This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.

ClinicalTrials.gov ID: NCT06758401

Public ClinicalTrials.gov record NCT06758401. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 5, 2026, 12:22 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

AN OPEN-LABEL, RANDOMIZED, CONTROLLED PHASE 3 STUDY OF SIGVOTATUG VEDOTIN IN COMBINATION WITH PEMBROLIZUMAB COMPARED WITH PEMBROLIZUMAB MONOTHERAPY AS FIRST-LINE TREATMENT IN PARTICIPANTS WITH PD-L1 HIGH (≥50% OF TUMOR CELLS EXPRESSING PD-L1), LOCALLY ADVANCED, UNRESECTABLE, OR METASTATIC NON-SMALL CELL LUNG CANCER (BE6A LUNG-02)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of the study is to compare how the new combination treatment (Sigvotatug Vedotin plus pembrolizumab) works compared to pembrolizumab alone in patients with non-small cell lung cancer (NSCLC) with high levels of PD-L1. This is a protein that acts as a kind of "brake" to keep the body's immune responses under control. The study is seeking for participants who: * Are confirmed to have NSCLC (Stage 3 or 4). * Have PD-L1 levels in more than 50% of the cancer cells. All participants in this study will receive pembrolizumab at the study clinic once every 6 weeks as an intravenous (IV) infusion (give directly into a vein). In addition, half of the participants will also receive Sigvotatug Vedotin once every 2 weeks as an IV infusion in addition to receiving pembrolizumab. Participants may receive pembrolizumab for up to about two years. Those participants taking Sigvotatug Vedotin can continue until their NSCLC is no longer responding. The study team will monitorsee how each participant is doing with the study treatment during regular visits at the clinic.

Study identification

NCT ID: NCT06758401
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Pfizer; Industry
Enrollment: 714 participants

Conditions and interventions

Conditions

Interventions

Sigvotatug Vedotin Drug
Pembrolizumab Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jul 22, 2025
Primary completion: Sep 4, 2028
Completion: Feb 28, 2029
Last update posted: Jul 21, 2026

