Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial

ClinicalTrials.gov ID: NCT06770582

Public ClinicalTrials.gov record NCT06770582. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 9, 2026, 9:32 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Randomized Phase II Trial of Pembrolizumab and Radiation vs. Radiation and Concurrent Chemotherapy for High-Grade T1 Bladder Cancer (PARRC Trial)

Study identification

NCT ID: NCT06770582
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: National Cancer Institute (NCI); NIH
Enrollment: 160 participants

Conditions and interventions

Conditions

Interventions

Biospecimen Collection Procedure
Cisplatin Drug
Computed Tomography Procedure
Fluorouracil Drug
Gemcitabine Drug
Magnetic Resonance Imaging Procedure
Mitomycin Drug
Pembrolizumab Biological
Questionnaire Administration Other
Radiation Therapy Radiation

Procedure · Drug · Biological + 2 more

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 2, 2025
Primary completion: Jan 31, 2032
Completion: Jan 31, 2032
Last update posted: May 7, 2026

2025 – 2032

United States locations

U.S. sites: 124
U.S. states: 24
U.S. cities: 87

Facility	City	State	ZIP	Site status
AIS Cancer Center at San Joaquin Community Hospital	Bakersfield	California	93301	Recruiting
Los Angeles General Medical Center	Los Angeles	California	90033	Recruiting
USC / Norris Comprehensive Cancer Center	Los Angeles	California	90033	Recruiting
Shaw Cancer Center	Edwards	Colorado	81632	Recruiting
Helen F Graham Cancer Center	Newark	Delaware	19713	Recruiting
Medical Oncology Hematology Consultants PA	Newark	Delaware	19713	Recruiting
UF Health Cancer Institute - Gainesville	Gainesville	Florida	32610	Recruiting
Mount Sinai Medical Center	Miami Beach	Florida	33140	Recruiting
Grady Health System	Atlanta	Georgia	30303	Recruiting
Emory Proton Therapy Center	Atlanta	Georgia	30308	Recruiting
Emory University Hospital Midtown	Atlanta	Georgia	30308	Recruiting
Emory University Hospital/Winship Cancer Institute	Atlanta	Georgia	30322	Recruiting
Emory Saint Joseph's Hospital	Atlanta	Georgia	30342	Recruiting
Rush MD Anderson Cancer Center	Chicago	Illinois	60612	Recruiting
Carle at The Riverfront	Danville	Illinois	61832	Suspended
Cancer Care Specialists of Illinois - Decatur	Decatur	Illinois	62526	Recruiting
Decatur Memorial Hospital	Decatur	Illinois	62526	Recruiting
Carle Physician Group-Effingham	Effingham	Illinois	62401	Suspended
Crossroads Cancer Center	Effingham	Illinois	62401	Recruiting
Carle Physician Group-Mattoon/Charleston	Mattoon	Illinois	61938	Suspended
Carle BroMenn Medical Center	Normal	Illinois	61761	Suspended
Carle Cancer Institute Normal	Normal	Illinois	61761	Suspended
Southern Illinois University School of Medicine	Springfield	Illinois	62702	Recruiting
Springfield Clinic	Springfield	Illinois	62702	Recruiting
Springfield Memorial Hospital	Springfield	Illinois	62781	Recruiting
Carle Cancer Center	Urbana	Illinois	61801	Suspended
Mary Greeley Medical Center	Ames	Iowa	50010	Recruiting
McFarland Clinic - Ames	Ames	Iowa	50010	Recruiting
UI Health Care Mission Cancer and Blood - Ankeny Clinic	Ankeny	Iowa	50023	Recruiting
Mercy Cancer Center-West Lakes	Clive	Iowa	50325	Recruiting
UI Health Care Mission Cancer and Blood - West Des Moines Clinic	Clive	Iowa	50325	Recruiting
Iowa Methodist Medical Center	Des Moines	Iowa	50309	Recruiting
UI Health Care Mission Cancer and Blood - Des Moines Clinic	Des Moines	Iowa	50309	Recruiting
