ClinicalTrials.gov record
Recruiting Phase 3 Interventional

Study of PF-07220060 With Letrozole in Adults With HR-positive HER2-negative Breast Cancer Who Have Not Received Anticancer Treatment for Advanced/Metastatic Disease

ClinicalTrials.gov ID: NCT06760637

Public ClinicalTrials.gov record NCT06760637. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced May 8, 2026, 8:09 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

AN INTERVENTIONAL, OPEN-LABEL, RANDOMIZED, MULTICENTER PHASE 3 STUDY OF PF-07220060 PLUS LETROZOLE COMPARED TO CDK4/6 INHIBITOR PLUS LETROZOLE IN PARTICIPANTS OVER 18 YEARS OF AGE WITH HORMONE RECEPTOR (HR)-POSITIVE, HER2-NEGATIVE ADVANCED/METASTATIC BREAST CANCER WHO HAVE NOT RECEIVED ANY PRIOR SYSTEMIC ANTICANCER TREATMENT FOR ADVANCED/METASTATIC DISEASE (FOURLIGHT-3)

Study identification

NCT ID
NCT06760637
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Pfizer
Industry
Enrollment
1,020 participants

Conditions and interventions

Conditions

Interventions

  • PF-07220060 Drug
  • abemaciclib Drug
  • letrozole Drug
  • palbociclib Drug
  • ribociclib Drug

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jan 5, 2025
Primary completion
Jan 1, 2029
Completion
Dec 28, 2037
Last update posted
Mar 1, 2026

