A Double-blind Dual Study Assessing Safety and Efficacy of Buntanetap in Participants With Early AD

ClinicalTrials.gov ID: NCT06709014

Public ClinicalTrials.gov record NCT06709014. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 6, 2026, 7:32 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A 6-month & 18-month Prospective, Randomized, Placebo-controlled, Double-blind Dual Clinical Trial Investigating Efficacy and Safety of Buntanetap in Treating Participants of Early Alzheimer's Disease

Study identification

NCT ID: NCT06709014
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Annovis Bio Inc.; Industry
Enrollment: 760 participants

Conditions and interventions

Conditions

Early Alzheimers Disease

Interventions

Placebo Drug
buntanetap/posiphen Drug

Drug

Eligibility (public fields only)

Age range: 55 Years to 85 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Feb 3, 2025
Primary completion: Nov 30, 2027
Completion: May 31, 2028
Last update posted: Apr 22, 2026

2025 – 2028

United States locations

U.S. sites: 81
U.S. states: 30
U.S. cities: 78

Facility	City	State	ZIP	Site status
MD First Research	Chandler	Arizona	85286	Recruiting
Xenoscience	Phoenix	Arizona	85004	Recruiting
Clinical Endpoints	Scottsdale	Arizona	85258	Recruiting
Advanced Research Center	Anaheim	California	92805	Recruiting
Hope Clinical Research	Canoga Park	California	91303	Recruiting
Sun Valley Research	Imperial	California	92251	Recruiting
Mary S. Easton Center for Alzheimer's Research and Care, UCLA	Los Angeles	California	90095	Recruiting
UC Davis Alzheimer's Disease Research Center	Sacramento	California	95816	Recruiting
The Neuron Clinic	San Marcos	California	92069	Recruiting
Mountain Neurological Center	Basalt	Colorado	81621	Recruiting
CenExel Rocky Mountain	Englewood	Colorado	80113	Recruiting
Research Center for Clinical Trials	Norwalk	Connecticut	06851	Recruiting
Visionary Investigators Network	Aventura	Florida	33180	Recruiting
SFM Clinical Research	Boca Raton	Florida	33487	Recruiting
K2 Medical Research	Clermont	Florida	34711	Recruiting
K2 Medical Research Daytona	Daytona Beach	Florida	32114	Recruiting
Neuropsychiatric Research Center	Fort Myers	Florida	33912	Recruiting
Velocity Clinical	Hallandale	Florida	33009	Recruiting
Jacksonville Center for Clinical Research	Jacksonville	Florida	32216	Active, not recruiting
K2 Medical Research	Lady Lake	Florida	32159	Recruiting
Headlands Research JEM	Lake Worth	Florida	33462	Recruiting
Accel Research Sites Lakeland (Alcanza)	Lakeland	Florida	33803	Recruiting
K2 Medical Research	Maitland	Florida	32751	Recruiting
ClinCloud Clinical Research	Melbourne	Florida	32940	Recruiting
Flourish Research/Merritt Island Medical Research	Merritt Island	Florida	32952	Recruiting
Miami Jewish Health	Miami	Florida	33137	Recruiting
Aqualane Clinical Research	Naples	Florida	34102	Recruiting
Suncoast Clinical Research	New Port Richey	Florida	34652	Recruiting
Conquest Research	Orlando	Florida	32832	Recruiting
Axiom Brain Health, LLC	Tampa	Florida	33609	Recruiting
Conquest Research	Winter Park	Florida	32789	Recruiting
Accel Neurosciences	Decatur	Georgia	30030	Recruiting
CARE (Center for Advanced Research & Education)	Gainesville	Georgia	30501	Recruiting
Hawaii Pacific Neuroscience	Honolulu	Hawaii	96817	Recruiting
Re:Cognition Chicago	Chicago	Illinois	60611	Recruiting
Rush University Medical Center	Chicago	Illinois	60612	Recruiting
Charter Research Chicago	Chicago	Illinois	60618	Recruiting
Great Lakes Clinical Trials/Flourish Research	Chicago	Illinois	60640	Recruiting
Southern Illinois University	Springfield	Illinois	62702	Recruiting
JWM Research	Indianaopolis	Indiana	46256	Recruiting
Ascension via Christi Research	Wichita	Kansas	37214	Recruiting
Tandem Intermediate	Metairie	Louisiana	70006	Recruiting
Headlands Research Pharmasite	Pikesville	Maryland	21208	Recruiting
Neurology Center of New England, PC	Foxborough	Massachusetts	02035	Recruiting
Headlands Research Easter Massachusetts	Plymouth	Massachusetts	02360	Recruiting
Mayflower Clinical	Russells Mills	Massachusetts	02747	Recruiting
Elixia MA	Springfield	Massachusetts	01103	Recruiting
Quest Research Institute	Farmington Hills	Michigan	48334	Recruiting
Precise Research Center	Flowood	Mississippi	39232	Recruiting
Clinical Research Professionals - Headlands Research	Chesterfield	Missouri	63005	Recruiting
Oasis Clinical Trials LLC	Las Vegas	Nevada	89121	Recruiting
Cenexel Advanced Medical Research of New Jersey (AMRI)	Toms River	New Jersey	08755	Recruiting
Advanced Clinical Institute	West Long Branch	New Jersey	07764	Recruiting
Dent Neurologic Institute	Amherst	New York	14226	Recruiting
SPRI	Brooklyn	New York	11235	Recruiting
Neurological Associates of Long Island	Lake Success	New York	11042	Recruiting
Parker Jewish Institute for Health Care and Rehab	New Hyde Park	New York	11040	Active, not recruiting
New York Neurology Associates	New York	New York	10003	Recruiting
Richmond Behavioral Associates	Staten Island	New York	10314	Recruiting
Ichor Research	Syracuse	New York	13210	Recruiting
Duke University	Durham	North Carolina	27705	Recruiting
AMC Research/Flourish Research	Matthews	North Carolina	28105	Recruiting
Eximia Clinical Research	Raleigh	North Carolina	27607	Active, not recruiting
American Clinical Research Center	Beavercreek	Ohio	45432	Recruiting
Valley Medical Research	Centerville	Ohio	45459	Recruiting
Insight Clinical Trials	Independence	Ohio	44131	Recruiting
Lynn Health Science Institute	Oklahoma City	Oklahoma	73112	Recruiting
Summit Headlands	Portland	Oregon	97210	Recruiting
Suburban Research Associates	Media	Pennsylvania	19063	Recruiting
K2 Keystone	Plymouth Meeting	Pennsylvania	19462	Recruiting
Rhode Island Mood and Memory Research Institute	East Providence	Rhode Island	02914	Recruiting
Palmetto Primary Care & Specialty Physicians	Summerville	South Carolina	29486	Recruiting
Neurology Clinic, P.C.	Cordova	Tennessee	38018	Recruiting
K2 Medical Research Nashville	Nashville	Tennessee	37204	Recruiting
Senior Adults Specialty Research	Austin	Texas	78757	Recruiting
NeuroMind Clinical Trials	Houston	Texas	77094	Recruiting
Central Texas Neurology Associates	Round Rock	Texas	78681	Recruiting
Grayline Research Center	Wichita Falls	Texas	76309	Recruiting
Memory Clinic, Inc.	Bennington	Vermont	05201	Recruiting
Sana Research	Arlington	Virginia	22205	Recruiting
Re:Cognition Fairfax	Fairfax	Virginia	22031	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06709014, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 22, 2026 · Synced May 6, 2026

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The complete protocol, eligibility criteria, and contact information for NCT06709014 live on ClinicalTrials.gov.

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