ClinicalTrials.gov record
Study of PF-07220060 With Letrozole in Adults With HR-positive HER2-negative Breast Cancer Who Have Not Received Anticancer Treatment for Advanced/Metastatic Disease
ClinicalTrials.gov ID: NCT06760637
Public ClinicalTrials.gov record NCT06760637. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
AN INTERVENTIONAL, OPEN-LABEL, RANDOMIZED, MULTICENTER PHASE 3 STUDY OF PF-07220060 PLUS LETROZOLE COMPARED TO CDK4/6 INHIBITOR PLUS LETROZOLE IN PARTICIPANTS OVER 18 YEARS OF AGE WITH HORMONE RECEPTOR (HR)-POSITIVE, HER2-NEGATIVE ADVANCED/METASTATIC BREAST CANCER WHO HAVE NOT RECEIVED ANY PRIOR SYSTEMIC ANTICANCER TREATMENT FOR ADVANCED/METASTATIC DISEASE (FOURLIGHT-3)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to determine the safety and efficacy of PF-07220060 with letrozole compared to approved treatments (ie, palbociclib, ribociclib or abemaciclib with letrozole) in people with breast cancer: * HR-positive (breast cancer cells that need estrogen or progesterone to grow) * HER2-negative (cells that have a small amount or none of a protein called HER2 on their surface); * locally advanced (that has spread from where it started to nearby tissue or lymph nodes) or metastatic disease (the spread of cancer to other places in the body) * who have not received any prior systemic anti-cancer treatment for advanced/metastatic disease. Approximately half of the participants will receive PF-07220060 plus letrozole while the other half of participants will receive the investigator's choice of treatment plus letrozole. The study team will monitor how each participant is doing with the study treatment during regular visits at the study clinic.
Study identification
- NCT ID
- NCT06760637
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,035 participants
Conditions and interventions
Conditions
Interventions
- PF-07220060 Drug
- letrozole Drug
- abemaciclib Drug
- palbociclib Drug
- ribociclib Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 6, 2025 (Actual)
- Primary completion
- Jan 2, 2029 (Estimated)
- Completion
- Dec 29, 2037 (Estimated)
- Last update posted
- Oct 16, 2026
2025 – 2037
United States locations
- U.S. sites
- 216
- U.S. states
- 26
- U.S. cities
- 135
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| The Kirklin Clinic of UAB Hospital | Birmingham | Alabama | 35233 | — |
| The University of Alabama at Birmingham | Birmingham | Alabama | 35249 | — |
| University of Alabama at Birmingham Hospital | Birmingham | Alabama | 35249 | — |
| Ironwood Cancer & Research Centers | Chandler | Arizona | 85224 | — |
| Ironwood Cancer & Research Centers | Gilbert | Arizona | 85297 | — |
| Ironwood Cancer & Research Centers | Glendale | Arizona | 85306 | — |
| Ironwood Cancer & Research Centers | Goodyear | Arizona | 85395 | — |
| Ironwood Cancer & Research Centers | Mesa | Arizona | 85202 | — |
| Ironwood Cancer & Research Centers | Mesa | Arizona | 85206 | — |
| Ironwood Cancer & Research Centers | Phoenix | Arizona | 85028 | — |
| Ironwood Cancer & Research Centers | Scottsdale | Arizona | 85260 | — |
| CARTI Cancer Center Saline County | Bryant | Arkansas | 72022 | — |
| CARTI Cancer Center Conway | Conway | Arkansas | 72034 | — |
| Highlands Oncology Group, PA | Fayetteville | Arkansas | 72703 | — |
| CARTI Cancer Center | Little Rock | Arkansas | 72205 | — |
| CARTI Cancer Center North Little Rock Urology | North Little Rock | Arkansas | 72117 | — |
| CARTI Cancer Center North Little Rock | North Little Rock | Arkansas | 72117 | — |
| CARTI Cancer Center Pine Bluff | Pine Bluff | Arkansas | 71603 | — |
| Highlands Oncology Group, PA | Rogers | Arkansas | 72758 | — |
| Highlands Oncology Group, PA | Springdale | Arkansas | 72762 | — |
| Sutter Auburn Faith Hospital | Auburn | California | 95602 | — |
