A Double-blind Dual Study Assessing Safety and Efficacy of Buntanetap in Participants With Early AD
Public ClinicalTrials.gov record NCT06709014. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
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Official title
A 6-month & 18-month Prospective, Randomized, Placebo-controlled, Double-blind Dual Clinical Trial Investigating Efficacy and Safety of Buntanetap in Treating Participants of Early Alzheimer's Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The goal of this clinical trial is to learn if buntanetap/Posiphen works to treat early Alzheimer's disease in adults aged 55-85. It will also learn about the safety of buntanetap/Posiphen. The main questions it aims to answer are: * Does buntanetap/Posiphen improve cognition as measured by ADAS-Cog13? * Does buntanetap/Posiphen improve function as measured by ADCS-iADL? * What medical issues do participants have, if any, when taking buntanetap/Posiphen? Researchers will compare buntanetap/Posiphen to a placebo (a look-alike substance that contains no drug) to see if buntanetap/Posiphen works to treat early Alzheimer's disease. Participants will: * Take buntanetap/Posiphen or a placebo every day for 18 months * Visit the clinic periodically for checkups, tests, and questionnaires (screening visits, enrollment, month 1, month 3, month 6, month 9, month 12, month 15, month 18), including a volumetric MRI at month 6 and month 18 * Complete pre- and post-clinic visit phone calls
Study identification
- NCT ID
- NCT06709014
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 760 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 55 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 4, 2025 (Actual)
- Primary completion
- Dec 2027 (Estimated)
- Completion
- Jun 2028 (Estimated)
- Last update posted
- May 18, 2026
2025 – 2028
United States locations
- U.S. sites
- 78
- U.S. states
- 29
- U.S. cities
- 75
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| MD First Research | Chandler | Arizona | 85286 | — |
| Xenoscience | Phoenix | Arizona | 85004 | — |
| Clinical Endpoints | Scottsdale | Arizona | 85258 | — |
| Advanced Research Center | Anaheim | California | 92805 | — |
| Hope Clinical Research | Canoga Park | California | 91303 | — |
| Sun Valley Research | Imperial | California | 92251 | — |
| Mary S. Easton Center for Alzheimer's Research and Care, UCLA | Los Angeles | California | 90095 | — |
| UC Davis Alzheimer's Disease Research Center | Sacramento | California | 95816 | — |
| The Neuron Clinic | San Marcos | California | 92069 | — |
| Mountain Neurological Center | Basalt | Colorado | 81621 | — |
| CenExel Rocky Mountain | Englewood | Colorado | 80113 | — |
| Research Center for Clinical Trials | Norwalk | Connecticut | 06851 | — |
| Visionary Investigators Network | Aventura | Florida | 33180 | — |
| SFM Clinical Research | Boca Raton | Florida | 33487 | — |
| K2 Medical Research | Clermont | Florida | 34711 | — |
| K2 Medical Research Daytona | Daytona Beach | Florida | 32114 | — |
| Neuropsychiatric Research Center | Fort Myers | Florida | 33912 | — |
| Velocity Clinical | Hallandale | Florida | 33009 | — |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | — |
| K2 Medical Research | Lady Lake | Florida | 32159 | — |
| Headlands Research JEM | Lake Worth | Florida | 33462 | — |
| Accel Research Sites Lakeland (Alcanza) | Lakeland | Florida | 33803 | — |
| K2 Medical Research | Maitland | Florida | 32751 | — |
| ClinCloud Clinical Research | Melbourne | Florida | 32940 | — |
| Flourish Research/Merritt Island Medical Research | Merritt Island | Florida | 32952 | — |
| Miami Jewish Health | Miami | Florida | 33137 | — |