2025 โ€“ 2037

United States locations

U.S. sites
240
U.S. states
26
U.S. cities
150
Facility City State ZIP Site status
The Kirklin Clinic of UAB Hospital Birmingham Alabama 35233 Recruiting
The University of Alabama at Birmingham Birmingham Alabama 35249 Recruiting
University of Alabama at Birmingham Hospital Birmingham Alabama 35249 Recruiting
Ironwood Cancer & Research Centers Chandler Arizona 85224 Recruiting
Ironwood Cancer & Research Centers Gilbert Arizona 85297 Recruiting
Ironwood Cancer & Research Centers Glendale Arizona 85306 Recruiting
Ironwood Cancer & Research Centers Goodyear Arizona 85395 Recruiting
Ironwood Cancer & Research Centers Mesa Arizona 85202 Recruiting
Ironwood Cancer & Research Centers Mesa Arizona 85206 Recruiting
Ironwood Cancer & Research Centers Phoenix Arizona 85028 Recruiting
Ironwood Cancer & Research Centers Scottsdale Arizona 85260 Recruiting
CARTI Cancer Center Saline County Bryant Arkansas 72022 Recruiting
CARTI Cancer Center Conway Conway Arkansas 72034 Recruiting
Highlands Oncology Fayetteville Arkansas 72703 Recruiting
CARTI Cancer Center Little Rock Arkansas 72205 Recruiting
CARTI Cancer Center North Little Rock Urology North Little Rock Arkansas 72117 Recruiting
CARTI Cancer Center North Little Rock North Little Rock Arkansas 72117 Recruiting
CARTI Cancer Center Pine Bluff Pine Bluff Arkansas 71603 Recruiting
Highlands Oncology Rogers Arkansas 72758 Recruiting
Highlands Oncology Group Springdale Arkansas 72762 Recruiting
Sutter Auburn Faith Hospital Auburn California 95602 Recruiting
Sutter Health Alta Bates Berkeley California 94704 Recruiting
Cedars-Sinai Cancer Beverly Hills (drug treatment and dispensing location) Beverly Hills California 90211 Recruiting
Cedars-Sinai Cancer Beverly Hills Beverly Hills California 90211 Recruiting
Marshall Cancer Center Cameron Park California 95682 Recruiting
Enloe Medical Center Chico California 95926 Recruiting
Enloe Regional Cancer Center Chico California 95926 Recruiting
City of Hope Investigational Drug Service (IDS) Duarte California 91010 Recruiting
City of Hope(City of Hope National Medical Center,City of Hope Medical Center) Duarte California 91010 Recruiting
UCSF Washington Hospital Cancer Center/ Washington Hospital Healthcare System Fremont California 94538 Recruiting
Premier Cancer Care and Infusion Center - Fresno - North Thesta Street Fresno California 93710 Recruiting
Providence Medical Foundation Fullerton California 92835 Recruiting
Providence St. Jude Medical Center Fullerton California 92835 Recruiting
City of Hope at Irvine Lennar Irvine California 92618 Recruiting
City of Hope Investigational Drug Service (IDS) Irvine California 92618 Recruiting
Hoag Health Center Irvine Irvine California 92618 Recruiting
Hoag Hospital Irvine Irvine California 92618 Recruiting
City of Hope-Antelope Valley Lancaster California 93534 Recruiting
City of Hope at Long Beach Elm Long Beach California 90813 Recruiting
Cancer and Blood Research Center, LLC Los Alamitos California 90720 Recruiting
Cancer and Blood Specialty Clinic / Cancer and Blood Research Center, LLC Los Alamitos California 90720 Recruiting
Keck Hospital of USC Los Angeles California 90033 Recruiting
Los Angeles General Medical Center Los Angeles California 90033 Recruiting
Norris Healthcare Center 3 (HC3) Los Angeles California 90033 Recruiting
USC/Norris Comprehensive Cancer Center Los Angeles California 90033 Recruiting
Cedars-Sinai Cancer at Cedars-Sinai Medical Center (drug treatment and dispensing location) Los Angeles California 90048 Recruiting
Cedars-Sinai Medical Center Los Angeles California 90048 Recruiting
Ellison Medical Institute Los Angeles California 90064 Recruiting
UCLA Department of Medicine - Hematology/Oncology Los Angeles California 90095 Recruiting
Hoag Memorial Hospital Presbyterian Newport Beach California 92663 Recruiting
Keck Medicine of USC Norris Oncology/Hematology - Newport Beach Treatment Center Newport Beach California 92663 Recruiting
USC Norris Oncology/Hematology - Newport Beach Newport Beach California 92663 Recruiting
Sutter Health Palo Alto Palo Alto California 94301 Recruiting
Clinical and Translational Research Unit (CTRU) Palo Alto California 94304 Recruiting
Stanford Cancer Center Palo Alto California 94304 Recruiting
Stanford Women's Cancer Center Palo Alto California 94304 Recruiting
Keck Medical Center of USC Pasadena Pasadena California 91105 Recruiting
Marshall Hospital Placerville California 95667 Recruiting
UCLA Hematology/Oncology - Porter Ranch Porter Ranch California 91326 Recruiting