| Sutter Health Alta Bates | Berkeley | California | 94704 | — |
| Cedars-Sinai Cancer Beverly Hills (drug treatment and dispensing location) | Beverly Hills | California | 90211 | — |
| Cedars-Sinai Cancer Beverly Hills | Beverly Hills | California | 90211 | — |
| Marshall Cancer Center | Cameron Park | California | 95682 | — |
| Enloe Medical Center | Chico | California | 95926 | — |
| Enloe Regional Cancer Center | Chico | California | 95926 | — |
| City of Hope Investigational Drug Service (IDS) | Duarte | California | 91010 | — |
| City of Hope(City of Hope National Medical Center,City of Hope Medical Center) | Duarte | California | 91010 | — |
| UCSF Washington Hospital Cancer Center/ Washington Hospital Healthcare System | Fremont | California | 94538 | — |
| Premier Cancer Care and Infusion Center - Fresno - North Thesta Street | Fresno | California | 93710 | — |
| Providence Medical Foundation | Fullerton | California | 92835 | — |
| Providence St. Jude Medical Center Virginia K Crosson Cancer Center & Infusion Center | Fullerton | California | 92835 | — |
| City of Hope - Seacliff | Huntington Beach | California | 92648 | — |
| City of Hope at Irvine Lennar | Irvine | California | 92618 | — |
| City of Hope Investigational Drug Service (IDS) | Irvine | California | 92618 | — |
| Hoag Health Center Irvine | Irvine | California | 92618 | — |
| Hoag Hospital Irvine | Irvine | California | 92618 | — |
| City of Hope-Antelope Valley | Lancaster | California | 93534 | — |
| City of Hope at Long Beach Elm | Long Beach | California | 90813 | — |
| Cancer and Blood Research Center, LLC | Los Alamitos | California | 90720 | — |
| Cancer and Blood Specialty Clinic / Cancer and Blood Research Center, LLC | Los Alamitos | California | 90720 | — |
| Keck Hospital of USC | Los Angeles | California | 90033 | — |
| Los Angeles General Medical Center | Los Angeles | California | 90033 | — |
| Norris Healthcare Center 3 (HC3) | Los Angeles | California | 90033 | — |
| USC/Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| Cedars-Sinai Cancer at Cedars-Sinai Medical Center (drug treatment and dispensing location) | Los Angeles | California | 90048 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| Ellison Medical Institute | Los Angeles | California | 90064 | — |
| UCLA Department of Medicine - Hematology/Oncology | Los Angeles | California | 90095 | — |
| Hoag Memorial Hospital Presbyterian | Newport Beach | California | 92663 | — |
| Keck Medicine of USC Norris Oncology/Hematology - Newport Beach Treatment Center | Newport Beach | California | 92663 | — |
| USC Norris Oncology/Hematology - Newport Beach | Newport Beach | California | 92663 | — |
| Sutter Health Palo Alto | Palo Alto | California | 94301 | — |
| Clinical and Translational Research Unit (CTRU) | Palo Alto | California | 94304 | — |
| Stanford Cancer Center | Palo Alto | California | 94304 | — |
| Stanford Women's Cancer Center | Palo Alto | California | 94304 | — |
| Keck Medical Center of USC Pasadena | Pasadena | California | 91105 | — |
| Marshall Hospital | Placerville | California | 95667 | — |
| UCLA Hematology/Oncology - Porter Ranch | Porter Ranch | California | 91326 | — |
| Sutter Roseville Medical Center | Roseville | California | 95661 | — |
| Sutter Health - Sutter Institute for Medical Research | Sacramento | California | 95816 | — |
| University of California Davis (UC Davis) Comprehensive Cancer Center | Sacramento | California | 95817 | — |
| University of California Davis Medical Center | Sacramento | California | 95817 | — |
| University of California, San Francisco (UCSF) Helen Diller Family Comprehensive Cancer Center | San Francisco | California | 94158 | — |