Broadlawns Medical Center	Des Moines	Iowa	50314	Recruiting
Mercy Medical Center - Des Moines	Des Moines	Iowa	50314	Recruiting
UI Health Care Mission Cancer and Blood - Laurel Clinic	Des Moines	Iowa	50314	Recruiting
UI Health Care Mission Cancer and Blood - Waukee Clinic	Waukee	Iowa	50263	Recruiting
The Iowa Clinic PC	West Des Moines	Iowa	50266	Recruiting
University of Kansas Cancer Center	Kansas City	Kansas	66160	Recruiting
University of Kansas Cancer Center-Overland Park	Overland Park	Kansas	66210	Recruiting
University of Kansas Hospital-Indian Creek Campus	Overland Park	Kansas	66211	Recruiting
University of Kansas Hospital-Westwood Cancer Center	Westwood	Kansas	66205	Recruiting
Louisiana Hematology Oncology Associates LLC	Baton Rouge	Louisiana	70809	Recruiting
Mary Bird Perkins Cancer Center	Baton Rouge	Louisiana	70809	Recruiting
Mary Bird Perkins Cancer Center - Gonzales	Gonzales	Louisiana	70737	Recruiting
Mary Bird Perkins Cancer Center - Metairie	Metairie	Louisiana	70002	Recruiting
Massachusetts General Hospital Cancer Center	Boston	Massachusetts	02114	Recruiting
Trinity Health Saint Joseph Mercy Hospital Ann Arbor	Ann Arbor	Michigan	48106	Recruiting
Trinity Health Medical Center - Brighton	Brighton	Michigan	48114	Recruiting
Trinity Health Medical Center - Canton	Canton	Michigan	48188	Recruiting
Chelsea Hospital	Chelsea	Michigan	48118	Recruiting
University of Michigan Health - Sparrow Lansing	Lansing	Michigan	48912	Recruiting
Trinity Health Saint Mary Mercy Livonia Hospital	Livonia	Michigan	48154	Recruiting
Michigan Healthcare Professionals Pontiac	Pontiac	Michigan	48341	Recruiting
Trinity Health Saint Joseph Mercy Oakland Hospital	Pontiac	Michigan	48341	Recruiting
Sanford Joe Lueken Cancer Center	Bemidji	Minnesota	56601	Active, not recruiting
Essentia Health Saint Joseph's Medical Center	Brainerd	Minnesota	56401	Recruiting
Essentia Health - Deer River Clinic	Deer River	Minnesota	56636	Recruiting
Essentia Health Cancer Center	Duluth	Minnesota	55805	Recruiting
Essentia Health Saint Mary's Medical Center	Duluth	Minnesota	55805	Recruiting
Miller-Dwan Hospital	Duluth	Minnesota	55805	Recruiting
Essentia Health Hibbing Clinic	Hibbing	Minnesota	55746	Recruiting
Essentia Health Sandstone	Sandstone	Minnesota	55072	Recruiting
Essentia Health Virginia Clinic	Virginia	Minnesota	55792	Recruiting
Saint Francis Medical Center	Cape Girardeau	Missouri	63703	Recruiting
Parkland Health Center - Farmington	Farmington	Missouri	63640	Recruiting
University of Kansas Cancer Center - Briarcliff	Kansas City	Missouri	64116	Recruiting
University of Kansas Cancer Center - North	Kansas City	Missouri	64154	Recruiting
University of Kansas Cancer Center - Lee's Summit	Lee's Summit	Missouri	64064	Recruiting
Lake Regional Hospital	Osage Beach	Missouri	65065	Recruiting
Sainte Genevieve County Memorial Hospital	Sainte Genevieve	Missouri	63670	Recruiting
Mercy Hospital South	St Louis	Missouri	63128	Recruiting
Missouri Baptist Medical Center	St Louis	Missouri	63131	Recruiting
Mercy Hospital Saint Louis	St Louis	Missouri	63141	Recruiting
Missouri Baptist Sullivan Hospital	Sullivan	Missouri	63080	Recruiting
BJC Outpatient Center at Sunset Hills	Sunset Hills	Missouri	63127	Recruiting
Memorial Sloan Kettering Basking Ridge	Basking Ridge	New Jersey	07920	Recruiting
Memorial Sloan Kettering Monmouth	Middletown	New Jersey	07748	Recruiting
Memorial Sloan Kettering Bergen	Montvale	New Jersey	07645	Recruiting
Memorial Sloan Kettering Commack	Commack	New York	11725	Recruiting