Sutter Roseville Medical Center Roseville California 95661 Recruiting
Sutter Health - Sutter Institute for Medical Research Sacramento California 95816 Recruiting
University of California Davis (UC Davis) Comprehensive Cancer Center Sacramento California 95817 Recruiting
University of California Davis Medical Center Sacramento California 95817 Recruiting
University of California, San Francisco (UCSF) Helen Diller Family Comprehensive Cancer Center San Francisco California 94158 Recruiting
UCLA Hematology/Oncology - San Luis Obispo San Luis Obispo California 93401 Recruiting
Tower Saint John's Imaging Santa Monica California 90403 Recruiting
Providence Saint John's Health Center Santa Monica California 90404 Recruiting
UCLA Hematology/Oncology - Parkside Santa Monica California 90404 Recruiting
UCLA Hematology/Oncology - Santa Monica Santa Monica California 90404 Recruiting
Stanford Health Care, Investigational Drug Service Stanford California 94305 Recruiting
Sutter Health Sunnyvale Sunnyvale California 94086 Recruiting
Cedars-Sinai Cancer Tarzana Tarzana California 91356 Recruiting
Cancer AND Blood Specialty Clinic Torrance California 90505 Recruiting
Hunt Cancer Institute, an Affiliate of Cedars-Sinai Cancer Torrance California 90505 Recruiting
Tahoe Forest Cancer Center Truckee California 96161 Recruiting
City of Hope - Upland Upland California 91786 Recruiting
Wellness Oncology Hematology West Hills California 91307 Recruiting
Breast Health Services Building West Hollywood California 90048 Recruiting
UCLA Hematology/Oncology - Westlake Westlake Village California 91361 Recruiting
Denver Health and Hospital Authority Denver Colorado 80204 Recruiting
Intermountain Health St. Joseph Hospital Denver Colorado 80218 Recruiting
Saint Joseph Hospital - Cancer Centers of Colorado Denver Colorado 80218 Recruiting
Intermountain Health Lutheran Hospital Golden Colorado 80401 Recruiting
Lutheran Hospital - Cancer Centers of Colorado Golden Colorado 80401 Recruiting
Cancer Centers of Colorado St. Mary's Regional Hospital Grand Junction Colorado 81501 Recruiting
Intermountain Health Saint Mary's Regional Hospital Grand Junction Colorado 81501 Recruiting
Intermountain Health Grand Junction Colorado 81505 Recruiting
MedStar Washington Hospital Center Washington D.C. District of Columbia 20010 Recruiting
AdventHealth Altamonte Infusion Center Altamonte Springs Florida 32701 Recruiting
AdventHealth Altamonte Springs Altamonte Springs Florida 32701 Recruiting
AdventHealth Medical Group Altamonte Altamonte Springs Florida 32701 Recruiting
Mount Sinai Medical Center, Aventura Aventura Florida 33180 Recruiting
Boca Raton Regional Hospital Boca Raton Florida 33486 Recruiting
Baptist MD Anderson Cancer Center Jacksonville Florida 32207 Recruiting
Mount Sinai Comprehensive Cancer Center Miami Beach Florida 33140 Recruiting
Mount Sinai Medical Center Miami Beach Florida 33140 Recruiting
Mid Florida Hematology and Oncology Center Orange City Florida 32763 Recruiting
AdventHealth Orlando Orlando Florida 32803 Recruiting
AdventHealth Medical Group Orlando Orlando Florida 32804 Recruiting
AdventHealth Orlando Infusion Center Orlando Florida 32804 Recruiting
Cleveland Clinic Florida Weston Florida 33331 Not yet recruiting
University Cancer & Blood Center, LLC Athens Georgia 30607 Not yet recruiting
Grady Health System Correll Pavilion Atlanta Georgia 30303 Not yet recruiting
Emory University Hospital Midtown Atlanta Georgia 30308 Not yet recruiting
Emory University Hospital Atlanta Georgia 30322 Not yet recruiting
Winship Cancer Institute Atlanta Georgia 30322 Not yet recruiting
Emory Saint Joseph's Hospital Atlanta Georgia 30342 Not yet recruiting
Emory Decatur Hospital Decatur Georgia 30033 Not yet recruiting
Emory Johns Creek Hospital Johns Creek Georgia 30097 Not yet recruiting
Summit Cancer Care, PC Savannah Georgia 31405 Recruiting
St. Luke's Cancer Institute: Boise Boise Idaho 83712 Recruiting
St. Luke's Regional Medical Center Boise Idaho 83712 Recruiting
St. Luke's Cancer Institute-Fruitland Fruitland Idaho 83619 Recruiting
St. Luke's Cancer Institute-Meridian Meridian Idaho 83642 Recruiting
St. Lukes Meridian Medical Center Meridian Idaho 83642 Recruiting
St. Luke's Cancer Institute-Nampa Nampa Idaho 83687 Recruiting
Advocate Good Shepherd Hospital Barrington Illinois 60010 Recruiting
Ingalls Family Care Center Calumet City Illinois 60409 Recruiting
UChicago Medicine - River East Chicago Illinois 60611 Recruiting