| UCLA Hematology/Oncology - San Luis Obispo | San Luis Obispo | California | 93401 | — |
| Tower Saint John's Imaging | Santa Monica | California | 90403 | — |
| Providence Saint John's Health Center | Santa Monica | California | 90404 | — |
| UCLA Hematology/Oncology - Parkside | Santa Monica | California | 90404 | — |
| UCLA Hematology/Oncology - Santa Monica | Santa Monica | California | 90404 | — |
| City of Hope-South Pasadena | South Pasadena | California | 91030 | — |
| Stanford Health Care, Investigational Drug Service | Stanford | California | 94305 | — |
| Sutter Health Sunnyvale | Sunnyvale | California | 94086 | — |
| Cedars-Sinai Cancer Tarzana | Tarzana | California | 91356 | — |
| Cancer AND Blood Specialty Clinic | Torrance | California | 90505 | — |
| Hunt Cancer Institute, an Affiliate of Cedars-Sinai Cancer | Torrance | California | 90505 | — |
| Tahoe Forest Cancer Center | Truckee | California | 96161 | — |
| City of Hope - Upland | Upland | California | 91786 | — |
| Wellness Oncology Hematology | West Hills | California | 91307 | — |
| Breast Health Services Building | West Hollywood | California | 90048 | — |
| UCLA Hematology/Oncology - Westlake | Westlake Village | California | 91361 | — |
| Denver Health and Hospital Authority | Denver | Colorado | 80204 | — |
| Intermountain Health Lutheran Hospital | Golden | Colorado | 80401 | — |
| Lutheran Hospital - Cancer Centers of Colorado | Golden | Colorado | 80401 | — |
| Cancer Centers of Colorado St. Mary's Regional Hospital | Grand Junction | Colorado | 81501 | — |
| Intermountain Health Saint Mary's Regional Hospital | Grand Junction | Colorado | 81501 | — |
| Intermountain Health | Grand Junction | Colorado | 81505 | — |
| MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| AdventHealth Altamonte Infusion Center | Altamonte Springs | Florida | 32701 | — |
| AdventHealth Altamonte Springs | Altamonte Springs | Florida | 32701 | — |
| AdventHealth Medical Group Altamonte | Altamonte Springs | Florida | 32701 | — |
| Boca Raton Regional Hospital | Boca Raton | Florida | 33486 | — |
| Baptist MD Anderson Cancer Center | Jacksonville | Florida | 32207 | — |
| AdventHealth Orlando | Orlando | Florida | 32803 | — |
| AdventHealth Medical Group Orlando | Orlando | Florida | 32804 | — |
| AdventHealth Orlando Infusion Center | Orlando | Florida | 32804 | — |
| Summit Cancer Care, PC | Savannah | Georgia | 31405 | — |
| St. Luke's Cancer Institute: Boise | Boise | Idaho | 83712 | — |
| St. Luke's Regional Medical Center | Boise | Idaho | 83712 | — |
| St. Luke's Cancer Institute-Fruitland | Fruitland | Idaho | 83619 | — |
| St. Luke's Cancer Institute-Meridian | Meridian | Idaho | 83642 | — |
| St. Lukes Meridian Medical Center | Meridian | Idaho | 83642 | — |
| St. Luke's Cancer Institute-Nampa | Nampa | Idaho | 83687 | — |
| Ingalls Family Care Center | Calumet City | Illinois | 60409 | — |
| UChicago Medicine - River East | Chicago | Illinois | 60611 | — |
| University of Illinois at Chicago | Chicago | Illinois | 60612 | — |
| University of Illinois Hospital and Health Sciences System | Chicago | Illinois | 60612 | — |
| University of Chicago Medical Center, CCD | Chicago | Illinois | 60637 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| Endeavor Health Cancer Institute at Swedish Hospital, Nancy W. Knowles Cancer Center | Elmhurst | Illinois | 60126 | — |
| Endeavor Health | Evanston | Illinois | 60201 | — |
| Prime Saint Francis-Infusion Services Evanston | Evanston | Illinois | 60202 | — |
| UChicago Medicine at Ingalls - Flossmoor | Flossmoor | Illinois | 60422 | — |
| UChicago Medicine Ingalls Memorial | Harvey | Illinois | 60426 | — |
| Hope and Healing Cancer Services | Hinsdale | Illinois | 60521 | — |
