A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease

ClinicalTrials.gov ID: NCT06680830

Public ClinicalTrials.gov record NCT06680830. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Apr 20, 2026, 7:28 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study and Open-Label Extension to Evaluate the Safety and Efficacy of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease (NEULARK)

Study identification

NCT ID: NCT06680830
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Neuron23 Inc.; Industry
Enrollment: 150 participants

Conditions and interventions

Conditions

Interventions

NEU-411 Drug
Placebo Other

Drug · Other

Eligibility (public fields only)

Age range: 40 Years to 80 Years
Sex: All
Healthy volunteers: Not listed

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jan 16, 2025
Primary completion: Aug 31, 2026
Completion: Aug 31, 2027
Last update posted: Apr 12, 2026

2025 – 2027

United States locations

U.S. sites: 45
U.S. states: 29
U.S. cities: 43

Facility	City	State	ZIP	Site status
Banner Sun Health Research Institute	Sun City	Arizona	85351	Recruiting
University of Arkansas	Little Rock	Arkansas	72205	Recruiting
Neuro-Pain Medical Center	Fresno	California	93710	Recruiting
University of California, Irvine	Irvine	California	92697	Recruiting
University of California, Los Angeles	Los Angeles	California	90095	Recruiting
Esperanza Clinical	Murrieta	California	92562	Recruiting
Parkinson's Research Centers of America - Palo Alto	Palo Alto	California	94301	Recruiting
Sutter Neuroscience Institute	Sacramento	California	95816	Recruiting
University of Colorado - Anschutz Medical Campus	Aurora	Colorado	80045	Recruiting
Parkinson's Disease and Movement Disorders Center of Boca Raton	Boca Raton	Florida	33486	Recruiting
University of Florida	Gainesville	Florida	32608	Recruiting
Neurology One	Orlando	Florida	32825	Recruiting
USF Parkinson's & Movement Disorders Clinic	Tampa	Florida	33613	Recruiting
Emory University	Atlanta	Georgia	30329	Recruiting
Augusta University	Augusta	Georgia	30912	Recruiting
Northwestern Medical Group, Department of Neurology	Chicago	Illinois	60611	Recruiting
University of Kansas Medical Center	Kansas City	Kansas	66160	Recruiting
University of Kentucky	Lexington	Kentucky	40536	Recruiting
Ochsner Clinic Foundation	New Orleans	Louisiana	70121	Recruiting
University of Maryland	Baltimore	Maryland	21201	Recruiting
Beth Israel Deaconess Medical Center	Boston	Massachusetts	02215	Recruiting
Quest Research Institute	Farmington Hills	Michigan	48334	Recruiting
Struthers Parkinson Center	Golden Valley	Minnesota	55427	Recruiting
Cleveland Clinic	Las Vegas	Nevada	89106	Recruiting
University of New Mexico	Albuquerque	New Mexico	87106	Not yet recruiting
Northwell Health	Great Neck	New York	11021	Recruiting
Icahn School of Medicine at Mount Sinai/Mount Sinai West	New York	New York	10019	Recruiting
Columbia University	New York	New York	10032	Recruiting
University of Rochester	Rochester	New York	14618	Recruiting
University of North Carolina - Chapel Hill	Chapel Hill	North Carolina	27599	Recruiting
The Ohio State University	Columbus	Ohio	43210	Recruiting
The Movement Disorder Clinic of Oklahoma	Tulsa	Oklahoma	74136	Recruiting
Oregon Health & Science University (OHSU)	Portland	Oregon	97239	Recruiting
Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	19107	Recruiting
Medical University of South Carolina	Charleston	South Carolina	29425	Recruiting
Vanderbilt University	Nashville	Tennessee	37232	Recruiting
Neurology Consultants of Dallas PA	Dallas	Texas	75243	Not yet recruiting
Baylor College of Medicine	Houston	Texas	77030	Recruiting
The University of Texas Health Science Center at Houston	Houston	Texas	77030	Recruiting
Central Texas Neurology Consultants	Round Rock	Texas	78681	Recruiting
University of Utah Movement Division	Salt Lake City	Utah	84108	Recruiting
University of Virginia	Charlottesville	Virginia	22903	Recruiting
EvergreenHealth	Kirkland	Washington	98034	Recruiting
Inland Northwest Research	Spokane	Washington	99202	Not yet recruiting
Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 25 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06680830, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 12, 2026 · Synced Apr 20, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06680830 live on ClinicalTrials.gov.

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