University of Illinois at Chicago Chicago Illinois 60612 Recruiting
University of Illinois Hospital and Health Sciences System Chicago Illinois 60612 Recruiting
University of Chicago Medical Center, CCD Chicago Illinois 60637 Recruiting
University of Chicago Medical Center Chicago Illinois 60637 Recruiting
AMG Crystal Lake -Oncology Crystal Lake Illinois 60014 Recruiting
Endeavor Health Cancer Institute at Swedish Hospital, Nancy W. Knowles Cancer Center Elmhurst Illinois 60126 Recruiting
Prime Saint Francis-Infusion Services Evanston Evanston Illinois 60202 Recruiting
UChicago Medicine at Ingalls - Flossmoor Flossmoor Illinois 60422 Recruiting
UChicago Medicine Ingalls Memorial Harvey Illinois 60426 Recruiting
Hope and Healing Cancer Services Hinsdale Illinois 60521 Recruiting
Advocate Medical Group - Libertyville Oncology Libertyville Illinois 60048 Recruiting
Endeavor Health Cancer Institute at Swedish Hospital Naperville Illinois 60540 Recruiting
Hope and Healing Cancer Services New Lenox Illinois 60451 Recruiting
University of Chicago Comprehensive Cancer Center at Silver Cross Hospital New Lenox Illinois 60451 Recruiting
Advocate Christ Medical Center Oak Lawn Illinois 60453 Recruiting
The University of Chicago Medicine Center for Advanced Care Orland Park. Orland Park Illinois 60462 Recruiting
Advocate Lutheran General Hospital Park Ridge Illinois 60068 Recruiting
Advocate Medical Group Park Ridge Illinois 60068 Recruiting
Memorial Hospital Shiloh Illinois 62269 Recruiting
Siteman Cancer Center - Shiloh Shiloh Illinois 62269 Recruiting
Orchard Healthcare Research Inc. Skokie Illinois 60077 Recruiting
Prime Saint Francis-Infusion Services Skokie Skokie Illinois 60077 Recruiting
UChicago Medicine at Ingalls - Tinley Park Tinley Park Illinois 60477 Recruiting
UChicago Medicine - Northwest Indiana Crown Point Indiana 46307 Recruiting
Velocity Clinical Research Annapolis Maryland 21401 Recruiting
Mercy Medical Center - Baltimore Baltimore Maryland 21202 Recruiting
Brigham and Women's Hospital Boston Massachusetts 02115 Recruiting
Boston Medical Center (Investigational Pharmacy services, IP delivery) Boston Massachusetts 02118 Not yet recruiting
Boston Medical Center Boston Massachusetts 02118 Not yet recruiting
Beth Israel Deaconess Medical Center Boston Massachusetts 02215 Recruiting
Dana-Farber Cancer Institute Boston Massachusetts 02215 Recruiting
Dana-Farber Cancer Institute - Chestnut Hill Newton Massachusetts 02459 Recruiting
Allina Health Cancer Institute - Mercy Hospital Coon Rapids Minnesota 55433 Recruiting
Allina Health Cancer Institute - Abbott Northwestern Hospital Minneapolis Minnesota 55407 Recruiting
Allina Health Cancer Institute - WestHealth Plymouth Minnesota 55441 Recruiting
Allina Health Cancer Institute - United Hospital Saint Paul Minnesota 55102 Recruiting
St. Francis Cancer Center Shakopee Minnesota 55379 Recruiting
Siteman Cancer Center - St Peters City of Saint Peters Missouri 63376 Recruiting
Siteman Cancer Center - West County Creve Coeur Missouri 63141 Recruiting
Siteman Cancer Center - North County Florissant Missouri 63031 Recruiting
Saint Luke's Cancer Institute Kansas City Missouri 64111 Recruiting
Siteman Cancer Center St Louis Missouri 63108 Recruiting
Barnes-Jewish Hospital St Louis Missouri 63110 Recruiting
Washington University School of Medicine - Siteman Cancer Center St Louis Missouri 63110 Recruiting
Siteman Cancer Center - South County St Louis Missouri 63129 Recruiting
Bozeman Health Deaconess Hospital Bozeman Montana 59715 Recruiting
Renown Health Medical Oncology Reno Nevada 89502 Recruiting
Renown Office of Clinical Research Reno Nevada 89502 Recruiting
Renown Regional Medical Center Reno Nevada 89502 Recruiting
Renown Health Conrad Breast Center Reno Nevada 89521 Recruiting
Renown South Meadows Medical Center Reno Nevada 89521 Recruiting
Cooperman Barnabas Medical Center Livingston New Jersey 07039 Recruiting
Jack & Sheryl Morris Cancer Center New Brunswick New Jersey 08901 Recruiting
Rutgers Cancer Institute New Brunswick New Jersey 08901 Recruiting
Robert Wood Johnson University Hospital Somerset Somerville New Jersey 08876 Recruiting
NYU Langone Health - Brooklyn Brooklyn New York 11220 Recruiting
Perlmutter Cancer Center - Sunset Park Brooklyn New York 11220 Recruiting
Perlmutter Cancer Center at NYU Langone Hospital - Long Island Mineola New York 11501 Recruiting
Perlmutter Cancer Center at NYU Winthrop Hospital Infusion Center Mineola New York 11501 Recruiting
Laura and Isaac Perlmutter Cancer Center New York New York 10016 Recruiting
