ClinicalTrials.gov record
Using Biomarker Tests to Select and Test New, Personalized Treatments for Extensive Stage Small Cell Lung Cancer, PRISM Study
ClinicalTrials.gov ID: NCT06769126
Public ClinicalTrials.gov record NCT06769126. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced Apr 22, 2026, 8:48 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
PRISM: PRecIsion in SCLC Via a Multicohort Study: Randomized Phase II Studies Evaluating Maintenance Durvalumab With or Without Biomarker-Directed Therapy for Extensive Stage Small Cell Lung Cancer (ES-SCLC)
Study identification
- NCT ID
- NCT06769126
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- SWOG Cancer Research Network
- Network
- Enrollment
- 900 participants
Conditions and interventions
Conditions
Interventions
- Biospecimen Collection Procedure
- Ceralasertib Drug
- Computed Tomography Procedure
- Durvalumab Biological
- Etoposide Drug
- Magnetic Resonance Imaging Procedure
- Monalizumab Biological
- Platinum Compound Drug
- Positron Emission Tomography Procedure
- Saruparib Drug
- Thoracic Radiation Therapy Radiation
Procedure · Drug · Biological + 1 more
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 5, 2025
- Primary completion
- Dec 30, 2028
- Completion
- Dec 30, 2029
- Last update posted
- Mar 29, 2026
2025 – 2029
United States locations
- U.S. sites
- 148
- U.S. states
- 27
- U.S. cities
- 121
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Loma Linda University Medical Center | Loma Linda | California | 92354 | Recruiting |
| Eisenhower Medical Center | Rancho Mirage | California | 92270 | Recruiting |
| University of California Davis Comprehensive Cancer Center | Sacramento | California | 95817 | Recruiting |
| UCHealth University of Colorado Hospital | Aurora | Colorado | 80045 | Recruiting |
| UCHealth Memorial Hospital Central | Colorado Springs | Colorado | 80909 | Recruiting |
| Memorial Hospital North | Colorado Springs | Colorado | 80920 | Recruiting |
| Poudre Valley Hospital | Fort Collins | Colorado | 80524 | Recruiting |
| Cancer Care and Hematology-Fort Collins | Fort Collins | Colorado | 80528 | Recruiting |
| Lutheran Hospital - Cancer Centers of Colorado | Golden | Colorado | 80401 | Recruiting |
| UCHealth Greeley Hospital | Greeley | Colorado | 80631 | Recruiting |
| Medical Center of the Rockies | Loveland | Colorado | 80538 | Recruiting |
| Smilow Cancer Hospital-Derby Care Center | Derby | Connecticut | 06418 | Recruiting |
| Smilow Cancer Hospital Care Center-Fairfield | Fairfield | Connecticut | 06824 | Recruiting |
| Smilow Cancer Hospital Care Center - Guilford | Guilford | Connecticut | 06437 | Recruiting |
| Yale University | New Haven | Connecticut | 06520 | Recruiting |
| Yale-New Haven Hospital North Haven Medical Center | North Haven | Connecticut | 06473 | Recruiting |
| Smilow Cancer Hospital-Torrington Care Center | Torrington | Connecticut | 06790 | Recruiting |
| Smilow Cancer Hospital Care Center-Trumbull | Trumbull | Connecticut | 06611 | Recruiting |
| Smilow Cancer Hospital-Waterbury Care Center | Waterbury | Connecticut | 06708 | Recruiting |
| Smilow Cancer Hospital Care Center - Waterford | Waterford | Connecticut | 06385 | Recruiting |
| Helen F Graham Cancer Center | Newark | Delaware | 19713 | Recruiting |
| Medical Oncology Hematology Consultants PA | Newark | Delaware | 19713 | Recruiting |
| Lewis Cancer and Research Pavilion at Saint Joseph's/Candler | Savannah | Georgia | 31405 | Recruiting |
