Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

ClinicalTrials.gov ID: NCT06736574

Public ClinicalTrials.gov record NCT06736574. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 3:54 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Multi-Center, Double-Blind, Randomized, Placebo-Controlled Trial to Assess Efficacy and Safety of Omecamtiv Mecarbil in Patients With Symptomatic Heart Failure With Severely Reduced Ejection Fraction (COMET-HF)

Study identification

NCT ID: NCT06736574
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Cytokinetics; Industry
Enrollment: 1,800 participants

Conditions and interventions

Conditions

Interventions

Omecamtiv Mecarbil (OM) Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 85 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 18, 2024
Primary completion: Aug 31, 2027
Completion: Nov 30, 2027
Last update posted: May 4, 2026

2024 – 2027

United States locations

U.S. sites: 88
U.S. states: 33
U.S. cities: 80

Facility	City	State	ZIP	Site status
Advanced Cardiovascular, LLC	Alexander City	Alabama	35010	Recruiting
University of Alabama at Birmingham	Birmingham	Alabama	35233	Recruiting
Pima Heart and Vascular Clinical Research	Tucson	Arizona	85741	Withdrawn
National Heart Institute	Beverly Hills	California	90211	Recruiting
UC San Diego Health - Sulpizio Cardiovascular Center	La Jolla	California	92037	Recruiting
Nutrition Research Center (SPH)	Loma Linda	California	92350	Recruiting
Keck Medical Center of USC (outpatient clinic)	Los Angeles	California	90033	Recruiting
UCLA Medical Center Cardiovascular Clinic	Los Angeles	California	90095	Recruiting
University of California, Irvine Medical Center	Orange	California	92868	Recruiting
Sutter Institute for Medical Research (SIMR)	Sacramento	California	95816	Recruiting
UC Davis Health	Sacramento	California	95817	Recruiting
San Diego Cardiac Center	San Diego	California	92123	Recruiting
California Pacific Medical Center Van Ness Campus	San Francisco	California	94109	Recruiting
Kaiser Permanente Santa Clara	Santa Clara	California	95051	Recruiting
Stanford University Hospital / Stanford Health Care	Stanford	California	94303	Recruiting
Lundquist Institute for Biomedical Innovation at Harbor - UCLA Medical Center	Torrance	California	90502	Recruiting
Rocky Mountain Regional VA Medical Center	Aurora	Colorado	80045	Recruiting
Cardiology Associates of Fairfield County, P.C	Bridgeport	Connecticut	06606	Recruiting
Hartford Hospital	Hartford	Connecticut	06102	Recruiting
Yale New Haven Health Heart & Vascular Center Outpatient Services	New Haven	Connecticut	06519	Recruiting
CHF Heart Clinical (Subject Visits & IP Shipments)	Clearwater	Florida	33756	Recruiting
Holy Cross Medical Group - Cardiology Associates	Fort Lauderdale	Florida	33308	Recruiting
South Florida Research Solutions, LLC	Hollywood	Florida	33351	Recruiting
UF Health Jacksonville	Jacksonville	Florida	32209	Recruiting
Broward Research Center	Miami Beach	Florida	33140	Recruiting
Ocala Cardiovascular Research	Ocala	Florida	34471	Recruiting
AdventHealth	Orlando	Florida	32803	Recruiting
USF Health South Tampa Center for Advanced Healthcare	Tampa	Florida	33606	Recruiting
Grady Health System	Atlanta	Georgia	30303	Recruiting
Piedmont Atlanta Hospital	Atlanta	Georgia	30309	Recruiting
Emory Clinic	Atlanta	Georgia	30322	Recruiting
Piedmont Fayette Hospital	Fayetteville	Georgia	30214	Recruiting
The Queen's Medical Center - Punchbowl	Honolulu	Hawaii	96813	Recruiting
Midwest Cardiovascular Institute	Naperville	Illinois	60540	Recruiting
Cardiovascular Research of Northwest Indiana, LLC.	Munster	Indiana	46321	Recruiting
Deaconess Heart Group	Newburgh	Indiana	47630	Recruiting
Reid Physician Associates	Richmond	Indiana	47374	Recruiting
The University of Kansas Medical Center	Kansas City	Kansas	66160	Recruiting
AHMG Cardiology and Surgery	Overland Park	Kansas	66211	Recruiting
University Medical Center New Orleans	New Orleans	Louisiana	70112	Recruiting
Eastern Main Medical Center dba Northern Light Eastern Maine Medical Center	Bangor	Maine	04401	Recruiting
