Randomised Clinical Trial to Investigate Efficacy and Safety of Benralizumab 30 mg SC as an add-on Therapy in Uncontrolled Eosinophilic Asthma Patients Treated With Medium-dose ICS-LABA Compared to Conventional Escalation to High-dose ICS-LABA Treatment
Public ClinicalTrials.gov record NCT06750289. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
BRISOTE: A Multicentre, Randomised, Double-Blind, Parallel Group, Active-Controlled, Phase 3b Study to Evaluate the Efficacy and Safety of Benralizumab 30 mg SC in Eosinophilic Asthma Patients Uncontrolled on Medium-Dose Inhaled Corticosteroid Plus Long-acting β2-Agonist.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study evaluates the efficacy and safety of benralizumab as an add-on therapy in uncontrolled eosinophilic asthma participants treated with medium-dose ICS-LABA compared to the conventional treatment step of escalation of inhaled therapy to high-dose ICS-LABA.
Study identification
- NCT ID
- NCT06750289
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 130 participants
Conditions and interventions
Conditions
Interventions
- ICS-LABA Combination Product
- benralizumab Combination Product
- Placebo for Benralizumab Combination Product
Combination Product
Eligibility (public fields only)
- Age range
- 12 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 28, 2025 (Actual)
- Primary completion
- Sep 21, 2026 (Actual)
- Completion
- Sep 21, 2026 (Actual)
- Last update posted
- Oct 16, 2026
2025 – 2026
United States locations
- U.S. sites
- 20
- U.S. states
- 11
- U.S. cities
- 20
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Sun City | Arizona | 85351 | — |
| Research Site | Tucson | Arizona | 85704 | — |
| Research Site | Inglewood | California | 90301 | — |
| Research Site | Newport Beach | California | 92663 | — |
| Research Site | Pasadena | California | 91101 | — |
| Research Site | Cape Coral | Florida | 33990 | — |
| Research Site | Lauderdale Lakes | Florida | 33313 | — |
| Research Site | Leesburg | Florida | 34748 | — |
| Research Site | Miami | Florida | 33175 | — |
| Research Site | Tampa | Florida | 33607 | — |
| Research Site | Winter Park | Florida | 32789 | — |
| Research Site | Ann Arbor | Michigan | 48109 | — |
| Research Site | Henderson | Nevada | 89052 | — |
| Research Site | Northfield | New Jersey | 08225 | — |
| Research Site | New Hyde Park | New York | 11042 | — |
| Research Site | The Bronx | New York | 10459 | — |
| Research Site | DuBois | Pennsylvania | 15801 | — |
| Research Site | Warwick | Rhode Island | 02886 | — |
| Research Site | Greenville | South Carolina | 29607 | — |
| Research Site | San Antonio | Texas | 78251 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 66 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06750289, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 16, 2026 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06750289 live on ClinicalTrials.gov.