| Endeavor Health Cancer Institute at Swedish Hospital | Naperville | Illinois | 60540 | — |
| Hope and Healing Cancer Services | New Lenox | Illinois | 60451 | — |
| University of Chicago Comprehensive Cancer Center at Silver Cross Hospital | New Lenox | Illinois | 60451 | — |
| The University of Chicago Medicine Center for Advanced Care Orland Park. | Orland Park | Illinois | 60462 | — |
| Memorial Hospital | Shiloh | Illinois | 62269 | — |
| Siteman Cancer Center - Shiloh | Shiloh | Illinois | 62269 | — |
| Orchard Healthcare Research Inc. | Skokie | Illinois | 60077 | — |
| Prime Saint Francis-Infusion Services Skokie | Skokie | Illinois | 60077 | — |
| UChicago Medicine at Ingalls - Tinley Park | Tinley Park | Illinois | 60477 | — |
| UChicago Medicine - Northwest Indiana | Crown Point | Indiana | 46307 | — |
| Velocity Clinical Research | Annapolis | Maryland | 21401 | — |
| Mercy Medical Center - Baltimore | Baltimore | Maryland | 21202 | — |
| MedStar Health Research Institute, Inc | Columbia | Maryland | 21044 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| Dana-Farber Cancer Institute - Chestnut Hill | Newton | Massachusetts | 02459 | — |
| Allina Health Cancer Institute - Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Allina Health Cancer Institute - Abbott Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Allina Health Cancer Institute - WestHealth | Plymouth | Minnesota | 55441 | — |
| Allina Health Cancer Institute - United Hospital | Saint Paul | Minnesota | 55102 | — |
| St. Francis Cancer Center | Shakopee | Minnesota | 55379 | — |
| Siteman Cancer Center - St Peters | City of Saint Peters | Missouri | 63376 | — |
| Siteman Cancer Center - West County | Creve Coeur | Missouri | 63141 | — |
| Siteman Cancer Center - North County | Florissant | Missouri | 63031 | — |
| Saint Luke's Cancer Institute | Kansas City | Missouri | 64111 | — |
| Saint Luke's Hospital of Kansas City | Kansas City | Missouri | 64111 | — |
| Siteman Cancer Center | St Louis | Missouri | 63108 | — |
| Barnes-Jewish Hospital | St Louis | Missouri | 63110 | — |
| Washington University School of Medicine - Siteman Cancer Center | St Louis | Missouri | 63110 | — |
| Siteman Cancer Center - South County | St Louis | Missouri | 63129 | — |
| Bozeman Health Deaconess Hospital | Bozeman | Montana | 59715 | — |
| Renown Health Medical Oncology | Reno | Nevada | 89502 | — |
| Renown Office of Clinical Research | Reno | Nevada | 89502 | — |
| Renown Regional Medical Center | Reno | Nevada | 89502 | — |
| Renown Health Conrad Breast Center | Reno | Nevada | 89521 | — |
| Renown South Meadows Medical Center | Reno | Nevada | 89521 | — |
| Cooperman Barnabas Medical Center | Livingston | New Jersey | 07039 | — |
| Jack & Sheryl Morris Cancer Center | New Brunswick | New Jersey | 08901 | — |
| Rutgers Cancer Institute | New Brunswick | New Jersey | 08901 | — |
| NYU Langone Health - Brooklyn | Brooklyn | New York | 11220 | — |
| Perlmutter Cancer Center - Sunset Park | Brooklyn | New York | 11220 | — |
| Perlmutter Cancer Center at NYU Langone Hospital - Long Island | Mineola | New York | 11501 | — |
| Perlmutter Cancer Center at NYU Winthrop Hospital Infusion Center | Mineola | New York | 11501 | — |
| Laura and Isaac Perlmutter Cancer Center | New York | New York | 10016 | — |
| NYU Langone Medical Center - Tisch Hospital | New York | New York | 10016 | — |
| University of Rochester Cancer Center Pharmacy | Rochester | New York | 14642 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| Stony Brook University | Stony Brook | New York | 11794 | — |
| University of North Carolina Medical Center | Chapel Hill | North Carolina | 27514 | — |
| University of North Carolina Hospitals at Hillsborough | Hillsborough | North Carolina | 27278 | — |
