JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS (Master Record)
Public ClinicalTrials.gov record NCT06703073. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase 2 Clinical Platform Trial Investigating Multiple Therapeutic Options for the Treatment of Hospitalized Patients With Acute Respiratory Distress Syndrome (ARDS)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase 2 multicenter, randomized, double-blinded, placebo-controlled study that will evaluate the safety and efficacy of host-directed therapeutics in hospitalized adults diagnosed with Acute Respiratory Distress Syndrome (ARDS) utilizing a platform trial design. Participants will be randomized to receive either a placebo or one of the active treatments. This record describes the default procedures and analyses for all cohorts. Each specific cohort may have additional eligibility requirements, safety and efficacy procedures, or endpoints, which will be described in the corresponding intervention-specific records on clinicaltrials.gov listed below in the detailed description.
Study identification
- NCT ID
- NCT06703073
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 600 participants
Conditions and interventions
Conditions
Interventions
- Cohort A: vilobelimab Drug
- Cohort A: placebo Drug
- Cohort B: paridiprubart Drug
- Cohort B: placebo Drug
- Cohort C: bevacizumab Drug
- Cohort C: placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 9, 2025
- Primary completion
- Jun 30, 2028
- Completion
- Aug 31, 2028
- Last update posted
- Jul 30, 2026
2025 – 2028
United States locations
- U.S. sites
- 41
- U.S. states
- 23
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama Hospital | Birmingham | Alabama | 35233-1932 | Not yet recruiting |
| Community Regional Medical Center | Fresno | California | 93721-1324 | Recruiting |
| Long Beach Memorial Medical Center | Long Beach | California | 90806-1701 | Recruiting |
| University of California Irvine Medical Center | Orange | California | 92868-3201 | Recruiting |
| University of California Davis Medical Center - Pulmonary Medicine | Sacramento | California | 95816-4300 | Recruiting |
| Stanford Medical Center | Stanford | California | 94305-2200 | Recruiting |
| Denver Health Hospital and Authority | Denver | Colorado | 80204-4532 | Not yet recruiting |
| MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010-3017 | Recruiting |
| Nova Clinical Research | Bradenton | Florida | 34209-4617 | Recruiting |
| North Florida / South Georgia Veterans Health System | Gainesville | Florida | 32608-1135 | Recruiting |
| Sarasota Memorial Hospital | Sarasota | Florida | 34239 | Recruiting |
| St. Luke's Boise Medical Center | Boise | Idaho | 83712-6241 | Recruiting |
| Northshore University Healthsystem Research Institute | Evanston | Illinois | 60201-1700 | Not yet recruiting |
| OSF Saint Francis Medical Center- | Peoria | Illinois | 61637-0001 | Recruiting |
| Tufts Medical Center | Boston | Massachusetts | 02111 | Not yet recruiting |
| Lahey Hospital and Medical Center | Burlington | Massachusetts | 01805-0001 | Recruiting |
| University of Michigan Hospital | Ann Arbor | Michigan | 48109-5000 | Recruiting |
| Henry Ford Health Hospital | Detroit | Michigan | 48202-2608 | Recruiting |
| Mayo Clinic | Rochester | Minnesota | 55905-0001 | Recruiting |
| Renown Institute for Heart & Vascular Health | Reno | Nevada | 89502-1576 | Withdrawn |
| Robert Wood Johnson Medical School | New Brunswick | New Jersey | 08901-1928 | Recruiting |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065-6007 | Not yet recruiting |
| Weill Cornell Medical College | New York | New York | 10065-8722 | Not yet recruiting |
| Montefiore Hospital - Moses Campus | The Bronx | New York | 10467 | Recruiting |
| Westchester Medical Center | Valhalla | New York | 10595-1530 | Not yet recruiting |
| University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27599-0001 | Recruiting |
| Durham VA Medical Center | Durham | North Carolina | 27705-3875 | Recruiting |
| Duke Lung Transplant Clinic - Clinic 2F/2G - PPDS | Durham | North Carolina | 27710-4000 | Not yet recruiting |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106-1716 | Not yet recruiting |
| Cleveland Clinic | Cleveland | Ohio | 44195 | Not yet recruiting |
| Mercy Health - St. Vincent Medical Center | Toledo | Ohio | 43608-2603 | Recruiting |
| The University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104-3609 | Recruiting |
| Oregon Health and Science University | Portland | Oregon | 97239-3011 | Recruiting |
| Medical University of South Carolina (MUSC) | Charleston | South Carolina | 29425-8908 | Recruiting |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232-0004 | Recruiting |
| Baylor All Saints Medical Center | Fort Worth | Texas | 76104-4110 | Recruiting |
| Baylor St Luke's Medical Center | Houston | Texas | 77030-4202 | Not yet recruiting |
| Houston Methodist Hospital | Houston | Texas | 77030 | Not yet recruiting |
| Intermountain Medical Center | Murray | Utah | 84107-5701 | Recruiting |
| University of Virginia Health System | Charlottesville | Virginia | 22908-0816 | Not yet recruiting |
| Swedish Medical Center | Seattle | Washington | 98122-4379 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06703073, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 30, 2026 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06703073 live on ClinicalTrials.gov.