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Recruiting Phase 3 Interventional

The AIRTIVITY™ Study: A Study to Find Out Whether BI 1291583 Helps People With Bronchiectasis

ClinicalTrials.gov ID: NCT06872892

Public ClinicalTrials.gov record NCT06872892. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 4, 2026, 6:25 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase III, Randomised, Double-blind, Placebo-controlled Study to Assess the Efficacy, Safety, and Tolerability of BI 1291583 2.5 mg Administered Once Daily for up to 76 Weeks in Patients With Bronchiectasis (The AIRTIVITY™ Study)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This study is open to adults and adolescents aged 12 to under 18 with bronchiectasis. People can participate in this study if they produce sputum and have had flare-ups (also called exacerbations). The purpose of this study is to find out whether a medicine called BI 1291583 helps people with bronchiectasis. Participants are put into 2 groups randomly, which means by chance. One group takes BI 1291583 tablets and the other group takes placebo tablets. A placebo tablet looks like the BI 1291583 tablet but does not contain any medicine. Participants take 1 tablet once a day for up to 1 year and 6 months. Participants are in the study for up to 1 year and 8 months. During this time, participants visit the study site up to 10 times and get about 13 phone calls from the site staff. Participants regularly complete a diary on a smartphone about their bronchiectasis symptoms and study doctors regularly check for any changes. The study doctors document when participants experience flare-ups. The number of flare-ups is compared between the participants who receive BI 1291583 and those who receive the placebo. The study doctors also regularly check participants' health and take note of any unwanted effects.

Study identification

NCT ID
NCT06872892
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Boehringer Ingelheim
Industry
Enrollment
1,755 participants

Conditions and interventions

Conditions

Interventions

Drug

Eligibility (public fields only)

Age range
12 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jun 8, 2025
Primary completion
Jun 14, 2027
Completion
Dec 19, 2027
Last update posted
Sep 2, 2026

