AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF
Public ClinicalTrials.gov record NCT06793371. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CK-4021586 in Adults With Symptomatic Heart Failure With Preserved Ejection Fraction
Study identification
- NCT ID
- NCT06793371
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Cytokinetics
- Industry
- Enrollment
- 60 participants
Conditions and interventions
Interventions
- CK-4021586 (150 mg, 300 mg, 450 mg, and 600 mg) Drug
- Placebo to match CK-4021586 Drug
Drug
Eligibility (public fields only)
- Age range
- 40 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 5, 2025
- Primary completion
- Aug 31, 2026
- Completion
- Aug 31, 2026
- Last update posted
- May 28, 2026
2025 – 2026
United States locations
- U.S. sites
- 25
- U.S. states
- 18
- U.S. cities
- 24
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Eastern Shore Research Institute, LLC | Fairhope | Alabama | 36532 | Recruiting |
| University of Arizona Sarver Heart Center | Tucson | Arizona | 85724 | Recruiting |
| John L. McClellan Memorial Veterans Hospital | Little Rock | Arkansas | 72205 | Recruiting |
| BioSolutions Clinical Research Center | Imperial | California | 92251 | Recruiting |
| Profound Research LLC | Pasadena | California | 91105 | Recruiting |
| University of California, San Francisco - Heart and Vascular Center | San Francisco | California | 94143 | Recruiting |
| FOMAT - Comprehensive Cardiovascular Care | Santa Maria | California | 93454 | Recruiting |
| Blue Coast Research Center, LLC | Vista | California | 92081 | Recruiting |
| New Generation of Medical Research | Hialeah | Florida | 33016 | Recruiting |
| Cleveland Clinic Florida | Weston | Florida | 33331 | Recruiting |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61636 | Recruiting |
| Louisiana Heart Center | Slidell | Louisiana | 70458 | Recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02214 | Recruiting |
| Mayo Clinic | Rochester | Minnesota | 55905 | Recruiting |
| Washington University Center for Advanced Medicine | St Louis | Missouri | 63110 | Recruiting |
| Morristown Medical Center | Morristown | New Jersey | 07960 | Recruiting |
| NYU Langone Health | New York | New York | 10016 | Recruiting |
| Mount Sinai West | New York | New York | 10019 | Recruiting |
| The Lindner Center for Research & Education at The Christ Hospital | Cincinnati | Ohio | 45219 | Recruiting |
| Oregon Health and Science University | Portland | Oregon | 97239 | Recruiting |
| University of Texas Southwestern Medical Center, Dallas | Dallas | Texas | 75390 | Recruiting |
| Center for Advanced Heart Failure | Houston | Texas | 77030 | Recruiting |
| DelRicht Research | Vienna | Virginia | 22182 | Withdrawn |
| Swedish Heart & Vascular Institute, Advanced Cardiac Support Program | Seattle | Washington | 98122 | Recruiting |
| Froedtert Hospital - Center for Advanced Care | Milwaukee | Wisconsin | 53226 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06793371, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 28, 2026 · Synced Jun 26, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06793371 live on ClinicalTrials.gov.