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Recruiting Phase 3 Interventional

Randomised Clinical Trial to Investigate Efficacy and Safety of Benralizumab 30 mg SC as an add-on Therapy in Uncontrolled Eosinophilic Asthma Patients Treated With Medium-dose ICS-LABA Compared to Conventional Escalation to High-dose ICS-LABA Treatment

ClinicalTrials.gov ID: NCT06750289

Public ClinicalTrials.gov record NCT06750289. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jul 22, 2026, 5:47 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

BRISOTE: A Multicentre, Randomised, Double-Blind, Parallel Group, Active-Controlled, Phase 3b Study to Evaluate the Efficacy and Safety of Benralizumab 30 mg SC in Eosinophilic Asthma Patients Uncontrolled on Medium-Dose Inhaled Corticosteroid Plus Long-acting β2-Agonist.

Study identification

NCT ID
NCT06750289
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
AstraZeneca
Industry
Enrollment
400 participants

Conditions and interventions

Interventions

  • ICS-LABA Combination Product
  • benralizumab Combination Product
  • Placebo for Benralizumab Combination Product

Combination Product

Eligibility (public fields only)

Age range
12 Years to 75 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Mar 27, 2025
Primary completion
Nov 2, 2028
Completion
Nov 2, 2028
Last update posted
May 12, 2026

2025 – 2028

United States locations

U.S. sites
34
U.S. states
13
U.S. cities
31
Facility City State ZIP Site status
Research Site Chandler Arizona 85224 Withdrawn
Research Site Sun City Arizona 85351 Recruiting
Research Site Tucson Arizona 85704 Recruiting
Research Site Bakersfield California 93301 Not yet recruiting
Research Site Inglewood California 90301 Recruiting
Research Site Modesto California 95355 Not yet recruiting
Research Site Newport Beach California 92663 Recruiting
Research Site Pasadena California 91101 Recruiting
Research Site Denver Colorado 80206 Withdrawn
Research Site Cape Coral Florida 33990 Recruiting
Research Site Hialeah Florida 33015 Not yet recruiting
Research Site Lauderdale Lakes Florida 33313 Recruiting
Research Site Leesburg Florida 34748 Recruiting
Research Site Miami Florida 33122 Not yet recruiting
Research Site Miami Florida 33155 Not yet recruiting
Research Site Miami Florida 33175 Recruiting
Research Site Orlando Florida 32819 Recruiting
Research Site Plantation Florida 33324 Not yet recruiting
Research Site Tampa Florida 33607 Recruiting
Research Site Winter Park Florida 32789 Recruiting
Research Site Ann Arbor Michigan 48109 Recruiting
Research Site Henderson Nevada 89052 Recruiting
Research Site Northfield New Jersey 08225 Recruiting
Research Site Union City New Jersey 07087 Not yet recruiting
Research Site New Hyde Park New York 11042 Recruiting
Research Site The Bronx New York 10459 Recruiting
Research Site Oklahoma City Oklahoma 73103 Withdrawn
Research Site Oklahoma City Oklahoma 73111 Recruiting
Research Site DuBois Pennsylvania 15801 Recruiting
Research Site Warwick Rhode Island 02886 Recruiting
Research Site Greenville South Carolina 29607 Recruiting
Research Site Houston Texas 77099 Not yet recruiting
Research Site McKinney Texas 75069 Recruiting
Research Site San Antonio Texas 78251 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 125 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06750289, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted May 12, 2026 · Synced Jul 22, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06750289 live on ClinicalTrials.gov.

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