ClinicalTrials.gov record
Testing the Addition of AZD6738 (Ceralasertib) to Immunotherapy to Increase Time Without Cancer for Patients With Non-Small Cell Lung Cancer
ClinicalTrials.gov ID: NCT06732401
Public ClinicalTrials.gov record NCT06732401. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Phase III Trial of Checkpoint Blockade in Lung CancEr Patients in the Adjuvant Setting Based on Pathologic Response Following Neoadjuvant Therapy (CLEAR)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This phase III trial compares the effect of adding AZD6738 to durvalumab versus durvalumab alone to increase time without cancer in patients with non-small cell lung cancer, following treatment with chemotherapy and surgery. AZD6738 may stop the growth of tumor cells and may kill them by blocking some of the enzymes needed for cell growth. Durvalumab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. A monoclonal antibody is a type of protein that can bind to certain targets in the body, such as molecules that cause the body to make an immune response (antigens). Adding AZD6738 to durvalumab may increase time without cancer in patients with non-small cell lung cancer, following treatment with chemotherapy and surgery.
Study identification
- NCT ID
- NCT06732401
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 630 participants
Conditions and interventions
Conditions
Interventions
- Biospecimen Collection Procedure
- Ceralasertib Drug
- Computed Tomography Procedure
- Durvalumab Biological
- Echocardiography Test Procedure
Procedure · Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 7, 2025 (Actual)
- Primary completion
- Jun 30, 2028 (Estimated)
- Completion
- Jun 30, 2028 (Estimated)
- Last update posted
- Sep 21, 2026
2025 – 2028
United States locations
- U.S. sites
- 192
- U.S. states
- 31
- U.S. cities
- 166
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro | Jonesboro | Arkansas | 72401 | — |
| Tower Cancer Research Foundation | Beverly Hills | California | 90211 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| Cedars-Sinai Cancer - Tarzana | Tarzana | California | 91356 | — |
| Torrance Memorial Physician Network - Cancer Care | Torrance | California | 90505 | — |
| Hartford Hospital | Hartford | Connecticut | 06102 | — |
| Midstate Medical Center | Meriden | Connecticut | 06451 | — |
| The Hospital of Central Connecticut | New Britain | Connecticut | 06050 | — |
| Beebe South Coastal Health Campus | Millville | Delaware | 19967 | — |
| Helen F Graham Cancer Center | Newark | Delaware | 19713 | — |
| Medical Oncology Hematology Consultants PA | Newark | Delaware | 19713 | — |
| Beebe Health Campus | Rehoboth Beach | Delaware | 19971 | — |
| MedStar Georgetown University Hospital | Washington D.C. | District of Columbia | 20007 | — |
| MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| Emory University Hospital Midtown | Atlanta | Georgia | 30308 | — |
| Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| Emory Saint Joseph's Hospital | Atlanta | Georgia | 30342 | — |
| Emory Decatur Hospital | Decatur | Georgia | 30033 | — |
| Emory Johns Creek Hospital | Johns Creek | Georgia | 30097 | — |
| Saint Luke's Cancer Institute - Boise | Boise | Idaho | 83712 | — |
| Kootenai Health - Coeur d'Alene | Coeur d'Alene | Idaho | 83814 | — |
| Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho | 83619 | — |
| Saint Luke's Cancer Institute - Meridian | Meridian | Idaho | 83642 | — |
| Saint Alphonsus Cancer Care Center-Nampa | Nampa | Idaho | 83687 | — |
| Saint Luke's Cancer Institute - Nampa | Nampa | Idaho | 83687 | — |
| Kootenai Clinic Cancer Services - Post Falls | Post Falls | Idaho | 83854 | — |
| Kootenai Clinic Cancer Services - Sandpoint | Sandpoint | Idaho | 83864 | — |
| Illinois CancerCare-Bloomington | Bloomington | Illinois | 61704 | — |
| Illinois CancerCare-Canton | Canton | Illinois | 61520 | — |
