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Recruiting Phase 3 Interventional

Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.

ClinicalTrials.gov ID: NCT06846281

Public ClinicalTrials.gov record NCT06846281. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 19, 2026, 9:19 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, Open-label, Parallel-group, Non-inferiority Study Comparing Efficacy, Safety, and Tolerability of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis, Followed by Open-label Treatment With Remibrutinib

Study identification

NCT ID
NCT06846281
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Novartis Pharmaceuticals
Industry
Enrollment
360 participants

Conditions and interventions

Interventions

  • Ocrelizumab Drug
  • Remibrutinib oral treatment Drug

Drug

Eligibility (public fields only)

Age range
40 Years to 70 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jul 22, 2025
Primary completion
Jul 19, 2029
Completion
Jun 19, 2031
Last update posted
May 18, 2026

2025 – 2031

United States locations

U.S. sites
37
U.S. states
20
U.S. cities
36
Facility City State ZIP Site status
Perseverance Research Center Scottsdale Arizona 85253 Recruiting
Medstar Washington Hospital Center Washington D.C. District of Columbia 20010-2975 Recruiting
Neurology of Central FL Res Ctr Altamonte Springs Florida 32714 Recruiting
University of Florida Gainesville Florida 32610 Recruiting
Neurology Associates PA Maitland Florida 32751 Recruiting
Aqualane Clinical Research Naples Florida 34105 Recruiting
Advent Health Orlando Orlando Florida 32803 Recruiting
Orlando Health Clinical Trials Orlando Florida 32806 Recruiting
Tallahassee Neurological Clinic Tallahassee Florida 32308 Recruiting
University Of South Florida Tampa Florida 33612 Recruiting
Vero Beach Neurology Vero Beach Florida 32960 Recruiting
Rush University Medical Center Chicago Illinois 60607 Recruiting
University of Kansas Hospital Kansas City Kansas 66160 Recruiting
MedStar Montgomery Medical Center Olney Maryland 20832 Recruiting
Tufts Medical Center Boston Massachusetts 02111 Recruiting
Lahey Hospital and Medical Center Burlington Massachusetts 01805 Recruiting
Neurology Center of New England PC Foxborough Massachusetts 02035 Recruiting
Michigan Institute of Neurological Farmington Hills Michigan 48334 Recruiting
Memorial HC Ins for Neuroscience Owosso Michigan 48867 Recruiting
WA Uni School Of Med St Louis Missouri 63110 Recruiting
Cleveland Clinic Foundation Las Vegas Nevada 89106 Recruiting
Holy Name Medical Center Teaneck New Jersey 07666 Recruiting
University of New Mexico Albuquerque New Mexico 87131-0001 Recruiting
SUNY Buffalo The Jacobs Neuro Inst Buffalo New York 14203 Recruiting
Velocity Clinical Research Raleigh North Carolina 27607 Recruiting
Sanford Health Fargo North Dakota 58122 Recruiting
Premier Health Centerville Ohio 45459 Recruiting
Univ of Cincinnati Medical Center Cincinnati Ohio 45219 Recruiting
Cleveland Clinic Foundation Cleveland Ohio 44195 Recruiting
Ohio Health Research Institute Columbus Ohio 43214 Recruiting
Premier Neurology Greenville South Carolina 29605 Recruiting
Sibyl Wray MD Neurology PC Knoxville Tennessee 37922 Recruiting
Austin Regional Clinic Austin Texas 78731 Recruiting
Univ of Texas Southwest Med Center Dallas Texas 75390-9034 Recruiting
John Peter Smith Hospital Fort Worth Texas 76104 Recruiting
Saturn Research Solutions LLC Plano Texas 75024 Recruiting
Center for Neurological Disorders G Greenfield Wisconsin 53228-1321 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 65 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06846281, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted May 18, 2026 · Synced May 19, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06846281 live on ClinicalTrials.gov.

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