A Study to Evaluate the Efficacy and Safety of Once-Weekly MET097 in Adults With Obesity or Overweight and T2DM
Public ClinicalTrials.gov record NCT06897202. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2b, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Once-Weekly MET097 in Adults With Obesity or Overweight, and Type 2 Diabetes Mellitus (VESPER-2)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is designed to test how well once-weekly MET097 (an ultra-long-acting GLP-1 receptor agonist) works to treat adults with obesity or overweight and type 2 diabetes mellitus (T2DM) compared to placebo. MET097 or placebo will be administered to individuals via subcutaneous injection once weekly for 28 weeks. If an individual is randomly assigned to MET097 they will receive one of four different dose regimens.
Study identification
- NCT ID
- NCT06897202
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 133 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 13, 2025
- Primary completion
- Dec 28, 2025
- Completion
- Mar 17, 2026
- Last update posted
- Jun 11, 2026
2025 – 2026
United States locations
- U.S. sites
- 29
- U.S. states
- 12
- U.S. cities
- 26
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| KUR Research | Bessemer | Alabama | 35022 | — |
| ProSciento, Inc. | Chula Vista | California | 91911 | — |
| Michael Roberts Opthamologist (Eye Exam) | Glendale | California | 91204 | — |
| Eye Treatment Center | Long Beach | California | 90807 | — |
| Collaborative Neuroscience Research, LLC | Los Alamitos | California | 90720 | — |
| Velocity Clinical Research, Los Angeles | Los Angeles | California | 90017 | — |
| Clinical Innovations, Inc dba CITrials | Riverside | California | 92506 | — |
| Synergy Healthcare | Bradenton | Florida | 34209 | — |
| Miami Eye Institute | Hollywood | Florida | 33024 | — |
| Research Centers of America | Hollywood | Florida | 33024 | — |
| ForCare Clinical Research | Tampa | Florida | 33613 | — |
| CenExel iResearch, LLC | Decatur | Georgia | 30030 | — |
| EmVenio Research Centre at PRIME Healthcare | Riverdale | Georgia | 30274 | — |
| CenExel iResearch, LLC | Savannah | Georgia | 31405 | — |
| Koch Family Medicine Clinical Research | Morton | Illinois | 61550 | — |
| Bioluminux Clinical Research | Naperville | Illinois | 60540 | — |
| EmVenio Research Centre at PRIME Healthcare | Kansas City | Kansas | 66112 | — |
| Eagle Eye Care | Columbia | Maryland | 21045 | — |
| KUR Research, LLC | Columbia | Maryland | 21045 | — |
| CBH Health, LLC. | Gaithersburg | Maryland | 20877 | — |
| Emvenio Research | Garden City | Michigan | 48135 | — |
| Velocity Clinical Research | Omaha | Nebraska | 68134 | — |
| Advocare Berlin Medical Associates | Berlin | New Jersey | 08009 | — |
| Hassman Research Institute | Marlton | New Jersey | 08053 | — |
| Onsite Clinical Solutions, LLC (Satellite site) | Charlotte | North Carolina | 28277 | — |
| Onsite Clinical Solutions, LLC | Charlotte | North Carolina | 28277 | — |
| EmVenio Research Centre at PRIME Healthcare | Farmers Branch | Texas | 75234 | — |
| Research Your Health | Plano | Texas | 75093 | — |
| Revival Research Institute, LLC | Sherman | Texas | 75092 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06897202, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 11, 2026 · Synced Sep 8, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06897202 live on ClinicalTrials.gov.