| Illinois CancerCare-Carthage | Carthage | Illinois | 62321 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois | 62526 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Northwestern Medicine Cancer Center Kishwaukee | DeKalb | Illinois | 60115 | — |
| Illinois CancerCare-Dixon | Dixon | Illinois | 61021 | — |
| Crossroads Cancer Center | Effingham | Illinois | 62401 | — |
| Illinois CancerCare-Eureka | Eureka | Illinois | 61530 | — |
| Illinois CancerCare-Galesburg | Galesburg | Illinois | 61401 | — |
| Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | 60134 | — |
| Northwestern Medicine Glenview Outpatient Center | Glenview | Illinois | 60026 | — |
| Northwestern Medicine Grayslake Outpatient Center | Grayslake | Illinois | 60030 | — |
| Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois | 61443 | — |
| Northwestern Medicine Lake Forest Hospital | Lake Forest | Illinois | 60045 | — |
| Illinois CancerCare-Macomb | Macomb | Illinois | 61455 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Cancer Care Center of O'Fallon | O'Fallon | Illinois | 62269 | — |
| HSHS Saint Elizabeth's Hospital | O'Fallon | Illinois | 62269 | — |
| Northwestern Medicine Oak Brook | Oak Brook | Illinois | 60523 | — |
| Northwestern Medicine Orland Park | Orland Park | Illinois | 60462 | — |
| Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | 61350 | — |
| Illinois CancerCare-Pekin | Pekin | Illinois | 61554 | — |
| Illinois CancerCare-Peoria | Peoria | Illinois | 61615 | — |
| Illinois CancerCare-Peru | Peru | Illinois | 61354 | — |
| Illinois CancerCare-Princeton | Princeton | Illinois | 61356 | — |
| Southern Illinois University School of Medicine | Springfield | Illinois | 62702 | — |
| Springfield Clinic | Springfield | Illinois | 62702 | — |
| Springfield Memorial Hospital | Springfield | Illinois | 62781 | — |
| Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | 60555 | — |
| Illinois CancerCare - Washington | Washington | Illinois | 61571 | — |
| Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | 46202 | — |
| Cancer Center of Kansas - El Dorado | El Dorado | Kansas | 67042 | — |
| Lawrence Memorial Hospital | Lawrence | Kansas | 66044 | — |
| Cancer Center of Kansas - Newton | Newton | Kansas | 67114 | — |
| The University of Kansas Cancer Center - Olathe | Olathe | Kansas | 66061 | — |
| Salina Regional Health Center | Salina | Kansas | 67401 | — |
| University of Kansas Health System Saint Francis Campus | Topeka | Kansas | 66606 | — |
| Cancer Center of Kansas - Wellington | Wellington | Kansas | 67152 | — |
| Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita | Kansas | 67208 | — |
| Ascension Via Christi Hospitals Wichita | Wichita | Kansas | 67214 | — |
| Cancer Center of Kansas - Wichita | Wichita | Kansas | 67214 | — |
| Cancer Center of Kansas - Winfield | Winfield | Kansas | 67156 | — |
| University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | 21201 | — |
| UM Baltimore Washington Medical Center/Tate Cancer Center | Glen Burnie | Maryland | 21061 | — |
| Beverly Hospital | Beverly | Massachusetts | 01915 | — |
| Lahey Clinic | Burlington | Massachusetts | 01805 | — |
| Addison Gilbert Hospital | Gloucester | Massachusetts | 01930 | — |
| Lahey Clinic Peabody | Peabody | Massachusetts | 01960 | — |
| Baystate Medical Center | Springfield | Massachusetts | 01199 | — |
| Bronson Battle Creek | Battle Creek | Michigan | 49017 | — |
| Trinity Health IHA Medical Group Hematology Oncology - Brighton | Brighton | Michigan | 48114 | — |
| Trinity Health IHA Medical Group Hematology Oncology - Canton | Canton | Michigan | 48188 | — |
| Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital | Chelsea | Michigan | 48118 | — |
| Cancer Hematology Centers - Flint | Flint | Michigan | 48503 | — |
| Genesee Hematology Oncology PC | Flint | Michigan | 48503 | — |
| Genesys Hurley Cancer Institute | Flint | Michigan | 48503 | — |
| Hurley Medical Center | Flint | Michigan | 48503 | — |
| Corewell Health Grand Rapids Hospitals - Butterworth Hospital | Grand Rapids | Michigan | 49503 | — |
