A Study to Test Different Doses of BI 1584862 in People With a Distinct Form of Age-related Macular Degeneration (AMD) Called Geographic Atrophy
Public ClinicalTrials.gov record NCT06769048. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
JADE: Phase II Trial in Patients With Geographic Atrophy: A Randomized, Double-masked, Placebo-controlled, Dose-finding Study to Evaluate the Efficacy and Safety of BI 1584862
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is open to adults aged 50 years and older with geographic atrophy that was diagnosed by imaging of the retina. The purpose of this study is to find out whether a medicine called BI 1584862 improves the eyes in people with geographic atrophy and to find the most suitable dose. This study has 4 treatment groups. Participants are put into groups randomly, which means by chance. Initially participants can join a BI 1584862 and a placebo group; then more participants are put randomly in 2 additional BI 1584862 groups and a placebo group. Participants are in the study for 1 year. During this time, they visit the study site 13 times. At the visits, doctors check the severity of participants' eye disease and collect information on any health problems. They take detailed pictures of the back of the eye, the retina, with imaging methods called fundus autofluorescence (FAF), near-infrared reflectance (NIR), and optical coherence tomography (OCT). They measure areas of the retina that appear healthy (bright) or start to waste away (dark, atrophy). The changes over time are then compared between the treatment groups.
Study identification
- NCT ID
- NCT06769048
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 150 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 31, 2025 (Actual)
- Primary completion
- Dec 22, 2026 (Estimated)
- Completion
- Jan 5, 2027 (Estimated)
- Last update posted
- Sep 30, 2026
2025 – 2027
United States locations
- U.S. sites
- 43
- U.S. states
- 19
- U.S. cities
- 41
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Associated Retina Consultants | Gilbert | Arizona | 85297 | — |
| Associated Retina Consultants, Ltd. | Phoenix | Arizona | 85020 | — |
| Cameron Ria, LLC | Phoenix | Arizona | 85050 | — |
| Retina Macula Institute of Arizona | Scottsdale | Arizona | 85255 | — |
| Retina-Vitreous Associates Medical Group | Beverly Hills | California | 90211 | — |
| Global Research Management | Glendale | California | 91204 | — |
| Retina Associates of Southern California | Huntington Beach | California | 92647 | — |
| Retinal Consultants Medical Group, Inc | Modesto | California | 95356 | — |
| Northern California Retina Vitreous Associates MedicalGroup, Inc. | Mountain View | California | 94040 | — |
| Eye Research Foundation | Newport Beach | California | 92663 | — |
| Retina Consultants of San Diego | Poway | California | 92064 | — |
| Retinal Consultants Medical Group | Sacramento | California | 95825 | — |
| Bay Area Retina Associates - Walnut Creek | Walnut Creek | California | 94598 | — |
| Retina Specialists of Colorado Research, LLC | Denver | Colorado | 80222 | — |
| Coastal Eye Surgeons | Greenwich | Connecticut | 06830 | — |
| Vitreo Retinal Associates - Gainesville | Gainesville | Florida | 32605 | — |
| MedEye Associates | Miami | Florida | 33143 | — |
| Eye Associates of Pinellas | Pinellas Park | Florida | 33782 | — |
| East Florida Eye Institute | Stuart | Florida | 34994 | — |
| Center for Retina and Macular Disease | Winter Haven | Florida | 33880 | — |
| Southeast Retina Center, PC | Augusta | Georgia | 30909 | — |
| Illinois Retina Associates - Oak Park | Oak Park | Illinois | 60304 | — |
| The Eye Care Institute | Louisville | Kentucky | 40206 | — |
| Cumberland Valley Retina Consultants | Hagerstown | Maryland | 21740 | — |
| Ophthalmic Consultants of Boston | Boston | Massachusetts | 02114 | — |
| University of Missouri Health System | Columbia | Missouri | 65212 | — |
| NJRetina | Teaneck | New Jersey | 07666 | — |
| Verum Research, LLC | Eugene | Oregon | 97401 | — |
| Retina Northwest | Portland | Oregon | 97221 | — |
| EyeHealth Northwest | Portland | Oregon | 97225 | — |
| Mid Atlantic Retina - Wills Eye Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Charleston Neuroscience Institute - Charleston | Charleston | South Carolina | 29414 | — |
| Tennessee Retina | Nashville | Tennessee | 37203 | — |
| Austin Clinical Research, LLC | Austin | Texas | 78750 | — |
| Retina Consultants of Texas - Beaumont | Beaumont | Texas | 77707 | — |
| Retina Foundation of the Southwest | Dallas | Texas | 75231 | — |
| Red River Research Partners, LLC - Plano | Plano | Texas | 75024 | — |
| Retinal Consultants of San Antonio | San Antonio | Texas | 78240 | — |
| Retina Consultants of Texas - Schertz | Schertz | Texas | 78154 | — |
| Retina Consultants of Texas-The Woodlands-67575 | The Woodlands | Texas | 77384 | — |
| Emerson Clinical Research Institute | Falls Church | Virginia | 22042 | — |
| Piedmont Eye Center | Lynchburg | Virginia | 24502 | — |
| Pacific Northwest Retina | Bellevue | Washington | 98004 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06769048, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 30, 2026 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06769048 live on ClinicalTrials.gov.