| Kootenai Health - Coeur d'Alene | Coeur d'Alene | Idaho | 83814 | Recruiting |
| Saint Alphonsus Cancer Care Center-Nampa | Nampa | Idaho | 83687 | Recruiting |
| Kootenai Clinic Cancer Services - Post Falls | Post Falls | Idaho | 83854 | Recruiting |
| Kootenai Clinic Cancer Services - Sandpoint | Sandpoint | Idaho | 83864 | Recruiting |
| Northwestern University | Chicago | Illinois | 60611 | Recruiting |
| Northwestern Medicine Cancer Center Kishwaukee | DeKalb | Illinois | 60115 | Recruiting |
| Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | 60134 | Recruiting |
| Northwestern Medicine Glenview Outpatient Center | Glenview | Illinois | 60026 | Recruiting |
| Northwestern Medicine Grayslake Outpatient Center | Grayslake | Illinois | 60030 | Recruiting |
| Northwestern Medicine Lake Forest Hospital | Lake Forest | Illinois | 60045 | Recruiting |
| Loyola University Medical Center | Maywood | Illinois | 60153 | Recruiting |
| Northwestern Medicine Oak Brook | Oak Brook | Illinois | 60523 | Recruiting |
| Northwestern Medicine Orland Park | Orland Park | Illinois | 60462 | Recruiting |
| Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | 60555 | Recruiting |
| Mary Greeley Medical Center | Ames | Iowa | 50010 | Recruiting |
| McFarland Clinic - Ames | Ames | Iowa | 50010 | Recruiting |
| UI Health Care Mission Cancer and Blood - Ankeny Clinic | Ankeny | Iowa | 50023 | Recruiting |
| McFarland Clinic - Boone | Boone | Iowa | 50036 | Suspended |
| Mercy Hospital | Cedar Rapids | Iowa | 52403 | Recruiting |
| Oncology Associates at Mercy Medical Center | Cedar Rapids | Iowa | 52403 | Recruiting |
| UI Health Care Mission Cancer and Blood - West Des Moines Clinic | Clive | Iowa | 50325 | Recruiting |
| Iowa Methodist Medical Center | Des Moines | Iowa | 50309 | Recruiting |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic | Des Moines | Iowa | 50309 | Recruiting |
| Mercy Medical Center - Des Moines | Des Moines | Iowa | 50314 | Recruiting |
| UI Health Care Mission Cancer and Blood - Laurel Clinic | Des Moines | Iowa | 50314 | Recruiting |
| McFarland Clinic - Trinity Cancer Center | Fort Dodge | Iowa | 50501 | Recruiting |
| McFarland Clinic - Jefferson | Jefferson | Iowa | 50129 | Suspended |
| McFarland Clinic - Marshalltown | Marshalltown | Iowa | 50158 | Recruiting |
| UI Health Care Mission Cancer and Blood - Waukee Clinic | Waukee | Iowa | 50263 | Recruiting |
| The Iowa Clinic PC | West Des Moines | Iowa | 50266 | Recruiting |
| University of Kansas Clinical Research Center | Fairway | Kansas | 66205 | Recruiting |
| University of Kansas Cancer Center | Kansas City | Kansas | 66160 | Recruiting |
| The University of Kansas Cancer Center - Olathe | Olathe | Kansas | 66061 | Recruiting |
| University of Kansas Cancer Center-Overland Park | Overland Park | Kansas | 66210 | Recruiting |
| Salina Regional Health Center | Salina | Kansas | 67401 | Recruiting |
| University of Kansas Hospital-Westwood Cancer Center | Westwood | Kansas | 66205 | Recruiting |
| Baptist Health Corbin | Corbin | Kentucky | 40701 | Recruiting |
| Baptist Health Lexington | Lexington | Kentucky | 40503 | Recruiting |
| Baptist Health Hamburg | Lexington | Kentucky | 40509 | Recruiting |
| University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | 21201 | Recruiting |
| Tufts Medical Center | Boston | Massachusetts | 02111 | Recruiting |
| Lahey Hospital and Medical Center | Burlington | Massachusetts | 01805 | Recruiting |
| Lahey Medical Center-Peabody | Peabody | Massachusetts | 01960 | Recruiting |