Memorial Sloan Kettering Westchester	Harrison	New York	10604	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
Memorial Sloan Kettering Nassau	Uniondale	New York	11553	Recruiting
UNC Lineberger Comprehensive Cancer Center	Chapel Hill	North Carolina	27599	Recruiting
Sanford Broadway Medical Center	Fargo	North Dakota	58122	Active, not recruiting
Sanford Roger Maris Cancer Center	Fargo	North Dakota	58122	Active, not recruiting
Riverside Methodist Hospital	Columbus	Ohio	43214	Recruiting
Grant Medical Center	Columbus	Ohio	43215	Recruiting
Doctors Hospital	Columbus	Ohio	43228	Recruiting
Dublin Methodist Hospital	Dublin	Ohio	43016	Recruiting
OhioHealth Mansfield Hospital	Mansfield	Ohio	44903	Recruiting
OhioHealth Marion General Hospital	Marion	Ohio	43302	Recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Recruiting
Christiana Care Health System-Concord Health Center	Chadds Ford	Pennsylvania	19317	Recruiting
Geisinger Medical Center	Danville	Pennsylvania	17822	Recruiting
Geisinger Cancer Center Dickson City	Dickson City	Pennsylvania	18519	Recruiting
UPMC Hillman Cancer Center Erie	Erie	Pennsylvania	16505	Recruiting
UPMC Cancer Center at UPMC Horizon	Farrell	Pennsylvania	16121	Recruiting
UPMC Cancer Centers - Arnold Palmer Pavilion	Greensburg	Pennsylvania	15601	Recruiting
Penn State Milton S Hershey Medical Center	Hershey	Pennsylvania	17033-0850	Recruiting
Geisinger Medical Oncology-Lewisburg	Lewisburg	Pennsylvania	17837	Recruiting
UPMC Cancer Center - Monroeville	Monroeville	Pennsylvania	15146	Recruiting
UPMC Hillman Cancer Center - Monroeville	Monroeville	Pennsylvania	15146	Recruiting
UPMC Hillman Cancer Center - New Castle	New Castle	Pennsylvania	16105	Recruiting
UPMC-Saint Margaret	Pittsburgh	Pennsylvania	15215	Recruiting
University of Pittsburgh Cancer Institute (UPCI)	Pittsburgh	Pennsylvania	15232	Recruiting
UPMC-Shadyside Hospital	Pittsburgh	Pennsylvania	15232	Recruiting
UPMC-Passavant Hospital	Pittsburgh	Pennsylvania	15237	Recruiting
UPMC Cancer Center at UPMC Northwest	Seneca	Pennsylvania	16346	Recruiting
UPMC Cancer Center-Washington	Washington	Pennsylvania	15301	Recruiting
UPMC Washington Hospital Radiation Oncology	Washington	Pennsylvania	15301	Recruiting
Geisinger Wyoming Valley/Henry Cancer Center	Wilkes-Barre	Pennsylvania	18711	Recruiting
Central Vermont Medical Center/National Life Cancer Treatment	Berlin Corners	Vermont	05602	Recruiting
University of Vermont Medical Center	Burlington	Vermont	05401	Recruiting
University of Vermont and State Agricultural College	Burlington	Vermont	05405	Recruiting
Bon Secours Memorial Regional Medical Center	Mechanicsville	Virginia	23116	Recruiting
Bon Secours Saint Francis Medical Center	Midlothian	Virginia	23114	Recruiting
Bon Secours Saint Mary's Hospital	Richmond	Virginia	23226	Recruiting
Bon Secours Cancer Institute at Reynolds Crossing	Richmond	Virginia	23230	Recruiting
VCU Massey Comprehensive Cancer Center	Richmond	Virginia	23298	Recruiting
VCU Community Memorial Health Center	South Hill	Virginia	23970	Recruiting
West Virginia University Healthcare	Morgantown	West Virginia	26506	Recruiting
Duluth Clinic Ashland	Ashland	Wisconsin	54806	Recruiting
Northwest Wisconsin Cancer Center	Ashland	Wisconsin	54806	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06770582, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 7, 2026 · Synced May 9, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06770582 live on ClinicalTrials.gov.

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