Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.

ClinicalTrials.gov ID: NCT06846281

Public ClinicalTrials.gov record NCT06846281. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 8, 2026, 5:15 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, Open-label, Parallel-group, Non-inferiority Study Comparing Efficacy, Safety, and Tolerability of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis, Followed by Open-label Treatment With Remibrutinib

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this Phase 3b study is to assess the efficacy, safety and tolerability of remibrutinib after switching from ocrelizumab and compared to continuous ocrelizumab treatment, in patients living with relapsing multiple sclerosis (plwRMS).

Study identification

NCT ID: NCT06846281
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Novartis Pharmaceuticals; Industry
Enrollment: 400 participants

Conditions and interventions

Conditions

Relapsing Multiple Sclerosis

Interventions

Remibrutinib oral treatment Drug
Ocrelizumab Drug

Drug

Eligibility (public fields only)

Age range: 40 Years to 70 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 22, 2025
Primary completion: Jul 24, 2029
Completion: Jun 24, 2031
Last update posted: Aug 25, 2026

2025 – 2031

United States locations

U.S. sites: 44
U.S. states: 23
U.S. cities: 42

Facility	City	State	ZIP	Site status
Perseverance Research Center	Scottsdale	Arizona	85253	Recruiting
University of California Irvine	Irvine	California	92697	Recruiting
Medstar Washington Hospital Center	Washington D.C.	District of Columbia	20010-2975	Recruiting
Neurology of Central FL Res Ctr	Altamonte Springs	Florida	32714	Recruiting
University of Florida	Gainesville	Florida	32610	Recruiting
Memorial Healthcare System	Hollywood	Florida	33021	Recruiting
Neurology Associates PA	Maitland	Florida	32751	Recruiting
Elite Clinical Research	Miami	Florida	33144	Recruiting
Aqualane Clinical Research	Naples	Florida	34105	Recruiting
Advent Health Orlando	Orlando	Florida	32803	Recruiting
Orlando Health Clinical Trials	Orlando	Florida	32806	Recruiting
Tallahassee Neurological Clinic	Tallahassee	Florida	32308	Recruiting
University Of South Florida	Tampa	Florida	33612	Recruiting
Vero Beach Neurology	Vero Beach	Florida	32960	Recruiting
Rush University Medical Center	Chicago	Illinois	60607	Recruiting
University of Chicago	Chicago	Illinois	60637	Recruiting
University of Kansas Hospital	Kansas City	Kansas	66160	Recruiting
MedStar Montgomery Medical Center	Olney	Maryland	20832	Recruiting
Tufts Medical Center	Boston	Massachusetts	02111	Withdrawn
Lahey Hospital and Medical Center	Burlington	Massachusetts	01805	Recruiting
Neurology Center of New England PC	Foxborough	Massachusetts	02035	Recruiting
Michigan Institute of Neurological	Farmington Hills	Michigan	48334	Recruiting
Memorial HC Ins for Neuroscience	Owosso	Michigan	48867	Recruiting
WA Uni School Of Med	St Louis	Missouri	63110	Recruiting
Cleveland Clinic Foundation	Las Vegas	Nevada	89106	Recruiting
Holy Name Medical Center	Teaneck	New Jersey	07666	Recruiting
University of New Mexico	Albuquerque	New Mexico	87131-0001	Recruiting
SUNY Buffalo The Jacobs Neuro Inst	Buffalo	New York	14203	Recruiting
Velocity Clinical Research	Raleigh	North Carolina	27607	Recruiting
Sanford Health	Fargo	North Dakota	58122	Recruiting
Premier Health	Centerville	Ohio	45459	Recruiting
Univ of Cincinnati Medical Center	Cincinnati	Ohio	45219	Recruiting
Cleveland Clinic Foundation	Cleveland	Ohio	44195	Recruiting
Ohio Health Research Institute	Columbus	Ohio	43214	Recruiting
Providence Neurological Services West	Portland	Oregon	97225	Recruiting
Premier Neurology	Greenville	South Carolina	29605	Recruiting
Sibyl Wray MD Neurology PC	Knoxville	Tennessee	37922	Recruiting
Austin Regional Clinic	Austin	Texas	78731	Recruiting
Univ of Texas Southwest Med Center	Dallas	Texas	75390-9034	Recruiting
John Peter Smith Hospital	Fort Worth	Texas	76104	Recruiting
Saturn Research Solutions LLC	Plano	Texas	75024	Recruiting
Virginia Commonwealth University	Richmond	Virginia	23298-0111	Recruiting
Center for Neurological Disorders G	Greenfield	Wisconsin	53228-1321	Recruiting
Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 85 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06846281, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Aug 25, 2026 · Synced Sep 8, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06846281 live on ClinicalTrials.gov.

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