| Trinity Health Grand Rapids Hospital | Grand Rapids | Michigan | 49503 | — |
| Bronson Methodist Hospital | Kalamazoo | Michigan | 49007 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | — |
| University of Michigan Health - Sparrow Lansing | Lansing | Michigan | 48912 | — |
| Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan | 48154 | — |
| Trinity Health Muskegon Hospital | Muskegon | Michigan | 49444 | — |
| Corewell Health Lakeland Hospitals - Niles Hospital | Niles | Michigan | 49120 | — |
| Cancer and Hematology Centers of Western Michigan - Norton Shores | Norton Shores | Michigan | 49444 | — |
| Trinity Health Saint Joseph Mercy Oakland Hospital | Pontiac | Michigan | 48341 | — |
| Corewell Health Reed City Hospital | Reed City | Michigan | 49677 | — |
| Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center | Saint Joseph | Michigan | 49085 | — |
| Corewell Health Lakeland Hospitals - Saint Joseph Hospital | Saint Joseph | Michigan | 49085 | — |
| Munson Medical Center | Traverse City | Michigan | 49684 | — |
| University of Michigan Health - West | Wyoming | Michigan | 49519 | — |
| Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus | Ypsilanti | Michigan | 48197 | — |
| Essentia Health Saint Joseph's Medical Center | Brainerd | Minnesota | 56401 | — |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Essentia Health - Deer River Clinic | Deer River | Minnesota | 56636 | — |
| Essentia Health Cancer Center | Duluth | Minnesota | 55805 | — |
| Fairview Southdale Hospital | Edina | Minnesota | 55435 | — |
| Essentia Health Hibbing Clinic | Hibbing | Minnesota | 55746 | — |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Minneapolis VA Medical Center | Minneapolis | Minnesota | 55417 | — |
| Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | 55416 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| United Hospital | Saint Paul | Minnesota | 55102 | — |
| Essentia Health Sandstone | Sandstone | Minnesota | 55072 | — |
| Essentia Health Virginia Clinic | Virginia | Minnesota | 55792 | — |
| Baptist Memorial Hospital and Cancer Center-Golden Triangle | Columbus | Mississippi | 39705 | — |
| Baptist Cancer Center-Grenada | Grenada | Mississippi | 38901 | — |
| Baptist Memorial Hospital and Cancer Center-Union County | New Albany | Mississippi | 38652 | — |
| Baptist Memorial Hospital and Cancer Center-Oxford | Oxford | Mississippi | 38655 | — |
| Baptist Memorial Hospital and Cancer Center-Desoto | Southhaven | Mississippi | 38671 | — |
| Saint Francis Medical Center | Cape Girardeau | Missouri | 63703 | — |
| Parkland Health Center - Farmington | Farmington | Missouri | 63640 | — |
| Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri | 63670 | — |
| Mercy Hospital South | St Louis | Missouri | 63128 | — |
| Missouri Baptist Medical Center | St Louis | Missouri | 63131 | — |
| Missouri Baptist Sullivan Hospital | Sullivan | Missouri | 63080 | — |
| Community Hospital of Anaconda | Anaconda | Montana | 59711 | — |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | — |
| Saint Vincent Frontier Cancer Center | Billings | Montana | 59102 | — |
| Bozeman Health Deaconess Hospital | Bozeman | Montana | 59715 | — |
| Benefis Sletten Cancer Institute | Great Falls | Montana | 59405 | — |
| Community Medical Center | Missoula | Montana | 59804 | — |
| New Hampshire Oncology Hematology PA-Concord | Concord | New Hampshire | 03301 | — |
| Solinsky Center for Cancer Care | Manchester | New Hampshire | 03103 | — |
| Hunterdon Medical Center | Flemington | New Jersey | 08822 | — |
| Glens Falls Hospital | Glens Falls | New York | 12801 | — |
| Montefiore Medical Center-Einstein Campus | The Bronx | New York | 10461 | — |
| FirstHealth of the Carolinas-Moore Regional Hospital | Pinehurst | North Carolina | 28374 | — |
| Essentia Health Cancer Center-South University Clinic | Fargo | North Dakota | 58103 | — |
