A Study of TYRA-300 in Children With Achondroplasia: BEACH301

ClinicalTrials.gov ID: NCT06842355

Public ClinicalTrials.gov record NCT06842355. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 7, 2026, 1:42 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Multicenter, Phase 2, Dose-Escalation/Dose-Expansion Study of TYRA-300 in Children With Achondroplasia With Open Growth Plates: BEACH301

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this study is to evaluate the safety, tolerability, and identify potentially effective dose(s) of TYRA-300 in children with achondroplasia with open growth plates.

Study identification

NCT ID: NCT06842355
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Tyra Biosciences, Inc; Industry
Enrollment: 92 participants

Conditions and interventions

Conditions

Achondroplasia

Interventions

Drug

Eligibility (public fields only)

Age range: 3 Years to 10 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 3, 2025
Primary completion: Dec 31, 2029
Completion: May 31, 2030
Last update posted: Aug 30, 2026

2025 – 2030

United States locations

U.S. sites: 12
U.S. states: 9
U.S. cities: 12

Facility	City	State	ZIP	Site status
Lundquist Institute for Biomedical Innovation	Torrance	California	90502	Recruiting
Children's Hospital Colorado	Aurora	Colorado	80045	Recruiting
Nemours Alfred I duPont Hospital for Children	Wilmington	Delaware	19803	Recruiting
Johns Hopkins University School of Medicine	Baltimore	Maryland	21205	Recruiting
Uncommon Cures	Chevy Chase	Maryland	20815	Recruiting
University of Missouri	Columbia	Missouri	65201	Recruiting
Washington University	St Louis	Missouri	63130	Recruiting
Duke University Hospital	Durham	North Carolina	27710	Recruiting
Vanderbilt University Medical Center	Nashville	Tennessee	37232	Recruiting
Children's Medical Center, Dallas	Dallas	Texas	75235	Recruiting
University of Texas Health Science Center Medical School at Houston	Houston	Texas	77030	Recruiting
University of Wisconsin-Madison	Madison	Wisconsin	53715	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 13 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06842355, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Aug 30, 2026 · Synced Sep 7, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06842355 live on ClinicalTrials.gov.

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