| Trinity Health IHA Medical Group Hematology Oncology - Brighton | Brighton | Michigan | 48114 | Recruiting |
| Trinity Health IHA Medical Group Hematology Oncology - Canton | Canton | Michigan | 48188 | Recruiting |
| Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital | Chelsea | Michigan | 48118 | Recruiting |
| Henry Ford Health Saint John Hospital | Detroit | Michigan | 48236 | Recruiting |
| Henry Ford River District Hospital | East China Township | Michigan | 48054 | Recruiting |
| Henry Ford Saint John Hospital - Academic | Grosse Pointe Woods | Michigan | 48236 | Recruiting |
| Henry Ford Saint John Hospital - Breast | Grosse Pointe Woods | Michigan | 48236 | Recruiting |
| Henry Ford Saint John Hospital - Van Elslander | Grosse Pointe Woods | Michigan | 48236 | Recruiting |
| University of Michigan Health - Sparrow Lansing | Lansing | Michigan | 48912 | Recruiting |
| Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan | 48154 | Recruiting |
| Henry Ford Saint John Hospital - Macomb Medical | Macomb | Michigan | 48044 | Recruiting |
| Henry Ford Warren Hospital - Breast Macomb | Macomb | Michigan | 48044 | Recruiting |
| Trinity Health Saint Joseph Mercy Oakland Hospital | Pontiac | Michigan | 48341 | Recruiting |
| Henry Ford Health Warren Hospital | Warren | Michigan | 48093 | Recruiting |
| Henry Ford Madison Heights Hospital - Breast | Warren | Michigan | 48093 | Recruiting |
| Henry Ford Warren Hospital - GLCMS | Warren | Michigan | 48093 | Recruiting |
| Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus | Ypsilanti | Michigan | 48197 | Recruiting |
| Sanford Joe Lueken Cancer Center | Bemidji | Minnesota | 56601 | Recruiting |
| Essentia Health Saint Joseph's Medical Center | Brainerd | Minnesota | 56401 | Recruiting |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | Recruiting |
| Essentia Health - Deer River Clinic | Deer River | Minnesota | 56636 | Recruiting |
| Essentia Health Cancer Center | Duluth | Minnesota | 55805 | Recruiting |
| Fairview Southdale Hospital | Edina | Minnesota | 55435 | Recruiting |
| Essentia Health Hibbing Clinic | Hibbing | Minnesota | 55746 | Recruiting |
| Saint John's Hospital - Healtheast | Maplewood | Minnesota | 55109 | Recruiting |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | Recruiting |
| Hennepin County Medical Center | Minneapolis | Minnesota | 55415 | Recruiting |
| New Ulm Medical Center | New Ulm | Minnesota | 56073 | Recruiting |
| Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | 55416 | Recruiting |
| Regions Hospital | Saint Paul | Minnesota | 55101 | Recruiting |
| United Hospital | Saint Paul | Minnesota | 55102 | Recruiting |
| Essentia Health Sandstone | Sandstone | Minnesota | 55072 | Recruiting |
| Essentia Health Virginia Clinic | Virginia | Minnesota | 55792 | Recruiting |
| University of Kansas Cancer Center - Briarcliff | Kansas City | Missouri | 64116 | Recruiting |
| University of Kansas Cancer Center - North | Kansas City | Missouri | 64154 | Recruiting |
| University of Kansas Cancer Center - Lee's Summit | Lee's Summit | Missouri | 64064 | Recruiting |
| Mercy Hospital South | St Louis | Missouri | 63128 | Recruiting |
| Mercy Hospital Saint Louis | St Louis | Missouri | 63141 | Recruiting |
| Community Hospital of Anaconda | Anaconda | Montana | 59711 | Recruiting |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | Recruiting |
| Bozeman Health Deaconess Hospital | Bozeman | Montana | 59715 | Recruiting |
| Benefis Sletten Cancer Institute | Great Falls | Montana | 59405 | Recruiting |