| Ohio State University Hospital | Columbus | Ohio | 43210 | — |
| The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C | Columbus | Ohio | 43210 | — |
| Stefanie Spielman Comprehensive Breast Cancer | Columbus | Ohio | 43212 | — |
| Oncology Associates of Oregon, P.C. | Albany | Oregon | 97321 | — |
| Oncology Associates of Oregon, P.C. | Eugene | Oregon | 97401 | — |
| Providence Cancer Institute Franz Clinic | Portland | Oregon | 97213 | — |
| Providence Portland Medical Center Investigational Drug Services | Portland | Oregon | 97213 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| Providence Investigational Drug Service - Westside | Portland | Oregon | 97225 | — |
| Providence Oncology and Hematology Care Clinic - Westside | Portland | Oregon | 97225 | — |
| Providence St. Vincent Medical Center | Portland | Oregon | 97225 | — |
| Oncology Associates of Oregon, P.C. | Springfield | Oregon | 97477 | — |
| Texas Oncology - DFW | Arlington | Texas | 76012 | — |
| Texas Oncology - DFW | Arlington | Texas | 76014 | — |
| Texas Oncology - DFW | Bedford | Texas | 76022 | — |
| Texas Oncology - DFW | Dallas | Texas | 75203 | — |
| Texas Oncology - DFW | Dallas | Texas | 75230 | — |
| Texas Oncology - DFW | Dallas | Texas | 75231 | — |
| Texas Oncology - DFW | Dallas | Texas | 75237 | — |
| Texas Oncology - DFW | Dallas | Texas | 75246 | — |
| Texas Oncology - DFW | Fort Worth | Texas | 76104 | — |
| Texas Oncology - DFW | Grapevine | Texas | 76051 | — |
| US Oncology Investigational Product Center (IPC) | Irving | Texas | 75063 | — |
| US Oncology Investigational Products Center | Irving | Texas | 75063 | — |
| US Oncology lnvestigational Products Center (IPC) | Irving | Texas | 75063 | — |
| Texas Oncology - DFW | Plano | Texas | 75075 | — |
| Texas Oncology - DFW | Plano | Texas | 75093 | — |
| Baylor Scott & White Health - Round Rock | Round Rock | Texas | 78665 | — |
| Baylor Scott & White Research Institute - Round Rock | Round Rock | Texas | 78665 | — |
| The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center | Tyler | Texas | 75701 | — |
| The University of Texas Health Science Center at Tyler on behalf of UT Health East Texas HOPE Cancer | Tyler | Texas | 75708 | — |
| Utah Cancer Specialists | Bountiful | Utah | 84010 | — |
| Utah Cancer Specialists | Layton | Utah | 84041 | — |
| Utah Cancer Specialists | Murray | Utah | 84107 | — |
| Utah Cancer Specialists | Ogden | Utah | 84405 | — |
| Utah Cancer Specialists | Orem | Utah | 84057 | — |
| Utah Cancer Specialists | Pleasant Grove | Utah | 84062 | — |
| Utah Cancer Specialists | Provo | Utah | 84604 | — |
| Utah Cancer Specialists | Salt Lake City | Utah | 84102 | — |
| Utah Cancer Specialists | Salt Lake City | Utah | 84106 | — |
| Utah Cancer Specialists | West Jordan | Utah | 84088 | — |
| Utah Cancer Specialists | West Valley City | Utah | 84119 | — |
| Virginia Cancer Specialists, PC | Fairfax | Virginia | 22031 | — |
| Virginia Cancer Specialists, PC | Manassas | Virginia | 20110 | — |
| Bon Secours Cancer Institute at Memorial Regional | Mechanicsville | Virginia | 23116 | — |
| Bon Secours St. Francis Medical Center | Midlothian | Virginia | 23114 | — |
| Virginia Cancer Specialists, PC | Reston | Virginia | 20190 | — |
| Bon Secours Cancer Institute at St. Mary's | Richmond | Virginia | 23226 | — |
| University of Wisconsin Carbone Cancer Center - Eastpark Medical Center | Madison | Wisconsin | 53718 | — |
| University of Wisconsin Carbone Cancer Center - University Hospital | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 244 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06760637, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 16, 2026 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06760637 live on ClinicalTrials.gov.