A Study to Investigate Tonlamarsen for the Treatment of Adults With Uncontrolled Hypertension (KARDINAL)
Public ClinicalTrials.gov record NCT06864104. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Monthly Subcutaneous Administration of Tonlamarsen in Participants With Uncontrolled Hypertension (KARDINAL)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the blood pressure (BP)-lowering efficacy of tonlamarsen in adult participants who, despite taking 2 or more antihypertensive medications, have not achieved their target blood pressure (BP).
Study identification
- NCT ID
- NCT06864104
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 206 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 10, 2025 (Actual)
- Primary completion
- Jan 12, 2026 (Actual)
- Completion
- Mar 17, 2026 (Actual)
- Last update posted
- Mar 31, 2026
2025 – 2026
United States locations
- U.S. sites
- 39
- U.S. states
- 18
- U.S. cities
- 39
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pinnacle Research Group | Anniston | Alabama | 36207 | — |
| Achieve Clinical Research, LLC | Birmingham | Alabama | 35216 | — |
| Elite Clinical Studies | Phoenix | Arizona | 85018 | — |
| Del Sol Research Management, LLC | Tucson | Arizona | 85715 | — |
| Cardiology and Medicine Clinic | Little Rock | Arkansas | 72204 | — |
| North Coast Cardiology | Encinitas | California | 92024 | — |
| Orange County Research Center | Lake Forest | California | 92630 | — |
| Clinical Trials Research | Lincoln | California | 95648 | — |
| American Institute of Research | Los Angeles | California | 90017 | — |
| Homestead Associates in Research, Inc. | Homestead | Florida | 33033 | — |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | — |
| Suncoast Clinical Research, Inc. | New Port Richey | Florida | 34652 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| Agile Clinical Research Trials, LLC | Atlanta | Georgia | 30328 | — |
| Velocity Clinical Reseach | Savannah | Georgia | 31406 | — |
| Eagle Clinical Research | Chicago | Illinois | 60621 | — |
| Clinical Investigation Specialists, Inc. | Gurnee | Illinois | 60031 | — |
| Koch Family Medicine Clinical Research | Morton | Illinois | 61550 | — |
| Tandem Clinical Research GI, LLC | Marrero | Louisiana | 70072 | — |
| IMA Clinical Research | Monroe | Louisiana | 71201 | — |
| DelRicht Clinical Research - New Orleans | New Orleans | Louisiana | 70115 | — |
| ActivMed Practices & Research, LLC | Methuen | Massachusetts | 01844 | — |
| Oakland Medical Research Center | Troy | Michigan | 48085 | — |
| Olive Branch Family Medical Center | Olive Branch | Mississippi | 38654 | — |
| Richmond University Medical Center | Staten Island | New York | 10310 | — |
| CHEAR Center LLC | The Bronx | New York | 10455 | — |
| IMA Clinical Research | Lenoir | North Carolina | 28645 | — |
| Clinical Trials of South Carolina | Moncks Corner | South Carolina | 29461 | — |
| Health Concepts | Rapid City | South Dakota | 57702 | — |
| Holston Medical Group | Kingsport | Tennessee | 37660 | — |
| Central Texas Clinical Research | Austin | Texas | 78705 | — |
| Advanced Medical Trials, LLC | Georgetown | Texas | 78628 | — |
| Juno Research, LLC | Houston | Texas | 77040 | — |
| Radiance Clinical Research | Lampasas | Texas | 76550 | — |
| Synergy Groups Medical, LLC | Missouri City | Texas | 77459 | — |
| North Hills Medical Research | North Richland Hills | Texas | 76180 | — |
| Sun Research Institute | San Antonio | Texas | 78215 | — |
| Manassas Clinical Research Center | Manassas | Virginia | 20110 | — |
| York Clinical Research LLC | Norfolk | Virginia | 23504 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06864104, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 31, 2026 · Synced Nov 1, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06864104 live on ClinicalTrials.gov.