A Phase 2b, Randomized, Double-blind, Active-controlled Study of Single Dose CVXGA Intranasal COVID-19 Vaccine in Adults
Public ClinicalTrials.gov record NCT06742281. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2b, Randomized, Double-blind, Active-controlled Study of Single Dose CVXGA (CVXGA50) Intranasal COVID-19 Vaccine in Adults
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this trial is to assess the safety and relative efficacy of CVXGA (CVXGA50), a KP.2 containing vaccine, compared to COMIRNATY® (COVID-19 Vaccine, mRNA; 2024-2025 Formula), a currently approved COVID-19 vaccine in the prevention of symptomatic, RT-PCR-confirmed SARS-CoV-2 infection. The trial will enroll up to 434 healthy participants.
Study identification
- NCT ID
- NCT06742281
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 432 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 100 Years
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 5, 2024 (Actual)
- Primary completion
- Jun 15, 2026 (Actual)
- Completion
- Jun 15, 2026 (Actual)
- Last update posted
- Oct 13, 2026
2024 – 2026
United States locations
- U.S. sites
- 55
- U.S. states
- 22
- U.S. cities
- 47
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pinnacle Research Group, LLC | Anniston | Alabama | 36207 | — |
| Velocity Clinical Research, Phoenix | Phoenix | Arizona | 85006 | — |
| Velocity Clinical Research, Chula Vista | Chula Vista | California | 91911 | — |
| Velocity Clinical Research, San Diego | La Mesa | California | 91942 | — |
| Imax Clinical Trials | La Palma | California | 90623 | — |
| Artemis Institute for Clinical Research | Riverside | California | 92503 | — |
| Clinical Innovations Inc. dba CITrials | Riverside | California | 92506 | — |
| Avacare | Sacramento | California | 95864 | — |
| Collaborative Neuroscience Research, LLC | Torrance | California | 90504 | — |
| Velocity Clinical Research, Washington DC | Washington D.C. | District of Columbia | 20016 | — |
| Velocity Clinical Research, Hallandale Beach | Hallandale | Florida | 33009 | — |
| Homestead Associates in Research, Inc | Homestead | Florida | 33033 | — |
| Biscayne Clinical Research | North Miami Beach | Florida | 33169 | — |
| Headlands Research Orlando | Orlando | Florida | 32819 | — |
| Best Choice Medical and Research Service | Pembroke Pines | Florida | 33024 | — |
| Forcare Clinical Research | Tampa | Florida | 33613 | — |
| Guardian Angel Research Center | Tampa | Florida | 33614 | — |
| Lifeline Primary Care/Avacare | Lilburn | Georgia | 30047 | — |
| Velocity Clinical Research, Savannah | Savannah | Georgia | 31406 | — |
| Clinical Research Atlanta | Stockbridge | Georgia | 30281 | — |
| Velocity Clinical Research, Boise | Meridian | Idaho | 83642 | — |
| Velocity Clinical Research, Sioux City | Sioux City | Iowa | 51106 | — |
| Velocity Clinical Research, Covington | Covington | Louisiana | 70433 | — |
| Velocity Clinical Research, Lafayette | Lafayette | Louisiana | 70508 | — |
| Velocity Clinical Research, New Orleans | New Orleans | Louisiana | 70119 | — |
| CBH Health | Gaithersburg | Maryland | 20877 | — |
| Advanced Primary and Geriatric Care/Avacare | Rockville | Maryland | 20850 | — |
| Velocity Clinical Research, Rockville | Rockville | Maryland | 20854 | — |
| DM Clinical Research | Southfield | Michigan | 48076 | — |
| Velocity Clinical Research - Norfolk | Norfolk | Nebraska | 68701 | — |
| Quality Clinical Research, Inc | Omaha | Nebraska | 68114 | — |
| Velocity Clinical Research, Omaha | Omaha | Nebraska | 68134 | — |
| DM Clinical Research | Jersey City | New Jersey | 07306 | — |
| Velocity Clinical Research, Binghamton | Binghamton | New York | 13905 | — |
| Rochester Clinical Research | Rochester | New York | 14609 | — |
| Trial Management Associates, LLC | Wilmington | North Carolina | 28403 | — |
| Velocity Clinical Research, Cleveland | Beachwood | Ohio | 44122 | — |
| Velocity Clinical Research, Mt. Auburn | Cincinnati | Ohio | 45219 | — |
| Velocity Clinical Research, Springdale | Cincinnati | Ohio | 45246 | — |
| Tekton Research, LLC | Yukon | Oklahoma | 73099 | — |
| DM Clinical Research | Philadelphia | Pennsylvania | 19107 | — |
| Velocity Clinical Research, Anderson | Anderson | South Carolina | 29621 | — |
| Velocity Clinical Research Gaffney | Gaffney | South Carolina | 29340 | — |
| Avacare | Austin | Texas | 78705 | — |
| Tekton Research, LLC | Austin | Texas | 78745 | — |
| Velocity Clinical Research, Austin | Austin | Texas | 78759 | — |
| Pan American Clinical Research, LLC | Brownsville | Texas | 78520 | — |
| Avacare | Fort Worth | Texas | 76135 | — |
| DM Clinical Research | Houston | Texas | 77065 | — |
| DM Clinical Research | Houston | Texas | 77081 | — |
| Avacare | San Angelo | Texas | 76904 | — |
| Tekton Research, LLC | San Antonio | Texas | 78229 | — |
| Velocity Clinical Research, Salt Lake City | West Jordan | Utah | 84088 | — |
| Clinical Research Partners LLC | Richmond | Virginia | 23226 | — |
| Velocity Clinical Research, Suffolk | Suffolk | Virginia | 23435 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06742281, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 13, 2026 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06742281 live on ClinicalTrials.gov.