A Study of FG-3246 in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Public ClinicalTrials.gov record NCT06842498. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Dose Optimization Trial Evaluating a CD46-Targeted Antibody-Drug Conjugate (FG-3246) in Patients With Metastatic Castration-Resistant Prostate Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the safety, efficacy, tolerability, and pharmacokinetics (PK) of FG-3246, a cluster of differentiation 46 (CD46) targeting antibody-drug conjugate (ADC), in the treatment of participants with mCRPC who have progressed following treatment with one prior second-generation androgen receptor signaling inhibitor (ARSI) in any setting and no prior taxane therapy in the mCRPC setting.
Study identification
- NCT ID
- NCT06842498
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 75 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 21, 2026
- Primary completion
- Mar 30, 2028
- Completion
- Mar 30, 2028
- Last update posted
- Aug 16, 2026
2026 – 2028
United States locations
- U.S. sites
- 23
- U.S. states
- 14
- U.S. cities
- 21
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Western Regional Medical Center - City of Hope Phoenix Goodyear | Goodyear | Arizona | 85338 | Recruiting |
| HonorHealth Research Institute | Scottsdale | Arizona | 85258 | Recruiting |
| The University of Arizona Cancer Center - North Campus | Tucson | Arizona | 85719 | Recruiting |
| VA Greater Los Angeles Healthcare System | Los Angeles | California | 90073 | Recruiting |
| UCLA Clark Urology Center | Los Angeles | California | 90095 | Recruiting |
| University of California San Francisco | San Francisco | California | 94158 | Recruiting |
| New Haven Hospital - Yale Cancer Center | New Haven | Connecticut | 06519 | Recruiting |
| Bioresearch Partner - Aventura | Aventura | Florida | 33180 | Recruiting |
| Bioresearch Partner - Hialeah | Hialeah | Florida | 33013 | Recruiting |
| Biogenix Molecular, LLC | Miami | Florida | 33165 | Recruiting |
| Winship Cancer Institute, Emory University | Atlanta | Georgia | 30322 | Recruiting |
| East Jefferson General Hospital Metairie | New Orleans | Louisiana | 70112 | Recruiting |
| New Mexico Oncology Hematology Consultants, Ltd. | Albuquerque | New Mexico | 87109 | Recruiting |
| Duke University Medical Center - Duke Cancer Center | Durham | North Carolina | 27710 | Recruiting |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | Recruiting |
| Carolina Urologic Research Center | Myrtle Beach | South Carolina | 29572 | Recruiting |
| Henry-Joyce Cancer Clinic | Nashville | Tennessee | 37232 | Recruiting |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | Recruiting |
| Oncology Consultants | Houston | Texas | 77030 | Recruiting |
| University of Virginia Comprehensive Cancer Center | Charlottesville | Virginia | 22908 | Recruiting |
| Fred Hutchinson Cancer Center | Seattle | Washington | 98109 | Recruiting |
| University of Washington Medical Center | Seattle | Washington | 98195 | Recruiting |
| Northwest Medical Specialties, PLLC - Tacoma | Tacoma | Washington | 98405 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06842498, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 16, 2026 · Synced Sep 5, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06842498 live on ClinicalTrials.gov.