Study of the Theranostic Pair RYZ811 (Diagnostic) and RYZ801 (Therapeutic) to Identify and Treat Subjects With GPC3+ (Glypican-3) Unresectable HCC

ClinicalTrials.gov ID: NCT06726161

Public ClinicalTrials.gov record NCT06726161. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jul 24, 2026, 1:36 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase 1/2 Randomized, Controlled, Open-label Trial of Theranostic Pair RYZ811 (Diagnostic) and RYZ801 (Therapeutic) to Identify and Treat Subjects With GPC3+ Unresectable Hepatocellular Carcinoma (HCC)

Study identification

NCT ID: NCT06726161
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: RayzeBio, Inc.; Industry
Enrollment: 590 participants

Conditions and interventions

Conditions

Hepatocellular Carcinoma (HCC)

Interventions

RYZ811 Diagnostic Test
RYZ801 Drug

Diagnostic Test · Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Sep 4, 2025
Primary completion: May 31, 2030
Completion: May 31, 2031
Last update posted: Apr 12, 2026

2025 – 2031

United States locations

U.S. sites: 13
U.S. states: 12
U.S. cities: 13

Facility	City	State	ZIP	Site status
Research Facility	Birmingham	Alabama	35233	Recruiting
Research Facility	Phoenix	Arizona	85054	Recruiting
Research Facility	Tucson	Arizona	85719	Recruiting
Research Facility	Orange	California	92868	Recruiting
Research Facility	Jacksonville	Florida	32224	Recruiting
Research Facility	Lexington	Kentucky	40536	Recruiting
Research Facility	Baltimore	Maryland	21287	Recruiting
Research Facility	Rochester	Minnesota	55905	Recruiting
Research Facility	Omaha	Nebraska	68130	Recruiting
Research Facility	New York	New York	10065	Recruiting
Research Facility	Houston	Texas	77030	Recruiting
Research Facility	Charlottesville	Virginia	22908	Recruiting
Research Facility	Seattle	Washington	98109	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06726161, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 12, 2026 · Synced Jul 24, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06726161 live on ClinicalTrials.gov.

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