| Aultman Health Foundation | Canton | Ohio | 44710 | — |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Providence Newberg Medical Center | Newberg | Oregon | 97132 | — |
| Providence Willamette Falls Medical Center | Oregon City | Oregon | 97045 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| Providence Saint Vincent Medical Center | Portland | Oregon | 97225 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania | 18103 | — |
| Lehigh Valley Hospital - Muhlenberg | Bethlehem | Pennsylvania | 18017 | — |
| Bryn Mawr Hospital | Bryn Mawr | Pennsylvania | 19010 | — |
| Pocono Medical Center | East Stroudsburg | Pennsylvania | 18301 | — |
| UPMC Hillman Cancer Center Erie | Erie | Pennsylvania | 16505 | — |
| UPMC Cancer Centers - Arnold Palmer Pavilion | Greensburg | Pennsylvania | 15601 | — |
| UPMC Pinnacle Cancer Center/Community Osteopathic Campus | Harrisburg | Pennsylvania | 17109 | — |
| Lehigh Valley Hospital-Hazleton | Hazleton | Pennsylvania | 18201 | — |
| UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion | Mechanicsburg | Pennsylvania | 17050 | — |
| Riddle Memorial Hospital | Media | Pennsylvania | 19063 | — |
| UPMC Hillman Cancer Center - Monroeville | Monroeville | Pennsylvania | 15146 | — |
| Paoli Memorial Hospital | Paoli | Pennsylvania | 19301 | — |
| University of Pennsylvania/Abramson Cancer Center | Philadelphia | Pennsylvania | 19104 | — |
| UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | — |
| UPMC-Saint Clair Hospital Cancer Center | Pittsburgh | Pennsylvania | 15243 | — |
| Reading Hospital | West Reading | Pennsylvania | 19611 | — |
| Lankenau Medical Center | Wynnewood | Pennsylvania | 19096 | — |
| Tidelands Georgetown Memorial Hospital | Georgetown | South Carolina | 29440 | — |
| Baptist Memorial Hospital and Cancer Center-Collierville | Collierville | Tennessee | 38017 | — |
| Baptist Memorial Hospital and Cancer Center-Memphis | Memphis | Tennessee | 38120 | — |
| Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee | 37232 | — |
| University of Virginia Cancer Center | Charlottesville | Virginia | 22908 | — |
| Hematology Oncology Associates of Fredericksburg Inc | Fredericksburg | Virginia | 22408 | — |
| Virginia Cancer Institute | Richmond | Virginia | 23229 | — |
| VCU Massey Cancer Center at Stony Point | Richmond | Virginia | 23235 | — |
| VCU Massey Comprehensive Cancer Center | Richmond | Virginia | 23298 | — |
| VCU Community Memorial Health Center | South Hill | Virginia | 23970 | — |
| Edwards Comprehensive Cancer Center | Huntington | West Virginia | 25701 | — |
| West Virginia University Healthcare | Morgantown | West Virginia | 26506 | — |
| Camden Clark Medical Center | Parkersburg | West Virginia | 26101 | — |
| Aspirus Cancer Care-Antigo-Volm Cancer Center | Antigo | Wisconsin | 54409 | — |
| ThedaCare Regional Cancer Center | Appleton | Wisconsin | 54911 | — |
| Duluth Clinic Ashland | Ashland | Wisconsin | 54806 | — |
| Essentia Health-Hayward Clinic | Hayward | Wisconsin | 54843 | — |
| Gundersen Lutheran Medical Center | La Crosse | Wisconsin | 54601 | — |
| Aspirus Medford Hospital | Medford | Wisconsin | 54451 | — |
| ProHealth D N Greenwald Center | Mukwonago | Wisconsin | 53149 | — |
| ProHealth Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin | 53066 | — |
| Aspirus Cancer Care-Rhinelander-James Beck Cancer Center | Rhinelander | Wisconsin | 54501 | — |
| Essentia Health-Spooner Clinic | Spooner | Wisconsin | 54801 | — |
| Aspirus Cancer Care - Stevens Point | Stevens Point | Wisconsin | 54481 | — |
| Essentia Health Saint Mary's Hospital - Superior | Superior | Wisconsin | 54880 | — |
| UW Cancer Center at ProHealth Care | Waukesha | Wisconsin | 53188 | — |
| Aspirus Cancer Care-Wausau | Wausau | Wisconsin | 54401 | — |
| Aspirus Cancer Care - Wisconsin Rapids | Wisconsin Rapids | Wisconsin | 54494 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06732401, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 21, 2026 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06732401 live on ClinicalTrials.gov.