NYU Langone Medical Center - Tisch Hospital New York New York 10016 Recruiting
University of Rochester Cancer Center Pharmacy Rochester New York 14642 Recruiting
University of Rochester Medical Center Rochester New York 14642 Recruiting
Stony Brook University Stony Brook New York 11794 Recruiting
SUNY Upstate Medical University Syracuse New York 13210 Recruiting
University of North Carolina Medical Center Chapel Hill North Carolina 27514 Recruiting
University of North Carolina Hospitals at Hillsborough Hillsborough North Carolina 27278 Recruiting
Ohio State University Hospital Columbus Ohio 43210 Recruiting
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C Columbus Ohio 43210 Recruiting
Stefanie Spielman Comprehensive Breast Cancer Columbus Ohio 43212 Recruiting
Oncology Associates of Oregon, P.C. Albany Oregon 97321 Recruiting
Oncology Associates of Oregon, P.C. Eugene Oregon 97401 Recruiting
Providence Cancer Institute Franz Clinic Portland Oregon 97213 Recruiting
Providence Portland Medical Center Investigational Drug Services Portland Oregon 97213 Recruiting
Providence Portland Medical Center Portland Oregon 97213 Recruiting
Providence Investigational Drug Service - Westside Portland Oregon 97225 Recruiting
Providence Oncology and Hematology Care Clinic - Westside Portland Oregon 97225 Recruiting
Providence St. Vincent Medical Center Portland Oregon 97225 Recruiting
Oncology Associates of Oregon, P.C. Springfield Oregon 97477 Recruiting
Texas Oncology - DFW Arlington Texas 76012 Recruiting
Texas Oncology - DFW Arlington Texas 76014 Recruiting
Texas Oncology - DFW Bedford Texas 76022 Recruiting
Texas Oncology - DFW Dallas Texas 75203 Recruiting
Texas Oncology - DFW Dallas Texas 75230 Recruiting
Texas Oncology - DFW Dallas Texas 75231 Recruiting
Texas Oncology - DFW Dallas Texas 75237 Recruiting
Texas Oncology - DFW Dallas Texas 75246 Recruiting
Texas Oncology - DFW Fort Worth Texas 76104 Recruiting
Texas Oncology - DFW Grapevine Texas 76051 Recruiting
US Oncology Investigational Products Center Irving Texas 75063 Recruiting
US Oncology lnvestigational Products Center (IPC) Irving Texas 75063 Recruiting
Texas Oncology - DFW Plano Texas 75075 Recruiting
Texas Oncology - DFW Plano Texas 75093 Recruiting
Baylor Scott & White Medical Center - Round Rock Round Rock Texas 78665 Recruiting
The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center Tyler Texas 75701 Recruiting
The University of Texas Health Science Center at Tyler on behalf of UT Health East Texas HOPE Cancer Tyler Texas 75708 Recruiting
Utah Cancer Specialists Bountiful Utah 84010 Recruiting
Utah Cancer Specialists Layton Utah 84041 Recruiting
Utah Cancer Specialists Murray Utah 84107 Recruiting
Utah Cancer Specialists Ogden Utah 84405 Recruiting
Utah Cancer Specialists Orem Utah 84057 Recruiting
Utah Cancer Specialists Pleasant Grove Utah 84062 Recruiting
Utah Cancer Specialists Provo Utah 84604 Recruiting
Utah Cancer Specialists Salt Lake City Utah 84102 Recruiting
Utah Cancer Specialists Salt Lake City Utah 84106 Recruiting
Utah Cancer Specialists West Jordan Utah 84088 Recruiting
Utah Cancer Specialists West Valley City Utah 84119 Recruiting
Virginia Cancer Specialists, PC Fairfax Virginia 22031 Recruiting
Virginia Cancer Specialists, PC Manassas Virginia 20110 Recruiting
Bon Secours Cancer Institute at Memorial Regional Mechanicsville Virginia 23116 Recruiting
Bon Secours St. Francis Medical Center Midlothian Virginia 23114 Recruiting
Virginia Cancer Specialists, PC Reston Virginia 20190 Recruiting
Bon Secours Cancer Institute at St. Mary's Richmond Virginia 23226 Recruiting
Aurora Medical Center Grafton Wisconsin 53024 Recruiting
Aurora BayCare Medical Center Green Bay Wisconsin 54311 Recruiting
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center Madison Wisconsin 53718 Recruiting
University of Wisconsin Carbone Cancer Center - University Hospital Madison Wisconsin 53792 Recruiting
Aurora Cancer Care - Milwaukee / Good Hope Milwaukee Wisconsin 53209 Recruiting
Aurora Cancer Care Milwaukee Wisconsin 53215 Recruiting
Aurora St Luke's Medical Center Milwaukee Wisconsin 53215 Recruiting
Aurora Sinai Medical Center Milwaukee Wisconsin 53233 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 278 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06760637, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Mar 1, 2026 ยท Synced May 8, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06760637 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record โ†’