A Study to Investigate Tonlamarsen for the Treatment of Adults With Uncontrolled Hypertension (KARDINAL)
Public ClinicalTrials.gov record NCT06864104. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Monthly Subcutaneous Administration of Tonlamarsen in Participants With Uncontrolled Hypertension (KARDINAL)
Study identification
- NCT ID
- NCT06864104
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Kardigan, Inc.
- Industry
- Enrollment
- 206 participants
Conditions and interventions
Conditions
Interventions
- Tonlamarsen Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 9, 2025
- Primary completion
- Jan 11, 2026
- Completion
- Mar 16, 2026
- Last update posted
- Mar 30, 2026
2025 – 2026
United States locations
- U.S. sites
- 39
- U.S. states
- 18
- U.S. cities
- 39
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pinnacle Research Group | Anniston | Alabama | 36207 | — |
| Achieve Clinical Research, LLC | Birmingham | Alabama | 35216 | — |
| Elite Clinical Studies | Phoenix | Arizona | 85018 | — |
| Del Sol Research Management, LLC | Tucson | Arizona | 85715 | — |
| Cardiology and Medicine Clinic | Little Rock | Arkansas | 72204 | — |
| North Coast Cardiology | Encinitas | California | 92024 | — |
| Orange County Research Center | Lake Forest | California | 92630 | — |
| Clinical Trials Research | Lincoln | California | 95648 | — |
| American Institute of Research | Los Angeles | California | 90017 | — |
| Homestead Associates in Research, Inc. | Homestead | Florida | 33033 | — |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | — |
| Suncoast Clinical Research, Inc. | New Port Richey | Florida | 34652 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| Agile Clinical Research Trials, LLC | Atlanta | Georgia | 30328 | — |
| Velocity Clinical Reseach | Savannah | Georgia | 31406 | — |
| Eagle Clinical Research | Chicago | Illinois | 60621 | — |
| Clinical Investigation Specialists, Inc. | Gurnee | Illinois | 60031 | — |
| Koch Family Medicine Clinical Research | Morton | Illinois | 61550 | — |
| Tandem Clinical Research GI, LLC | Marrero | Louisiana | 70072 | — |
| IMA Clinical Research | Monroe | Louisiana | 71201 | — |
| DelRicht Clinical Research - New Orleans | New Orleans | Louisiana | 70115 | — |
| ActivMed Practices & Research, LLC | Methuen | Massachusetts | 01844 | — |
| Oakland Medical Research Center | Troy | Michigan | 48085 | — |
| Olive Branch Family Medical Center | Olive Branch | Mississippi | 38654 | — |
| Richmond University Medical Center | Staten Island | New York | 10310 | — |
| CHEAR Center LLC | The Bronx | New York | 10455 | — |
| IMA Clinical Research | Lenoir | North Carolina | 28645 | — |
| Clinical Trials of South Carolina | Moncks Corner | South Carolina | 29461 | — |
| Health Concepts | Rapid City | South Dakota | 57702 | — |
| Holston Medical Group | Kingsport | Tennessee | 37660 | — |
| Central Texas Clinical Research | Austin | Texas | 78705 | — |
| Advanced Medical Trials, LLC | Georgetown | Texas | 78628 | — |
| Juno Research, LLC | Houston | Texas | 77040 | — |
| Radiance Clinical Research | Lampasas | Texas | 76550 | — |
| Synergy Groups Medical, LLC | Missouri City | Texas | 77459 | — |
| North Hills Medical Research | North Richland Hills | Texas | 76180 | — |
| Sun Research Institute | San Antonio | Texas | 78215 | — |
| Manassas Clinical Research Center | Manassas | Virginia | 20110 | — |
| York Clinical Research LLC | Norfolk | Virginia | 23504 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06864104, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 30, 2026 · Synced Jul 22, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06864104 live on ClinicalTrials.gov.