| Community Medical Center | Missoula | Montana | 59804 | Recruiting |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | Recruiting |
| University of Rochester | Rochester | New York | 14642 | Recruiting |
| Wilmot Cancer Institute at Webster | Webster | New York | 14580 | Recruiting |
| FirstHealth of the Carolinas-Moore Regional Hospital | Pinehurst | North Carolina | 28374 | Recruiting |
| Sanford Bismarck Medical Center | Bismarck | North Dakota | 58501 | Recruiting |
| Essentia Health Cancer Center-South University Clinic | Fargo | North Dakota | 58103 | Recruiting |
| Sanford Broadway Medical Center | Fargo | North Dakota | 58122 | Recruiting |
| Sanford Roger Maris Cancer Center | Fargo | North Dakota | 58122 | Recruiting |
| Aultman Health Foundation | Canton | Ohio | 44710 | Recruiting |
| Miami Valley Hospital South | Centerville | Ohio | 45459 | Recruiting |
| Miami Valley Hospital | Dayton | Ohio | 45409 | Recruiting |
| Premier Blood and Cancer Center | Dayton | Ohio | 45409 | Recruiting |
| Miami Valley Hospital North | Dayton | Ohio | 45415 | Recruiting |
| Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio | 45005-1066 | Recruiting |
| Miami Valley Cancer Care and Infusion | Greenville | Ohio | 45331 | Recruiting |
| Upper Valley Medical Center | Troy | Ohio | 45373 | Recruiting |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | Recruiting |
| Providence Newberg Medical Center | Newberg | Oregon | 97132 | Recruiting |
| Providence Willamette Falls Medical Center | Oregon City | Oregon | 97045 | Recruiting |
| Providence Portland Medical Center | Portland | Oregon | 97213 | Recruiting |
| Providence Saint Vincent Medical Center | Portland | Oregon | 97225 | Recruiting |
| Saint Joseph's/Candler - Bluffton Campus | Bluffton | South Carolina | 29910 | Recruiting |
| Prisma Health Cancer Institute - Spartanburg | Boiling Springs | South Carolina | 29316 | Recruiting |
| Prisma Health Cancer Institute - Easley | Easley | South Carolina | 29640 | Recruiting |
| Tidelands Georgetown Memorial Hospital | Georgetown | South Carolina | 29440 | Recruiting |
| Prisma Health Cancer Institute - Butternut | Greenville | South Carolina | 29605 | Recruiting |
| Prisma Health Cancer Institute - Faris | Greenville | South Carolina | 29605 | Recruiting |
| Prisma Health Cancer Institute - Eastside | Greenville | South Carolina | 29615 | Recruiting |
| Prisma Health Cancer Institute - Greer | Greer | South Carolina | 29650 | Recruiting |
| Prisma Health Cancer Institute - Seneca | Seneca | South Carolina | 29672 | Recruiting |
| Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota | 57104 | Recruiting |
| Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | 57117-5134 | Recruiting |
| M D Anderson Cancer Center | Houston | Texas | 77030 | Recruiting |
| VCU Massey Cancer Center at Stony Point | Richmond | Virginia | 23235 | Recruiting |
| VCU Massey Comprehensive Cancer Center | Richmond | Virginia | 23298 | Recruiting |
| VCU Community Memorial Health Center | South Hill | Virginia | 23970 | Recruiting |
| VCU Health Tappahannock Hospital | Tappahannock | Virginia | 22560 | Recruiting |
| Duluth Clinic Ashland | Ashland | Wisconsin | 54806 | Recruiting |
| Gundersen Lutheran Medical Center | La Crosse | Wisconsin | 54601 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06769126, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 29, 2026 · Synced Apr 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06769126 live on ClinicalTrials.gov.