Study of PF-07220060 With Letrozole in Adults With HR-positive HER2-negative Breast Cancer Who Have Not Received Anticancer Treatment for Advanced/Metastatic Disease
Public ClinicalTrials.gov record NCT06760637. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
AN INTERVENTIONAL, OPEN-LABEL, RANDOMIZED, MULTICENTER PHASE 3 STUDY OF PF-07220060 PLUS LETROZOLE COMPARED TO CDK4/6 INHIBITOR PLUS LETROZOLE IN PARTICIPANTS OVER 18 YEARS OF AGE WITH HORMONE RECEPTOR (HR)-POSITIVE, HER2-NEGATIVE ADVANCED/METASTATIC BREAST CANCER WHO HAVE NOT RECEIVED ANY PRIOR SYSTEMIC ANTICANCER TREATMENT FOR ADVANCED/METASTATIC DISEASE (FOURLIGHT-3)
Study identification
- NCT ID
- NCT06760637
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Pfizer
- Industry
- Enrollment
- 1,035 participants
Conditions and interventions
Conditions
Not listed
Interventions
Not listed
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 5, 2025
- Primary completion
- Jan 1, 2029
- Completion
- Dec 28, 2037
- Last update posted
- May 18, 2026
2025 – 2037
United States locations
- U.S. sites
- 31
- U.S. states
- 4
- U.S. cities
- 24
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| The Kirklin Clinic of UAB Hospital | Birmingham | Alabama | 35233 | — |
| The University of Alabama at Birmingham | Birmingham | Alabama | 35249 | — |
| University of Alabama at Birmingham Hospital | Birmingham | Alabama | 35249 | — |
| Ironwood Cancer & Research Centers | Chandler | Arizona | 85224 | — |
| Ironwood Cancer & Research Centers | Gilbert | Arizona | 85297 | — |
| Ironwood Cancer & Research Centers | Glendale | Arizona | 85306 | — |
| Ironwood Cancer & Research Centers | Goodyear | Arizona | 85395 | — |
| Ironwood Cancer & Research Centers | Mesa | Arizona | 85202 | — |
| Ironwood Cancer & Research Centers | Mesa | Arizona | 85206 | — |
| Ironwood Cancer & Research Centers | Phoenix | Arizona | 85028 | — |
| Ironwood Cancer & Research Centers | Scottsdale | Arizona | 85260 | — |
| CARTI Cancer Center Saline County | Bryant | Arkansas | 72022 | — |
| CARTI Cancer Center Conway | Conway | Arkansas | 72034 | — |
| Highlands Oncology | Fayetteville | Arkansas | 72703 | — |
| CARTI Cancer Center | Little Rock | Arkansas | 72205 | — |
| CARTI Cancer Center North Little Rock Urology | North Little Rock | Arkansas | 72117 | — |
| CARTI Cancer Center North Little Rock | North Little Rock | Arkansas | 72117 | — |
| CARTI Cancer Center Pine Bluff | Pine Bluff | Arkansas | 71603 | — |
| Highlands Oncology | Rogers | Arkansas | 72758 | — |
| Highlands Oncology Group | Springdale | Arkansas | 72762 | — |
| Providence Medical Foundation | Anaheim | California | 92805 | — |
| Sutter Auburn Faith Hospital | Auburn | California | 95602 | — |
| Sutter Health Alta Bates | Berkeley | California | 94704 | — |
| Cedars-Sinai Cancer Beverly Hills (drug treatment and dispensing location) | Beverly Hills | California | 90211 | — |
| Cedars-Sinai Cancer Beverly Hills | Beverly Hills | California | 90211 | — |
| Marshall Cancer Center | Cameron Park | California | 95682 | — |
| Enloe Medical Center | Chico | California | 95926 | — |
| Enloe Regional Cancer Center | Chico | California | 95926 | — |
| City of Hope Investigational Drug Service (IDS) | Duarte | California | 91010 | — |
| City of Hope(City of Hope National Medical Center,City of Hope Medical Center) | Duarte | California | 91010 | — |
| UCSF Washington Hospital Cancer Center/ Washington Hospital Healthcare System | Fremont | California | 94538 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06760637, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 18, 2026 · Synced May 21, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06760637 live on ClinicalTrials.gov.