2025 – 2029

United States locations

U.S. sites: 75
U.S. states: 18
U.S. cities: 50

Facility	City	State	ZIP	Site status
Providence Medical Foundation	Fullerton	California	92835	Recruiting
Providence St. Jude Medical Center Virginia K. Crosson Cancer Center and Infusion Center	Fullerton	California	92835	Recruiting
St. Jude Heritage Medical Group - Fullerton Plaza Multi-Specialty Clinic (Pulmonary Function Test)	Fullerton	California	92835	Recruiting
Intermountain Health Cancer Center Lutheran Hospital	Golden	Colorado	80401	Recruiting
Cancer Centers of Colorado St. Mary's Regional Hospital	Grand Junction	Colorado	81501	Recruiting
Intermountain Health St. Mary's Regional Hospital	Grand Junction	Colorado	81501	Recruiting
Intermountain Health	Grand Junction	Colorado	81505	Recruiting
Intermountain Health Lutheran Hospital	Wheat Ridge	Colorado	80401	Recruiting
Washington DC Veterans Affairs Medical Center	Washington D.C.	District of Columbia	20422	Recruiting
Mid Florida Hematology and Oncology Center	Orange City	Florida	32763	Recruiting
BRCR Global	Plantation	Florida	33322	Recruiting
Endeavor Health	Elmhurst	Illinois	60126	Recruiting
Hope and Healing Cancer Services	Hinsdale	Illinois	60521	Recruiting
Endeavor Health	Naperville	Illinois	60540	Recruiting
Hope and Healing Cancer Services	New Lenox	Illinois	60451	Recruiting
Saint Luke's South Hospital	Overland Park	Kansas	66213	Recruiting
Maine Medical Center	Portland	Maine	04102	Recruiting
MaineHealth Cancer Care - Scarborough	Scarborough	Maine	04074	Recruiting
MaineHealth Cancer Care and Blood Disorders Scarborough	Scarborough	Maine	04074	Recruiting
Southcoast Centers for Cancer Care	Fairhaven	Massachusetts	02719	Recruiting
Southcoast Centers for Cancer Care	Fall River	Massachusetts	02720	Recruiting
Corewell Health - Butterworth Hospital	Grand Rapids	Michigan	49503	Not yet recruiting
Corewell Health - Lemmen Holton Cancer Pavilion	Grand Rapids	Michigan	49503	Not yet recruiting
Corewell Health - Research Specimen Processing Area	Grand Rapids	Michigan	49503	Not yet recruiting
Corewell Health Investigational Drug Services	Grand Rapids	Michigan	49503	Not yet recruiting
Corewell Health	Grand Rapids	Michigan	49503	Not yet recruiting
Minnesota Oncology Hematology, PA	Burnsville	Minnesota	55337	Recruiting
Minnesota Oncology Hematology PA	Coon Rapids	Minnesota	55433	Recruiting
M Health Fairview Cancer Clinic-Edina	Edina	Minnesota	55435	Recruiting
Minnesota Oncology Hematology PA	Edina	Minnesota	55435	Recruiting
Minnesota Oncology Hematology PA	Maple Grove	Minnesota	55369	Recruiting
M Health Fairview St. John's Hospital	Maplewood	Minnesota	55109	Recruiting
Minnesota Oncology Hematology PA	Maplewood	Minnesota	55109	Recruiting
Hennepin County Medical Center	Minneapolis	Minnesota	55415	Recruiting
North Memorial Health Cancer Center	Robbinsdale	Minnesota	55422	Recruiting
Metro Minnesota Community Oncology Research Consortium (MMCORC)	Saint Louis Park	Minnesota	55426	Recruiting
Park Nicollet Frauenshuh Cancer Center	Saint Louis Park	Minnesota	55426	Recruiting
Regions Hospital	Saint Paul	Minnesota	55101	Recruiting
Minnesota Oncology Hematology, P.A. Cornerstone Medical Specialty Center	Woodbury	Minnesota	55125	Recruiting
Jackson Oncology Associates, PLLC	Jackson	Mississippi	39202	Recruiting
Jackson Oncology Associates, PLLC	Jackson	Mississippi	39216	Recruiting
Saint Luke's Cancer Institute	Kansas City	Missouri	64111	Recruiting
Saint Luke's Hospital of Kansas City	Kansas City	Missouri	64111	Recruiting
Saint Luke's East Hospital	Lee's Summit	Missouri	64086	Recruiting
Oncology Hematology West, PC dba Nebraska Cancer Specialists - Fremont	Fremont	Nebraska	68025	Recruiting
Oncology Hematology West, PC dba Nebraska Cancer Specialists - Grand Island	Grand Island	Nebraska	68803	Recruiting
Oncology Hematology West, PC dba Nebraska Cancer Specialists - Regional	Grand Island	Nebraska	68803	Recruiting
Cancer Partners of Nebraska	Lincoln	Nebraska	68516	Recruiting
Oncology Hematology West P.C. dba Nebraska Cancer Specialists - Methodist	Omaha	Nebraska	68114	Recruiting
Oncology Hematology West, PC dba Nebraska Cancer Specialists - Bergan	Omaha	Nebraska	68124	Recruiting
Oncology Hematology West P.C. dba Nebraska Cancer Specialists	Omaha	Nebraska	68130	Recruiting
Hematology Oncology Associates of Rockland	Nyack	New York	10960	Recruiting
Brody School of Medicine at East Carolina University	Greenville	North Carolina	27834	Recruiting
ECU Health Medical Center	Greenville	North Carolina	27834	Recruiting
Carolina Cancer Research Center	Wilson	North Carolina	27893	Recruiting
University Hospitals Seidman Cancer Center at UH Avon Health Center	Avon	Ohio	44011	Recruiting
Gabrail Cancer Center Research	Canton	Ohio	44718	Recruiting
University Hospitals Cleveland Medical Center	Cleveland	Ohio	44106	Recruiting
University Hospitals Seidman Cancer Center at UH Mentor Health Center	Mentor	Ohio	44060	Recruiting
UH Minoff Health Center at Chagrin Highlands	Orange	Ohio	44122	Recruiting
The University of Texas, MD Anderson Cancer Center - Woodlands	Conroe	Texas	77384	Recruiting
Renovatio Clinical - El Paso	El Paso	Texas	79915	Recruiting
The University of Texas MD Anderson Cancer Center Diagnostic Imaging	Houston	Texas	77030	Recruiting
The University of Texas MD Anderson Cancer Center Investigational Pharmacy Services	Houston	Texas	77030	Recruiting
The University of Texas, MD Anderson Cancer Center- Interventional Radiology	Houston	Texas	77030	Recruiting
University of Texas MD Anderson Cancer Center	Houston	Texas	77030	Recruiting
The University of Texas MD Anderson Cancer Center Clinical Research Imaging	Houston	Texas	77054	Recruiting
The University of Texas, MD Anderson Cancer Center - West Houston	Houston	Texas	77079	Recruiting
Community Clinical Trials	Kingwood	Texas	77339	Recruiting
The University of Texas, MD Anderson Cancer Center - League City	League City	Texas	77573	Recruiting
The University of Texas, MD Anderson Cancer Center - Sugar Land	Sugar Land	Texas	77478	Recruiting
Renovatio Clinical	The Woodlands	Texas	77380	Recruiting
Woodlands Radiology	The Woodlands	Texas	77381	Recruiting
American Oncology Network Vista Oncology Division-West office	Olympia	Washington	98502	Recruiting
American Oncology Network Vista Oncology Division-East office	Olympia	Washington	98506	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 297 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06758401, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jul 21, 2026 · Synced Sep 5, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06758401 live on ClinicalTrials.gov.

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