University of Maryland Medical Center	Baltimore	Maryland	21201	Recruiting
Tufts Medical Center	Boston	Massachusetts	02111	Recruiting
Henry Ford Hospital	Detroit	Michigan	48202	Recruiting
Midwest Heart and Vascular Specialists, LLC	Independence	Missouri	64057	Recruiting
Saint Luke's Hospital of Kansas City	Kansas City	Missouri	64111	Recruiting
Washington University Center for Advanced Medicine	St Louis	Missouri	63110	Recruiting
St. Louis Heart and Vascular	St Louis	Missouri	63136	Withdrawn
University of Nebraska Medical Center	Omaha	Nebraska	68198	Recruiting
Advanced Heart Care, LLC	Bridgewater	New Jersey	08807	Recruiting
Monmouth Cardiology Associates, LLC	Eatontown	New Jersey	07724	Recruiting
Capital Cardiology Associates	Albany	New York	12205	Recruiting
Northwell Health North Shore University Hospital	Manhasset	New York	11030	Recruiting
Mount Sinai Hospital	New York	New York	10029	Recruiting
Columbia University Medical Center / New York - Presbyterian	New York	New York	10032	Recruiting
Montefiore Medical Center (Moses Campus)	The Bronx	New York	10467	Recruiting
WakeMed Heart & Vascular - Cary Cardiology	Cary	North Carolina	27518	Recruiting
Clinical and Translational Research Center - University of North Carolina at Chapel Hill	Chapel Hill	North Carolina	27599-7064	Recruiting
Duke University Hospital	Durham	North Carolina	27710	Recruiting
Moses H. Cone Memorial Hospital Operating Corporation d/b/a Cone Health	Greensboro	North Carolina	27401	Recruiting
Wake Forest University Health Sciences	Winston-Salem	North Carolina	27157	Recruiting
The Lindner Research Center at the Christ Hospital	Cincinnati	Ohio	45219	Recruiting
University Hospitals Cleveland Medical Center	Cleveland	Ohio	44106	Recruiting
Cleveland Clinic	Cleveland	Ohio	44195	Recruiting
K&R Research LLC	Marion	Ohio	43302	Withdrawn
University of Hospitals North Ohio Heart	Sandusky	Ohio	44870	Recruiting
Oklahoma State University Center for Health Sciences	Tulsa	Oklahoma	74127	Recruiting
Oregon Health and Science University	Portland	Oregon	97239	Recruiting
Capital Area Research, LLC	Camp Hill	Pennsylvania	17011	Recruiting
Penn State Health Milton S. Hershey Medical Center	Hershey	Pennsylvania	17033	Recruiting
Hospital of the University of Pennsylvania (University of Pennsylvania School of Medicine)	Philadelphia	Pennsylvania	19104	Recruiting
Medical University of South Carolina - Gazes Research Institute	Charleston	South Carolina	29425	Recruiting
Monument Health Clinical Research, a department of Monument Health Rapid City Hospital, Inc.	Rapid City	South Dakota	57701	Recruiting
Stern Cardiovascular Foundation, Inc.	Germantown	Tennessee	38138	Recruiting
Tennova Healthcare-Turkey Creek Medical Center	Knoxville	Tennessee	37934	Recruiting
Vanderbilt University Medical Center	Nashville	Tennessee	37232	Recruiting
Tennessee Center for Clinical Trials	Tullahoma	Tennessee	37388	Recruiting
Baylor University Medical Center	Dallas	Texas	75246	Recruiting
The University of Texas Southwestern Medical Center	Dallas	Texas	75390	Recruiting
Medresearch Inc	El Paso	Texas	79902	Recruiting
University of Texas Medical Branch - UTMB	Galveston	Texas	77555	Recruiting
CHI St. Luke's Health Baylor College of Medicine Medical Center	Houston	Texas	77030	Recruiting
Baylor Scott & White Medical Center- The Hearth Hospital	Plano	Texas	75093	Recruiting
Intermountain Medical Center	Murray	Utah	84107	Recruiting
University of Utah Health	Salt Lake City	Utah	84132	Recruiting
Sentara Norfolk General Hospital	Norfolk	Virginia	23507	Recruiting
Providence Advanced Heart Disease and Transplant	Spokane	Washington	99204	Recruiting
Medical College of Wisconsin / Froedtert Hospital	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 97 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06736574, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 4, 2026 · Synced May 8, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06736574 live on ClinicalTrials.gov.

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