio	43606	Not yet recruiting
Research Site	Norman	Oklahoma	73069	Withdrawn
Research Site	Oklahoma City	Oklahoma	73111	Recruiting
Research Site	Oklahoma City	Oklahoma	73120	Recruiting
Research Site	Medford	Oregon	97504	Withdrawn
Research Site	Camp Hill	Pennsylvania	17011	Recruiting
Research Site	Horsham	Pennsylvania	19044	Recruiting
Research Site	Philadelphia	Pennsylvania	19114	Recruiting
Research Site	Scottdale	Pennsylvania	15683	Recruiting
Research Site	Smithfield	Pennsylvania	15478	Recruiting
Research Site	West Chester	Pennsylvania	19380	Not yet recruiting
Research Site	Columbia	South Carolina	29209	Not yet recruiting
Research Site	Fort Mill	South Carolina	29715	Recruiting
Research Site	Greenville	South Carolina	29615	Withdrawn
Research Site	Mt. Pleasant	South Carolina	29464	Recruiting
Research Site	North Charleston	South Carolina	29405	Recruiting
Research Site	Spartanburg	South Carolina	29301	Recruiting
Research Site	Cleveland	Tennessee	37312	Recruiting
Research Site	Morristown	Tennessee	37813	Recruiting
Research Site	Nashville	Tennessee	37203	Recruiting
Research Site	Abilene	Texas	79606	Suspended
Research Site	Austin	Texas	78704	Recruiting
Research Site	Beaumont	Texas	77702	Recruiting
Research Site	Brownsville	Texas	78526	Not yet recruiting
Research Site	Dallas	Texas	75390-9015	Recruiting
Research Site	Duncanville	Texas	75137	Recruiting
Research Site	El Paso	Texas	79905	Suspended
Research Site	El Paso	Texas	79935	Not yet recruiting
Research Site	Houston	Texas	77084	Recruiting
Research Site	Houston	Texas	77089	Recruiting
Research Site	Lewisville	Texas	75067	Withdrawn
Research Site	Mansfield	Texas	76063	Withdrawn
Research Site	McAllen	Texas	78501	Recruiting
Research Site	McAllen	Texas	78503	Recruiting
Research Site	Mesquite	Texas	75149	Recruiting
Research Site	Paris	Texas	75462	Recruiting
Research Site	Pearland	Texas	77584	Suspended
Research Site	San Antonio	Texas	78231	Not yet recruiting
Research Site	San Antonio	Texas	78257	Recruiting
Research Site	Stephenville	Texas	76401	Recruiting
Research Site	Sugar Land	Texas	77479	Recruiting
Research Site	Tomball	Texas	77375	Recruiting
Research Site	Weslaco	Texas	78596	Recruiting
Research Site	Woodway	Texas	76712	Recruiting
Research Site	Clearfield	Utah	84015	Recruiting
Research Site	Ogden	Utah	84405	Recruiting
Research Site	Burlington	Vermont	05401	Not yet recruiting
Research Site	Burke	Virginia	22015	Recruiting
Research Site	Charlottesville	Virginia	22911	Recruiting
Research Site	Fairfax	Virginia	22033	Not yet recruiting
Research Site	Falls Church	Virginia	22042	Recruiting
Research Site	Manassas	Virginia	20110	Not yet recruiting
Research Site	Midlothian	Virginia	23112	Recruiting
Research Site	Norfolk	Virginia	23502	Recruiting
Research Site	Norfolk	Virginia	23504	Not yet recruiting
Research Site	Richmond	Virginia	23249	Withdrawn
Research Site	Salem	Virginia	24153	Recruiting
Research Site	Puyallup	Washington	98372	Not yet recruiting
Research Site	Redmond	Washington	98052	Recruiting
Research Site	Renton	Washington	98057	Recruiting
Research Site	Kingwood	West Virginia	26537	Recruiting
Research Site	Morgantown	West Virginia	26505	Recruiting
Research Site	Green Bay	Wisconsin	54303	Withdrawn
Research Site	Milwaukee	Wisconsin	53226	Withdrawn

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 741 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06677060, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 17, 2026 · Synced May 19, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06677060 live on ClinicalTrials.gov.

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