2025 – 2027

United States locations

U.S. sites
78
U.S. states
33
U.S. cities
70
Facility City State ZIP Site status
University of Alabama at Birmingham Birmingham Alabama 35233 Recruiting
Dignity Health, St. Joseph's Hospital and Medical Center Phoenix Arizona 85013 Not yet recruiting
University of Arizona Tucson Arizona 85724 Active, not recruiting
Newport Native MD, Inc Newport Beach California 92663 Active, not recruiting
Paradigm Clinical Research - Redding Redding California 96001 Active, not recruiting
University of California Davis Sacramento California 95817 Active, not recruiting
University of California San Francisco San Francisco California 94143 Active, not recruiting
Ventura County Medical Center Ventura California 93003 Completed
National Jewish Health Denver Colorado 80206 Active, not recruiting
Yale University School of Medicine North Haven Connecticut 06473 Active, not recruiting
Georgetown University Washington D.C. District of Columbia 20007 Active, not recruiting
Central Florida Pulmonary Group Altamonte Springs Florida 32701 Not yet recruiting
Meris Clinical Research-Brandon-69466 Brandon Florida 33511 Active, not recruiting
St. Francis Medical Institute Clearwater Florida 33765 Completed
North Florida/South Georgia Veterans Health System Gainesville Florida 32608 Completed
University of Florida College of Medicine Jacksonville Florida 32209 Completed
Mayo Clinic - Florida Jacksonville Florida 32224 Active, not recruiting
University of Miami Miami Florida 33136 Active, not recruiting
Essence MD Research Naples Florida 34102 Active, not recruiting
Vantage Clinical Trials - Tampa Tampa Florida 33614 Active, not recruiting
Cleveland Clinic Florida Weston Florida 33331 Active, not recruiting
Emory University Atlanta Georgia 30342 Recruiting
Augusta University Augusta Georgia 30912 Recruiting
Northwestern University Chicago Illinois 60611 Not yet recruiting
Indiana University Indianapolis Indiana 46202 Completed
University of Iowa Hospitals and Clinics Iowa City Iowa 52242 Completed
University of Kansas Medical Center Kansas City Kansas 66160 Active, not recruiting
Johns Hopkins Hospital Baltimore Maryland 21287 Recruiting
University of Maryland St. Joseph Medical Group Pulmonary Care and Sleep Medicine Towson Maryland 21286 Completed
Massachusetts General Hospital Boston Massachusetts 02114 Active, not recruiting
UMASS Memorial Medical Center Worcester Massachusetts 01655 Active, not recruiting
University of Michigan Ann Arbor Michigan 48109 Active, not recruiting
Mayo Clinic, Rochester Rochester Minnesota 55902 Active, not recruiting
HealthPartners Specialty Center 401 Building Saint Paul Minnesota 55130 Active, not recruiting
University Of Mississippi Medical Center Jackson Mississippi 39216 Active, not recruiting
The Lung Research Center, LLC Chesterfield Missouri 63017 Completed
Washington University School of Medicine St Louis Missouri 63110 Completed
University of Nebraska Medical Center Omaha Nebraska 68198-1230 Active, not recruiting
Dartmouth-Hitchcock Medical Center Lebanon New Hampshire 03766 Recruiting
Rutgers Robert Wood Johnson Medical School New Brunswick New Jersey 08901 Recruiting
New York Medical College - Hawthorne Hawthorne New York 10532 Recruiting
Northwell Health New Hyde Park New York 11040 Active, not recruiting
New York University Langone Medical Center New York New York 10016 Completed
Icahn School of Medicine at Mount Sinai New York New York 10029 Active, not recruiting
Columbia University Medical Center-New York Presbyterian Hospital New York New York 10032 Active, not recruiting
NewYork-Presbyterian/Weill Cornell Medical Center New York New York 10065 Completed
The University of North Carolina at Chapel Hill Chapel Hill North Carolina 27514 Completed
Stern Research Partners, LLC Huntersville North Carolina 28078 Active, not recruiting
Pinehurst Medical Clinic, Inc. - East Pinehurst North Carolina 28374 Active, not recruiting
Akron Children's Hospital Akron Ohio 44308 Recruiting
University of Cincinnati Cincinnati Ohio 45219 Active, not recruiting
University Hospitals Cleveland Medical Center Cleveland Ohio 44106 Active, not recruiting
ProMedica Physicians Pulmonary and Sleep Medicine - Toledo Toledo Ohio 43606 Not yet recruiting
Oregon Health and Sciences University Portland Oregon 97239 Recruiting
Clinical Research Associates of Central PA DuBois Pennsylvania 15801 Active, not recruiting
University of Pennsylvania Philadelphia Pennsylvania 19104 Active, not recruiting
Jefferson Health Honickman Center Philadelphia Pennsylvania 19107 Active, not recruiting
Medical University of South Carolina Charleston South Carolina 29425 Completed
Clinical Research of Rock Hill Rock Hill South Carolina 29732 Active, not recruiting
Horizon Clinical Research Group Cypress Texas 77429 Active, not recruiting
Baylor University Medical Center Dallas Texas 75246 Active, not recruiting
University of Texas Southwestern Medical Center Dallas Texas 75390 Active, not recruiting
El Paso Pulmonary Association El Paso Texas 79902 Active, not recruiting
University of Texas Medical Branch at Galveston Galveston Texas 77555 Active, not recruiting
Baylor College of Medicine Houston Texas 77030 Active, not recruiting
Metroplex Pulmonary & Sleep Center McKinney Texas 75069 Active, not recruiting
Methodist Heart and Lung Institute San Antonio Texas 78229 Not yet recruiting
University of Texas Health Science Center at San Antonio San Antonio Texas 78229 Recruiting
Element Research Group San Antonio Texas 78258 Completed
University of Texas Health Science Center at Tyler Tyler Texas 75708 Active, not recruiting
Intermountain Healthcare Murray Utah 84107 Active, not recruiting
University of Vermont Burlington Vermont 05401 Active, not recruiting
Inova Fairfax Medical Campus Falls Church Virginia 22042 Active, not recruiting
Virginia Commonwealth University Health Systems Richmond Virginia 23219 Active, not recruiting
University of Washington Seattle Washington 98195 Active, not recruiting
Providence Medical Research Center Spokane Washington 99204 Active, not recruiting
University of Wisconsin Madison Wisconsin 53792 Active, not recruiting
Froedtert and The Medical College of Wisconsin Milwaukee Wisconsin 53226 Active, not recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 391 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06872892, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Sep 2, 2026 · Synced Sep 4, 2026

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The complete protocol, eligibility criteria, and contact information for NCT06872892 live on ClinicalTrials.gov.

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