| Aqualane Clinical Research | Naples | Florida | 34102 | — |
| Suncoast Clinical Research | New Port Richey | Florida | 34652 | — |
| Conquest Research | Orlando | Florida | 32832 | — |
| Axiom Brain Health, LLC | Tampa | Florida | 33609 | — |
| Conquest Research | Winter Park | Florida | 32789 | — |
| Accel Neurosciences | Decatur | Georgia | 30030 | — |
| CARE (Center for Advanced Research & Education) | Gainesville | Georgia | 30501 | — |
| Hawaii Pacific Neuroscience | Honolulu | Hawaii | 96817 | — |
| Re:Cognition Chicago | Chicago | Illinois | 60611 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Charter Research Chicago | Chicago | Illinois | 60618 | — |
| Great Lakes Clinical Trials/Flourish Research | Chicago | Illinois | 60640 | — |
| Southern Illinois University | Springfield | Illinois | 62702 | — |
| JWM Research | Indianaopolis | Indiana | 46256 | — |
| Ascension via Christi Research | Wichita | Kansas | 37214 | — |
| Tandem Intermediate | Metairie | Louisiana | 70006 | — |
| Headlands Research Pharmasite | Pikesville | Maryland | 21208 | — |
| Neurology Center of New England, PC | Foxborough | Massachusetts | 02035 | — |
| Headlands Research Easter Massachusetts | Plymouth | Massachusetts | 02360 | — |
| Mayflower Clinical | Russells Mills | Massachusetts | 02747 | — |
| Elixia MA | Springfield | Massachusetts | 01103 | — |
| Quest Research Institute | Farmington Hills | Michigan | 48334 | — |
| Precise Research Center | Flowood | Mississippi | 39232 | — |
| Clinical Research Professionals - Headlands Research | Chesterfield | Missouri | 63005 | — |
| Oasis Clinical Trials LLC | Las Vegas | Nevada | 89121 | — |
| Cenexel Advanced Medical Research of New Jersey (AMRI) | Toms River | New Jersey | 08755 | — |
| Advanced Clinical Institute | West Long Branch | New Jersey | 07764 | — |
| Dent Neurologic Institute | Amherst | New York | 14226 | — |
| SPRI | Brooklyn | New York | 11235 | — |
| Neurological Associates of Long Island | Lake Success | New York | 11042 | — |
| New York Neurology Associates | New York | New York | 10003 | — |
| Richmond Behavioral Associates | Staten Island | New York | 10314 | — |
| Ichor Research | Syracuse | New York | 13210 | — |
| Duke University | Durham | North Carolina | 27705 | — |
| AMC Research/Flourish Research | Matthews | North Carolina | 28105 | — |
| American Clinical Research Center | Beavercreek | Ohio | 45432 | — |
| Valley Medical Research | Centerville | Ohio | 45459 | — |
| Insight Clinical Trials | Independence | Ohio | 44131 | — |
| Summit Headlands | Portland | Oregon | 97210 | — |
| Suburban Research Associates | Media | Pennsylvania | 19063 | — |
| K2 Keystone | Plymouth Meeting | Pennsylvania | 19462 | — |
| Rhode Island Mood and Memory Research Institute | East Providence | Rhode Island | 02914 | — |
| Palmetto Primary Care & Specialty Physicians | Summerville | South Carolina | 29486 | — |
| Neurology Clinic, P.C. | Cordova | Tennessee | 38018 | — |
| K2 Medical Research Nashville | Nashville | Tennessee | 37204 | — |
| Senior Adults Specialty Research | Austin | Texas | 78757 | — |
| NeuroMind Clinical Trials | Houston | Texas | 77094 | — |
| Central Texas Neurology Associates | Round Rock | Texas | 78681 | — |
| Grayline Research Center | Wichita Falls | Texas | 76309 | — |
| Memory Clinic, Inc. | Bennington | Vermont | 05201 | — |
| Sana Research | Arlington | Virginia | 22205 | — |
| Re:Cognition Fairfax | Fairfax | Virginia | 22031 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06709014, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 18, 2026 · Synced Nov 4, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06709014 live on ClinicalTrials.gov.